LOCUS       NM_001037132            6701 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens neuronal cell adhesion molecule (NRCAM), transcript
            variant 1, mRNA.
ACCESSION   NM_001037132 XM_005250373
VERSION     NM_001037132.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6701)
  AUTHORS   Wang,C., Wang,Z., Fu,L., Du,J., Ji,F. and Qiu,X.
  TITLE     CircNRCAM up-regulates NRCAM to promote papillary thyroid carcinoma
            progression
  JOURNAL   J Endocrinol Invest 47 (5), 1215-1226 (2024)
   PUBMED   38485895
  REMARK    GeneRIF: CircNRCAM up-regulates NRCAM to promote papillary thyroid
            carcinoma progression.
REFERENCE   2  (bases 1 to 6701)
  AUTHORS   Zhou,L., He,L., Liu,C.H., Qiu,H., Zheng,L., Sample,K.M., Wu,Q.,
            Li,J., Xie,K., Ampuero,J., Li,Z., Lv,D., Liu,M., Romero-Gomez,M.,
            Hu,Y. and Tang,H.
  TITLE     Liver cancer stem cell dissemination and metastasis: uncovering the
            role of NRCAM in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 311 (2023)
   PUBMED   37993901
  REMARK    GeneRIF: Liver cancer stem cell dissemination and metastasis:
            uncovering the role of NRCAM in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6701)
  AUTHORS   Sannes,A.C., Christensen,J.O., Nielsen,M.B. and Gjerstad,J.
  TITLE     Stress-induced headache in the general working population is
            moderated by the NRCAM rs2300043 genotype
  JOURNAL   Scand J Pain 23 (2), 326-332 (2022)
   PUBMED   36181733
  REMARK    GeneRIF: Stress-induced headache in the general working population
            is moderated by the NRCAM rs2300043 genotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6701)
  AUTHORS   Bai,C. and Chen,D.G.
  TITLE     NRCAM acts as a prognostic biomarker and promotes the tumor
            progression in gastric cancer via EMT pathway
  JOURNAL   Tissue Cell 77, 101859 (2022)
   PUBMED   35763884
  REMARK    GeneRIF: NRCAM acts as a prognostic biomarker and promotes the
            tumor progression in gastric cancer via EMT pathway.
REFERENCE   5  (bases 1 to 6701)
  AUTHORS   Huang,F.J., Liu,Y.L., Wang,J., Zhou,Y.Y., Zhao,S.Y. and Qin,G.J.
  TITLE     LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by
            regulating NrCAM transcription in Graves' disease
  JOURNAL   Cell Cycle 21 (9), 921-933 (2022)
   PUBMED   35220890
  REMARK    GeneRIF: LncRNA RUNX1-IT1 affects the differentiation of Th1 cells
            by regulating NrCAM transcription in Graves' disease.
REFERENCE   6  (bases 1 to 6701)
  AUTHORS   Wang,B., Williams,H., Du,J.S., Terrett,J. and Kenwrick,S.
  TITLE     Alternative splicing of human NrCAM in neural and nonneural tissues
  JOURNAL   Mol Cell Neurosci 10 (5-6), 287-295 (1998)
   PUBMED   9604207
REFERENCE   7  (bases 1 to 6701)
  AUTHORS   Grumet,M.
  TITLE     Nr-CAM: a cell adhesion molecule with ligand and receptor functions
  JOURNAL   Cell Tissue Res 290 (2), 423-428 (1997)
   PUBMED   9321706
  REMARK    Review article
REFERENCE   8  (bases 1 to 6701)
  AUTHORS   Sakurai,T., Lustig,M., Nativ,M., Hemperly,J.J., Schlessinger,J.,
            Peles,E. and Grumet,M.
  TITLE     Induction of neurite outgrowth through contactin and Nr-CAM by
            extracellular regions of glial receptor tyrosine phosphatase beta
  JOURNAL   J Cell Biol 136 (4), 907-918 (1997)
   PUBMED   9049255
REFERENCE   9  (bases 1 to 6701)
  AUTHORS   Volkmer,H., Leuschner,R., Zacharias,U. and Rathjen,F.G.
  TITLE     Neurofascin induces neurites by heterophilic interactions with
            axonal NrCAM while NrCAM requires F11 on the axonal surface to
            extend neurites
  JOURNAL   J Cell Biol 135 (4), 1059-1069 (1996)
   PUBMED   8922386
REFERENCE   10 (bases 1 to 6701)
  AUTHORS   Lane,R.P., Chen,X.N., Yamakawa,K., Vielmetter,J., Korenberg,J.R.
            and Dreyer,W.J.
