LOCUS       NM_001371166            6270 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens neuronal cell adhesion molecule (NRCAM), transcript
            variant 44, mRNA.
ACCESSION   NM_001371166
VERSION     NM_001371166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6270)
  AUTHORS   Wang,C., Wang,Z., Fu,L., Du,J., Ji,F. and Qiu,X.
  TITLE     CircNRCAM up-regulates NRCAM to promote papillary thyroid carcinoma
            progression
  JOURNAL   J Endocrinol Invest 47 (5), 1215-1226 (2024)
   PUBMED   38485895
  REMARK    GeneRIF: CircNRCAM up-regulates NRCAM to promote papillary thyroid
            carcinoma progression.
REFERENCE   2  (bases 1 to 6270)
  AUTHORS   Zhou,L., He,L., Liu,C.H., Qiu,H., Zheng,L., Sample,K.M., Wu,Q.,
            Li,J., Xie,K., Ampuero,J., Li,Z., Lv,D., Liu,M., Romero-Gomez,M.,
            Hu,Y. and Tang,H.
  TITLE     Liver cancer stem cell dissemination and metastasis: uncovering the
            role of NRCAM in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 311 (2023)
   PUBMED   37993901
  REMARK    GeneRIF: Liver cancer stem cell dissemination and metastasis:
            uncovering the role of NRCAM in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6270)
  AUTHORS   Sannes,A.C., Christensen,J.O., Nielsen,M.B. and Gjerstad,J.
  TITLE     Stress-induced headache in the general working population is
            moderated by the NRCAM rs2300043 genotype
  JOURNAL   Scand J Pain 23 (2), 326-332 (2022)
   PUBMED   36181733
  REMARK    GeneRIF: Stress-induced headache in the general working population
            is moderated by the NRCAM rs2300043 genotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6270)
  AUTHORS   Bai,C. and Chen,D.G.
  TITLE     NRCAM acts as a prognostic biomarker and promotes the tumor
            progression in gastric cancer via EMT pathway
  JOURNAL   Tissue Cell 77, 101859 (2022)
   PUBMED   35763884
  REMARK    GeneRIF: NRCAM acts as a prognostic biomarker and promotes the
            tumor progression in gastric cancer via EMT pathway.
REFERENCE   5  (bases 1 to 6270)
  AUTHORS   Huang,F.J., Liu,Y.L., Wang,J., Zhou,Y.Y., Zhao,S.Y. and Qin,G.J.
  TITLE     LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by
            regulating NrCAM transcription in Graves' disease
  JOURNAL   Cell Cycle 21 (9), 921-933 (2022)
   PUBMED   35220890
  REMARK    GeneRIF: LncRNA RUNX1-IT1 affects the differentiation of Th1 cells
            by regulating NrCAM transcription in Graves' disease.
REFERENCE   6  (bases 1 to 6270)
  AUTHORS   Wang,B., Williams,H., Du,J.S., Terrett,J. and Kenwrick,S.
  TITLE     Alternative splicing of human NrCAM in neural and nonneural tissues
  JOURNAL   Mol Cell Neurosci 10 (5-6), 287-295 (1998)
   PUBMED   9604207
REFERENCE   7  (bases 1 to 6270)
  AUTHORS   Grumet,M.
  TITLE     Nr-CAM: a cell adhesion molecule with ligand and receptor functions
  JOURNAL   Cell Tissue Res 290 (2), 423-428 (1997)
   PUBMED   9321706
  REMARK    Review article
REFERENCE   8  (bases 1 to 6270)
  AUTHORS   Sakurai,T., Lustig,M., Nativ,M., Hemperly,J.J., Schlessinger,J.,
            Peles,E. and Grumet,M.
  TITLE     Induction of neurite outgrowth through contactin and Nr-CAM by
            extracellular regions of glial receptor tyrosine phosphatase beta
  JOURNAL   J Cell Biol 136 (4), 907-918 (1997)
   PUBMED   9049255
REFERENCE   9  (bases 1 to 6270)
  AUTHORS   Volkmer,H., Leuschner,R., Zacharias,U. and Rathjen,F.G.
