LOCUS       NM_030759               1813 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear receptor binding factor 2 (NRBF2), transcript
            variant 1, mRNA.
ACCESSION   NM_030759
VERSION     NM_030759.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Kim,J., Kang,H., Son,B., Kim,M.J., Kang,J., Park,K.H., Jeon,J.,
            Jo,S., Kim,H.Y., Youn,H. and Youn,B.
  TITLE     NRBF2-mediated autophagy contributes to metabolite replenishment
            and radioresistance in glioblastoma
  JOURNAL   Exp Mol Med 54 (11), 1872-1885 (2022)
   PUBMED   36333468
  REMARK    GeneRIF: NRBF2-mediated autophagy contributes to metabolite
            replenishment and radioresistance in glioblastoma.
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Wu,M.Y., Liu,L., Wang,E.J., Xiao,H.T., Cai,C.Z., Wang,J., Su,H.,
            Wang,Y., Tan,J., Zhang,Z., Wang,J., Yao,M., Ouyang,D.F., Yue,Z.,
            Li,M., Chen,Y., Bian,Z.X. and Lu,J.H.
  TITLE     PI3KC3 complex subunit NRBF2 is required for apoptotic cell
            clearance to restrict intestinal inflammation
  JOURNAL   Autophagy 17 (5), 1096-1111 (2021)
   PUBMED   32160108
  REMARK    GeneRIF: PI3KC3 complex subunit NRBF2 is required for apoptotic
            cell clearance to restrict intestinal inflammation.
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Flores,A.M., Li,L. and Aneskievich,B.J.
  TITLE     Isolation and functional analysis of a keratinocyte-derived,
            ligand-regulated nuclear receptor comodulator
  JOURNAL   J Invest Dermatol 123 (6), 1092-1101 (2004)
   PUBMED   15610520
  REMARK    GeneRIF: The activation domain, their small size (COPR1, 26.9 kDa;
            COPR2, 32.4 kDa), and strict dependence on AF-2 for interaction
            distinguish COPR1 and COPR2 from the SMRT/NCoR type of corepressor
            and may dampen rather than repress NR-mediated gene expression.
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Yasumo,H., Masuda,N., Furusawa,T., Tsukamoto,T., Sadano,H. and
            Osumi,T.
  TITLE     Nuclear receptor binding factor-2 (NRBF-2), a possible gene
            activator protein interacting with nuclear hormone receptors
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 189-197 (2000)
   PUBMED   10786636
REFERENCE   10 (bases 1 to 1813)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU310836.1, BC011707.1 and BC001345.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030759.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136656.1, SRR3476690.1160841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277746.11/ ENSP00000277746.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AU310836.1         82-126
            46-1495             BC011707.1         1-1450
            1496-1813           BC001345.1         1161-1478
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..1813
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /note="nuclear receptor binding factor 2"
                     /db_xref="GeneID:29982"
                     /db_xref="HGNC:HGNC:19692"
                     /db_xref="MIM:616477"
     exon            1..173
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1007
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     comodulator of PPAR and RXR 1; comodulator of PPAR and RXR
                     2"
                     /codon_start=1
                     /product="nuclear receptor-binding factor 2 isoform 1"
                     /protein_id="NP_110386.2"
                     /db_xref="CCDS:CCDS7268.1"
                     /db_xref="GeneID:29982"
                     /db_xref="HGNC:HGNC:19692"
                     /db_xref="MIM:616477"
                     /translation="MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEA
                     MKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAQREERLKAQQNTDKDAAAHLQTSH
                     KPSAEDAEGQSPLSQKYSPSTEKCLPEIQGIFDRDPDTLLYLLQQKSEPAEPCIGSKA
                     PKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPIEKELDVD
                     ADFVETSELWSLPPHAETATASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMEL
                     SEDILKGFMNN"
     exon            174..258
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..299
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..1813
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /note="hexamer: AATAAA"
     polyA_site      1813
                     /gene="NRBF2"
                     /gene_synonym="COPR; COPR1; COPR2; NRBF-2"
                     /note="major polyA site"
ORIGIN      
        1 gctccttcag cgcctatcgc tggctcttgg ggcgcagaga ggggccgcag tctccgcggc
       61 tgcgtcgagc tcccttgcag tcccctccat gttccccggc gccactactc cccttcctaa
      121 ggccgccgct taccccgggg tctatggaag taatggaagg acccctcaac ctggctcatc
      181 aacagagcag acgagcagac cgtttattag ctgcaggcaa atacgaagag gctatttctt
      241 gtcacaaaaa ggctgcagca tatctttctg aagccatgaa gctgacacag tcagagcagg
      301 ctcatctttc actggaattg caaagggata gccatatgaa acagctcctc ctcatccaag
      361 agagatggaa aagggcccag cgtgaagaaa gattgaaagc ccagcagaac acagacaagg
      421 atgcagctgc ccatcttcag acatctcaca aaccctctgc agaggatgca gagggccaga
      481 gtcccctttc tcagaagtac agcccttcca cagagaaatg cctgcctgag attcagggga
      541 tctttgacag ggatccagac acactacttt atttacttca gcaaaagagt gagccagcag
      601 agccatgtat tggaagcaaa gccccaaaag atgataaaac aattatagag gagcaggcaa
      661 ccaaaattgc agatttgaag aggcatgtgg aattccttgt ggctgagaat gaaagattaa
      721 ggaaagaaaa taaacaacta aaggctgaaa aggccagact tctaaaaggt ccaatagaaa
      781 aggagctgga tgtagatgct gattttgtag aaacgtcaga gttatggagc ttgccaccac
      841 atgcagaaac tgctacagcc tcctcaacct ggcagaagtt cgcagcaaat actgggaaag
      901 ccaaggacat tccaatcccc aatcttcctc ccttggattt tccatctcca gaacttcctc
      961 ttatggagct ctctgaggat attctgaaag gatttatgaa taattaaaat ggaaggccac
     1021 agaaaagggg aaaagaggaa ataatacagt aatcgttaat ccagcaaaaa gaaatgaaaa
     1081 gggaaaacca catagaaggg taatcccgga aatgcttcat ctggtggact gtgggagcag
     1141 aggcattgcc aggacttggg aaacagtcac tgtgaaatgc gctgcgtatc tcattcactc
     1201 acttcagcta atgattccga cttggcagac gctaaactca tggaggttcg gtttctcctg
     1261 atacaaacca aatggctacc tggaagaatt tctttcaagc aacagttatt tttcttatct
     1321 tcagggttaa aatgtataaa agttatgtgt aattaatcta taatgccata aatgataatg
     1381 caaaacctaa ataatatggt ggccggaggg gctgccttat atttgaaaca tgctttctat
     1441 catgcattga ctgtatgcat tttgttaatg cacattctgt ttgtttaagg tgtgtaagat
     1501 acacaccctt ctagatgaaa ctatatgtgc cacactttgc actactcata atgataacct
     1561 caagactatc agaagaaata tttaaatttc cattttatga agaaaggaac caaattatta
     1621 tgctttttaa aacaaattac cagtttacat aattaatcag ggtgcatttt aagttctaac
     1681 ttcgtttatt gtataatgca tcatttgaaa ataccaagga ggaaataccc tttgttttta
     1741 atgatgcaag agtggacgta atgctagttg gcagtatttt attgtaagaa atcaataaag
     1801 taattgtgtt tta
//
