LOCUS       NM_001142475            2651 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens neuronal regeneration related protein (NREP),
            transcript variant 3, mRNA.
ACCESSION   NM_001142475
VERSION     NM_001142475.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   De Jesus,D.F., Kimura,T., Gupta,M.K. and Kulkarni,R.N.
  TITLE     NREP contributes to development of NAFLD by regulating one-carbon
            metabolism in primary human hepatocytes
  JOURNAL   Cell Chem Biol 30 (9), 1144-1155 (2023)
   PUBMED   37354909
  REMARK    GeneRIF: NREP contributes to development of NAFLD by regulating
            one-carbon metabolism in primary human hepatocytes.
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
  REMARK    GeneRIF: P311 Promotes IL-4 Receptor-Mediated M2 Polarization of
            Macrophages to Enhance Angiogenesis for Efficient Skin Wound
            Healing.
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Duan,F.F., Barron,G., Meliton,A., Mutlu,G.M., Dulin,N.O. and
            Schuger,L.
  TITLE     P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth
            Factor-beta1, -beta2, and -beta3 Translation
  JOURNAL   Am J Respir Cell Mol Biol 60 (2), 221-231 (2019)
   PUBMED   30230348
  REMARK    GeneRIF: P311 expression in the in the lungs of patients with
            idiopathic pulmonary fibrosis.
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Cheng,T., Yue,M., Aslam,M.N., Wang,X., Shekhawat,G., Varani,J. and
            Schuger,L.
  TITLE     Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar
            Collagen Deposition and Tensile Strength due to Impaired
            Transforming Growth Factor-beta1 to -beta3 Translation
  JOURNAL   Am J Pathol 187 (2), 292-303 (2017)
   PUBMED   27939132
  REMARK    GeneRIF: These studies demonstrate that P311 is required for the
            production of normal cutaneous scars
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Taylor,G.A., Hudson,E., Resau,J.H. and Vande Woude,G.F.
  TITLE     Regulation of P311 expression by Met-hepatocyte growth
            factor/scatter factor and the ubiquitin/proteasome system
  JOURNAL   J Biol Chem 275 (6), 4215-4219 (2000)
   PUBMED   10660586
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Studler,J.M., Glowinski,J. and Levi-Strauss,M.
  TITLE     An abundant mRNA of the embryonic brain persists at a high level in
            cerebellum, hippocampus and olfactory bulb during adulthood
  JOURNAL   Eur J Neurosci 5 (6), 614-623 (1993)
   PUBMED   8261136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025182.4, DC365764.1 and AC022108.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001142475.1.
            
            Transcript Variant: This variant (3) includes alternate exons in
            the 5' UTR and 5' coding region, compared to variant 1. It encodes
            isoform c, which is longer and has a distinct N-terminus, compared
            to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.178415.1, AK298779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2467143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC025182.4         16927-16927         c
            2-544               DC365764.1         1-543
            545-2150            AC022108.4         161347-162952       c
            2151-2651           AC022108.4         160846-161346       c
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..2651
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
     exon            1..223
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..532
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="isoform c is encoded by transcript variant 3;
                     neuronal protein 3.1; protein p311; neuronal regeneration
                     related protein homolog"
                     /codon_start=1
                     /product="neuronal regeneration-related protein isoform c"
                     /protein_id="NP_001135947.1"
