LOCUS       NM_001101662            3594 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens nardilysin convertase (NRDC), transcript variant 2,
            mRNA.
ACCESSION   NM_001101662
VERSION     NM_001101662.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3594)
  AUTHORS   Liu,A., Liang,J. and Wen,J.
  TITLE     CircNRD1 elevates THAP domain containing 11 through sequestering
            microRNA-421 to inhibit gastric cancer growth and tumorigenesis
  JOURNAL   J Biochem Mol Toxicol 38 (4), e23705 (2024)
   PUBMED   38602237
  REMARK    GeneRIF: CircNRD1 elevates THAP domain containing 11 through
            sequestering microRNA-421 to inhibit gastric cancer growth and
            tumorigenesis.
REFERENCE   2  (bases 1 to 3594)
  AUTHORS   Vaishnav,J., Jadeja,S.D., Singh,M., Khan,F., Yadav,M. and Begum,R.
  TITLE     Altered Levels of Negative Costimulatory Molecule V-Set
            Domain-Containing T-Cell Activation Inhibitor-1 (VTCN1) and
            Metalloprotease Nardilysin (NRD1) are Associated with Generalized
            Active Vitiligo
  JOURNAL   Immunol Invest 51 (7), 2035-2052 (2022)
   PUBMED   35815687
  REMARK    GeneRIF: Altered Levels of Negative Costimulatory Molecule V-Set
            Domain-Containing T-Cell Activation Inhibitor-1 (VTCN1) and
            Metalloprotease Nardilysin (NRD1) are Associated with Generalized
            Active Vitiligo.
REFERENCE   3  (bases 1 to 3594)
  AUTHORS   Miao,C.Q., Lu,Q., Liu,P., Bai,L., Qu,H. and Ma,A.Q.
  TITLE     Increased serum nardilysin is associated with worse long-term
            outcome of ST-elevation myocardial infarction
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (22), 7938-7944 (2018)
   PUBMED   30536341
  REMARK    GeneRIF: Increased serum nardilysin at admission is associated with
            a higher risk of all-cause mortality for ST-elevation myocardial
            infarction patients.
REFERENCE   4  (bases 1 to 3594)
  AUTHORS   Chen,P.M., Ohno,M., Hiwasa,T., Nishi,K., Saijo,S., Sakamoto,J.,
            Morita,Y., Matsuda,S., Watanabe,S., Kuwabara,Y., Ono,K., Imai,M.,
            Inoue,K., Murai,T., Inada,T., Tanaka,M., Kita,T., Kimura,T. and
            Nishi,E.
  TITLE     Nardilysin is a promising biomarker for the early diagnosis of
            acute coronary syndrome
  JOURNAL   Int J Cardiol 243, 1-8 (2017)
   PUBMED   28747015
  REMARK    GeneRIF: NRDC expression was reduced in infarcted regions in
            autopsy samples from acute myocardial ischemia patients.
REFERENCE   5  (bases 1 to 3594)
  AUTHORS   Yoon,W.H., Sandoval,H., Nagarkar-Jaiswal,S., Jaiswal,M.,
            Yamamoto,S., Haelterman,N.A., Putluri,N., Putluri,V., Sreekumar,A.,
            Tos,T., Aksoy,A., Donti,T., Graham,B.H., Ohno,M., Nishi,E.,
            Hunter,J., Muzny,D.M., Carmichael,J., Shen,J., Arboleda,V.A.,
            Nelson,S.F., Wangler,M.F., Karaca,E., Lupski,J.R. and Bellen,H.J.
  TITLE     Loss of Nardilysin, a Mitochondrial Co-chaperone for
            alpha-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and
            Neurodegeneration
  JOURNAL   Neuron 93 (1), 115-131 (2017)
   PUBMED   28017472
REFERENCE   6  (bases 1 to 3594)
  AUTHORS   Ma,Z., Csuhai,E., Chow,K.M. and Hersh,L.B.
