LOCUS       NM_013392               2176 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nuclear receptor binding protein 1 (NRBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_013392
VERSION     NM_013392.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Zhang,A., Peng,S., Sun,S., Ye,S., Zhao,Y. and Wu,Q.
  TITLE     NRBP1 promotes malignant phenotypes of glioblastoma by regulating
            PI3K/Akt activation
  JOURNAL   Cancer Med 13 (16), e70100 (2024)
   PUBMED   39149873
  REMARK    GeneRIF: NRBP1 promotes malignant phenotypes of glioblastoma by
            regulating PI3K/Akt activation.
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Cao,C., Sun,G., Le,K., Xu,Q. and Liu,C.
  TITLE     The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression
            Through NRBP1/miR-497-5p Axis
  JOURNAL   Biochem Genet 61 (5), 1775-1790 (2023)
   PUBMED   36790665
  REMARK    GeneRIF: The Circular RNA Circ_0085494 Regulates Prostate Cancer
            Progression Through NRBP1/miR-497-5p Axis.
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Yang,X., Cruz,M.I., Nguyen,E.V., Huang,C., Schittenhelm,R.B.,
            Luu,J., Cowley,K.J., Shin,S.Y., Nguyen,L.K., Lim Kam Sian,T.C.C.,
            Clark,K.C., Simpson,K.J., Ma,X. and Daly,R.J.
  TITLE     The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive
            oncogenic signalling in triple-negative breast cancer
  JOURNAL   Oncogene 42 (11), 833-847 (2023)
   PUBMED   36693952
  REMARK    GeneRIF: The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to
            drive oncogenic signalling in triple-negative breast cancer.
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Qin,L., Sun,X., Zhou,F. and Liu,C.
  TITLE     CircLRP6 contributes to prostate cancer growth and metastasis by
            binding to miR-330-5p to up-regulate NRBP1
  JOURNAL   World J Surg Oncol 19 (1), 184 (2021)
   PUBMED   34158077
  REMARK    GeneRIF: CircLRP6 contributes to prostate cancer growth and
            metastasis by binding to miR-330-5p to up-regulate NRBP1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Chua,J.J., Ng,M.M. and Chow,V.T.
  TITLE     The non-structural 3 (NS3) protein of dengue virus type 2 interacts
            with human nuclear receptor binding protein and is associated with
            alterations in membrane structure
  JOURNAL   Virus Res 102 (2), 151-163 (2004)
   PUBMED   15084397
  REMARK    GeneRIF: NS3 protein of dengue virus type 2 interacted specifically
            with nuclear receptor binding protein, a host cellular protein that
            influences trafficking between the endoplasmic reticulum and Golgi,
            and that interacts with Rac3
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Lim,R., Winteringham,L.N., Williams,J.H., McCulloch,R.K.,
            Ingley,E., Tiao,J.Y., Lalonde,J.P., Tsai,S., Tilbrook,P.A., Sun,Y.,
            Wu,X., Morris,S.W. and Klinken,S.P.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
  REMARK    GeneRIF: mediates phosphorylation of the 14-3-3 binding site of
            myeloid leukemia factor 1
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   De Langhe,S., Haataja,L., Senadheera,D., Groffen,J. and
            Heisterkamp,N.
  TITLE     Interaction of the small GTPase Rac3 with NRBP, a protein with a
            kinase-homology domain
  JOURNAL   Int J Mol Med 9 (5), 451-459 (2002)
   PUBMED   11956649
  REMARK    GeneRIF: Interaction of the small GTPase Rac3 with NRBP: results
            suggest that NRBP functions in subcellular trafficking and may be
            directed to specific subcellular locations through interaction with
            small GTPases of the Rho family
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Hooper,J.D., Baker,E., Ogbourne,S.M., Sutherland,G.R. and
            Antalis,T.M.
  TITLE     Cloning of the cDNA and localization of the gene encoding human
            NRBP, a ubiquitously expressed, multidomain putative adapter
            protein
  JOURNAL   Genomics 66 (1), 113-118 (2000)
   PUBMED   10843813
REFERENCE   10 (bases 1 to 2176)
  AUTHORS   Martinez,P.
