LOCUS       NM_004772               1942 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens neuronal regeneration related protein (NREP),
            transcript variant 1, mRNA.
ACCESSION   NM_004772
VERSION     NM_004772.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   De Jesus,D.F., Kimura,T., Gupta,M.K. and Kulkarni,R.N.
  TITLE     NREP contributes to development of NAFLD by regulating one-carbon
            metabolism in primary human hepatocytes
  JOURNAL   Cell Chem Biol 30 (9), 1144-1155 (2023)
   PUBMED   37354909
  REMARK    GeneRIF: NREP contributes to development of NAFLD by regulating
            one-carbon metabolism in primary human hepatocytes.
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
  REMARK    GeneRIF: P311 Promotes IL-4 Receptor-Mediated M2 Polarization of
            Macrophages to Enhance Angiogenesis for Efficient Skin Wound
            Healing.
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Duan,F.F., Barron,G., Meliton,A., Mutlu,G.M., Dulin,N.O. and
            Schuger,L.
  TITLE     P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth
            Factor-beta1, -beta2, and -beta3 Translation
  JOURNAL   Am J Respir Cell Mol Biol 60 (2), 221-231 (2019)
   PUBMED   30230348
  REMARK    GeneRIF: P311 expression in the in the lungs of patients with
            idiopathic pulmonary fibrosis.
REFERENCE   5  (bases 1 to 1942)
  AUTHORS   Cheng,T., Yue,M., Aslam,M.N., Wang,X., Shekhawat,G., Varani,J. and
            Schuger,L.
  TITLE     Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar
            Collagen Deposition and Tensile Strength due to Impaired
            Transforming Growth Factor-beta1 to -beta3 Translation
  JOURNAL   Am J Pathol 187 (2), 292-303 (2017)
   PUBMED   27939132
  REMARK    GeneRIF: These studies demonstrate that P311 is required for the
            production of normal cutaneous scars
REFERENCE   6  (bases 1 to 1942)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
REFERENCE   7  (bases 1 to 1942)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   8  (bases 1 to 1942)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   9  (bases 1 to 1942)
  AUTHORS   Taylor,G.A., Hudson,E., Resau,J.H. and Vande Woude,G.F.
  TITLE     Regulation of P311 expression by Met-hepatocyte growth
            factor/scatter factor and the ubiquitin/proteasome system
  JOURNAL   J Biol Chem 275 (6), 4215-4219 (2000)
   PUBMED   10660586
REFERENCE   10 (bases 1 to 1942)
  AUTHORS   Studler,J.M., Glowinski,J. and Levi-Strauss,M.
  TITLE     An abundant mRNA of the embryonic brain persists at a high level in
            cerebellum, hippocampus and olfactory bulb during adulthood
  JOURNAL   Eur J Neurosci 5 (6), 614-623 (1993)
   PUBMED   8261136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072443.1 and CN415439.1.
            
            On Jul 10, 2019 this sequence version replaced NM_004772.3.
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (a). Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072443.1, DA603512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257435.12/ ENSP00000257435.7
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1342              BC072443.1         19-1360
            1343-1347           CN415439.1         574-578
            1348-1942           BC072443.1         1366-1960
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..1942
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
     exon            1..59
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            60..120
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..324
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="isoform a is encoded by transcript variant 1;
                     neuronal protein 3.1; protein p311; neuronal regeneration
                     related protein homolog"
                     /codon_start=1
                     /product="neuronal regeneration-related protein isoform a"
                     /protein_id="NP_004763.1"
                     /db_xref="CCDS:CCDS4105.1"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
                     /translation="MVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDET
                     NAASLTPLGSSELRSPRISYLHFF"
     exon            121..198
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            199..1942
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      1942
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 acatttgtgt ttcaggtgta gagaggagag agagtgaaca gggagcgggg cttttgtctg
       61 ttggtctccc tggactgaag agagggagaa tagaagccca agactaagat tctcaaaatg
      121 gtttattacc cagaactctt tgtctgggtc agtcaagaac catttccaaa caaggacatg
      181 gagggaaggc ttcctaaggg aagacttcct gtcccaaagg aagtgaaccg caagaagaac
      241 gatgagacaa acgctgcctc cctgactcca ctgggcagca gtgaactccg ctccccaaga
      301 atcagttacc tccacttttt ttaatcgtaa cacctccatt tgtattacat atggtgtatg
      361 ggtattgatg aggtcatggt atcatatatg ggattttttt ctgtgtaaat catcaagtat
      421 aagaagaaac tatgggactc tgagccttgc tttagagaat ttacagtgga caaataggtg
      481 tcatcaaacc agtttttaat cattctgact caagtgaaaa cgctcagaat ttcacactgt
      541 gaatccacgt ttacaaccct tacaggtggg ccttcaggcc tggttcgcta caacaatgtc
      601 ttccacaact caaactccca ccgcgctcac acaaccggtc cactcctgcc ttttcactca
      661 cacagctccc gactgcttct tgcagaggct gagagtcccc cccccacctt ttttttcatt
      721 tagatgtaac aaacctagta gtttatgttc atcaattgtc tgtatatctc tatattttat
      781 ccatgtactc ttttgatgta tagaagtagt ttgaaactca ttgtttcctt gtggtaagtg
      841 accgagatgc tgccacagga cctgagacac tgatgaatgg tgctattttg gactttcaac
      901 atgctccttg gcgaggtagc tctgatggag ttatttttta tttccatgtt ctaagaaggt
      961 gttggtactc tgtttccctg aatgttgttc tctagactgg attgacttgt tttccttgtg
     1021 tcttcagtgt ggctttcttc ctcagtgttg taggttgagc gaatgctacc agagtgtgag
     1081 agaccattgt ctcgttggct ggcgctcacg gacatgcagt cacggtagcg ggagcaatca
     1141 caaaactgta atttacttac caaatctctt cctttccgta gcctcgcctg cctgacttag
     1201 agaaagaaaa gcaataattt tacaggcatt ttgaggtgtc tctttgggtt ctttctgttt
     1261 gaaaggatat ttgtcgaaaa aaagagcaaa accgttttaa ataaactccc cctggaaaaa
     1321 aacccaaaac actggcatct gagtgggaat atgaaaatga caccttttcc aaatattaaa
     1381 ttggaaaaca aggtctacaa aatcatgata cttttttaaa aggcagagca ttcttttttc
     1441 ggcaattttg ataagcaagg tgtagattta catttttgtc cttgctccca acgaaatgga
     1501 taaacaaaaa taaattacca tctactcatg gaatgttgtt gtgttagcca gtctgaaagc
     1561 ccaccttaat ttttatataa ctgtctttag ctcttctttt gacagggcag gccttgttct
     1621 gaactgtttc gcttctgact gttaaacacc gatgacgcat gcactgcact tcttcgtttt
     1681 cttcttgctc ccccattggc ctgagtttct tgtgcattac tcctctccct ccttcgttag
     1741 aataggtata tcagctgtgt aaatagagca agaaaacagt attctgcatc tgtggcattt
     1801 atgtagagtt gcagttgtgt actgctgaaa atgcaggctt ttgtaacagt gtgatcttta
     1861 ctgatgcact catgacaagt acccaatgta ttttagctat tttagtagta tttgttcaat
     1921 aaatacgcaa gctgtaaggt aa
//