  TITLE     Expression of the acidic stretch of nardilysin as a functional
            binding domain
  JOURNAL   Biochemistry 40 (31), 9447-9452 (2001)
   PUBMED   11478915
  REMARK    GeneRIF: The acidic stretch of nardilysin, expressed as a fusion
            protein with glutathione S-transferase and compared to the native
            enzyme with respect to spermine binding, functions as an autonomous
            domain.
REFERENCE   7  (bases 1 to 3594)
  AUTHORS   Nishi,E., Prat,A., Hospital,V., Elenius,K. and Klagsbrun,M.
  TITLE     N-arginine dibasic convertase is a specific receptor for
            heparin-binding EGF-like growth factor that mediates cell migration
  JOURNAL   EMBO J 20 (13), 3342-3350 (2001)
   PUBMED   11432822
  REMARK    GeneRIF: N-arginine dibasic convertase is a specific receptor for
            heparin-binding EGF-like growth factor (HB-EGF) that modulates
            HB-EGF-induced cell migration.
REFERENCE   8  (bases 1 to 3594)
  AUTHORS   Winter,A.G. and Pierotti,A.R.
  TITLE     Gene expression of the dibasic-pair cleaving enzyme NRD convertase
            (N-arginine dibasic convertase) is differentially regulated in the
            GH3 pituitary and Mat-Lu prostate cell lines
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 755-764 (2000)
   PUBMED   11042131
REFERENCE   9  (bases 1 to 3594)
  AUTHORS   Fumagalli,P., Accarino,M., Egeo,A., Scartezzini,P., Rappazzo,G.,
            Pizzuti,A., Avvantaggiato,V., Simeone,A., Arrigo,G., Zuffardi,O.,
            Ottolenghi,S. and Taramelli,R.
  TITLE     Human NRD convertase: a highly conserved metalloendopeptidase
            expressed at specific sites during development and in adult tissues
  JOURNAL   Genomics 47 (2), 238-245 (1998)
   PUBMED   9479496
REFERENCE   10 (bases 1 to 3594)
  AUTHORS   Hospital,V., Prat,A., Joulie,C., Cherif,D., Day,R. and Cohen,P.
  TITLE     Human and rat testis express two mRNA species encoding variants of
            NRD convertase, a metalloendopeptidase of the insulinase family
  JOURNAL   Biochem J 327 (Pt 3) (Pt 3), 773-779 (1997)
   PUBMED   9581555
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA245717.1, BC008775.2,
            X93209.1 and AY360265.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001101662.1.
            
            Summary: This gene encodes a zinc-dependent endopeptidase that
            cleaves peptide substrates at the N-terminus of arginine residues
            in dibasic moieties and is a member of the peptidase M16 family.
            This protein interacts with heparin-binding EGF-like growth factor
            and plays a role in cell migration and proliferation. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (2) lacks alternate in-frame
            exons, compared to variant 1, resulting in a shorter protein
            (isoform b), compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X93209.1, BC008775.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352171.12/ ENSP00000262679.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA245717.1         85-97
            14-571              BC008775.2         1-558
            572-1122            X93209.1           595-1145
            1123-3369           AY360265.1         908-3154
            3370-3594           BC008775.2         3354-3578
FEATURES             Location/Qualifiers
     source          1..3594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3594
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /note="nardilysin convertase"
                     /db_xref="GeneID:4898"
                     /db_xref="HGNC:HGNC:7995"
                     /db_xref="MIM:602651"
     exon            1..453
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..3568
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /EC_number="3.4.24.61"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; NRD convertase; nardilysin (N-arginine dibasic
                     convertase)"
                     /codon_start=1
                     /product="nardilysin isoform b precursor"
                     /protein_id="NP_001095132.1"
                     /db_xref="CCDS:CCDS41335.1"
