LOCUS       NM_002524               4326 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens NRAS proto-oncogene, GTPase (NRAS), mRNA.
ACCESSION   NM_002524
VERSION     NM_002524.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4326)
  AUTHORS   Valcikova,B., Vadovicova,N., Smolkova,K., Zacpalova,M., Krejci,P.,
            Lee,S., Rauch,J., Kolch,W., von Kriegsheim,A., Dorotikova,A.,
            Andrysik,Z., Vichova,R., Vacek,O., Soucek,K. and Uldrijan,S.
  TITLE     eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS
            mutations
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2321305121 (2024)
   PUBMED   39436655
  REMARK    GeneRIF: eIF4F controls ERK MAPK signaling in melanomas with BRAF
            and NRAS mutations.
REFERENCE   2  (bases 1 to 4326)
  AUTHORS   Yi,M., Soppet,D., McCormick,F. and Nissley,D.V.
  TITLE     The prominent pervasive oncogenic role and tissue specific
            permissiveness of RAS gene mutations
  JOURNAL   Sci Rep 14 (1), 25452 (2024)
   PUBMED   39455841
  REMARK    GeneRIF: The prominent pervasive oncogenic role and tissue specific
            permissiveness of RAS gene mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4326)
  AUTHORS   Lints,R., Walker,C.A., Delfi,O., Prouse,M., PohLui De Silva,M.,
            Bohlander,S.K. and Wood,A.C.
  TITLE     Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic
            NRAS in zebrafish myeloid leukaemia
  JOURNAL   Biol Open 13 (9) (2024)
   PUBMED   39177514
  REMARK    GeneRIF: Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and
            oncogenic NRAS in zebrafish myeloid leukaemia.
REFERENCE   4  (bases 1 to 4326)
  AUTHORS   Soloveva,M., Solovev,M., Risinskaya,N., Nikulina,E., Yakutik,I.,
            Biderman,B., Obukhova,T., Chabaeva,Y., Kulikov,S., Sudarikov,A. and
            Mendeleeva,L.
  TITLE     Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes
            in Tumor Cells of Various Loci in Multiple Myeloma
  JOURNAL   Int J Mol Sci 25 (17), 9426 (2024)
   PUBMED   39273371
  REMARK    GeneRIF: Loss of Heterozygosity and Mutations in the RAS-ERK
            Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4326)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   6  (bases 1 to 4326)
  AUTHORS   Dracopoli,N.C. and Meisler,M.H.
  TITLE     Mapping the human amylase gene cluster on the proximal short arm of
            chromosome 1 using a highly informative (CA)n repeat
  JOURNAL   Genomics 7 (1), 97-102 (1990)
   PUBMED   1692298
REFERENCE   7  (bases 1 to 4326)
  AUTHORS   Yuasa,Y., Kamiyama,T., Kato,M., Iwama,T., Ikeuchi,T. and
            Tonomura,A.
  TITLE     Transforming genes from familial adenomatous polyposis patient
            cells detected by a tumorigenicity assay
  JOURNAL   Oncogene 5 (4), 589-596 (1990)
   PUBMED   1970154
REFERENCE   8  (bases 1 to 4326)
  AUTHORS   Hancock,J.F., Magee,A.I., Childs,J.E. and Marshall,C.J.
  TITLE     All ras proteins are polyisoprenylated but only some are
            palmitoylated
  JOURNAL   Cell 57 (7), 1167-1177 (1989)
   PUBMED   2661017
REFERENCE   9  (bases 1 to 4326)
  AUTHORS   Hirai,H., Tanaka,S., Azuma,M., Anraku,Y., Kobayashi,Y.,
            Fujisawa,M., Okabe,T., Urabe,A. and Takaku,F.
  TITLE     Transforming genes in human leukemia cells
  JOURNAL   Blood 66 (6), 1371-1378 (1985)
   PUBMED   2998510
REFERENCE   10 (bases 1 to 4326)
  AUTHORS   Hall,A. and Brown,R.
  TITLE     Human N-ras: cDNA cloning and gene structure
  JOURNAL   Nucleic Acids Res 13 (14), 5255-5268 (1985)
   PUBMED   2991860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL096773.6, BC005219.1,
            AY941101.1, BC013214.1 and AW021410.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002524.4.