  TITLE     Neurofascin induces neurites by heterophilic interactions with
            axonal NrCAM while NrCAM requires F11 on the axonal surface to
            extend neurites
  JOURNAL   J Cell Biol 135 (4), 1059-1069 (1996)
   PUBMED   8922386
REFERENCE   10 (bases 1 to 6270)
  AUTHORS   Lane,R.P., Chen,X.N., Yamakawa,K., Vielmetter,J., Korenberg,J.R.
            and Dreyer,W.J.
  TITLE     Characterization of a highly conserved human homolog to the chicken
            neural cell surface protein Bravo/Nr-CAM that maps to chromosome
            band 7q31
  JOURNAL   Genomics 35 (3), 456-465 (1996)
   PUBMED   8812479
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005058.1, AC007567.2 and
            AC005683.2.
            
            Summary: Cell adhesion molecules (CAMs) are members of the
            immunoglobulin superfamily. This gene encodes a neuronal cell
            adhesion molecule with multiple immunoglobulin-like C2-type domains
            and fibronectin type-III domains. This ankyrin-binding protein is
            involved in neuron-neuron adhesion and promotes directional
            signaling during axonal cone growth. This gene is also expressed in
            non-neural tissues and may play a general role in cell-cell
            communication via signaling from its intracellular domain to the
            actin cytoskeleton during directional cell migration. Allelic
            variants of this gene have been associated with autism and
            addiction vulnerability. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (44), as well as variant 43,
            encodes isoform O.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC005058.1         63513-63706         c
            195-312             AC005058.1         8686-8803           c
            313-470             AC005058.1         6706-6863           c
            471-537             AC007567.2         107148-107214       c
            538-749             AC007567.2         34442-34653         c
            750-767             AC007567.2         32235-32252         c
            768-873             AC007567.2         29066-29171         c
            874-1070            AC007567.2         26809-27005         c
            1071-1193           AC007567.2         25514-25636         c
            1194-1364           AC007567.2         20691-20861         c
            1365-1476           AC007567.2         18208-18319         c
            1477-1661           AC007567.2         3904-4088           c
            1662-1793           AC007567.2         2011-2142           c
            1794-1937           AC005683.2         66912-67055         c
            1938-2049           AC005683.2         64717-64828         c
            2050-2216           AC005683.2         63218-63384         c
            2217-2364           AC005683.2         62980-63127         c
            2365-2489           AC005683.2         60685-60809         c
            2490-2519           AC005683.2         60210-60239         c
            2520-2621           AC005683.2         58601-58702         c
            2622-2819           AC005683.2         53373-53570         c
            2820-2890           AC005683.2         53197-53267         c
            2891-3116           AC005683.2         51651-51876         c
            3117-3232           AC005683.2         50778-50893         c
            3233-3437           AC005683.2         49179-49383         c
            3438-3560           AC005683.2         46947-47069         c
            3561-3692           AC005683.2         29318-29449         c
            3693-3771           AC005683.2         28420-28498         c
            3772-6270           AC005683.2         16606-19104         c
FEATURES             Location/Qualifiers
     source          1..6270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..6270
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="neuronal cell adhesion molecule"
                     /db_xref="GeneID:4897"
                     /db_xref="HGNC:HGNC:7994"
