LOCUS       NM_178564               3724 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear receptor binding protein 2 (NRBP2), mRNA.
ACCESSION   NM_178564
VERSION     NM_178564.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Chi,F., Jin,X., Chen,L., He,G. and Han,S.
  TITLE     TRG16, targeted by miR-765, inhibits breast cancer stem cell-like
            properties via regulating the NF-kappaB pathway
  JOURNAL   Mol Cell Biochem 477 (12), 2801-2816 (2022)
   PUBMED   35648115
  REMARK    GeneRIF: TRG16, targeted by miR-765, inhibits breast cancer stem
            cell-like properties via regulating the NF-kappaB pathway.
REFERENCE   2  (bases 1 to 3724)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3724)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 3724)
  AUTHORS   Gil-Cayuela,C., Lopez,A., Martinez-Dolz,L., Gonzalez-Juanatey,J.R.,
            Lago,F., Rosello-Lleti,E., Rivera,M. and Portoles,M.
  TITLE     The altered expression of autophagy-related genes participates in
            heart failure: NRBP2 and CALCOCO2 are associated with left
            ventricular dysfunction parameters in human dilated cardiomyopathy
  JOURNAL   PLoS One 14 (4), e0215818 (2019)
   PUBMED   31009519
  REMARK    GeneRIF: The altered expression of NRBP2 and CALCOCO2 is associated
            with left ventricular dysfunction parameters in human dilated
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3724)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3724)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   7  (bases 1 to 3724)
  AUTHORS   Larsson,J., Forsberg,M., Brannvall,K., Zhang,X.Q., Enarsson,M.,
            Hedborg,F. and Forsberg-Nilsson,K.
  TITLE     Nuclear receptor binding protein 2 is induced during neural
            progenitor differentiation and affects cell survival
  JOURNAL   Mol Cell Neurosci 39 (1), 32-39 (2008)
   PUBMED   18619852
  REMARK    GeneRIF: Data show that NRBP2 protein levels increase as neural
            progenitor cells differentiate, and its down regulation renders
            neural progenitor cells more vulnerable to apoptosis, which suggest
            a role in stem cell survival.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK293943.1, BC071605.1, AI094905.1 and AC234917.3.
            
            On Nov 23, 2018 this sequence version replaced NM_178564.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.222364.1,
                                           SRR3476690.1010888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442628.7/ ENSP00000414055.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1398              AK293943.1         2-1399
            1399-3710           BC071605.1         1563-3874
            3711-3722           AI094905.1         1-12                c
            3723-3724           AC234917.3         35169-35170
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3724
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /note="nuclear receptor binding protein 2"
                     /db_xref="GeneID:340371"
                     /db_xref="HGNC:HGNC:19339"
                     /db_xref="MIM:615563"
     exon            1..268
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1645
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /note="transformation-related protein 16"
                     /codon_start=1
                     /product="nuclear receptor-binding protein 2"
                     /protein_id="NP_848659.2"
                     /db_xref="CCDS:CCDS34959.2"
                     /db_xref="GeneID:340371"