            
            Summary: This is an N-ras oncogene encoding a membrane protein that
            shuttles between the Golgi apparatus and the plasma membrane. This
            shuttling is regulated through palmitoylation and depalmitoylation
            by the ZDHHC9-GOLGA7 complex. The encoded protein, which has
            intrinsic GTPase activity, is activated by a guanine
            nucleotide-exchange factor and inactivated by a GTPase activating
            protein. Mutations in this gene have been associated with somatic
            rectal cancer, follicular thyroid cancer, autoimmune
            lymphoproliferative syndrome, Noonan syndrome, and juvenile
            myelomonocytic leukemia. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.226704.1,
                                           SRR11853564.1616.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369535.5/ ENSP00000358548.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL096773.6         88338-88351
            15-1012             BC005219.1         5-1002
            1013-1806           AL096773.6         97327-98120
            1807-2423           AY941101.1         414-1030
            2424-4321           BC013214.1         150-2047
            4322-4326           AW021410.1         13-17               c
FEATURES             Location/Qualifiers
     source          1..4326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..4326
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /note="NRAS proto-oncogene, GTPase"
                     /db_xref="GeneID:4893"
                     /db_xref="HGNC:HGNC:7989"
                     /db_xref="MIM:164790"
     exon            1..114
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     exon            115..242
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..701
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /EC_number="3.6.5.2"
                     /note="v-ras neuroblastoma RAS viral oncogene homolog;
                     N-ras protein part 4; neuroblastoma RAS viral (v-ras)
                     oncogene homolog; transforming protein N-Ras;
                     proto-oncogene GTPase"
                     /codon_start=1
                     /product="GTPase NRas"
                     /protein_id="NP_002515.1"
                     /db_xref="CCDS:CCDS877.1"
                     /db_xref="GeneID:4893"
                     /db_xref="HGNC:HGNC:7989"
                     /db_xref="MIM:164790"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKR
                     VKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLV
                     REIRQYRMKKLNSSDDGTQGCMGLPCVVM"
     exon            243..421
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     exon            422..581
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     exon            582..705
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     exon            706..744
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     exon            745..4326
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1811..1816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /note="hexamer: AATATA"
     polyA_site      1832
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
     regulatory      4294..4299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /note="hexamer: AATAAA"
     polyA_site      4326
                     /gene="NRAS"
                     /gene_synonym="ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6"
                     /note="major polyA site"
ORIGIN      
        1 ggggccggaa gtgccgctcc ttggtggggg ctgttcatgg cggttccggg gtctccaaca
       61 tttttcccgg ctgtggtcct aaatctgtcc aaagcagagg cagtggagct tgaggttctt
      121 gctggtgtga aatgactgag tacaaactgg tggtggttgg agcaggtggt gttgggaaaa
      181 gcgcactgac aatccagcta atccagaacc actttgtaga tgaatatgat cccaccatag
      241 aggattctta cagaaaacaa gtggttatag atggtgaaac ctgtttgttg gacatactgg
      301 atacagctgg acaagaagag tacagtgcca tgagagacca atacatgagg acaggcgaag
      361 gcttcctctg tgtatttgcc atcaataata gcaagtcatt tgcggatatt aacctctaca
      421 gggagcagat taagcgagta aaagactcgg atgatgtacc tatggtgcta gtgggaaaca
      481 agtgtgattt gccaacaagg acagttgata caaaacaagc ccacgaactg gccaagagtt
      541 acgggattcc attcattgaa acctcagcca agaccagaca gggtgttgaa gatgcttttt
      601 acacactggt aagagaaata cgccagtacc gaatgaaaaa actcaacagc agtgatgatg
      661 ggactcaggg ttgtatggga ttgccatgtg tggtgatgta acaagatact tttaaagttt
      721 tgtcagaaaa gagccacttt caagctgcac tgacaccctg gtcctgactt ccctggagga