                     /db_xref="GeneID:4898"
                     /db_xref="HGNC:HGNC:7995"
                     /db_xref="MIM:602651"
                     /translation="MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARP
                     FPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEGRRGSLSNAGDPE
                     IVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDS
                     GAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVG
                     VGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQF
                     DVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLA
                     RPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTL
                     EKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQ
                     QHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISI
                     TLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVE
                     NMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKE
                     KWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVK
                     IVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPA
                     YEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQL
                     KKTYFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLF
                     VEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKG
                     DANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGI
                     LGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDT
                     HLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVV
                     GYGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLADCIIPITDIRAFTTTLNLLPY
                     HKIVK"
     exon            454..742
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..824
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..978
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1052
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1148
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1271
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1329
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1403
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1473
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1551
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1672
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1731
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1786
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1891
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2015
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2102
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2222
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2274
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2425
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2553
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2716
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2748
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2887
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..2935
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..2988
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3072
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3163
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3280
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3370
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3594
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3568..3573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /note="hexamer: AATAAA"
     polyA_site      3594
                     /gene="NRDC"
                     /gene_synonym="hNRD1; hNRD2; NRD1"
                     /note="major polyA site"
ORIGIN      
        1 aggcctgttc cccgcggctg cggcagcacc agggccggcc gccaccgcct ctagaacgcg
       61 gaggaggtgg gtcctgggaa gcgggatgtc catcgctcca gcttggtggt gaatgctgag
      121 gagagtcact gttgctgcag tctgtgccac ccggaggaag ttgtgtgagg ccgggcggga
      181 gctcgcggcg ctctggggaa tcgaaacgcg gggtcggtgc gaagactctg ctgctgccag
      241 accctttcct attctggcca tgcctggaag gaacaaggcg aagtctacct gcagctgccc
