LOCUS       NM_001142474            2621 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens neuronal regeneration related protein (NREP),
            transcript variant 2, mRNA.
ACCESSION   NM_001142474
VERSION     NM_001142474.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   De Jesus,D.F., Kimura,T., Gupta,M.K. and Kulkarni,R.N.
  TITLE     NREP contributes to development of NAFLD by regulating one-carbon
            metabolism in primary human hepatocytes
  JOURNAL   Cell Chem Biol 30 (9), 1144-1155 (2023)
   PUBMED   37354909
  REMARK    GeneRIF: NREP contributes to development of NAFLD by regulating
            one-carbon metabolism in primary human hepatocytes.
REFERENCE   3  (bases 1 to 2621)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
  REMARK    GeneRIF: P311 Promotes IL-4 Receptor-Mediated M2 Polarization of
            Macrophages to Enhance Angiogenesis for Efficient Skin Wound
            Healing.
REFERENCE   4  (bases 1 to 2621)
  AUTHORS   Duan,F.F., Barron,G., Meliton,A., Mutlu,G.M., Dulin,N.O. and
            Schuger,L.
  TITLE     P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth
            Factor-beta1, -beta2, and -beta3 Translation
  JOURNAL   Am J Respir Cell Mol Biol 60 (2), 221-231 (2019)
   PUBMED   30230348
  REMARK    GeneRIF: P311 expression in the in the lungs of patients with
            idiopathic pulmonary fibrosis.
REFERENCE   5  (bases 1 to 2621)
  AUTHORS   Cheng,T., Yue,M., Aslam,M.N., Wang,X., Shekhawat,G., Varani,J. and
            Schuger,L.
  TITLE     Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar
            Collagen Deposition and Tensile Strength due to Impaired
            Transforming Growth Factor-beta1 to -beta3 Translation
  JOURNAL   Am J Pathol 187 (2), 292-303 (2017)
   PUBMED   27939132
  REMARK    GeneRIF: These studies demonstrate that P311 is required for the
            production of normal cutaneous scars
REFERENCE   6  (bases 1 to 2621)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
REFERENCE   7  (bases 1 to 2621)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   8  (bases 1 to 2621)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   9  (bases 1 to 2621)
  AUTHORS   Taylor,G.A., Hudson,E., Resau,J.H. and Vande Woude,G.F.
  TITLE     Regulation of P311 expression by Met-hepatocyte growth
            factor/scatter factor and the ubiquitin/proteasome system
  JOURNAL   J Biol Chem 275 (6), 4215-4219 (2000)
   PUBMED   10660586
REFERENCE   10 (bases 1 to 2621)
  AUTHORS   Studler,J.M., Glowinski,J. and Levi-Strauss,M.
  TITLE     An abundant mRNA of the embryonic brain persists at a high level in
            cerebellum, hippocampus and olfactory bulb during adulthood
  JOURNAL   Eur J Neurosci 5 (6), 614-623 (1993)
   PUBMED   8261136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025182.4, DA027062.1, DA694580.1 and AC022108.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001142474.1.
            
            Transcript Variant: This variant (2) includes alternate exons in
            the 5' UTR and 5' coding region, compared to variant 1. It encodes
            isoform b, which is longer and has a distinct N-terminus, compared
            to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA694580.1, DA027062.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC025182.4         16927-16927         c
            2-106               DA027062.1         1-105
            107-526             DA694580.1         1-420
            527-2120            AC022108.4         161347-162940       c
            2121-2621           AC022108.4         160846-161346       c
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..2621
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
     exon            1..223
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..502
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="isoform b is encoded by transcript variant 2;
                     neuronal protein 3.1; protein p311; neuronal regeneration
                     related protein homolog"
                     /codon_start=1