                     /db_xref="HGNC:HGNC:19339"
                     /db_xref="MIM:615563"
                     /translation="MAAPEPAPRRAREREREREDESEDESDILEESPCGRWQKRREQV
                     NQGNMPGLQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNI
                     VKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSA
                     LSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWHRIFSNALPDDLRSPIRAEREEL
                     RNLHFFPPEYGEVADGTAVDIFSFGMCALEMAVLEIQTNGDTRVTEEAIARARHSLSD
                     PNMREFILCCLARDPARRPSAHSLLFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEE
                     KTKAMDLHAVLAELPRPRRPPLQWRYSEVSFMELDKFLEDVRNGIYPLMNFAATRPLG
                     LPRVLAPPPEEVQKAKTPTPEPFDSETRKVIQMQCNLERSEDKARWHLTLLLVLEDRL
                     HRQLTYDLLPTDSAQDLASELVHYGFLHEDDRMKLAAFLESTFLKYRGTQA"
     exon            269..391
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            392..493
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            494..583
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            584..624
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            625..719
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            720..743
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            744..827
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            828..883
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            884..979
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1112
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1215
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1266
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1402
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1456
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1520
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1576
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..3724
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3541..3546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /note="hexamer: ATTAAA"
     polyA_site      3561
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /note="major polyA site"
     regulatory      3690..3695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
                     /note="hexamer: AATAAA"
     polyA_site      3724
                     /gene="NRBP2"
                     /gene_synonym="pp9320; TRG16"
ORIGIN      
        1 attcccagag ccggggctgg ggctctaggc tgccgcggcg gctctaggct gggctgctgg
       61 gcgcgaggcc agggcgggcc gggagaggct gcgccggcgg cggatcgcgc agagggcggt
      121 ggcctgggct ggccgaacca tggcggcccc ggagccggcg ccgaggcggg cccgggaacg
      181 ggagcgggag cgggaggacg agagcgagga cgagagcgac atcctggagg aaagcccgtg
      241 tggtcgctgg caaaagcgac gggagcaggt aaaccaaggg aacatgccag ggcttcagag
      301 caccttccta gccatggaca cggaggaggg ggtagaggtg gtgtggaacg agctccactt
      361 cggagacagg aaggccttcg cggcgcacga ggagaagatc cagaccgtgt tcgagcagct
      421 ggtgctggtg gaccacccga acatcgtgaa gttgcacaag tactggctgg atacctctga
      481 ggcctgcgcg agggtcatct tcatcacaga gtacgtgtca tcaggcagcc tcaagcaatt
      541 cctcaaaaag accaagaaga accacaaggc catgaacgcc cgggcctgga agcgctggtg
      601 cacgcagatc ctgtctgcgc tcagcttcct gcacgcctgc agccccccaa tcatccacgg
      661 gaacctgacc agcgacacca tcttcattca gcacaacggc ctcatcaaga tcggctccgt
      721 gtggcaccga atcttctcca atgcacttcc agatgatctc cgaagcccca tccgcgctga
      781 gcgagaggaa cttcggaacc tgcacttctt ccccccagag tatggagagg tggccgatgg
      841 gaccgctgtg gacatcttct cctttgggat gtgtgcgctg gagatggctg tactggaaat