                     /db_xref="MIM:601581"
     exon            1..194
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            195..312
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            313..470
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            471..537
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            538..749
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             644..4009
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="isoform O precursor is encoded by transcript
                     variant 44; NgCAM-related cell adhesion molecule; neuronal
                     surface protein Bravo"
                     /codon_start=1
                     /product="neuronal cell adhesion molecule isoform O
                     precursor"
                     /protein_id="NP_001358095.1"
                     /db_xref="GeneID:4897"
                     /db_xref="HGNC:HGNC:7994"
                     /db_xref="MIM:601581"
                     /translation="MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQ
                     PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTG
                     TLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSG
                     QSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYIC
                     YARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE
                     GLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTI
                     SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRK
                     IDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN
                     RPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVA
                     RNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN
                     RELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPV
                     YDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS
                     GTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSE
                     PDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPY
                     LIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIR
                     GHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNG
                     KGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQP
                     TMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQ
                     PMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGS
                     FIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV"
     exon            750..767
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            768..873
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1070
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1193
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1364
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1476
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1661
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1793
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1937
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2049
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2216
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2364
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2489
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2519
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2621
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2819
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2890
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3116
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3232
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3437
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3560
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3692
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3771
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..6270
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6122..6127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="hexamer: ATTAAA"
     polyA_site      6140
