LOCUS       NM_005011               3518 bp    mRNA    linear   PRI 16-NOV-2024
DEFINITION  Homo sapiens nuclear respiratory factor 1 (NRF1), transcript
            variant 1, mRNA.
ACCESSION   NM_005011
VERSION     NM_005011.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Dewanjee,S., Bhattacharya,H., Bhattacharyya,C., Chakraborty,P.,
            Fleishman,J., Alexiou,A., Papadakis,M. and Jha,S.K.
  TITLE     Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new
            horizon in brain tumor management
  JOURNAL   Cell Commun Signal 22 (1), 497 (2024)
   PUBMED   39407193
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Ward,M.A., Vangala,J.R., Kamber Kaya,H.E., Byers,H.A., Hosseini,N.,
            Diaz,A., Cuervo,A.M., Kaushik,S. and Radhakrishnan,S.K.
  TITLE     Transcription factor Nrf1 regulates proteotoxic stress-induced
            autophagy
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38656405
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Liu,K., Li,W., Xiao,Y., Lei,M., Zhang,M. and Min,J.
  TITLE     Molecular mechanism of specific DNA sequence recognition by NRF1
  JOURNAL   Nucleic Acids Res 52 (2), 953-966 (2024)
   PUBMED   38055835
  REMARK    GeneRIF: Molecular mechanism of specific DNA sequence recognition
            by NRF1.
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Liu,K., Hu,S., Qiu,L., Wang,M., Zhang,Z., Sun,G. and Zhang,Y.
  TITLE     Nrf1 is not a direct target gene of SREBP1, albeit both are
            integrated into the rapamycin-responsive regulatory network in
            human hepatoma cells
  JOURNAL   PLoS One 18 (11), e0294508 (2023)
   PUBMED   38011090
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Spelbrink,J.N. and Van den Bogert,C.
  TITLE     The pre-mRNA of nuclear respiratory factor 1, a regulator of
            mitochondrial biogenesis, is alternatively spliced in human tissues
            and cell lines
  JOURNAL   Hum Mol Genet 4 (9), 1591-1596 (1995)
   PUBMED   8541844
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Gopalakrishnan,L. and Scarpulla,R.C.
  TITLE     Structure, expression, and chromosomal assignment of the human gene
            encoding nuclear respiratory factor 1
  JOURNAL   J Biol Chem 270 (30), 18019-18025 (1995)
   PUBMED   7629110
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Tiranti,V., Rossi,E., Rocchi,M., DiDonato,S., Zuffardi,O. and
            Zeviani,M.
  TITLE     The gene (NFE2L1) for human NRF-1, an activator involved in
            nuclear-mitochondrial interactions, maps to 7q32
  JOURNAL   Genomics 27 (3), 555-557 (1995)
   PUBMED   7558044
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Efiok,B.J., Chiorini,J.A. and Safer,B.
  TITLE     A key transcription factor for eukaryotic initiation factor-2 alpha
            is strongly homologous to developmental transcription factors and
            may link metabolic genes to cellular growth and development
  JOURNAL   J Biol Chem 269 (29), 18921-18930 (1994)
   PUBMED   8034649
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Virbasius,J.V. and Scarpulla,R.C.
  TITLE     Activation of the human mitochondrial transcription factor A gene
            by nuclear respiratory factors: a potential regulatory link between
            nuclear and mitochondrial gene expression in organelle biogenesis
  JOURNAL   Proc Natl Acad Sci U S A 91 (4), 1309-1313 (1994)
   PUBMED   8108407
REFERENCE   10 (bases 1 to 3518)
  AUTHORS   Jacob,W.F., Silverman,T.A., Cohen,R.B. and Safer,B.
  TITLE     Identification and characterization of a novel transcription factor
            participating in the expression of eukaryotic initiation factor 2
            alpha
  JOURNAL   J Biol Chem 264 (34), 20372-20384 (1989)
   PUBMED   2584221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY166547.1, AK290891.1,
            AK293351.1, AC084864.4 and BM993780.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005011.4.
            
            Summary: This gene encodes a protein that homodimerizes and
            functions as a transcription factor which activates the expression
            of some key metabolic genes regulating cellular growth and nuclear
            genes required for respiration, heme biosynthesis, and
            mitochondrial DNA transcription and replication. The protein has
            also been associated with the regulation of neurite outgrowth.
            Alternative splicing results in multiple transcript variants.