                     /product="neuronal regeneration-related protein isoform b"
                     /protein_id="NP_001135946.1"
                     /db_xref="GeneID:9315"
                     /db_xref="HGNC:HGNC:16834"
                     /db_xref="MIM:607332"
                     /translation="MKGVWNYSALSRREDETRTQRSRMTDRVPCSKCFQVYYPELFVW
                     VSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLTPLGSSELRSPRISYLHFF
                     "
     exon            224..298
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            299..376
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            377..2621
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="NREP"
                     /gene_synonym="C5orf13; D4S114; P311; PRO1873; PTZ17;
                     SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 cagaatgact gttgccagca tctagaagga attacttttc caggcagtgc aatcatgcta
       61 tttatcaaaa gaaacattgg acaatcagaa tgggctgcag agctgtgtcc tgagctgtct
      121 ggccaactcc cggcaagaag cttctttgtc ctttaaagac tgaactttat cctcaagcag
      181 taacaggact ggaatgaaag gagtttggaa ttattctgct ttgagccgaa gagaagatga
      241 aacacgaacc cagaggagca ggatgacaga cagagtccct tgttccaaat gtttccaggt
      301 ttattaccca gaactctttg tctgggtcag tcaagaacca tttccaaaca aggacatgga
      361 gggaaggctt cctaagggaa gacttcctgt cccaaaggaa gtgaaccgca agaagaacga
      421 tgagacaaac gctgcctccc tgactccact gggcagcagt gaactccgct ccccaagaat
      481 cagttacctc cacttttttt aatcgtaaca cctccatttg tattacatat ggtgtatggg
      541 tattgatgag gtcatggtat catatatggg atttttttct gtgtaaatca tcaagtataa
      601 gaagaaacta tgggactctg agccttgctt tagagaattt acagtggaca aataggtgtc
      661 atcaaaccag tttttaatca ttctgactca agtgaaaacg ctcagaattt cacactgtga
      721 atccacgttt acaaccctta caggtgggcc ttcaggcctg gttcgctaca acaatgtctt
      781 ccacaactca aactcccacc gcgctcacac aaccggtcca ctcctgcctt ttcactcaca
      841 cagctcccga ctgcttcttg cagaggctga gagtcccccc cccacctttt ttttcattta
      901 gatgtaacaa acctagtagt ttatgttcat caattgtctg tatatctcta tattttatcc
      961 atgtactctt ttgatgtata gaagtagttt gaaactcatt gtttccttgt ggtaagtgac
     1021 cgagatgctg ccacaggacc tgagacactg atgaatggtg ctattttgga ctttcaacat
     1081 gctccttggc gaggtagctc tgatggagtt attttttatt tccatgttct aagaaggtgt
     1141 tggtactctg tttccctgaa tgttgttctc tagactggat tgacttgttt tccttgtgtc
     1201 ttcagtgtgg ctttcttcct cagtgttgta ggttgagcga atgctaccag agtgtgagag
     1261 accattgtct cgttggctgg cgctcacgga catgcagtca cggtagcggg agcaatcaca
     1321 aaactgtaat ttacttacca aatctcttcc tttccgtagc ctcgcctgcc tgacttagag
     1381 aaagaaaagc aataatttta caggcatttt gaggtgtctc tttgggttct ttctgtttga
     1441 aaggatattt gtcgaaaaaa agagcaaaac cgttttaaat aaactccccc tggaaaaaaa
     1501 cccaaaacac tggcatctga gtgggaatat gaaaatgaca ccttttccaa atattaaatt
     1561 ggaaaacaag gtctacaaaa tcatgatact tttttaaaag gcagagcatt cttttttcgg
     1621 caattttgat aagcaaggtg tagatttaca tttttgtcct tgctcccaac gaaatggata
     1681 aacaaaaata aattaccatc tactcatgga atgttgttgt gttagccagt ctgaaagccc
     1741 accttaattt ttatataact gtctttagct cttcttttga cagggcaggc cttgttctga
     1801 actgtttcgc ttctgactgt taaacaccga tgacgcatgc actgcacttc ttcgttttct
     1861 tcttgctccc ccattggcct gagtttcttg tgcattactc ctctccctcc ttcgttagaa
     1921 taggtatatc agctgtgtaa atagagcaag aaaacagtat tctgcatctg tggcatttat
     1981 gtagagttgc agttgtgtac tgctgaaaat gcaggctttt gtaacagtgt gatctttact
     2041 gatgcactca tgacaagtac ccaatgtatt ttagctattt tagtagtatt tgttcaataa
     2101 atacgcaagc tgtaaggtaa ctgtctgatt tggctcatca ttgaagaggc ctagttttga
     2161 atgtcttctc tggttcttgc taattcatgt gtttccagag ccccagaagt caggccagca
     2221 aacccaaggg caaatatcaa aagagagaga atcagctctg cctttcatgc gttttccctt
     2281 ttgaggattt tatgagatta ggggctaggc agtggctcat taagatggta tttgcagagc
     2341 tgcctctgga cacaaagcag aattagacca agatcctttt atttctacac tttttctccc
     2401 ttccaaggca ttcccatacg cttcaaaact tactctttct cactccttgc cattaagacc
     2461 cactctgtgg tattctttaa gacccactct gtggtattct ttctttttcc ctgccaaaag
     2521 agatctgacc tcccttcttc atggaatatg tgcacttttc ctcagacaaa aagcttaaac
     2581 ttttgtaaga ggataaaaat ttgagacaga atttaaagtc a
//
