LOCUS       NM_001004354            2641 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens NOTCH regulated ankyrin repeat protein (NRARP), mRNA.
ACCESSION   NM_001004354 XM_497087
VERSION     NM_001004354.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Pinto,I., Duque,M., Goncalves,J., Akkapeddi,P., Oliveira,M.L.,
            Cabrita,R., Yunes,J.A., Durum,S.K., Barata,J.T. and Fragoso,R.
  TITLE     NRARP displays either pro- or anti-tumoral roles in T-cell acute
            lymphoblastic leukemia depending on Notch and Wnt signaling
  JOURNAL   Oncogene 39 (5), 975-986 (2020)
   PUBMED   31586130
  REMARK    GeneRIF: NRARP displays either pro- or anti-tumoral roles in T-cell
            acute lymphoblastic leukemia depending on Notch and Wnt signaling.
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Jarrett,S.M., Seegar,T.C.M., Andrews,M., Adelmant,G., Marto,J.A.,
            Aster,J.C. and Blacklow,S.C.
  TITLE     Extension of the Notch intracellular domain ankyrin repeat stack by
            NRARP promotes feedback inhibition of Notch signaling
  JOURNAL   Sci Signal 12 (606) (2019)
   PUBMED   31690634
  REMARK    GeneRIF: Extension of the Notch intracellular domain ankyrin repeat
            stack by NRARP promotes feedback inhibition of Notch signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Zhang,M., Qin,Y., Zuo,B., Gong,W., Zhang,S., Gong,Y., Quan,Z. and
            Chu,B.
  TITLE     Overexpression of NOTCH-regulated Ankyrin Repeat Protein is
            associated with papillary thyroid carcinoma progression
  JOURNAL   PLoS One 12 (2), e0167782 (2017)
   PUBMED   28207739
  REMARK    GeneRIF: High NRARP expression is associated with papillary thyroid
            carcinoma progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Chu,B.F., Qin,Y.Y., Zhang,S.L., Quan,Z.W., Zhang,M.D. and Bi,J.W.
  TITLE     Downregulation of Notch-regulated Ankyrin Repeat Protein Exerts
            Antitumor Activities against Growth of Thyroid Cancer
  JOURNAL   Chin Med J (Engl) 129 (13), 1544-1552 (2016)
   PUBMED   27364790
  REMARK    GeneRIF: Downregulation of NRARP expression exerts significant
            antitumor activities against cell growth and invasion of thyroid
            cancer, that suggests a potential role of NRARP in thyroid cancer
            targeted therapy.
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Imaoka,T., Okutani,T., Daino,K., Iizuka,D., Nishimura,M. and
            Shimada,Y.
  TITLE     Overexpression of NOTCH-regulated ankyrin repeat protein is
            associated with breast cancer cell proliferation
  JOURNAL   Anticancer Res 34 (5), 2165-2171 (2014)
   PUBMED   24778018
  REMARK    GeneRIF: NRARP may stimulate cell proliferation in human breast
            cancer.
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Krebs,L.T., Bradley,C.K., Norton,C.R., Xu,J., Oram,K.F.,
            Starling,C., Deftos,M.L., Bevan,M.J. and Gridley,T.
  TITLE     The Notch-regulated ankyrin repeat protein is required for proper
            anterior-posterior somite patterning in mice
  JOURNAL   Genesis 50 (4), 366-374 (2012)
   PUBMED   21998026
REFERENCE   8  (bases 1 to 2641)
  AUTHORS   Phng,L.K., Potente,M., Leslie,J.D., Babbage,J., Nyqvist,D.,
            Lobov,I., Ondr,J.K., Rao,S., Lang,R.A., Thurston,G. and Gerhardt,H.
  TITLE     Nrarp coordinates endothelial Notch and Wnt signaling to control
            vessel density in angiogenesis
  JOURNAL   Dev Cell 16 (1), 70-82 (2009)
   PUBMED   19154719
REFERENCE   9  (bases 1 to 2641)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 2641)
  AUTHORS   Lamar,E., Deblandre,G., Wettstein,D., Gawantka,V., Pollet,N.,
            Niehrs,C. and Kintner,C.
