LOCUS       NM_006175               5508 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens nebulin related anchoring protein (NRAP), transcript
            variant 1, mRNA.
ACCESSION   NM_006175
VERSION     NM_006175.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5508)
  AUTHORS   Koskenvuo,J.W., Saarinen,I., Ahonen,S., Tommiska,J., Weckstrom,S.,
            Seppala,E.H., Tuupanen,S., Kangas-Kontio,T., Schleit,J., Helio,K.,
            Hathaway,J., Gummesson,A., Dahlberg,P., Ojala,T.H., Vepsalainen,V.,
            Kytola,V., Muona,M., Sistonen,J., Salmenpera,P., Gentile,M.,
            Paananen,J., Myllykangas,S., Alastalo,T.P. and Helio,T.
  TITLE     Biallelic loss-of-function in NRAP is a cause of recessive dilated
            cardiomyopathy
  JOURNAL   PLoS One 16 (2), e0245681 (2021)
   PUBMED   33534821
  REMARK    GeneRIF: Biallelic loss-of-function in NRAP is a cause of recessive
            dilated cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5508)
  AUTHORS   Jirka,C., Pak,J.H., Grosgogeat,C.A., Marchetii,M.M. and Gupta,V.A.
  TITLE     Dysregulation of NRAP degradation by KLHL41 contributes to
            pathophysiology in nemaline myopathy
  JOURNAL   Hum Mol Genet 28 (15), 2549-2560 (2019)
   PUBMED   30986853
REFERENCE   3  (bases 1 to 5508)
  AUTHORS   Truszkowska,G.T., Bilinska,Z.T., Muchowicz,A., Pollak,A.,
            Biernacka,A., Kozar-Kaminska,K., Stawinski,P., Gasperowicz,P.,
            Kosinska,J., Zielinski,T. and Ploski,R.
  TITLE     Homozygous truncating mutation in NRAP gene identified by whole
            exome sequencing in a patient with dilated cardiomyopathy
  JOURNAL   Sci Rep 7 (1), 3362 (2017)
   PUBMED   28611399
  REMARK    GeneRIF: Loss-of-function mutation in NRAP gene is associated with
            dilated cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5508)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5508)
  AUTHORS   Chen,X., Li,X., Wang,P., Liu,Y., Zhang,Z., Zhao,G., Xu,H., Zhu,J.,
            Qin,X., Chen,S., Hu,L. and Kong,X.
  TITLE     Novel association strategy with copy number variation for
            identifying new risk Loci of human diseases
  JOURNAL   PLoS One 5 (8), e12185 (2010)
   PUBMED   20808825
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5508)
  AUTHORS   Mohiddin,S.A., Lu,S., Cardoso,J.P., Carroll,S., Jha,S., Horowits,R.
            and Fananapazir,L.
  TITLE     Genomic organization, alternative splicing, and expression of human
            and mouse N-RAP, a nebulin-related LIM protein of striated muscle
  JOURNAL   Cell Motil Cytoskeleton 55 (3), 200-212 (2003)
   PUBMED   12789664
  REMARK    GeneRIF: Highly conserved and exclusively expressed in cardiac and
            skeletal muscle.  Candidate cause for cardiac and skeletal
            myopathies
REFERENCE   7  (bases 1 to 5508)
  AUTHORS   Luo,G., Herrera,A.H. and Horowits,R.
  TITLE     Molecular interactions of N-RAP, a nebulin-related protein of
            striated muscle myotendon junctions and intercalated disks
  JOURNAL   Biochemistry 38 (19), 6135-6143 (1999)
   PUBMED   10320340
REFERENCE   8  (bases 1 to 5508)
  AUTHORS   Luo,G., Leroy,E., Kozak,C.A., Polymeropoulos,M.H. and Horowits,R.
  TITLE     Mapping of the gene (NRAP) encoding N-RAP in the mouse and human
            genomes
  JOURNAL   Genomics 45 (1), 229-232 (1997)
   PUBMED   9339382
REFERENCE   9  (bases 1 to 5508)
  AUTHORS   Luo,G., Zhang,J.Q., Nguyen,T.P., Herrera,A.H., Paterson,B. and
            Horowits,R.
  TITLE     Complete cDNA sequence and tissue localization of N-RAP, a novel
            nebulin-related protein of striated muscle
  JOURNAL   Cell Motil Cytoskeleton 38 (1), 75-90 (1997)
   PUBMED   9295142
REFERENCE   10 (bases 1 to 5508)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA564310.1, AY177621.1, AL390197.19 and F30818.1.