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="major polyA site"
     regulatory      6250..6255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="hexamer: ATTAAA"
     polyA_site      6270
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgctt cgccagggtc gctggcggac gcgcgccgca gtccgagcct cagacgcgcg
       61 ggcgcggggg acggcgcagg ggccgcctgg ctggagcagc cagaggggat agcttcgtcg
      121 agaacggagg acaccggcgg tccagggtcc tgggcagtcg cgccagagct gagcggaggg
      181 cgcggcgcga gaacgatctt cctctgttgc ccaggctgca gtgcagtggc atgatcttgg
      241 ctcactgcag cctcctcctc actggctcaa actatcctct cacctcagcc tctggagtag
      301 cggggaccac aggaatcttt gtgacattct ctctcagcat tctttatccc ctgtttgctg
      361 aagacttcga caaaagctgg tcttagctgt tggcattctc ctgagaaaag gatagcttca
      421 gaaatcagaa aaacatttgg gaggtgtcta gcccagtgga ccttctgaag agcaatgcta
      481 agaagacgtt tggtttaaag aattaaaagg aagaacaact taagagcttc ttcaaagttt
      541 cccgcatgaa aattacttaa acgttgcaca caacgtttca caaaatcttt tgtgaaagaa
      601 gaaaaggaaa ttcagtgtgt gagtctcagc aggagttaag ctaatgcagc ttaaaataat
      661 gccgaaaaag aagcgcttat ctgcgggcag agtgcccctg attctcttcc tgtgccagat
      721 gattagtgca ctggaagtac ctcttgatcc aaaacttctt gaagacttgg tacagcctcc
      781 aaccatcacc caacagtctc caaaagatta cattattgac cctcgggaga atattgtaat
      841 ccagtgtgaa gccaaaggga aaccgccccc aagcttttcc tggacccgta atgggactca
      901 ttttgacatc gataaagacc ctctggtcac catgaagcct ggcacaggaa cgctcataat
      961 taacatcatg agcgaaggga aagctgagac ctatgaagga gtctatcagt gtacagcaag
     1021 gaacgaacgc ggagctgcag tttctaataa cattgttgtc cgcccatcca gatcaccatt
     1081 gtggaccaaa gaaaaacttg aaccaatcac acttcaaagt ggtcagtctt tagtacttcc
     1141 ctgcagaccc ccaattggat taccaccacc tataatattt tggatggata attcctttca
     1201 aagacttcca caaagtgaga gagtttctca aggtttgaat ggggaccttt atttttccaa
     1261 tgtcctccca gaggacaccc gcgaagacta tatctgttat gctagattta atcatactca
     1321 aaccatacag cagaagcaac ctatttctgt gaaggtgatt tcagctaaat caagtagaga
     1381 gaggccacca acatttttaa ctccagaagg caatgcaagt aacaaagagg aattaagagg
     1441 aaatgtgctt tcactggagt gcattgcaga aggactgcct accccaatta tttactgggc
     1501 aaaggaagat ggaatgctac ccaaaaacag gacagtttat aagaactttg agaaaacctt
     1561 gcagatcatt catgtttcag aagcagactc tggaaattac caatgtatag caaaaaacgc
     1621 attaggagcc atccaccata ccatttctgt tagagttaaa gcggctccat actggatcac
     1681 agcccctcaa aatcttgtgc tgtccccagg agaggatggg accttgatct gcagagctaa
     1741 tggcaacccc aaacccagaa ttagctggtt aacaaatgga gtcccaatag aaattgcccc
     1801 tgatgacccc agcagaaaaa tagatggcga taccattatt ttttcaaatg ttcaagaaag
     1861 atcaagtgca gtctatcagt gcaatgcctc taatgaatat ggatatttac tggcaaacgc
     1921 atttgtaaat gtgctggctg agccaccacg aatcctcaca cctgcaaaca cactctacca
     1981 ggtcattgca aacaggcctg ctttactaga ctgtgccttc tttgggtctc ctctcccaac
     2041 catcgagtgg tttaaaggag ctaaaggaag tgctcttcat gaagatattt atgttttaca
     2101 tgaaaatgga actttggaaa ttcctgtggc ccaaaaggac agtacaggaa cttatacgtg
     2161 tgttgcaagg aataaattag ggatggcgaa gaatgaagtt cacttagaaa tcaaagatcc
     2221 tacatggatc gttaaacagc ccgaatatgc agttgtgcaa agagggagca tggtgtcctt
     2281 tgaatgcaaa gtgaaacatg atcacacctt atccctcact gtcctgtggc tgaaggacaa
     2341 cagggaactg cccagtgatg aaaggttcac tgttgacaag gatcatctag tggtagctga
     2401 tgtcagtgac gatgacagcg ggacctacac gtgtgtggcc aacaccactc tggacagcgt
     2461 ctccgccagc gctgtgctta gcgttgttgc tcctactcca actccagctc ccgtttacga
     2521 tgtcccaaat cctccctttg acttagaact gacagatcaa cttgacaaaa gtgttcagct
     2581 gtcatggacc ccaggcgatg acaacaatag ccccattaca aaattcatca tcgaatatga
     2641 agatgcaatg cacaagccag ggctgtggca ccaccaaact gaagtttctg gaacacagac
     2701 cacagcccag ctgaagctgt ctccttacgt gaactactcc ttccgcgtga tggcagtgaa
     2761 cagcattggg aagagcttgc ccagcgaggc gtctgagcag tatttgacga aagcctcaga
     2821 accagataaa aaccccacag ctgtggaagg actgggatca gagcctgata atttggtgat
     2881 tacgtggaag cccttgaatg gtttcgaatc taatgggcca ggccttcagt acaaagttag
     2941 ctggcgccag aaagatggtg atgatgaatg gacatctgtg gttgtggcaa atgtatccaa
     3001 atatattgtc tcaggcacgc caacctttgt tccatacctg atcaaagttc aggccctgaa
