LOCUS       NM_205860               4969 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens nuclear receptor subfamily 5 group A member 2 (NR5A2),
            transcript variant 1, mRNA.
ACCESSION   NM_205860
VERSION     NM_205860.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4969)
  AUTHORS   Li,L., Lai,F., Liu,L., Lu,X., Hu,X., Liu,B., Lin,Z., Fan,Q.,
            Kong,F., Xu,Q. and Xie,W.
  TITLE     Lineage regulators TFAP2C and NR5A2 function as bipotency
            activators in totipotent embryos
  JOURNAL   Nat Struct Mol Biol 31 (6), 950-963 (2024)
   PUBMED   38243114
  REMARK    GeneRIF: Lineage regulators TFAP2C and NR5A2 function as bipotency
            activators in totipotent embryos.
REFERENCE   2  (bases 1 to 4969)
  AUTHORS   Kobayashi,W., Sappler,A.H., Bollschweiler,D., Kummecke,M.,
            Basquin,J., Arslantas,E.N., Ruangroengkulrith,S., Hornberger,R.,
            Duderstadt,K. and Tachibana,K.
  TITLE     Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism
            by DNA minor groove anchor competition
  JOURNAL   Nat Struct Mol Biol 31 (5), 757-766 (2024)
   PUBMED   38409506
  REMARK    GeneRIF: Nucleosome-bound NR5A2 structure reveals pioneer factor
            mechanism by DNA minor groove anchor competition.
REFERENCE   3  (bases 1 to 4969)
  AUTHORS   Nishimagi,A., Kobayashi,M., Sugimoto,K., Kofunato,Y., Sato,N.,
            Haga,J., Ishigame,T., Kimura,T., Kenjo,A., Kobayashi,Y.,
            Hashimoto,Y., Marubashi,S. and Chiba,H.
  TITLE     Aberrant phosphorylation of human LRH1 at serine 510 is predictable
            of hepatocellular carcinoma recurrence
  JOURNAL   Clin Exp Med 23 (8), 4985-4995 (2023)
   PUBMED   37285077
  REMARK    GeneRIF: Aberrant phosphorylation of human LRH1 at serine 510 is
            predictable of hepatocellular carcinoma recurrence.
REFERENCE   4  (bases 1 to 4969)
  AUTHORS   Zapata,R.C., Zhang,D., Libster,A., Porcu,A., Montilla-Perez,P.,
            Nur,A., Xu,B., Zhang,Z., Correa,S.M., Liu,C., Telese,F. and
            Osborn,O.
  TITLE     Nuclear receptor 5A2 regulation of Agrp underlies
            olanzapine-induced hyperphagia
  JOURNAL   Mol Psychiatry 28 (5), 1857-1867 (2023)
   PUBMED   36765131
  REMARK    GeneRIF: Nuclear receptor 5A2 regulation of Agrp underlies
            olanzapine-induced hyperphagia.
            Review article
REFERENCE   5  (bases 1 to 4969)
  AUTHORS   Li,J., Gu,J., Wang,J., You,A., Zhang,Y., Rao,G., Li,S., Ge,X.,
            Zhang,K. and Wang,D.
  TITLE     MicroRNA-433-3p enhances chemosensitivity of glioma to cisplatin by
            downregulating NR5A2
  JOURNAL   Brain Behav 12 (12), e2632 (2022)
   PUBMED   36303447
  REMARK    GeneRIF: MicroRNA-433-3p enhances chemosensitivity of glioma to
            cisplatin by downregulating NR5A2.
REFERENCE   6  (bases 1 to 4969)
  AUTHORS   Nitta,M., Ku,S., Brown,C., Okamoto,A.Y. and Shan,B.
  TITLE     CPF: an orphan nuclear receptor that regulates liver-specific
            expression of the human cholesterol 7alpha-hydroxylase gene
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6660-6665 (1999)
   PUBMED   10359768
REFERENCE   7  (bases 1 to 4969)
  AUTHORS   Li,M., Xie,Y.H., Kong,Y.Y., Wu,X., Zhu,L. and Wang,Y.
  TITLE     Cloning and characterization of a novel human hepatocyte
            transcription factor, hB1F, which binds and activates enhancer II
            of hepatitis B virus
  JOURNAL   J Biol Chem 273 (44), 29022-29031 (1998)
   PUBMED   9786908
REFERENCE   8  (bases 1 to 4969)
  AUTHORS   Galarneau,L., Drouin,R. and Belanger,L.