  TITLE     [A nurse with the drug addicts]
  JOURNAL   Rev Infirm 26 (7), 557-562 (1976)
   PUBMED   1048605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ949042.1 and BC001221.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013392.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1162419.1, AF113249.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379852.8/ ENSP00000369181.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               BQ949042.1         26-564
            540-2176            BC001221.1         533-2169
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2176
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /note="nuclear receptor binding protein 1"
                     /db_xref="GeneID:29959"
                     /db_xref="HGNC:HGNC:7993"
                     /db_xref="MIM:606010"
     exon            1..101
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            102..331
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1729
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myeloid leukemia factor 1 adaptor molecule; multiple
                     domain putative nuclear protein; nuclear receptor-binding
                     protein"
                     /codon_start=1
                     /product="nuclear receptor-binding protein isoform 1"
                     /protein_id="NP_037524.1"
                     /db_xref="CCDS:CCDS1753.1"
                     /db_xref="GeneID:29959"
                     /db_xref="HGNC:HGNC:7993"
                     /db_xref="MIM:606010"
                     /translation="MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPE
                     EEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFS
                     ERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ
                     FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI
                     GSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQG
                     NGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLK
                     LLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDK
                     FLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCN
                     IESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLT
                     SLLEETLNKFNFARNSTLNSAAVTVSS"
     exon            332..454
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            455..556
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            557..646
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            647..687
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            688..782
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..866
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            867..925
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1024
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1157
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1263
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1314
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1450
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1504
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1568
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1624
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..2176
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="NRBP1"
                     /gene_synonym="BCON3; MADM; MUDPNP; NRBP"
                     /note="major polyA site"
ORIGIN      
        1 ggttgcgctg cggagcgcag ctgtgaggga gtcgctgtga tccggggccc cggaacccga
       61 gctggagctg aagcgcaggc tgcggggcgc ggagtcggga ggcctgagtg ttccttccag
      121 catgtcggag ggggagtccc agacagtact tagcagtggc tcagacccaa aggtagaatc
      181 ctcatcttca gctcctggcc tgacatcagt gtcacctcct gtgacctcca caacctcagc
      241 tgcttcccca gaggaagaag aagaaagtga agatgagtct gagattttgg aagagtcgcc
      301 ctgtgggcgc tggcagaaga ggcgagaaga ggtgaatcaa cggaatgtac caggtattga
      361 cagtgcatac ctggccatgg atacagagga aggtgtagag gttgtgtgga atgaggtaca
      421 gttctctgaa cgcaagaact acaagctgca ggaggaaaag gttcgtgctg tgtttgataa
      481 tctgattcaa ttggagcatc ttaacattgt taagtttcac aaatattggg ctgacattaa
      541 agagaacaag gccagggtca tttttatcac agaatacatg tcatctggga gtctgaagca
      601 atttctgaag aagaccaaaa agaaccacaa gacgatgaat gaaaaggcat ggaagcgttg
      661 gtgcacacaa atcctctctg ccctaagcta cctgcactcc tgtgaccccc ccatcatcca
      721 tgggaacctg acctgtgaca ccatcttcat ccagcacaac ggactcatca agattggctc
      781 tgtggctcct gacactatca acaatcatgt gaagacttgt cgagaagagc agaagaatct
      841 acacttcttt gcaccagagt atggagaagt cactaatgtg acaacagcag tggacatcta
      901 ctcctttggc atgtgtgcac tggagatggc agtgctggag attcagggca atggagagtc
      961 ctcatatgtg ccacaggaag ccatcagcag tgccatccag cttctagaag acccattaca
     1021 gagggagttc attcaaaagt gcctgcagtc tgagcctgct cgcagaccaa cagccagaga
     1081 acttctgttc cacccagcat tgtttgaagt gccctcgctc aaactccttg cggcccactg
     1141 cattgtggga caccaacaca tgatcccaga gaacgctcta gaggagatca ccaaaaacat
     1201 ggatactagt gccgtactgg ctgaaatccc tgcaggacca ggaagagaac cagttcagac
     1261 tttgtactct cagtcaccag ctctggaatt agataaattc cttgaagatg tcaggaatgg
     1321 gatctatcct ctgacagcct ttgggctgcc tcggccccag cagccacagc aggaggaggt
     1381 gacatcacct gtcgtgcccc cctctgtcaa gactccgaca cctgaaccag ctgaggtgga
     1441 gactcgcaag gtggtgctga tgcagtgcaa cattgagtcg gtggaggagg gagtcaaaca
     1501 ccacctgaca cttctgctga agttggagga caaactgaac cggcacctga gctgtgacct
     1561 gatgccaaat gagaatatcc ccgagttggc ggctgagctg gtgcagctgg gcttcattag
     1621 tgaggctgac cagagccggt tgacttctct gctagaagag accttgaaca agttcaattt
     1681 tgccaggaac agtaccctca actcagccgc tgtcaccgtc tcctcttaga gctcactcgg
     1741 gccaggccct gatctgcgct gtggctgtcc ctggacgtgc tgcagccctc ctgtcccttc
     1801 cccccagtca gtattaccct gtgaagcccc ttccctcctt tattattcag gagggctggg
     1861 ggggctccct ggttctgagc atcatccttt cccctcccct ctcttcctcc cctctgcact
     1921 ttgtttactt gttttgcaca gacgtgggcc tgggccttct cagcagccgc cttctagttg
     1981 ggggctagtc gctgatctgc cggctcccgc ccagcctgtg tggaaaggag gcccacgggc
     2041 actaggggag ccgaattcta caatcccgct ggggcggccg gggcgggaga gaaaggtggt
     2101 gctgcagtgg tggccctggg gggccattcg attcgcctca gttgctgctg taataaaagt
     2161 ctactttttg ctaaaa
//
