LOCUS       NM_001142476            2201 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens neuronal regeneration related protein (NREP),
            transcript variant 4, mRNA.
ACCESSION   NM_001142476
VERSION     NM_001142476.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2201)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   2  (bases 1 to 2201)
  AUTHORS   De Jesus,D.F., Kimura,T., Gupta,M.K. and Kulkarni,R.N.
  TITLE     NREP contributes to development of NAFLD by regulating one-carbon
            metabolism in primary human hepatocytes
  JOURNAL   Cell Chem Biol 30 (9), 1144-1155 (2023)
   PUBMED   37354909
  REMARK    GeneRIF: NREP contributes to development of NAFLD by regulating
            one-carbon metabolism in primary human hepatocytes.
REFERENCE   3  (bases 1 to 2201)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
  REMARK    GeneRIF: P311 Promotes IL-4 Receptor-Mediated M2 Polarization of
            Macrophages to Enhance Angiogenesis for Efficient Skin Wound
            Healing.
REFERENCE   4  (bases 1 to 2201)
  AUTHORS   Duan,F.F., Barron,G., Meliton,A., Mutlu,G.M., Dulin,N.O. and
            Schuger,L.
  TITLE     P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth
            Factor-beta1, -beta2, and -beta3 Translation
  JOURNAL   Am J Respir Cell Mol Biol 60 (2), 221-231 (2019)
   PUBMED   30230348
  REMARK    GeneRIF: P311 expression in the in the lungs of patients with
            idiopathic pulmonary fibrosis.
REFERENCE   5  (bases 1 to 2201)
  AUTHORS   Cheng,T., Yue,M., Aslam,M.N., Wang,X., Shekhawat,G., Varani,J. and
            Schuger,L.
  TITLE     Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar
            Collagen Deposition and Tensile Strength due to Impaired
            Transforming Growth Factor-beta1 to -beta3 Translation
  JOURNAL   Am J Pathol 187 (2), 292-303 (2017)
   PUBMED   27939132
  REMARK    GeneRIF: These studies demonstrate that P311 is required for the
            production of normal cutaneous scars
REFERENCE   6  (bases 1 to 2201)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
REFERENCE   7  (bases 1 to 2201)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   8  (bases 1 to 2201)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   9  (bases 1 to 2201)
  AUTHORS   Taylor,G.A., Hudson,E., Resau,J.H. and Vande Woude,G.F.
  TITLE     Regulation of P311 expression by Met-hepatocyte growth
            factor/scatter factor and the ubiquitin/proteasome system
  JOURNAL   J Biol Chem 275 (6), 4215-4219 (2000)
   PUBMED   10660586
REFERENCE   10 (bases 1 to 2201)
  AUTHORS   Studler,J.M., Glowinski,J. and Levi-Strauss,M.
  TITLE     An abundant mRNA of the embryonic brain persists at a high level in
            cerebellum, hippocampus and olfactory bulb during adulthood
  JOURNAL   Eur J Neurosci 5 (6), 614-623 (1993)
   PUBMED   8261136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA490948.1, DA526263.1 and AC022108.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA490948.1, SRR1660803.27651.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA490948.1         1-12
            13-570              DA526263.1         1-558
            571-2201            AC022108.4         161347-162977       c
FEATURES             Location/Qualifiers
     source          1..2201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..2201
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
     exon            1..274
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            275..318
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            319..379
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..583