  TITLE     Characterization of a highly conserved human homolog to the chicken
            neural cell surface protein Bravo/Nr-CAM that maps to chromosome
            band 7q31
  JOURNAL   Genomics 35 (3), 456-465 (1996)
   PUBMED   8812479
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005058.1, AC007567.2 and
            AC005683.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jul 3, 2019 this sequence version replaced
            XM_005250373.3, NM_001037132.3.
            
            Summary: Cell adhesion molecules (CAMs) are members of the
            immunoglobulin superfamily. This gene encodes a neuronal cell
            adhesion molecule with multiple immunoglobulin-like C2-type domains
            and fibronectin type-III domains. This ankyrin-binding protein is
            involved in neuron-neuron adhesion and promotes directional
            signaling during axonal cone growth. This gene is also expressed in
            non-neural tissues and may play a general role in cell-cell
            communication via signaling from its intracellular domain to the
            actin cytoskeleton during directional cell migration. Allelic
            variants of this gene have been associated with autism and
            addiction vulnerability. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), as well as variant 7, encodes
            isoform A.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ001057.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379028.8/ ENSP00000368314.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC005058.1         63513-63706         c
            195-352             AC005058.1         6706-6863           c
            353-419             AC007567.2         107148-107214       c
            420-631             AC007567.2         34442-34653         c
            632-649             AC007567.2         32235-32252         c
            650-755             AC007567.2         29066-29171         c
            756-952             AC007567.2         26809-27005         c
            953-1075            AC007567.2         25514-25636         c
            1076-1246           AC007567.2         20691-20861         c
            1247-1303           AC007567.2         20128-20184         c
            1304-1415           AC007567.2         18208-18319         c
            1416-1600           AC007567.2         3904-4088           c
            1601-1732           AC007567.2         2011-2142           c
            1733-1876           AC005683.2         66912-67055         c
            1877-1988           AC005683.2         64717-64828         c
            1989-2155           AC005683.2         63218-63384         c
            2156-2303           AC005683.2         62980-63127         c
            2304-2428           AC005683.2         60685-60809         c
            2429-2458           AC005683.2         60210-60239         c
            2459-2560           AC005683.2         58601-58702         c
            2561-2758           AC005683.2         53373-53570         c
            2759-2829           AC005683.2         53197-53267         c
            2830-3055           AC005683.2         51651-51876         c
            3056-3171           AC005683.2         50778-50893         c
            3172-3376           AC005683.2         49179-49383         c
            3377-3499           AC005683.2         46947-47069         c
            3500-3676           AC005683.2         45387-45563         c
            3677-3712           AC005683.2         44279-44314         c
            3713-3838           AC005683.2         37234-37359         c
            3839-3991           AC005683.2         35878-36030         c
            3992-4123           AC005683.2         29318-29449         c
            4124-4202           AC005683.2         28420-28498         c
            4203-6701           AC005683.2         16606-19104         c
FEATURES             Location/Qualifiers
     source          1..6701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..6701
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="neuronal cell adhesion molecule"
                     /db_xref="GeneID:4897"
                     /db_xref="HGNC:HGNC:7994"
                     /db_xref="MIM:601581"
     exon            1..194
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            195..352