  TITLE     Nrarp is a novel intracellular component of the Notch signaling
            pathway
  JOURNAL   Genes Dev 15 (15), 1885-1899 (2001)
   PUBMED   11485984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX255925.17, BC053618.1, CB066921.1, CB132749.1 and CK819901.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001004354.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC053618.1, SRR1163657.23525.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356628.4/ ENSP00000349041.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BX255925.17        97632-97651         c
            21-1581             BC053618.1         1-1561
            1582-1924           CB066921.1         1-343               c
            1925-2537           CB132749.1         52-664
            2538-2641           CK819901.1         19-122              c
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2641
                     /gene="NRARP"
                     /note="NOTCH regulated ankyrin repeat protein"
                     /db_xref="GeneID:441478"
                     /db_xref="HGNC:HGNC:33843"
                     /db_xref="MIM:619987"
     exon            1..2641
                     /gene="NRARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..688
                     /gene="NRARP"
                     /codon_start=1
                     /product="notch-regulated ankyrin repeat-containing
                     protein"
                     /protein_id="NP_001004354.1"
                     /db_xref="CCDS:CCDS35188.1"
                     /db_xref="GeneID:441478"
                     /db_xref="HGNC:HGNC:33843"
                     /db_xref="MIM:619987"
                     /translation="MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNV
                     NSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLY
                     LITKAKYAASGR"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRARP"
                     /note="hexamer: TATAAA"
     polyA_site      1796
                     /gene="NRARP"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRARP"
                     /note="hexamer: TATAAA"
     polyA_site      1926
                     /gene="NRARP"
                     /note="major polyA site"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRARP"
                     /note="hexamer: AATAAA"
     polyA_site      2194
                     /gene="NRARP"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRARP"
                     /note="hexamer: GATAAA"
     polyA_site      2545
                     /gene="NRARP"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRARP"
                     /note="hexamer: ATTAAA"
     polyA_site      2641
                     /gene="NRARP"
ORIGIN      
        1 agtgctgcgg cgcgtgggga ggcgccttgg gaccgcgtgg gagccgcagc cgaaccgagt
       61 agggaccggg accgcgcggc gccgccgtcc ccggccgggc ccggcccccg cgagccgagc
      121 gcgcgccccc gtcgcccacc cgggcgcggc tggatgcggc ggggtccccg cggcggcgac
      181 ccccggcccc gagcgcccgg agcgcccaga ggcggcgtgc ggggcccggg gacgccgcgc
      241 cctccatgcg ccgaggcgcg ccccgagaca gccgggggcc cgcgccgcag ccgccgcccg
      301 cgctgagccc cggcccggcc cgcggcccgc gcccggcggc agcatgagcc aggccgagct
      361 gtccacctgc tccgcgccgc agacgcagcg catcttccag gaggctgtgc gcaagggcaa
      421 cacgcaggag ctgcagtcgc tgctgcagaa catgaccaac tgcgagttca acgtgaactc
      481 gttcgggccc gagggccaga cggcgctgca ccagtcggtc atcgacggca acctggagct
      541 cgtgaagctg ctggtcaagt tcggcgccga catccgcctg gccaaccgcg acggctggag
      601 cgcgctgcac atcgccgcgt tcggtggcca ccaggacatc gtgctctatc tcatcaccaa
      661 ggcgaagtac gcggccagcg gccggtgatg cccgccggga ccccggaccc cggccctgcg
      721 cccgcgtcgt ctctgctgta ccttcccgcc aactacctcg gtgcgcgccc ggctcgcagg
      781 ccccgccaga aggcccgtgg ccacggcgaa tacggcgcgt gcgtcccggc cccagggtcc
      841 ggcagccccg ccggccgagc gcctccctgc ggcctagccg ggcccggccg ggccggagca
      901 gcttcccacg gcccccaccc gctcgcctgc ccgccgcctc gcgggtgggg gcggggcgcg
      961 ggctccagcc ccttttgaaa tttgagtctc gcaaccagca agttcggaat cccgagatac
     1021 cggatcctct gcgcaaaatg ttttctcccg aaggtgaaag gcgggcggcg ggagccgaag
     1081 gcggactcgg agcgctccgc cgccgccttc aggacccgcc cgcaggcccg ggacgcgccg
     1141 atgccggctg cagccgagga gcagccccga ggtccgaggt ccgcgccgct ggcgcgcggc
     1201 cgaggagacg ctcggctgtt cgctgttgct ggtgttctaa actatttatc ttgtgtgtgt
     1261 acatttgtgg gtggagtttg tgcgcctggt ttttttgttt ggaaaacact gcgtggtcaa
     1321 tgtggttatg ggggggagtg atgcattttt ttctagtctt aaaactaaaa acttgagtct
     1381 accatttctt ggttgcactg aaaataccgc ccagcctgat ggtgttcccg tgctgtccct
     1441 cccccttccc ttctccccgc gtctacctcc ccaccccgtt ctgttccccc tccctccttc
     1501 tccctctccc tcaaatccgt gagttttgga agccccaggg cctctctccc ccgcccctcc
     1561 tggatgaggc caccatcccc caaaccggct tgttttgcag tttccccagg atcctggaag
     1621 ctcgctggcg ctcgagggtg gcggggacac gggggggtgg gtgaaggttc gttacctttt
     1681 ctagtgcgtt ctatcatagt taacggttgc acactttttt aaaaaaagta aatggatttg
     1741 ccacaattaa atgtcataac atttatgaca gaatataaaa tattaacata ttttaagcca
     1801 agttttaggt gtattttttg aatcttggtt ataaacccaa ttttaaaggg cgatgtatcc
     1861 agcgttgtga aggcaacaga gtgtacccat atttatattt ttataaaata cctataagac
     1921 tgtgaatctc ttgtgctaat ggctgagtta attgaaggat cgttttgccc ctttttagcc
     1981 tcccagagct tcgaggactc aattcgaacc cgaaatcctg ccgtggggga ggggttgcgt
     2041 cgagacctgg gcccggggag gttctcctgc gtcactttct gtcctgaaag gcgcccttcc
     2101 tggtttctgt ggctccaatt ttctatgcag ccccacaccc cttgttgttt tgatcctgag
     2161 aaataaaagg gaggctgaat tattcaaatt taaatgaggt ttccccttca tggaagtgct
     2221 gctgaccctt cgtgcagaaa tggggagcac ttgaggacac aggtgggtgg aggccctttg
     2281 tgcgtggctg gtcgtattcg ggcagccctc cgtcgctttt tataaaactt tgtgtgagaa
     2341 gaatatattg ataatgtcag tgaaacaagc agacattgaa atggaggcac agattactcc
     2401 acaaggagtt cttctgtata ttttttctag atgcaaatac ctttttaatt atgttaatta
     2461 atgttaagac tttctaggct tatatcgaag ctgtgtgtgg gtcacggggt gatcactgct
     2521 aactggataa agtttgtgca gcacattcct gagtgtacga tattgacctg tagcccagcg
     2581 tgaaaaattt ataaataaat ttttcattga tctttttata ttaaaaaaaa gtttcttggt
     2641 c
//