      781 gaagtattcc tgttgctgtc ttcagtctca cagagaagct cctgctactt ccccagctct
      841 cagtagttta gtacaataat ctctatttga gaagttctca gaataactac ctcctcactt
      901 ggctgtctga ccagagaatg cacctcttgt tactccctgt tatttttctg ccctgggttc
      961 ttccacagca caaacacacc tctgccaccc caggtttttc atctgaaaag cagttcatgt
     1021 ctgaaacaga gaaccaaacc gcaaacgtga aattctattg aaaacagtgt cttgagctct
     1081 aaagtagcaa ctgctggtga tttttttttt ctttttactg ttgaacttag aactatgcta
     1141 atttttggag aaatgtcata aattactgtt ttgccaagaa tatagttatt attgctgttt
     1201 ggtttgttta taatgttatc ggctctattc tctaaactgg catctgctct agattcataa
     1261 atacaaaaat gaatactgaa ttttgagtct atcctagtct tcacaacttt gacgtaatta
     1321 aatccaactt tcacagtgaa gtgccttttt cctagaagtg gtttgtagac ttcctttata
     1381 atatttcagt ggaatagatg tctcaaaaat ccttatgcat gaaatgaatg tctgagatac
     1441 gtctgtgact tatctaccat tgaaggaaag ctatatctat ttgagagcag atgccatttt
     1501 gtacatgtat gaaattggtt ttccagaggc ctgttttggg gctttcccag gagaaagatg
     1561 aaactgaaag cacatgaata atttcactta ataattttta cctaatctcc acttttttca
     1621 taggttacta cctatacaat gtatgtaatt tgtttcccct agcttactga taaacctaat
     1681 attcaatgaa cttccatttg tattcaaatt tgtgtcatac cagaaagctc tacatttgca
     1741 gatgttcaaa tattgtaaaa ctttggtgca ttgttattta atagctgtga tcagtgattt
     1801 tcaaacctca aatatagtat attaacaaat tacattttca ctgtatatca tggtatctta
     1861 atgatgtata taattgcctt caatcccctt ctcaccccac cctctacagc ttcccccaca
     1921 gcaatagggg cttgattatt tcagttgagt aaagcatggt gctaatggac cagggtcaca
     1981 gtttcaaaac ttgaacaatc cagttagcat cacagagaaa gaaattcttc tgcatttgct
     2041 cattgcacca gtaactccag ctagtaattt tgctaggtag ctgcagttag ccctgcaagg
     2101 aaagaagagg tcagttagca caaacccttt accatgactg gaaaactcag tatcacgtat
     2161 ttaaacattt ttttttcttt tagccatgta gaaactctaa attaagccaa tattctcatt
     2221 tgagaatgag gatgtctcag ctgagaaacg ttttaaattc tctttattca taatgttctt
     2281 tgaagggttt aaaacaagat gttgataaat ctaagctgat gagtttgctc aaaacaggaa
     2341 gttgaaattg ttgagacagg aatggaaaat ataattaatt gatacctatg aggatttgga
     2401 ggcttggcat tttaatttgc agataatacc ctggtaattc tcatgaaaaa tagacttgga
     2461 taacttttga taaaagacta attccaaaat ggccactttg ttcctgtctt taatatctaa
     2521 atacttactg aggtcctcca tcttctatat tatgaatttt catttattaa gcaaatgtca
     2581 tattaccttg aaattcagaa gagaagaaac atatactgtg tccagagtat aatgaacctg
     2641 cagagttgtg cttcttactg ctaattctgg gagctttcac agtactgtca tcatttgtaa
     2701 atggaaattc tgcttttctg tttctgctcc ttctggagca gtgctactct gtaattttcc
     2761 tgaggcttat cacctcagtc atttcttttt taaatgtctg tgactggcag tgattctttt
     2821 tcttaaaaat ctattaaatt tgatgtcaaa ttagggagaa agatagttac tcatcttggg
     2881 ctcttgtgcc aatagccctt gtatgtatgt acttagagtt ttccaagtat gttctaagca
     2941 cagaagtttc taaatggggc caaaattcag acttgagtat gttctttgaa taccttaaga
     3001 agttacaatt agccgggcat ggtggcccgt gcctgtagtc ccagctactt gagaggctga
     3061 ggcaggagaa tcacttcaac ccaggaggtg gaggttacag tgagcagaga tcgtgccact
     3121 gcactccagc ctgggtgaca agagagactt gtctccaaaa aaaaagttac acctaggtgt
     3181 gaattttggc acaaaggagt gacaaactta tagttaaaag ctgaataact tcagtgtggt
     3241 ataaaacgtg gtttttaggc tatgtttgtg attgctgaaa agaattctag tttacctcaa
     3301 aatccttctc tttccccaaa ttaagtgcct ggccagctgt cataaattac atattccttt
     3361 tggttttttt aaaggttaca tgttcaagag tgaaaataag atgttctgtc tgaaggctac
     3421 catgccggat ctgtaaatga acctgttaaa tgctgtattt gctccaacgg cttactatag
     3481 aatgttactt aatacaatat catacttatt acaattttta ctataggagt gtaataggta
     3541 aaattaatct ctattttagt gggcccatgt ttagtctttc accatccttt aaactgctgt
     3601 gaattttttt gtcatgactt gaaagcaagg atagagaaac actttagaga tatgtggggt
     3661 ttttttacca ttccagagct tgtgagcata atcatatttg ctttatattt atagtcatga
     3721 actcctaagt tggcagctac aaccaagaac caaaaaatgg tgcgttctgc ttcttgtaat
     3781 tcatctctgc taataaatta taagaagcaa ggaaaattag ggaaaatatt ttatttggat
     3841 ggtttctata aacaagggac tataattctt gtacattatt tttcatcttt gctgtttctt
     3901 tgagcagtct aatgtgccac acaattatct aaggtatttg ttttctataa gaattgtttt
     3961 aaaagtattc ttgttaccag agtagttgta ttatatttca aaacgtaaga tgatttttaa
     4021 aagcctgagt actgacctaa gatggaattg tatgaactct gctctggagg gaggggagga
     4081 tgtccgtgga agttgtaaga cttttatttt tttgtgccat caaatatagg taaaaataat
     4141 tgtgcaattc tgctgtttaa acaggaacta ttggcctcct tggccctaaa tggaagggcc
     4201 gatattttaa gttgattatt ttattgtaaa ttaatccaac ctagttcttt ttaatttggt
     4261 tgaatgtttt ttcttgttaa atgatgttta aaaaataaaa actggaagtt cttggcttag
     4321 tcataa
//