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            353..419
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            420..631
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..4440
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="isoform A precursor is encoded by transcript
                     variant 1; NgCAM-related cell adhesion molecule; neuronal
                     surface protein Bravo"
                     /codon_start=1
                     /product="neuronal cell adhesion molecule isoform A
                     precursor"
                     /protein_id="NP_001032209.1"
                     /db_xref="CCDS:CCDS47686.1"
                     /db_xref="GeneID:4897"
                     /db_xref="HGNC:HGNC:7994"
                     /db_xref="MIM:601581"
                     /translation="MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQ
                     PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTG
                     TLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSG
                     QSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYIC
                     YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN
                     ASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEAD
                     SGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRI
                     SWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL
                     AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG
                     TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFE
                     CKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDS
                     VSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFII
                     EYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYL
                     TKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV
                     VVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNV
                     VNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGM
                     LPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEW
                     DPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYA
                     QTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEY
                     EGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVS
                     SEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKE
                     DAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGV
                     NGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV"
     exon            632..649
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            650..755
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            756..952
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1075
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1246
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1303
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1415
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1600
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1732
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1876
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1988
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2155
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2303
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2428
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2458
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2560
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2758
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2829
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3055
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3171
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3376
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3499
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3676
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3712
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3838
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3991
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..4123
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4202
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..6701
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6553..6558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="hexamer: ATTAAA"