            Confusion has occurred in bibliographic databases due to the shared
            symbol of NRF1 for this gene and for 'nuclear factor
            (erythroid-derived 2)-like 1' which has an official symbol of
            NFE2L1. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks an alternate in-frame exon in the 3' coding region, compared
            to variant 3. The encoded protein (isoform 1) is shorter, compared
            to isoform 2. Variants 1 and 2 encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660805.69841.1, SRR1660803.3113.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393232.6/ ENSP00000376924.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                HY166547.1         19-81
            64-1317             AK290891.1         1-1254
            1318-1662           AK293351.1         1187-1531
            1663-1869           AK290891.1         1600-1806
            1870-3084           AC084864.4         46471-47685
            3085-3518           BM993780.1         23-456              c
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..3518
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="nuclear respiratory factor 1"
                     /db_xref="GeneID:4899"
                     /db_xref="HGNC:HGNC:7996"
                     /db_xref="MIM:600879"
     exon            1..105
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            106..334
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1623
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="isoform 1 is encoded by transcript variant 1; alpha
                     palindromic-binding protein"
                     /codon_start=1
                     /product="nuclear respiratory factor 1 isoform 1"
                     /protein_id="NP_005002.3"
                     /db_xref="CCDS:CCDS5813.2"
                     /db_xref="GeneID:4899"
                     /db_xref="HGNC:HGNC:7996"
                     /db_xref="MIM:600879"
                     /translation="MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDS
                     PSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPS
                     IRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYK
                     SMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTG
                     RGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGRE
                     DLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADA
                     SELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAA
                     SQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG
                     LVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ"
     exon            335..449
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            450..576
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            577..717
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            718..876
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1074
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1176
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1334
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1459
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..3518
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2429..2434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="hexamer: ATTAAA"
     polyA_site      2457
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="major polyA site"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="hexamer: ATTAAA"
     polyA_site      3167
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="major polyA site"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="NRF1"
                     /gene_synonym="ALPHA-PAL"
ORIGIN      
        1 agaagcggca gcgctcgcca ttgccgctgg tggcaggagg ctgcgaggag ccggcgcggt
       61 cgcagtctcc acggcgcagg cccacggtag cgcagccgct ctgagaactt catggaggaa
      121 cacggagtga cccaaaccga acatatggct accatagaag cacatgcagt ggcccagcaa
      181 gtgcagcagg tccatgtggc tacttacacc gagcatagta tgctgagtgc tgatgaagac