            
            On Aug 14, 2020 this sequence version replaced NM_006175.4.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the shortest isoform (1, also known as
            isoform C).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY081943.2, AY177621.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA564310.1         33-50
            19-458              AY177621.1         1-440
            459-459             AL390197.19        171807-171807       c
            460-1538            AY177621.1         442-1520
            1539-1539           AL390197.19        148431-148431       c
            1540-3600           AY177621.1         1522-3582
            3601-3621           AL390197.19        124772-124792       c
            3622-5253           AY177621.1         3604-5235
            5254-5398           F30818.1           227-371
            5399-5508           AL390197.19        102991-103100       c
FEATURES             Location/Qualifiers
     source          1..5508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..5508
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /note="nebulin related anchoring protein"
                     /db_xref="GeneID:4892"
                     /db_xref="HGNC:HGNC:7988"
                     /db_xref="MIM:602873"
     exon            1..231
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..5247
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="nebulin-related-anchoring protein isoform 1"
                     /protein_id="NP_006166.3"
                     /db_xref="CCDS:CCDS7578.1"
                     /db_xref="GeneID:4892"
                     /db_xref="HGNC:HGNC:7988"
                     /db_xref="MIM:602873"
                     /translation="MNVQPCSRCGYGVYPAEKISCIDQIWHKACFHCEVCKMMLSVNN
                     FVSHQKKPYCHAHNPKNNTFTSVYHTPLNLNVRTFPEAISGIHDQEDGEQCKSVFHWD
                     MKSKDKEGAPNRQPLANERAYWTGYGEGNAWCPGALPDPEIVRMVEARKSLGEEYTED
                     YEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRGHDERISRFSTVVDTPELLRSKA
                     GAQLQSDVRYTEDYEQQRGKGSFPAMITPAYQIAKRANELASDVRYHQQYQKEMRGMA
                     GPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPAMITPAYQNAKKAHELASDIKY
                     RQDFNKMKGAAHYHSLPAQDNLVLKQAQSVNKLVSENKYKENYQNHMRGRYEGVGMDR
                     RTLHAMKVGSLASNVAYKADYKHDIVDYNYPATLTPSYQTAMKLVPLKDANYRQSIDK
                     LKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFS
                     EVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEKTKGKAMGTADSR
                     LLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKAQTLASDLDYRKKLHEY
                     TVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNLEQAKKAGQLVSEKN
                     YRQRVDELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPLFLQAR
                     ANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYERSRGKL
                     IGAKDVQGDSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHLVHARKAQHLAT
                     DVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQA
                     KKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENIKHHYTP
                     TADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISDYKY
                     KEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLDMAAL
                     VHAKKAQTLASNQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVAC
                     VIPGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFSNQITNERLYKA
                     AGEDARHEYTMTLGLPEFIRAKTNAANLSDARYKESWRNLRAQGYKLTIEALPFQAAR
                     ASGDIASDFLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSSQA
                     QFHLPMDMVHLVHAKNAQALASDHDYRTQYHKFTALPEDLKMAWAKKAHALQSELRYK
                     SDLIGMKGIGWLALRSPQMESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNS
                     YMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDF
                     RLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDN
                     EYKKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQK
                     AHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANARGLGLQGAYRGAEAVE
                     AGDHQSGEVNPDATEILHVKKKKALLL"
     exon            232..326
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            327..414
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            415..519
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            520..624
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            625..729
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            730..834
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            835..942
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1047