     polyA_site      6571
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="major polyA site"
     regulatory      6681..6686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="hexamer: ATTAAA"
     polyA_site      6701
                     /gene="NRCAM"
                     /gene_synonym="NEDNMS"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgctt cgccagggtc gctggcggac gcgcgccgca gtccgagcct cagacgcgcg
       61 ggcgcggggg acggcgcagg ggccgcctgg ctggagcagc cagaggggat agcttcgtcg
      121 agaacggagg acaccggcgg tccagggtcc tgggcagtcg cgccagagct gagcggaggg
      181 cgcggcgcga gaacgaatct ttgtgacatt ctctctcagc attctttatc ccctgtttgc
      241 tgaagacttc gacaaaagct ggtcttagct gttggcattc tcctgagaaa aggatagctt
      301 cagaaatcag aaaaacattt gggaggtgtc tagcccagtg gaccttctga agagcaatgc
      361 taagaagacg tttggtttaa agaattaaaa ggaagaacaa cttaagagct tcttcaaagt
      421 ttcccgcatg aaaattactt aaacgttgca cacaacgttt cacaaaatct tttgtgaaag
      481 aagaaaagga aattcagtgt gtgagtctca gcaggagtta agctaatgca gcttaaaata
      541 atgccgaaaa agaagcgctt atctgcgggc agagtgcccc tgattctctt cctgtgccag
      601 atgattagtg cactggaagt acctcttgat ccaaaacttc ttgaagactt ggtacagcct
      661 ccaaccatca cccaacagtc tccaaaagat tacattattg accctcggga gaatattgta
      721 atccagtgtg aagccaaagg gaaaccgccc ccaagctttt cctggacccg taatgggact
      781 cattttgaca tcgataaaga ccctctggtc accatgaagc ctggcacagg aacgctcata
      841 attaacatca tgagcgaagg gaaagctgag acctatgaag gagtctatca gtgtacagca
      901 aggaacgaac gcggagctgc agtttctaat aacattgttg tccgcccatc cagatcacca
      961 ttgtggacca aagaaaaact tgaaccaatc acacttcaaa gtggtcagtc tttagtactt
     1021 ccctgcagac ccccaattgg attaccacca cctataatat tttggatgga taattccttt
     1081 caaagacttc cacaaagtga gagagtttct caaggtttga atggggacct ttatttttcc
     1141 aatgtcctcc cagaggacac ccgcgaagac tatatctgtt atgctagatt taatcatact
     1201 caaaccatac agcagaagca acctatttct gtgaaggtga tttcagtgga tgaattgaat
     1261 gacactatag ctgctaattt gagtgacact gagttttatg gtgctaaatc aagtagagag
     1321 aggccaccaa catttttaac tccagaaggc aatgcaagta acaaagagga attaagagga
     1381 aatgtgcttt cactggagtg cattgcagaa ggactgccta ccccaattat ttactgggca
     1441 aaggaagatg gaatgctacc caaaaacagg acagtttata agaactttga gaaaaccttg
     1501 cagatcattc atgtttcaga agcagactct ggaaattacc aatgtatagc aaaaaacgca
     1561 ttaggagcca tccaccatac catttctgtt agagttaaag cggctccata ctggatcaca
     1621 gcccctcaaa atcttgtgct gtccccagga gaggatggga ccttgatctg cagagctaat
     1681 ggcaacccca aacccagaat tagctggtta acaaatggag tcccaataga aattgcccct
     1741 gatgacccca gcagaaaaat agatggcgat accattattt tttcaaatgt tcaagaaaga
     1801 tcaagtgcag tctatcagtg caatgcctct aatgaatatg gatatttact ggcaaacgca
     1861 tttgtaaatg tgctggctga gccaccacga atcctcacac ctgcaaacac actctaccag
     1921 gtcattgcaa acaggcctgc tttactagac tgtgccttct ttgggtctcc tctcccaacc
     1981 atcgagtggt ttaaaggagc taaaggaagt gctcttcatg aagatattta tgttttacat
     2041 gaaaatggaa ctttggaaat tcctgtggcc caaaaggaca gtacaggaac ttatacgtgt
     2101 gttgcaagga ataaattagg gatggcgaag aatgaagttc acttagaaat caaagatcct
     2161 acatggatcg ttaaacagcc cgaatatgca gttgtgcaaa gagggagcat ggtgtccttt
     2221 gaatgcaaag tgaaacatga tcacacctta tccctcactg tcctgtggct gaaggacaac
     2281 agggaactgc ccagtgatga aaggttcact gttgacaagg atcatctagt ggtagctgat
     2341 gtcagtgacg atgacagcgg gacctacacg tgtgtggcca acaccactct ggacagcgtc
     2401 tccgccagcg ctgtgcttag cgttgttgct cctactccaa ctccagctcc cgtttacgat
     2461 gtcccaaatc ctccctttga cttagaactg acagatcaac ttgacaaaag tgttcagctg
     2521 tcatggaccc caggcgatga caacaatagc cccattacaa aattcatcat cgaatatgaa
     2581 gatgcaatgc acaagccagg gctgtggcac caccaaactg aagtttctgg aacacagacc
     2641 acagcccagc tgaagctgtc tccttacgtg aactactcct tccgcgtgat ggcagtgaac
     2701 agcattggga agagcttgcc cagcgaggcg tctgagcagt atttgacgaa agcctcagaa
     2761 ccagataaaa accccacagc tgtggaagga ctgggatcag agcctgataa tttggtgatt
     2821 acgtggaagc ccttgaatgg tttcgaatct aatgggccag gccttcagta caaagttagc
     2881 tggcgccaga aagatggtga tgatgaatgg acatctgtgg ttgtggcaaa tgtatccaaa
     2941 tatattgtct caggcacgcc aacctttgtt ccatacctga tcaaagttca ggccctgaat
     3001 gacatggggt ttgcccccga gccagctgta gtcatgggac attctggaga agacctccca
     3061 atggtggctc ctgggaacgt gcgtgtgaat gtggtgaaca gtaccttagc cgaggtgcac
     3121 tgggacccag tacctctgaa aagcatccga ggacacctac aaggctatcg gatttactat
     3181 tggaagaccc agagttcatc taaaagaaac agacgtcaca ttgagaaaaa gatcctcacc