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="isoform a is encoded by transcript variant 4;
                     neuronal protein 3.1; protein p311; neuronal regeneration
                     related protein homolog"
                     /codon_start=1
                     /product="neuronal regeneration-related protein isoform a"
                     /protein_id="NP_001135948.1"
                     /db_xref="CCDS:CCDS4105.1"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
                     /translation="MVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDET
                     NAASLTPLGSSELRSPRISYLHFF"
     exon            380..457
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            458..2201
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2201
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcagcc acaggacctc tgggcccggc cttcaggggc gctccccgcc ccgggcttcc
       61 ccgcggaagg gagtggggcg cgcgtaccca gctgaggggc agggtccgac ccgaggccgt
      121 gtgcaaatgc atccttcgcg gactctttgt gtgtctgagc gcggctccgc gccgccgcag
      181 gcaccatttt ctgcttcgct caggacaggc acataaaagg aaggcggctg ccgcccgtcg
      241 ccgtcctctt ttcctcagat gccctctgct gcaggtgtag agaggagaga gagtgaacag
      301 ggagcggggc ttttgtctgt tggtctccct ggactgaaga gagggagaat agaagcccaa
      361 gactaagatt ctcaaaatgg tttattaccc agaactcttt gtctgggtca gtcaagaacc
      421 atttccaaac aaggacatgg agggaaggct tcctaaggga agacttcctg tcccaaagga
      481 agtgaaccgc aagaagaacg atgagacaaa cgctgcctcc ctgactccac tgggcagcag
      541 tgaactccgc tccccaagaa tcagttacct ccactttttt taatcgtaac acctccattt
      601 gtattacata tggtgtatgg gtattgatga ggtcatggta tcatatatgg gatttttttc
      661 tgtgtaaatc atcaagtata agaagaaact atgggactct gagccttgct ttagagaatt
      721 tacagtggac aaataggtgt catcaaacca gtttttaatc attctgactc aagtgaaaac
      781 gctcagaatt tcacactgtg aatccacgtt tacaaccctt acaggtgggc cttcaggcct
      841 ggttcgctac aacaatgtct tccacaactc aaactcccac cgcgctcaca caaccggtcc
      901 actcctgcct tttcactcac acagctcccg actgcttctt gcagaggctg agagtccccc
      961 ccccaccttt tttttcattt agatgtaaca aacctagtag tttatgttca tcaattgtct
     1021 gtatatctct atattttatc catgtactct tttgatgtat agaagtagtt tgaaactcat
     1081 tgtttccttg tggtaagtga ccgagatgct gccacaggac ctgagacact gatgaatggt
     1141 gctattttgg actttcaaca tgctccttgg cgaggtagct ctgatggagt tattttttat
     1201 ttccatgttc taagaaggtg ttggtactct gtttccctga atgttgttct ctagactgga
     1261 ttgacttgtt ttccttgtgt cttcagtgtg gctttcttcc tcagtgttgt aggttgagcg
     1321 aatgctacca gagtgtgaga gaccattgtc tcgttggctg gcgctcacgg acatgcagtc
     1381 acggtagcgg gagcaatcac aaaactgtaa tttacttacc aaatctcttc ctttccgtag
     1441 cctcgcctgc ctgacttaga gaaagaaaag caataatttt acaggcattt tgaggtgtct
     1501 ctttgggttc tttctgtttg aaaggatatt tgtcgaaaaa aagagcaaaa ccgttttaaa
     1561 taaactcccc ctggaaaaaa acccaaaaca ctggcatctg agtgggaata tgaaaatgac
     1621 accttttcca aatattaaat tggaaaacaa ggtctacaaa atcatgatac ttttttaaaa
     1681 ggcagagcat tcttttttcg gcaattttga taagcaaggt gtagatttac atttttgtcc
     1741 ttgctcccaa cgaaatggat aaacaaaaat aaattaccat ctactcatgg aatgttgttg
     1801 tgttagccag tctgaaagcc caccttaatt tttatataac tgtctttagc tcttcttttg
     1861 acagggcagg ccttgttctg aactgtttcg cttctgactg ttaaacaccg atgacgcatg
     1921 cactgcactt cttcgttttc ttcttgctcc cccattggcc tgagtttctt gtgcattact
     1981 cctctccctc cttcgttaga ataggtatat cagctgtgta aatagagcaa gaaaacagta
     2041 ttctgcatct gtggcattta tgtagagttg cagttgtgta ctgctgaaaa tgcaggcttt
     2101 tgtaacagtg tgatctttac tgatgcactc atgacaagta cccaatgtat tttagctatt
     2161 ttagtagtat ttgttcaata aatacgcaag ctgtaaggta a
//