  TITLE     Assignment of the fetoprotein transcription factor gene (FTF) to
            human chromosome band 1q32.11 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 269-270 (1998)
   PUBMED   9858833
REFERENCE   9  (bases 1 to 4969)
  AUTHORS   Wong,M., Ramayya,M.S., Chrousos,G.P., Driggers,P.H. and Parker,K.L.
  TITLE     Cloning and sequence analysis of the human gene encoding
            steroidogenic factor 1
  JOURNAL   J Mol Endocrinol 17 (2), 139-147 (1996)
   PUBMED   8938589
REFERENCE   10 (bases 1 to 4969)
  AUTHORS   Bernier,D., Thomassin,H., Allard,D., Guertin,M., Hamel,D.,
            Blaquiere,M., Beauchemin,M., LaRue,H., Estable-Puig,M. and
            Belanger,L.
  TITLE     Functional analysis of developmentally regulated
            chromatin-hypersensitive domains carrying the alpha 1-fetoprotein
            gene promoter and the albumin/alpha 1-fetoprotein intergenic
            enhancer
  JOURNAL   Mol Cell Biol 13 (3), 1619-1633 (1993)
   PUBMED   7680097
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF146343.1, AF124247.1,
            AC096633.2 and CA776772.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_205860.2.
            
            Summary: The protein encoded by this gene is a DNA-binding zinc
            finger transcription factor and is a member of the fushi tarazu
            factor-1 subfamily of orphan nuclear receptors. The encoded protein
            is involved in the expression of genes for hepatitis B virus and
            cholesterol biosynthesis, and may be an important regulator of
            embryonic development. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019246.1, U93553.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367362.8/ ENSP00000356331.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AF146343.1         70-207
            139-1764            AF124247.1         1-1626
            1765-1867           AF146343.1         1696-1798
            1868-4763           AC096633.2         8383-11278          c
            4764-4969           CA776772.1         18-223              c
FEATURES             Location/Qualifiers
     source          1..4969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..4969
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="nuclear receptor subfamily 5 group A member 2"
                     /db_xref="GeneID:2494"
                     /db_xref="HGNC:HGNC:7984"
                     /db_xref="MIM:604453"
     exon            1..202
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1764
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="isoform 1 is encoded by transcript variant 1; CYP7A
                     promoter-binding factor; fetoprotein-alpha 1 (AFP)
                     transcription factor; b1-binding factor, hepatocyte
                     transcription factor which activates enhancer II of
                     hepatitis B virus; hepatocytic transcription factor
                     hB1F-3"
                     /codon_start=1
                     /product="nuclear receptor subfamily 5 group A member 2
                     isoform 1"
                     /protein_id="NP_995582.1"
                     /db_xref="CCDS:CCDS1401.1"
                     /db_xref="GeneID:2494"
                     /db_xref="HGNC:HGNC:7984"
                     /db_xref="MIM:604453"
                     /translation="MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPK
                     VETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLT
                     CESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
                     MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHS
                     ASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDP
                     YTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRS
                     KHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIY
                     RQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVC
                     LKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRA
                     ISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA"
     exon            203..340
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..459
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..601
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1248
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1368
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1516
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..4969
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3143..3148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="hexamer: AATAAA"
     polyA_site      3170
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="major polyA site"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="hexamer: ATTAAA"
     polyA_site      3679
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="major polyA site"
     regulatory      4941..4946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="hexamer: AATAAA"
     polyA_site      4969
                     /gene="NR5A2"
                     /gene_synonym="B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta;
                     hB1F-2; LRH-1; LRH1"
                     /note="major polyA site"
ORIGIN      
        1 gctttttctt aactttcact aagggttact gtagtctgat gtgtccttcc caaggccacg
       61 aaatttgaca agctgcactt ttcttttgct caatgatttc tgctttaagc caaagaactg
      121 cctataattt cactaagaat gtcttctaat tcagatactg gggatttaca agagtcttta
      181 aagcacggac ttacacctat tggtgctggg cttccggacc gacacggatc ccccatcccc
      241 gcccgcggtc gccttgtcat gctgcccaaa gtggagacgg aagccctggg actggctcga
      301 tcgcatgggg aacagggcca gatgccggaa aacatgcaag tgtctcaatt taaaatggtg
      361 aattactcct atgatgaaga tctggaagag ctttgtcccg tgtgtggaga taaagtgtct
      421 gggtaccatt atgggctcct cacctgtgaa agctgcaagg gattttttaa gcgaacagtc
      481 caaaataata aaaggtacac atgtatagaa aaccagaact gccaaattga caaaacacag
      541 agaaagcgtt gtccttactg tcgttttcaa aaatgtctaa gtgttggaat gaagctagaa
      601 gctgtaaggg ccgaccgaat gcgtggagga aggaataagt ttgggccaat gtacaagaga
      661 gacagggccc tgaagcaaca gaaaaaagcc ctcatccgag ccaatggact taagctagaa
      721 gccatgtctc aggtgatcca agctatgccc tctgacctga ccatttcctc tgcaattcaa
      781 aacatccact ctgcctccaa aggcctacct ctgaaccatg ctgccttgcc tcctacagac
      841 tatgacagaa gtccctttgt aacatccccc attagcatga caatgccccc tcacggcagc
      901 ctgcaaggtt accaaacata tggccacttt cctagccggg ccatcaagtc tgagtaccca
      961 gacccctata ccagctcacc cgagtccata atgggctatt catatatgga tagttaccag
     1021 acgagctctc cagcaagcat cccacatctg atactggaac ttttgaagtg tgagccagat
     1081 gagcctcaag tccaggctaa aatcatggcc tatttgcagc aagagcaggc taaccgaagc
     1141 aagcacgaaa agctgagcac ctttgggctt atgtgcaaaa tggcagatca aactctcttc
     1201 tccattgtcg agtgggccag gagtagtatc ttcttcagag aacttaaggt tgatgaccaa
     1261 atgaagctgc ttcagaactg ctggagtgag ctcttaatcc tcgaccacat ttaccgacaa
     1321 gtggtacatg gaaaggaagg atccatcttc ctggttactg ggcaacaagt ggactattcc
     1381 ataatagcat cacaagccgg agccaccctc aacaacctca tgagtcatgc acaggagtta
     1441 gtggcaaaac ttcgttctct ccagtttgat caacgagagt tcgtatgtct gaaattcttg
     1501 gtgctcttta gtttagatgt caaaaacctt gaaaacttcc agctggtaga aggtgtccag
     1561 gaacaagtca atgccgccct gctggactac acaatgtgta actacccgca gcagacagag
     1621 aaatttggac agctacttct tcgactaccc gaaatccggg ccatcagtat gcaggctgaa
     1681 gaatacctct actacaagca cctgaacggg gatgtgccct ataataacct tctcattgaa
     1741 atgttgcatg ccaaaagagc ataagttaca acccctagga gctctgcttt caaaacaaaa
     1801 agagattggg ggagtgggga gggggaagaa gaacaggaag aaaaaaagta ctctgaactg
     1861 ctccaagtaa cgctaattaa aaacttgctt taaagatatt gaatttaaaa aggcataata