     3061 tgacatgggg tttgcccccg agccagctgt agtcatggga cattctggag aagacctccc
     3121 aatggtggct cctgggaacg tgcgtgtgaa tgtggtgaac agtaccttag ccgaggtgca
     3181 ctgggaccca gtacctctga aaagcatccg aggacaccta caaggctatc ggatttacta
     3241 ttggaagacc cagagttcat ctaaaagaaa cagacgtcac attgagaaaa agatcctcac
     3301 cttccaaggc agcaagactc atggcatgtt gccggggcta gagcccttta gccactacac
     3361 actgaatgtc cgagtggtca atgggaaagg ggagggccca gccagccctg acagagtctt
     3421 taatactcca gaaggagtcc ccagtgctcc ctcgtctttg aagattgtga atccaacact
     3481 ggactctctc actttggaat gggatccacc gagccacccg aatggcattt tgacagagta
     3541 caccttaaag tatcagccaa cgatggcaag ccggcaggtg gatattgcaa ctcagggctg
     3601 gttcattggt ctgatgtgtg ctgttgctct ccttatctta attttgctga ttgtttgctt
     3661 catcagaaga aacaagggtg gtaaatatcc agttaaagaa aaggaagatg cccatgctga
     3721 ccctgaaatc cagcctatga aggaagatga tgggacattt ggagaataca gtgatgcaga
     3781 agaccacaag cctttgaaaa aaggaagtcg aactccttca gacaggactg tgaaaaaaga
     3841 agatagtgac gacagcctag ttgactatgg agaaggggtt aatggccagt tcaatgagga
     3901 tggctccttt attggacaat acagtggtaa gaaagagaaa gagccggctg aaggaaacga
     3961 aagctcagag gcaccttctc ctgtcaacgc catgaattcc tttgtttaat ttttaagctc
     4021 tttgccaata ttccatttct ctagaatgtt tatcctaagc acttgtttgt cagccctctc
     4081 atactatgaa catatgggta gagagtatat tttctgctgt atgttagtat tatgagaata
     4141 gttacagcaa aaacataact cagtcaaatg atatgttaat atgaactgga atgcaaagtg
     4201 catacttttt cattcaaaat gggtattctt gatttcctca gaactgataa aaaataatgc
     4261 aacatcacca acagatcctg ttatttcctc tgcaggatac agttcaatat gatgcatgaa
     4321 aaatgctcca catttaaagg acatacccgt gtatgttatg aaaacatggt ttgatacttt
     4381 gtttatacta ccctcagctg aacccctata tatgaattcc gttttcattg tcaagaatgt
     4441 tactgtagta ttctctagaa cttcaatgtc tttgtggaca ttgttgtgaa attggtgact
     4501 atgtatagct gtcgttagtc tttttgggag actgttagga acagtttgta cagtatatac
     4561 ttgctaaatg agttcattat gacagtcaca ttgctgatgc ttactgagaa ctattaccta
     4621 ctcttggctc ctgttactcc gtaggcttct taatcttcca ggcattacag cagcacagtg
     4681 ttctactttt tacatcattt ctatgttcgg ttgtttttag gcataaacaa tgtgtattgc
     4741 agtgcatttc ggcatttgtg ccatactgaa agaatcaaaa acaaatcatc caaattaaat
     4801 ttcaaacatt atttcagaga acacagggca agacacatac agtgccttca gatattaagc
     4861 attccacaac atcgtgcatt ctgtatcagc tggtccagtc cattctgggt cctagattac
     4921 tgtcattgtc taaaagtaac ttttaaaaag cagagttcat gaaaactgca atgctgggaa
     4981 aagaaggaaa catgaaaata aaaataagac agtttattag aaatagcatt tcctcataag
     5041 cataaaaaga aaatctttgt tgccaactga agcacatgat gattttgtgg tcctttatgg
     5101 tttctattac attcagtaag aaagatgtca acatgctaga aaattaattt taaaactaag
     5161 ttattccaac actaaaagca tacaacagca tgccaacagt aatatattat tctccaagac
     5221 tttacctatg taagtgttca aaactctgca gcattaaaca acgtgtatgc aaattgttat
     5281 ggatacattt cagaatctaa gaaatcaggc aagtgcttaa aaggccaacg gtccaaggga
     5341 ttacatctgc agtttaaaaa gtaaatatat attctatcgt attcataaac aatatctatc
     5401 aaatgggtta cctccaaata tgaaaatcta taacaaccta tggttgaagg aatgctcagt
     5461 ttcatttgcc aataaattgg tttctcataa cttgcatcaa gtttaatttt aagtaaagct
     5521 ttttatatgt agatattttg ttgaatttgt aaatacactt aaaatgtaga tgctatatgc
     5581 ttataggtgt tacatacaaa taaacatgca atgtttatgt tgtactgtat aagaggtaag
     5641 ctaattaatg cagtgaatgg gattggaaag catctactta aatatctatt gggttccccc
     5701 ctccccccac cttttttgct gtgaaactga aatagtgaac ttttctacgt attgacagca
     5761 gatttttcga tgaaatcttc agagctttgc ctatggggca cagtaggcct agtaacctgg
     5821 catgtttgat atatgtaggt aaagcataat ttaaagtaat cccaggtaaa gatggcccta
     5881 aatactttca tgtctctata ttcatttttc acagatccac ctgtctcttg aaaatataaa
     5941 aagacaaaac aggtttgcct tggcatcaga gagcacaaag attaaaagtt actttaaatt
     6001 tgccaatatt ttgggagaac aataaaacta cattttttcc tcttccatac tggtagatgc
     6061 gaaatttatc tgtgcatgaa agggtcactt ctgtaatagt gcaacagatt tggtattaaa
     6121 aattaaatgt ggttttaaaa gttcctctct cttttgtaat ttatgttccc aattgagtgt
     6181 gaatgtccaa gtaatggtgt atgtaatggt acaggcaaat gtgactggat ttccctcaaa
     6241 aaagtaacta ttaaacagtc ttgatctctt
//