     3241 ttccaaggca gcaagactca tggcatgttg ccggggctag agccctttag ccactacaca
     3301 ctgaatgtcc gagtggtcaa tgggaaaggg gagggcccag ccagccctga cagagtcttt
     3361 aatactccag aaggagtccc cagtgctccc tcgtctttga agattgtgaa tccaacactg
     3421 gactctctca ctttggaatg ggatccaccg agccacccga atggcatttt gacagagtac
     3481 accttaaagt atcagccaat taacagcaca catgaattag gccctctggt agatttgaaa
     3541 attcctgcca acaagacacg gtggacttta aaaaatttaa atttcagcac tcgatataag
     3601 ttttatttct atgcacaaac atcagcagga tcaggaagtc aaattacaga ggaagcagta
     3661 acaactgtgg atgaagctgg tattcttcca cctgatgtag gtgcaggcaa agttcaagca
     3721 gtaaatccca ggatcagcaa tcttactgct gcagctgctg agacctatgc caatatcagt
     3781 tgggaatatg agggaccaga gcatgtgaac ttttatgttg aatatggtgt agcaggcagc
     3841 aaagaagaat ggagaaaaga aattgtaaat ggttctcgga gcttctttgg gttaaagggt
     3901 ctaatgccag gaacagcata caaagttcga gttggtgctg tgggggactc tggttttgtg
     3961 agttcagagg atgtgtttga gacaggccca gcgatggcaa gccggcaggt ggatattgca
     4021 actcagggct ggttcattgg tctgatgtgt gctgttgctc tccttatctt aattttgctg
     4081 attgtttgct tcatcagaag aaacaagggt ggtaaatatc cagttaaaga aaaggaagat
     4141 gcccatgctg accctgaaat ccagcctatg aaggaagatg atgggacatt tggagaatac
     4201 agtgatgcag aagaccacaa gcctttgaaa aaaggaagtc gaactccttc agacaggact
     4261 gtgaaaaaag aagatagtga cgacagccta gttgactatg gagaaggggt taatggccag
     4321 ttcaatgagg atggctcctt tattggacaa tacagtggta agaaagagaa agagccggct
     4381 gaaggaaacg aaagctcaga ggcaccttct cctgtcaacg ccatgaattc ctttgtttaa
     4441 tttttaagct ctttgccaat attccatttc tctagaatgt ttatcctaag cacttgtttg
     4501 tcagccctct catactatga acatatgggt agagagtata ttttctgctg tatgttagta
     4561 ttatgagaat agttacagca aaaacataac tcagtcaaat gatatgttaa tatgaactgg
     4621 aatgcaaagt gcatactttt tcattcaaaa tgggtattct tgatttcctc agaactgata
     4681 aaaaataatg caacatcacc aacagatcct gttatttcct ctgcaggata cagttcaata
     4741 tgatgcatga aaaatgctcc acatttaaag gacatacccg tgtatgttat gaaaacatgg
     4801 tttgatactt tgtttatact accctcagct gaacccctat atatgaattc cgttttcatt
     4861 gtcaagaatg ttactgtagt attctctaga acttcaatgt ctttgtggac attgttgtga
     4921 aattggtgac tatgtatagc tgtcgttagt ctttttggga gactgttagg aacagtttgt
     4981 acagtatata cttgctaaat gagttcatta tgacagtcac attgctgatg cttactgaga
     5041 actattacct actcttggct cctgttactc cgtaggcttc ttaatcttcc aggcattaca
     5101 gcagcacagt gttctacttt ttacatcatt tctatgttcg gttgttttta ggcataaaca
     5161 atgtgtattg cagtgcattt cggcatttgt gccatactga aagaatcaaa aacaaatcat
     5221 ccaaattaaa tttcaaacat tatttcagag aacacagggc aagacacata cagtgccttc
     5281 agatattaag cattccacaa catcgtgcat tctgtatcag ctggtccagt ccattctggg
     5341 tcctagatta ctgtcattgt ctaaaagtaa cttttaaaaa gcagagttca tgaaaactgc
     5401 aatgctggga aaagaaggaa acatgaaaat aaaaataaga cagtttatta gaaatagcat
     5461 ttcctcataa gcataaaaag aaaatctttg ttgccaactg aagcacatga tgattttgtg
     5521 gtcctttatg gtttctatta cattcagtaa gaaagatgtc aacatgctag aaaattaatt
     5581 ttaaaactaa gttattccaa cactaaaagc atacaacagc atgccaacag taatatatta
     5641 ttctccaaga ctttacctat gtaagtgttc aaaactctgc agcattaaac aacgtgtatg
     5701 caaattgtta tggatacatt tcagaatcta agaaatcagg caagtgctta aaaggccaac
     5761 ggtccaaggg attacatctg cagtttaaaa agtaaatata tattctatcg tattcataaa
     5821 caatatctat caaatgggtt acctccaaat atgaaaatct ataacaacct atggttgaag
     5881 gaatgctcag tttcatttgc caataaattg gtttctcata acttgcatca agtttaattt
     5941 taagtaaagc tttttatatg tagatatttt gttgaatttg taaatacact taaaatgtag
     6001 atgctatatg cttataggtg ttacatacaa ataaacatgc aatgtttatg ttgtactgta
     6061 taagaggtaa gctaattaat gcagtgaatg ggattggaaa gcatctactt aaatatctat
     6121 tgggttcccc cctcccccca ccttttttgc tgtgaaactg aaatagtgaa cttttctacg
     6181 tattgacagc agatttttcg atgaaatctt cagagctttg cctatggggc acagtaggcc
     6241 tagtaacctg gcatgtttga tatatgtagg taaagcataa tttaaagtaa tcccaggtaa
     6301 agatggccct aaatactttc atgtctctat attcattttt cacagatcca cctgtctctt
     6361 gaaaatataa aaagacaaaa caggtttgcc ttggcatcag agagcacaaa gattaaaagt
     6421 tactttaaat ttgccaatat tttgggagaa caataaaact acattttttc ctcttccata
     6481 ctggtagatg cgaaatttat ctgtgcatga aagggtcact tctgtaatag tgcaacagat
     6541 ttggtattaa aaattaaatg tggttttaaa agttcctctc tcttttgtaa tttatgttcc
     6601 caattgagtg tgaatgtcca agtaatggtg tatgtaatgg tacaggcaaa tgtgactgga
     6661 tttccctcaa aaaagtaact attaaacagt cttgatctct t
//