      301 tgacctgcag cccaatggac aggatctggg cgagaacagc cgggttgccc gtctaggagc
      361 ggatgaatct gaggaagagg gacggagggg gtctctcagt aatgctgggg accctgagat
      421 cgtcaagtct cccagcgacc ccaagcaata ccgatacatc aaattacaga atggcttgca
      481 ggcacttctg atttcagacc taagtaatat ggaaggtaaa acaggaaata caacagatga
      541 tgaagaagaa gaggaggtgg aggaagaaga agaagatgat gatgaagatt ctggagctga
      601 aatagaagat gacgatgaag agggttttga tgatgaagat gagtttgatg atgaacatga
      661 tgatgatctt gatactgagg ataatgaatt ggaagaatta gaagagagag cagaagctag
      721 aaaaaaaact actgaaaaac agtctgcagc ggctctttgt gttggagttg ggagtttcgc
      781 tgatccagat gacctgccgg ggctggcaca ctttttggag cacatggtat tcatgggtag
      841 tttgaaatat ccagatgaga atggatttga tgccttcctg aagaagcatg ggggtagtga
      901 taatgcctca actgattgtg aacgcactgt ctttcagttt gatgtccaga ggaagtactt
      961 caaggaagct cttgatagat gggcgcagtt cttcatccac ccactaatga tcagagatgc
     1021 aattgaccgt gaagttgaag ctgttgatag tgaatatcaa cttgcaaggc cttctgatgc
     1081 aaacagaaag gaaatgttgt ttggaagcct tgctagacct ggacatccta tgggaaaatt
     1141 tttttgggga aatgctgaga cgctcaagca tgagccaaga aagaataata ttgatacaca
     1201 tgctagattg agagaattct ggatgcgtta ctactcttct cattacatga ctttagtggt
     1261 tcaatccaaa gaaacactgg atactttgga aaagtgggtg actgaaatct tctctcagat
     1321 accaaacaat gggttaccca gaccaaactt tggccattta acggatccat ttgacacacc
     1381 agcatttaac aaactttata gagttgttcc aatcagaaaa attcatgctc tgaccatcac
     1441 atgggcactt cctcctcaac agcaacatta cagggtgaag ccacttcatt atatatcctg
     1501 gctggttgga catgaaggca aaggcagcat tctttctttc cttaggaaaa aatgctgggc
     1561 tcttgcactg tttggtggaa atggtgagac aggatttgag caaaattcta cttattcagt
     1621 gttcagcatt tctattacat tgactgatga gggttatgaa catttttatg aggttgctta
     1681 cactgtcttt cagtatttaa aaatgctgca gaagctaggc ccagaaaaaa gaatttttga
     1741 agagattcgg aaaattgagg ataatgaatt tcattaccaa gaacagacag atccagttga
     1801 gtatgtggaa aacatgtgtg agaacatgca gctgtaccca ttgcaggaca ttctcactgg
     1861 agatcagctt ctttttgaat acaagccaga agtcattggt gaagccttga atcagctagt
     1921 tcctcaaaaa gcaaatcttg ttttactgtc tggtgctaat gagggaaaat gtgacctcaa
     1981 ggagaaatgg tttggaactc aatatagtat agaagatatt gaaaactctt gggctgaact
     2041 gtggaatagt aatttcgaat taaatccaga tcttcatctt ccagctgaaa acaagtacat
     2101 agccacggac tttacgttga aggctttcga ttgcccggaa acagaatacc cagttaaaat
     2161 tgtgaatact ccacaaggtt gcctgtggta taagaaagac aacaaattca aaatccccaa
     2221 agcatatata cgtttccatc taatttcacc gttgatacag aaatctgcag caaatgtggt
     2281 cctctttgat atctttgtca atatccttac gcataacctt gcggaaccag cttatgaagc
     2341 agatgtggca cagctggagt ataaactggt agctggagaa catggtttaa ttattcgagt
     2401 gaaaggattt aaccacaaac tacctctact gtttcagctc attattgact acttagctga
     2461 gttcaattcc acaccagctg tctttacaat gataactgag cagttgaaga agacctactt
     2521 taacatcctc atcaagcccg agactttggc caaagatgta cggcttttaa tcttggaata
     2581 tgcccgttgg tctatgattg acaagtacca ggctttgatg gacggccttt cccttgagtc
     2641 tctgctgagc ttcgtcaaag aattcaaatc ccagctcttt gtggagggcc tggtacaagg
     2701 gaatgtcaca agcacagaat ctatggattt cctgaaatat gttgttgaca aactaaactt
     2761 caagcctctg gagcaggaga tgcctgtgca gttccaggtg gtagagctgc ccagtggcca
     2821 ccatctatgc aaagtgaaag ctctgaacaa gggtgatgcc aactctgaag tcactgtgta
     2881 ctaccagtca ggtaccagga gtctaagaga atatacgctt atggagctgc ttgtgatgca
     2941 catggaagaa ccttgttttg acttccttcg aaccaagcag acccttgggt accatgtcta
     3001 ccctacctgt aggaacacat ccgggattct aggattttct gtcactgtgg ggactcaggc
     3061 aaccaaatac aattctgaag ttgttgataa gaagatagaa gagtttcttt ctagctttga
     3121 ggagaagatt gagaacctca ctgaagaggc attcaacacc caggtcacag ctctcatcaa
     3181 gctgaaggag tgtgaggata cccaccttgg ggaggaggtg gataggaact ggaatgaagt
     3241 ggttacacag cagtacctct ttgaccgcct tgcccacgag attgaagcac tgaagtcatt
     3301 ctcaaaatca gacctggtca actggttcaa ggcccataga gggccaggaa gtaaaatgct
     3361 cagcgttcat gttgttggat atgggaagta tgaactggaa gaggatggta ccccttctag
     3421 tgaggattca aattcttctt gtgaagtgat gcagctgacc tacctgccaa cctctcctct
     3481 gctggcagat tgtatcatcc ccattactga tatcagggct ttcacaacaa cactcaacct
     3541 tctcccctac cataaaatag tcaaataaat aaactgcagt cacgttggcc tgaa
//