      901 ccagaccaat ggggacaccc gggtcacaga ggaggccatt gctcgcgcca ggcactcgct
      961 gagtgacccc aacatgcggg agttcatcct ttgctgcctg gcccgggacc ctgcccgccg
     1021 gccctctgcc cacagcctcc tcttccaccg cgtgctcttc gaggtgcact cgctgaagct
     1081 cctggcagcc cactgcttca tccagcacca gtacctcatg cctgagaatg tggtggagga
     1141 gaagaccaag gccatggacc tgcacgcggt cttggcggag cttccccggc cccgcaggcc
     1201 cccgctgcag tggcggtact cggaagtctc cttcatggag ctggacaaat tcctggagga
     1261 tgtcaggaat ggaatctacc cactgatgaa ctttgcagcc actcgacccc tggggctgcc
     1321 ccgtgtgctg gccccacccc cggaggaggt ccaaaaggcc aagaccccga cgccagagcc
     1381 ctttgactct gagaccagaa aggtcatcca gatgcagtgc aacctggaga gaagcgagga
     1441 caaggcgcgc tggcatctca ctctgcttct ggtgctggaa gaccggctgc accggcagct
     1501 gacctacgac ctgctcccaa cggacagcgc ccaggacctc gcctcggagc tcgtgcacta
     1561 tggcttcctc cacgaggacg accggatgaa gctggccgcc ttcctggaga gcaccttcct
     1621 caagtaccgt gggacccagg cctgacccgg agccccagcc ccaggggacc atgccggggt
     1681 gctgcctggg caggccatgt tggggagact ccagcaccgt ggggctgccc tcctccatgc
     1741 gcctgggagc acaaaggccc cggtagtgaa ggaacccccc gtctcctgag agtggggctg
     1801 accctgcctt gggcgccgag gggttggggg gtgggtgtgg gggagccgtt aggcctccca
     1861 ggtccttagg atcagggttg cccccagaac cccttcccat atcctccatt ctccgccctg
     1921 agttcctacc caggctgcct ggccggggcc actgcctcct cagcatgcag gaggctgccc
     1981 tgtagggaac cccagctctg gggcttgggg gtgagggtca gccctggaca gacctctgcc
     2041 cagggaactg ctccatgggg tctgggagag cagccatccc ctgctggcac catagaccca
     2101 cacaaggagc ctgcacagca agccagcggt gacacacctg caggtgtcag gcatggcact
     2161 gggcacaaca gggacctggc aggagaaaca gaccacagag aggtctggag ttgaggctgt
     2221 tgtcagcaaa gcccctggtc ccacacagct ctgccctaga gccacctctt tgacccttta
     2281 cccaccctga gaccagaact tgcagcccct ctgcagatct cctctggcca ctgcagcccc
     2341 tccaatgggc tttttctctc atgcattccc tggcctggag gcgtcaggga ccccacatcc
     2401 tccctgctcc tcagactcac agcccctcca tgttacctcc cgcacctcct ccctggggca
     2461 gctgctccct gggcctctga ggatgtcagc tcctggctcc ctgcctctct cccactccac
     2521 tcctggctca gtcttagaga tttctatgcc ctcatggatt ctacccctgc cttcctggcc
     2581 tcttgattct tggcttgcct ctcctccaat tccaaactta gtgaaatggc cttaagcatt
     2641 ttaaactgta tgtatacatt agcgcattca tgcctttcta aacgcatttc aaatgtcaac
     2701 caggaaggca caccactgta ttagttttat actgccgctg taaaatttac cacaaactta
     2761 gtgacttaac acaaatttat tgcaattctg taggctggaa gtctgactat gggtctcact
     2821 ggactagaat caaggctggc aggctgcctt ccttcctgga ggttctaggg gagactctgt
     2881 ctcctgctcc ttcaggctgc tggcagaatc cacatccttt cggtggcagg gccaaggtcc
     2941 ccactttctt gctgactgta aactaaggcc acttccagct tgtagaggct gcctacattc
     3001 cttggctctt ggccccctcc tccatcttca gagctagcag gttcagtctg tgtcacgaac
     3061 catttctctg gttccctgca gacaggaaag gttgtcccta aggactcatg agattaggtt
     3121 gggcccagcc agataataca tgataatctc cctcctcaag gtttttaata ttaaacacat
     3181 ctgcaggaca cattttgcca tgtaaactaa cattcactgg ttccagggat taaggaatga
     3241 acctcttttg ttggggaagg gtggcattct gctgaccaca gcactccaac caaaagccaa
     3301 aaaccaaagc aagacttact aacgcatatc aaataaatta aaggtacaaa atcgtgaatc
     3361 tcagttatct taaatattcc aatactattt acaaaattat tcaaattctc acgccttcca
     3421 actcaaaatt agcaatctaa agtaatttcc atatcctaga tggaaaccct catgctaaac
     3481 tgtctgatta tgcatggttc taaatggttt cagtggcaaa tacataacat tgtactactg
     3541 attaaactga acttaaaagc atcaatacca ccattgctgc acttaatcat gtctctgttg
     3601 aatttttcct tttaaatttt atcttttcag aattatatat gtattgtttt taaagtagaa
     3661 tagttttttt tttgaggcca ataataaata ataaatgcag gctcctactc tgatcctctc
     3721 caaa
//