      241 tcgccttctt ctcccgagga cacctcttac gatgactcag atatactcaa ctccacagca
      301 gctgatgagg tgacagctca tctggcagct gcaggtcctg tgggaatggc cgctgctgct
      361 gctgtggcaa caggaaagaa acggaaacgg cctcatgtat ttgagtctaa tccatctatc
      421 cggaagaggc aacaaacacg tttgcttcgg aaacttcgag ccacgttaga tgaatatact
      481 actcgtgtgg gacagcaagc tattgtcctc tgtatctcac cctccaaacc taaccctgtc
      541 tttaaagtgt ttggtgcagc acctttggag aatgtggtgc gtaagtacaa gagcatgatc
      601 ctggaagacc tggagtctgc tctggcagaa cacgcccctg cgccacagga ggttaactca
      661 gaactgccgc ctctcaccat cgacggaatt ccagtctctg tggacaaaat gacccaggcc
      721 cagcttcggg catttatccc agagatgctc aagtactcta caggtcgggg aaaaccaggc
      781 tgggggaaag aaagctgcaa gcccatctgg tggcctgaag atatcccctg ggcaaatgtc
      841 cggagtgatg tccgcacaga agagcaaaag cagagggttt catggaccca ggcactacgg
      901 accatagtta aaaactgtta taaacagcat gggcgggaag accttttgta tgcctttgaa
      961 gatcagcaaa cgcaaacaca ggccacagcc acacatagta tagctcatct tgtaccatca
     1021 cagactgtag tccagacttt tagtaaccct gatggcactg tctcacttat ccaggttggt
     1081 acgggggcaa cagtagccac attggctgat gcttcagaat tgccaaccac ggtcaccgtt
     1141 gcccaagtga attattctgc cgtggctgat ggagaggtgg aacaaaattg ggccacgtta
     1201 cagggaggtg agatgaccat ccagacgacg caagcatcag aggccaccca ggcggtggca
     1261 tcgttggcag aggccgcagt ggcagcttct caggagatgc agcagggagc tacagtcact
     1321 atggcgctta acagcgaagc tgccgcccat gctgtcgcca ccctggctga ggccacctta
     1381 caaggtgggg gacagatcgt cttgtctggg gaaaccgcag cagccgtcgg agcacttact
     1441 ggagtccaag atgctaatgg cctggtccag atccctgtga gcatgtacca gactgtggtg
     1501 accagcctcg cccagggcaa cggaccagtg caggtggcca tggcccctgt gaccaccagg
     1561 atatcagaca gcgcagtcac catggacggc caagctgtgg aggtggtgac attggaacag
     1621 tgacatacag ccatattatg gcatcgtttt ctagtctact tcaaaatttt ttacacgttt
     1681 gcagaggtgc aatcaaatgg aattaagtct ctcgactttg gaaggaaagt tttgttaacc
     1741 tttttttttt taaaaggaag aaagcggatt ttggaattgc attttttaaa gcaccactct
     1801 tgattttctg ggattggtga agaaactgca ttgtcaattt cactgtccca aaaaagccaa
     1861 attgtggcag gacttctttc tgcggaaatg tgtgtgtata cttatgtgtg tgtatgtgtg
     1921 agtgtgaata tatgtatatg tgtacatatg gacatacaca tttacatata tataaagtat
     1981 atatatacat atatatatat atatatgtat gaaacccgca tggaattatc tgtatgaaat
     2041 caaggtgcgc tgtggaaaca ataattcacc cagtttagtg ggtggtaggg tacgtggcca
     2101 gacacagtca cccagttttt gttcatacca gggtcatgcg ttgagctact gacaaactca
     2161 ggcggaggtg accatgccct tcaccaaagc tgcctcccag tggccacaca gaactctccc
     2221 tgctggactc acctgaggaa agaggctcca gcatggggtg ggtcagagat gtgcttgcaa
     2281 ggtccaggga ctgcgtggtc tgccagctga gatgctcctc gggctggccc aggtgctgac
     2341 cttgccacag gcagatgaat gtcttgaaag ctcccgggcc tcagcctccc atctcctctc
     2401 cttcccagga atccttgatc tcatgactat taaaatgttg ctctggtttt aaggtcagtc
     2461 ctgaattgct cgtatatatg aactgaaggt aaccgaagta ttaggggttt gaggagtgcg
     2521 tgcgtgtaag tgtgcttgtg tgtgtgcgtg catggtgggg gagaggatgg gaagggggcg
     2581 ggggcagtgg aagggaaagg aaggaaagaa aaatcgtcct agaccaggat acacccgtgg
     2641 gagcaatttt ctctactgtc tgtagcttca cagaggaggc gctggaatga acaagaagag
     2701 acatctggtc tgtggccaca gcaccctgaa cgcccctgat cttgtgtgat cttggaagct
     2761 aagcttggtt gggcccggtc agtacgcgga agggaagaag ggacacctgg ccatagaaaa
     2821 cagctgaggg tgtttgctgt gttcctggat caggccctgc ttcagaaggg actcctggag
     2881 gcccatgttc cttgatgcaa cctcgtggcc caggccggga gcagcttgcc tcctcagagg
     2941 tgttgactat ctgggtgttc ttggtaaccg ttaactctgt ctttctcagc tgcaagccct
     3001 gagtctccag tagctgaatt cacctgactt ttcaacaggc caaatctctg aaccttgagt
     3061 acagggacag ctcctcctcc ctcctcccag ctctccccat gtgtgtgatg gtgtatttaa
     3121 tgtgtttttt taatgcgaca ttaaaagatt ctccacgtct tgctcaacct ttgagagaag
     3181 tttcagattc ttgtatttgc ttgttttata taaaactatc taatgttctt tatatgttct
     3241 tttctgtacg taatgggggg aggggaggga aatttacata taaatagtcc tagttctaca
     3301 atttgttatt tttttaatta ttatttttta tcgtcattgt gaagttgtcc agggacttta
     3361 aagtccatgt tcctttgtgg tgaaataacc tccaaatagt ttgagaagtt gccaagacga
     3421 agaaaaaagc aaaaccccag tagcagagca tggattctgt gttgtttccc attctgtctt
     3481 tgactgcctc attcaataaa tagttaaaaa tgtggcaa
//
