LOCUS       NM_001142483            2304 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens neuronal regeneration related protein (NREP),
            transcript variant 11, mRNA.
ACCESSION   NM_001142483
VERSION     NM_001142483.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   De Jesus,D.F., Kimura,T., Gupta,M.K. and Kulkarni,R.N.
  TITLE     NREP contributes to development of NAFLD by regulating one-carbon
            metabolism in primary human hepatocytes
  JOURNAL   Cell Chem Biol 30 (9), 1144-1155 (2023)
   PUBMED   37354909
  REMARK    GeneRIF: NREP contributes to development of NAFLD by regulating
            one-carbon metabolism in primary human hepatocytes.
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
  REMARK    GeneRIF: P311 Promotes IL-4 Receptor-Mediated M2 Polarization of
            Macrophages to Enhance Angiogenesis for Efficient Skin Wound
            Healing.
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Duan,F.F., Barron,G., Meliton,A., Mutlu,G.M., Dulin,N.O. and
            Schuger,L.
  TITLE     P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth
            Factor-beta1, -beta2, and -beta3 Translation
  JOURNAL   Am J Respir Cell Mol Biol 60 (2), 221-231 (2019)
   PUBMED   30230348
  REMARK    GeneRIF: P311 expression in the in the lungs of patients with
            idiopathic pulmonary fibrosis.
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Cheng,T., Yue,M., Aslam,M.N., Wang,X., Shekhawat,G., Varani,J. and
            Schuger,L.
  TITLE     Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar
            Collagen Deposition and Tensile Strength due to Impaired
            Transforming Growth Factor-beta1 to -beta3 Translation
  JOURNAL   Am J Pathol 187 (2), 292-303 (2017)
   PUBMED   27939132
  REMARK    GeneRIF: These studies demonstrate that P311 is required for the
            production of normal cutaneous scars
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Taylor,G.A., Hudson,E., Resau,J.H. and Vande Woude,G.F.
  TITLE     Regulation of P311 expression by Met-hepatocyte growth
            factor/scatter factor and the ubiquitin/proteasome system
  JOURNAL   J Biol Chem 275 (6), 4215-4219 (2000)
   PUBMED   10660586
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Studler,J.M., Glowinski,J. and Levi-Strauss,M.
  TITLE     An abundant mRNA of the embryonic brain persists at a high level in
            cerebellum, hippocampus and olfactory bulb during adulthood
  JOURNAL   Eur J Neurosci 5 (6), 614-623 (1993)
   PUBMED   8261136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA534424.1, DA078027.1 and AC022108.4.
            
            Transcript Variant: This variant (11) differs in the 5' UTR,
            compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.76382.1,
                                           SRR1660807.240254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               DA534424.1         1-590
            591-867             DA078027.1         316-592
            868-2304            AC022108.4         161347-162783       c
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..2304
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
     exon            1..482
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..686
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="isoform a is encoded by transcript variant 11;
                     neuronal protein 3.1; protein p311; neuronal regeneration
                     related protein homolog"
                     /codon_start=1
                     /product="neuronal regeneration-related protein isoform a"
                     /protein_id="NP_001135955.1"
                     /db_xref="CCDS:CCDS4105.1"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
                     /translation="MVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDET
                     NAASLTPLGSSELRSPRISYLHFF"
     exon            483..560
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            561..2304
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2304
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 actctgaggc attacactac acggtggaag gctgattcct attctgtcgt cttgattgca
       61 aatatactgc cagtagtatg tctgggaaca aagagcagcc agaaaacaat ctatttttat
      121 cacttggttc tacttttaag ttgctaaacc ttttgaactc atgcaattta aagatgaacc
      181 aaacactaag aatagcccag gactctgcaa agccaagtac cagggattcc tttgtccctt
      241 agttaagcct ataggccact tggaaagctc tttcagaaat cccagtagtt aacaataatt
      301 tgcatgtaac ttatcttaac cacagaaaat ggttattcgt ctgtaacctc taaagaggca
      361 tttttcgttt gctgacctgt ggtgaggcga tgtgtctact gtatttaaac atattttgca
      421 ggttggtctc cctggactga agagagggag aatagaagcc caagactaag attctcaaaa
      481 tggtttatta cccagaactc tttgtctggg tcagtcaaga accatttcca aacaaggaca
      541 tggagggaag gcttcctaag ggaagacttc ctgtcccaaa ggaagtgaac cgcaagaaga
      601 acgatgagac aaacgctgcc tccctgactc cactgggcag cagtgaactc cgctccccaa
      661 gaatcagtta cctccacttt ttttaatcgt aacacctcca tttgtattac atatggtgta
      721 tgggtattga tgaggtcatg gtatcatata tgggattttt ttctgtgtaa atcatcaagt
      781 ataagaagaa actatgggac tctgagcctt gctttagaga atttacagtg gacaaatagg
      841 tgtcatcaaa ccagttttta atcattctga ctcaagtgaa aacgctcaga atttcacact
      901 gtgaatccac gtttacaacc cttacaggtg ggccttcagg cctggttcgc tacaacaatg
      961 tcttccacaa ctcaaactcc caccgcgctc acacaaccgg tccactcctg ccttttcact
     1021 cacacagctc ccgactgctt cttgcagagg ctgagagtcc cccccccacc ttttttttca
     1081 tttagatgta acaaacctag tagtttatgt tcatcaattg tctgtatatc tctatatttt
     1141 atccatgtac tcttttgatg tatagaagta gtttgaaact cattgtttcc ttgtggtaag
     1201 tgaccgagat gctgccacag gacctgagac actgatgaat ggtgctattt tggactttca
     1261 acatgctcct tggcgaggta gctctgatgg agttattttt tatttccatg ttctaagaag
     1321 gtgttggtac tctgtttccc tgaatgttgt tctctagact ggattgactt gttttccttg
     1381 tgtcttcagt gtggctttct tcctcagtgt tgtaggttga gcgaatgcta ccagagtgtg
     1441 agagaccatt gtctcgttgg ctggcgctca cggacatgca gtcacggtag cgggagcaat
     1501 cacaaaactg taatttactt accaaatctc ttcctttccg tagcctcgcc tgcctgactt
     1561 agagaaagaa aagcaataat tttacaggca ttttgaggtg tctctttggg ttctttctgt
     1621 ttgaaaggat atttgtcgaa aaaaagagca aaaccgtttt aaataaactc cccctggaaa
     1681 aaaacccaaa acactggcat ctgagtggga atatgaaaat gacacctttt ccaaatatta
     1741 aattggaaaa caaggtctac aaaatcatga tactttttta aaaggcagag cattcttttt
     1801 tcggcaattt tgataagcaa ggtgtagatt tacatttttg tccttgctcc caacgaaatg
     1861 gataaacaaa aataaattac catctactca tggaatgttg ttgtgttagc cagtctgaaa
     1921 gcccacctta atttttatat aactgtcttt agctcttctt ttgacagggc aggccttgtt
     1981 ctgaactgtt tcgcttctga ctgttaaaca ccgatgacgc atgcactgca cttcttcgtt
     2041 ttcttcttgc tcccccattg gcctgagttt cttgtgcatt actcctctcc ctccttcgtt
     2101 agaataggta tatcagctgt gtaaatagag caagaaaaca gtattctgca tctgtggcat
     2161 ttatgtagag ttgcagttgt gtactgctga aaatgcaggc ttttgtaaca gtgtgatctt
     2221 tactgatgca ctcatgacaa gtacccaatg tattttagct attttagtag tatttgttca
     2281 ataaatacgc aagctgtaag gtaa
//