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1152
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1269
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1377
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1482
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1581
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1686
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1794
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1896
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2094
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2199
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2298
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2403
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2511
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2823
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2928
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3027
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3132
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3240
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..3354
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3552
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3657
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3756
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3861
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3969
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4281
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4386
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4485
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4590
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4698
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..5010
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5011..5142
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5143..5508
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5369..5374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /note="hexamer: ATTAAA"
     regulatory      5374..5379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /note="hexamer: AATAAT"
     polyA_site      5392
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /note="major polyA site"
     polyA_site      5401
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
     regulatory      5480..5485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
                     /note="hexamer: AATAAA"
     polyA_site      5508
                     /gene="NRAP"
                     /gene_synonym="N-RAP"
ORIGIN      
        1 agaaggtcag caaaggaaag tggaagttgg attctgaaag atcgaggtgc ccacaggaat
       61 tttatggtcg tcggattttg aagacttgaa ctagactggg ggttctcctt gcatttcttg
      121 cctgttgcct atctttgtcc tctctcttcc ggcttcgaga tgaatgtgca gccctgttct
      181 aggtgtgggt atggggttta tcctgccgag aagatcagct gtatagatca gatatggcat
      241 aaagcctgtt ttcactgtga agtttgcaag atgatgctgt ctgttaataa ctttgtgagt
      301 caccagaaaa agccgtactg tcacgcccat aaccctaaga acaacacttt caccagtgtc
      361 tatcacactc cattaaatct aaatgtgagg acatttccag aggccatcag tgggatccat
      421 gaccaagaag atggtgaaca gtgtaaatca gtttttcact gggacatgaa atccaaggat
      481 aaggaaggtg cacctaacag gcagccactg gcaaatgaga gagcctattg gactggatat
      541 ggggaaggga atgcttggtg cccaggagct ctgccagacc ccgaaattgt aaggatggtt
      601 gaggctcgaa agtctcttgg tgaggaatat acagaagact atgagcaacc caggggcaag
      661 gggagctttc cagccatgat cacacctgct tatcaaaggg ccaagaaagc caaccagctg
      721 gccagccaag tggagtataa gagagggcat gatgaacgca tctccaggtt ctccacggtg
      781 gtggatactc ctgagctgct acggagcaag gctggggcac agcttcaaag tgatgtgaga
      841 tacacagagg actatgaaca acaaagaggg aaaggcagtt tccctgcgat gatcacaccc
      901 gcctatcaga tagccaaaag agccaatgag ctggcaagtg atgtgaggta ccatcaacaa
      961 tatcaaaaag aaatgagggg aatggctggt ccagccattg gagctgaggg catcttgaca
     1021 agggaatgtg cagaccaata tggccagggt tacccggagg agtatgagga gcacagggga
     1081 aagggcagct tcccagctat gatcactcca gcatatcaga acgccaagaa agctcacgaa
     1141 ctcgctagtg acataaaata caggcaggac ttcaataaga tgaaaggcgc tgcacattat
     1201 cactcgcttc cagctcaaga caacttggtt ctcaaacagg ctcagagcgt aaacaaactc
     1261 gtgagtgaga ataaatataa agaaaactac cagaaccaca tgagaggccg ctatgaagga
     1321 gttggtatgg acagacgcac tctgcatgct atgaaagttg gcagcctggc aagcaacgtt
     1381 gcctacaaag ctgattataa acatgatatt gtcgactaca actacccagc cactctcacg
     1441 ccttcctatc aaacagctat gaaactggtg cccttgaaag atgccaatta taggcagagc
     1501 atcgacaagt tgaagtacag ctcggtgact gacaccccac agattgttca agccaaaatc
     1561 aatgcccagc agctgagtca tgtgaattac cgtgctgact atgagaaaaa taagttgaat
     1621 tacacattgc cccaggatgt tcctcagctg gtgaaggcca aaaccaatgc caaactcttc
     1681 agtgaggtta agtataaaga aggctgggag aagacaaagg ggaaaggatt tgagatgaag