     1921 atcaaatact taatagcaaa taaatgatgt atcagggtat ttgtattgca aactgtgaat
     1981 caaaggcttc acagccccag aggattccat ataaaagaca ttgtaatgga gtggattgaa
     2041 ctcacagatg gataccaaca cggtcagaag aaaaacggac agaacggttc ttgtatattt
     2101 aaactgatct ccactatgaa gaaatttagg aactaatctt attaattagg cttatacagc
     2161 gggggatttg agcttacagg attcctccat ggtaaagctg aactgaaaca attctcaaga
     2221 atgcatcagc tgtacctaca atagcccctc cctcttcctt tgaaggcccc agcacctctg
     2281 ccctgtggtc accgaatctg tactaaggac ctgtgttcag ccacacccag tggtagctcc
     2341 accaaatcat gaacagccta attttgagtg tctgtgtctt agacctgcaa acagctaata
     2401 ggaaattcta ttaatatgtt agcttgccat tttaaatatg ttctgagggt tgttttgtct
     2461 cgtgttcatg atgttaagaa aatgcaggca gtatccctca tcttatgtaa gtgttaatta
     2521 atattaaggg aaatgactac aaactttcaa agcaaatgct ccatagctaa agcaacttag
     2581 accttatttc tgctactgtt gctgaaatgt ggctttggca ttgttggatt tcataaaaaa
     2641 tttctggcag gaagtcttgt tagtatacat cagtcttttt catcatccaa gtttgtagtt
     2701 catttaaaaa tacaacatta aacacatttt gctaggatgt caaatagtca cagttctaag
     2761 tagttggaaa caaaattgac gcatgttaat ctatgcaaag agaaaggaaa ggatgaggtg
     2821 atgtattgac tcaaggttca ttcttgctgc aattgaacat cctcaagagt tgggatggaa
     2881 atggtgattt ttacatgtgt cctggaaaga tattaaagta attcaaatct tccccaaagg
     2941 ggaaaggaag agagtgatac tgaccttttt aagtcataga ccaaagtctg ctgtagaaca
     3001 aatatgggag gacaaagaat cgcaaattct tcaaatgact attatcagta ttattaacat
     3061 gcgatgccac aggtatgaaa gtcttgcctt atttcacaat tttaaaaggt agctgtgcag
     3121 atgtggatca acatttgttt aaaataaagt attaatactt taaagtcaaa taagatatag
     3181 tgtttacatt ctttaggtcc tgaggggcag ggggatctgt gatataacaa aatagcaaaa
     3241 gcggtaattt ccttaatgtt atttttctga ttggtaatta tttttaacag tacttaatta
     3301 ttctatgtcg tgagacacta aaatcaaaaa cgggaatctc atttagactt taattttttt
     3361 gagattatcg gcggcacaat cactttgtag aaactgtaaa aaataaaagt atctcctagt
     3421 cccttaattt tttcataaat atttctggct tttgagtagt gtatttatat tgtatatcat
     3481 actttcaact gtagacaatt atgatgctaa tttattgttt cttggtttca cctttgtata
     3541 agatatagcc aagactgaag aaaccaaata tatgtgttta ctgtagcatg tcttcaaatt
     3601 agtggaactt agttcaggga catagaagag tcttaatgaa ttaaaatcat tcacttgatt
     3661 aaatgtctgt aaatcttcat cattcctact gtagtttatt taatatctat tgtaaattat
     3721 gtgacttgta gcttcctctg gttttcaagt aaactcaaca aggtggagtc ttacctggtt
     3781 ttcctttcca agcattgtaa attgtatacc aaagatatta gttattactt ctgtgtgtac
     3841 aaagaggatt attttattat gtttattaat cacctctaat actcatccac atgaagggta
     3901 cacattaggt aagctgggcg ttgactcatg cgcagtctca gtcacccgtg ttatcttcgt
     3961 ggctcaaagg acaatgcaaa atcgccgatc agagctcata cccaaagcat tacagagaac
     4021 agcagcatca ttgccctccc cagctgaaaa acaagttggc tagaagatac atggagagga
     4081 atggtgtggt caacagttaa tgaaacggtt ctatcatgca tgtgtaatgt ggatggagac
     4141 aattataaga tttgactata actatttgga gggtctttaa cattgccaaa aaaacaaata
     4201 tgttgatttt tattttattt tattttttat tttaagaggc gggatcttga tctcacatgt
     4261 tgcccaggct ggccttgaac tcctgggctc aagcattcct cctgcctcag cctcccccat
     4321 agctgggact aggggtgcat gccagcatac ctggctacgt tgactcttaa aatctatgtt
     4381 ctcttatttt aaagatacag tgctccccac tgaaaattaa acctaaaaaa tgtcacatat
     4441 tggtatgttg ttaacctggt agattaaatc atgagaatga ttagaaagac gggcaacaca
     4501 gcgggttaca tccacactgc tgatcacacc aacgacagga gctgataagc aagaaagcgt
     4561 cacagccagc gtctgttcac ccaaggttga caagtgaagt ttctctaatg ttgattgtta
     4621 gccgatttgt aacctggcat ttacttagca actgccttat caattacagg atttgccggt
     4681 aaaagcagac tcaaatataa aggtttttgg cttaacttgg tttattatag ttgctctatg
     4741 tttgtaaaca gacaatctct aatgtctgat tatttgtatc acagatctgc agctgccttg
     4801 gacttgaatc catgcaatgt ttagagtgtg aagtcagtta cttgttgatg ttttcttact
     4861 gtatcaatga aatacatatt gtcatgtcag ttcttgccag gaacttctca acaaaatgga
     4921 attttttttt tcagtatttc aataaatatt gatatgccca gcctgataa
//
