LOCUS       NM_001142477            2092 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens neuronal regeneration related protein (NREP),
            transcript variant 5, mRNA.
ACCESSION   NM_001142477
VERSION     NM_001142477.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   De Jesus,D.F., Kimura,T., Gupta,M.K. and Kulkarni,R.N.
  TITLE     NREP contributes to development of NAFLD by regulating one-carbon
            metabolism in primary human hepatocytes
  JOURNAL   Cell Chem Biol 30 (9), 1144-1155 (2023)
   PUBMED   37354909
  REMARK    GeneRIF: NREP contributes to development of NAFLD by regulating
            one-carbon metabolism in primary human hepatocytes.
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
  REMARK    GeneRIF: P311 Promotes IL-4 Receptor-Mediated M2 Polarization of
            Macrophages to Enhance Angiogenesis for Efficient Skin Wound
            Healing.
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Duan,F.F., Barron,G., Meliton,A., Mutlu,G.M., Dulin,N.O. and
            Schuger,L.
  TITLE     P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth
            Factor-beta1, -beta2, and -beta3 Translation
  JOURNAL   Am J Respir Cell Mol Biol 60 (2), 221-231 (2019)
   PUBMED   30230348
  REMARK    GeneRIF: P311 expression in the in the lungs of patients with
            idiopathic pulmonary fibrosis.
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Cheng,T., Yue,M., Aslam,M.N., Wang,X., Shekhawat,G., Varani,J. and
            Schuger,L.
  TITLE     Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar
            Collagen Deposition and Tensile Strength due to Impaired
            Transforming Growth Factor-beta1 to -beta3 Translation
  JOURNAL   Am J Pathol 187 (2), 292-303 (2017)
   PUBMED   27939132
  REMARK    GeneRIF: These studies demonstrate that P311 is required for the
            production of normal cutaneous scars
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
REFERENCE   7  (bases 1 to 2092)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   8  (bases 1 to 2092)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   9  (bases 1 to 2092)
  AUTHORS   Taylor,G.A., Hudson,E., Resau,J.H. and Vande Woude,G.F.
  TITLE     Regulation of P311 expression by Met-hepatocyte growth
            factor/scatter factor and the ubiquitin/proteasome system
  JOURNAL   J Biol Chem 275 (6), 4215-4219 (2000)
   PUBMED   10660586
REFERENCE   10 (bases 1 to 2092)
  AUTHORS   Studler,J.M., Glowinski,J. and Levi-Strauss,M.
  TITLE     An abundant mRNA of the embryonic brain persists at a high level in
            cerebellum, hippocampus and olfactory bulb during adulthood
  JOURNAL   Eur J Neurosci 5 (6), 614-623 (1993)
   PUBMED   8261136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA939543.1 and AC022108.4.
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA939543.1, SRR1660807.65605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               DA939543.1         1-581
            582-2092            AC022108.4         161347-162857       c
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..2092
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
     exon            1..165
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            166..209
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            210..270
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..474
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="isoform a is encoded by transcript variant 5;
                     neuronal protein 3.1; protein p311; neuronal regeneration
                     related protein homolog"
                     /codon_start=1
                     /product="neuronal regeneration-related protein isoform a"
                     /protein_id="NP_001135949.1"
                     /db_xref="CCDS:CCDS4105.1"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
                     /translation="MVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDET
                     NAASLTPLGSSELRSPRISYLHFF"
     exon            271..348
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            349..2092
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatgcat ccttcgcgga ctctttgtgt gtctgagcgc ggctccgcgc cgccgcaggc
       61 accattttct gcttcgctca ggacaggcac ataaaaggaa ggcggctgcc gcccgtcgcc
      121 gtcctctttt cctcagatgc cctctgctgc aggtttatta ttacagtgta gagaggagag
      181 agagtgaaca gggagcgggg cttttgtctg ttggtctccc tggactgaag agagggagaa
      241 tagaagccca agactaagat tctcaaaatg gtttattacc cagaactctt tgtctgggtc
      301 agtcaagaac catttccaaa caaggacatg gagggaaggc ttcctaaggg aagacttcct
      361 gtcccaaagg aagtgaaccg caagaagaac gatgagacaa acgctgcctc cctgactcca
      421 ctgggcagca gtgaactccg ctccccaaga atcagttacc tccacttttt ttaatcgtaa
      481 cacctccatt tgtattacat atggtgtatg ggtattgatg aggtcatggt atcatatatg
      541 ggattttttt ctgtgtaaat catcaagtat aagaagaaac tatgggactc tgagccttgc
      601 tttagagaat ttacagtgga caaataggtg tcatcaaacc agtttttaat cattctgact
      661 caagtgaaaa cgctcagaat ttcacactgt gaatccacgt ttacaaccct tacaggtggg
      721 ccttcaggcc tggttcgcta caacaatgtc ttccacaact caaactccca ccgcgctcac
      781 acaaccggtc cactcctgcc ttttcactca cacagctccc gactgcttct tgcagaggct
      841 gagagtcccc cccccacctt ttttttcatt tagatgtaac aaacctagta gtttatgttc
      901 atcaattgtc tgtatatctc tatattttat ccatgtactc ttttgatgta tagaagtagt
      961 ttgaaactca ttgtttcctt gtggtaagtg accgagatgc tgccacagga cctgagacac
     1021 tgatgaatgg tgctattttg gactttcaac atgctccttg gcgaggtagc tctgatggag
     1081 ttatttttta tttccatgtt ctaagaaggt gttggtactc tgtttccctg aatgttgttc
     1141 tctagactgg attgacttgt tttccttgtg tcttcagtgt ggctttcttc ctcagtgttg
     1201 taggttgagc gaatgctacc agagtgtgag agaccattgt ctcgttggct ggcgctcacg
     1261 gacatgcagt cacggtagcg ggagcaatca caaaactgta atttacttac caaatctctt
     1321 cctttccgta gcctcgcctg cctgacttag agaaagaaaa gcaataattt tacaggcatt
     1381 ttgaggtgtc tctttgggtt ctttctgttt gaaaggatat ttgtcgaaaa aaagagcaaa
     1441 accgttttaa ataaactccc cctggaaaaa aacccaaaac actggcatct gagtgggaat
     1501 atgaaaatga caccttttcc aaatattaaa ttggaaaaca aggtctacaa aatcatgata
     1561 cttttttaaa aggcagagca ttcttttttc ggcaattttg ataagcaagg tgtagattta
     1621 catttttgtc cttgctccca acgaaatgga taaacaaaaa taaattacca tctactcatg
     1681 gaatgttgtt gtgttagcca gtctgaaagc ccaccttaat ttttatataa ctgtctttag
     1741 ctcttctttt gacagggcag gccttgttct gaactgtttc gcttctgact gttaaacacc
     1801 gatgacgcat gcactgcact tcttcgtttt cttcttgctc ccccattggc ctgagtttct
     1861 tgtgcattac tcctctccct ccttcgttag aataggtata tcagctgtgt aaatagagca
     1921 agaaaacagt attctgcatc tgtggcattt atgtagagtt gcagttgtgt actgctgaaa
     1981 atgcaggctt ttgtaacagt gtgatcttta ctgatgcact catgacaagt acccaatgta
     2041 ttttagctat tttagtagta tttgttcaat aaatacgcaa gctgtaaggt aa
//