     1741 ctggatgcca tgtctctgct ggccgccaaa gcctctgggg agcttgctag caatattaaa
     1801 tataaagaag aatatgaaaa gacaaaaggc aaagccatgg gaacagccga ctctaggctt
     1861 ctgcactccc tgcagattgc taagatgagc agtgaggttg aatataagaa aggctttgaa
     1921 gagagtaaga cccggtttca cctgcccatg gatatggtaa acatcaggca tgctaagaag
     1981 gcccaaactc tcgccagtga cctggactac aggaagaaac tgcatgaata cactgtgctg
     2041 cctgaagata tgaagactca gtgggccaag aaggcctatg ggctccagag cgagctgcag
     2101 tacaaggctg acctggcatg gatgaaggga gttgggtggc tgacagaggg gagtctcaac
     2161 ttggaacaag ccaagaaggc tggacagctg gtcagcgaga aaaactaccg gcagagggtc
     2221 gatgagctga agttcaccag cgtgaccgac agctcccaga tggagcacgc caagaagagc
     2281 caggagctac agagcggggt ggcctacaag gcaggaaatg agcagtctgt ccatcagtat
     2341 accatcagca aagacgagcc tctcttcctg caggcccgag ccaatgctgc aaatctcagc
     2401 gagaaactgt ataagagcag ctgggaaaac cagaaagcaa aagggtttga gctgcgtctt
     2461 gattccttga ccttcctggc agccaaagcc aagagggacc tggctagcga ggtgaagtac
     2521 aaggaggatt atgagagatc cagagggaag ctcattgggg caaaagatgt acagggagat
     2581 tcgcaaatga gccactcact gcaaatgtcc aagctgcaga gtgagctgga gtacaagaag
     2641 ggattcgagg acaccaaatc ccaatgccac gtctccctgg acatggtcca cctcgtgcat
     2701 gcccgcaaag ctcagcattt agccacagac gtaggctaca agacagcgga acatcacttt
     2761 acggctttgc ccacagacat gaaggtggaa tgggccaaga aggcttatgg cttacagagt
     2821 gataaccaat acagggcaga tgtgaagtgg atgaaaggca tgggctgggt cgccaccggg
     2881 tcattaaatg tggagcaggc gaagaaggca ggagaactca ttagcgagaa gaagtaccgt
     2941 cagcatccag atgctttgaa gtttaccagt attaaagaca ctccggagat ggtccaggcc
     3001 agaattagtt atacccaagc agtggataga ttatacaggg aacaaggaga aaacataaag
     3061 catcattaca caccgactgc tgacctccct gaagtcctgc tggccaagct gaatgccatg
     3121 aatatcagtg agacgcgtta taaggaatcc tggagcaaac ttcgagatgg tggctataaa
     3181 ctgaggttgg atgcccttcc attccaagca gcaaaggctt ctggtgaaat cataagtgat
     3241 tacaaataca aagaggcatt tgagaaaatg aaaggacaga tgcttggttc ccggagcttg
     3301 gaagatgata tcagccttgc acattcagtg tatgcgacct cactgcagag tgatgtgaat
     3361 tacaagaaag gctttgaaca ctcaaaggcg cagttccatc tgccgttgga catggccgcc
     3421 ctggtgcatg ccaagaaggc tcagaccctg gccagcaatc aggactacaa acatccactg
     3481 ccccagtaca cttccttggc agaagacctg aggctgagct gtgccaagaa agctcacaaa
     3541 ttgcagagtg agaatttgta ccggtcagac ctgaacttta tgcgaggtgt tgcatgtgtc
     3601 attccaggca cgttagagat tgaagggagg aagaaagcat cggaactcat cagtgagagt
     3661 aaatatcggc agcatcccca ctcattcaag tacacagctg tgacagacac tcccaacctc
     3721 cttcatgcga aattcagcaa ccagataacg aatgagcgcc tctataaagc agctggagag
     3781 gatgcaagac acgagtatac aatgaccctg ggtctgcccg agttcatccg agcaaaaacg
     3841 aatgcagcca acctgagtga cgcaagatac aaagagtcct ggcgtaatct tcgtgctcaa
     3901 ggctacaagc tgacaataga agcgctcccc ttccaggctg cccgggcctc tggagatata
     3961 gccagtgatt ttctctacag acatgacttt gtgaaggagc gagggaaact catagggccc
     4021 cagagtgtaa gagacgaccc ccggatccag cactgccggc gcatgggcca gctgcagagc
     4081 gagcttcagt acaggagggg ggcgaccagc agccaagccc agttccatct gcccatggac
     4141 atggtgcacc tggtccatgc caagaatgcc caggctctgg ccagcgacca cgactacagg
     4201 acacagtatc acaagttcac agcactgccc gaggacctga agatggcctg ggccaagaaa
     4261 gcccatgccc tgcagagtga gttgcgctac aagtcagacc tgatcggcat gaagggcata
     4321 ggatggctgg cgctgagatc cccacagatg gagagtgcaa agaaggctgg agaactcatc
     4381 agcgagacca agtaccgtaa aaaaccagac agtatcaagt tcaccacagt ggttgactcc
     4441 ccagacctgg ttcatgccaa gaacagctat atgcactgca atgagcgcat gtatagatct
     4501 ggagatgcag aatccctgca cagatacacc ctgatccccg accatcccga tttcacccga
     4561 gctcgcctca atgcgctgca tctgagtgac aaagtctaca gaaactcctg ggagcagacc
     4621 cgggctggca gttatgactt caggctggat gccatcccct tccagactgc ccgggcatct
     4681 agggagatcg ccagtgattt ccggtacaaa gaggctttcc tgcgggaccg aggcctgcag
     4741 atcgggtacc gcagtgtcga cgatgaccca aggatgaagc atttcctcaa cgttggcagg
     4801 ctccagagtg acaatgagta caagaaggac tttgccaaga gtcggtccca gtttcacagc
     4861 agcacagacc agcccggcct ccttcaggcc aagaggagcc agcagctggc cagtgatgtg
     4921 cactacaggc agcccctgcc ccagcccacc tgcgacccgg agcagctggg cctcaggcat
     4981 gctcagaagg cccaccagct gcagagtgat gtcaagtata aatcagactt gaacctgacc
     5041 agaggtgttg gctggacccc tcctggctcc tacaaagtgg aaatggctcg gcgggctgcg
     5101 gaactggcca acgcaagggg cctgggtctc cagggagctt accggggggc agaagcagtg
     5161 gaggctggag atcatcagag tggggaggtg aacccagatg ccactgagat tctgcacgtc
     5221 aaaaagaaga aggccctgct gttgtgagcc atgtccaccc tgattcctga gaggccagag
     5281 aggaagtttg ttcaccagag acaggcttca gatggctttg atttcggcaa gctggaatgg
     5341 cccaccagcc catcccagat cttcctttat taaaataata actctgaaag cagatggaga
     5401 atgttgtatt tgtggtcctc tctgatacct agacgtggat ggctgattct gttgagtgcc
     5461 tcgagtgtct gggctgagga ataaagatgt gatggtggtt cccgctga
//