                     /db_xref="CCDS:CCDS47255.1"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
                     /translation="MKGVWNYSALSRREDETRTQRSRMTDRVPCSKCFQVHCQISVLN
                     CVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLTPLGSSELR
                     SPRISYLHFF"
     exon            224..328
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            329..406
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            407..2651
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2150
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 cagaatgact gttgccagca tctagaagga attacttttc caggcagtgc aatcatgcta
       61 tttatcaaaa gaaacattgg acaatcagaa tgggctgcag agctgtgtcc tgagctgtct
      121 ggccaactcc cggcaagaag cttctttgtc ctttaaagac tgaactttat cctcaagcag
      181 taacaggact ggaatgaaag gagtttggaa ttattctgct ttgagccgaa gagaagatga
      241 aacacgaacc cagaggagca ggatgacaga cagagtccct tgttccaaat gtttccaggt
      301 tcactgccag atttctgttc tgaattgtgt ttattaccca gaactctttg tctgggtcag
      361 tcaagaacca tttccaaaca aggacatgga gggaaggctt cctaagggaa gacttcctgt
      421 cccaaaggaa gtgaaccgca agaagaacga tgagacaaac gctgcctccc tgactccact
      481 gggcagcagt gaactccgct ccccaagaat cagttacctc cacttttttt aatcgtaaca
      541 cctccatttg tattacatat ggtgtatggg tattgatgag gtcatggtat catatatggg
      601 atttttttct gtgtaaatca tcaagtataa gaagaaacta tgggactctg agccttgctt
      661 tagagaattt acagtggaca aataggtgtc atcaaaccag tttttaatca ttctgactca
      721 agtgaaaacg ctcagaattt cacactgtga atccacgttt acaaccctta caggtgggcc
      781 ttcaggcctg gttcgctaca acaatgtctt ccacaactca aactcccacc gcgctcacac
      841 aaccggtcca ctcctgcctt ttcactcaca cagctcccga ctgcttcttg cagaggctga
      901 gagtcccccc cccacctttt ttttcattta gatgtaacaa acctagtagt ttatgttcat
      961 caattgtctg tatatctcta tattttatcc atgtactctt ttgatgtata gaagtagttt
     1021 gaaactcatt gtttccttgt ggtaagtgac cgagatgctg ccacaggacc tgagacactg
     1081 atgaatggtg ctattttgga ctttcaacat gctccttggc gaggtagctc tgatggagtt
     1141 attttttatt tccatgttct aagaaggtgt tggtactctg tttccctgaa tgttgttctc
     1201 tagactggat tgacttgttt tccttgtgtc ttcagtgtgg ctttcttcct cagtgttgta
     1261 ggttgagcga atgctaccag agtgtgagag accattgtct cgttggctgg cgctcacgga
     1321 catgcagtca cggtagcggg agcaatcaca aaactgtaat ttacttacca aatctcttcc
     1381 tttccgtagc ctcgcctgcc tgacttagag aaagaaaagc aataatttta caggcatttt
     1441 gaggtgtctc tttgggttct ttctgtttga aaggatattt gtcgaaaaaa agagcaaaac
     1501 cgttttaaat aaactccccc tggaaaaaaa cccaaaacac tggcatctga gtgggaatat
     1561 gaaaatgaca ccttttccaa atattaaatt ggaaaacaag gtctacaaaa tcatgatact
     1621 tttttaaaag gcagagcatt cttttttcgg caattttgat aagcaaggtg tagatttaca
     1681 tttttgtcct tgctcccaac gaaatggata aacaaaaata aattaccatc tactcatgga
     1741 atgttgttgt gttagccagt ctgaaagccc accttaattt ttatataact gtctttagct
     1801 cttcttttga cagggcaggc cttgttctga actgtttcgc ttctgactgt taaacaccga
     1861 tgacgcatgc actgcacttc ttcgttttct tcttgctccc ccattggcct gagtttcttg
     1921 tgcattactc ctctccctcc ttcgttagaa taggtatatc agctgtgtaa atagagcaag
     1981 aaaacagtat tctgcatctg tggcatttat gtagagttgc agttgtgtac tgctgaaaat
     2041 gcaggctttt gtaacagtgt gatctttact gatgcactca tgacaagtac ccaatgtatt
     2101 ttagctattt tagtagtatt tgttcaataa atacgcaagc tgtaaggtaa ctgtctgatt
     2161 tggctcatca ttgaagaggc ctagttttga atgtcttctc tggttcttgc taattcatgt
     2221 gtttccagag ccccagaagt caggccagca aacccaaggg caaatatcaa aagagagaga
     2281 atcagctctg cctttcatgc gttttccctt ttgaggattt tatgagatta ggggctaggc
     2341 agtggctcat taagatggta tttgcagagc tgcctctgga cacaaagcag aattagacca
     2401 agatcctttt atttctacac tttttctccc ttccaaggca ttcccatacg cttcaaaact
     2461 tactctttct cactccttgc cattaagacc cactctgtgg tattctttaa gacccactct
     2521 gtggtattct ttctttttcc ctgccaaaag agatctgacc tcccttcttc atggaatatg
     2581 tgcacttttc ctcagacaaa aagcttaaac ttttgtaaga ggataaaaat ttgagacaga
     2641 atttaaagtc a
//
