LOCUS       NM_173200               5676 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 4 group A member 3 (NR4A3),
            transcript variant 3, mRNA.
ACCESSION   NM_173200
VERSION     NM_173200.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5676)
  AUTHORS   Wu,Y., Jing,H., Li,Y., Li,M., Zheng,Y., Lin,Y., Ma,G., Cao,H. and
            Yang,H.
  TITLE     NOR1 promotes the osteoblastic differentiation of human periodontal
            ligament stem cells via TGF-beta signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 338 (2024)
   PUBMED   39120703
  REMARK    GeneRIF: NOR1 promotes the osteoblastic differentiation of human
            periodontal ligament stem cells via TGF-beta signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5676)
  AUTHORS   He,S., Jiang,W., Jiang,B., Yu,C., Zhao,G., Li,Y., Qi,L., Zhang,J.
            and Wang,D.
  TITLE     Potential Roles of Nr4a3-Mediated Inflammation in Immunological and
            Neurological Diseases
  JOURNAL   Mol Neurobiol 61 (8), 5958-5973 (2024)
   PUBMED   38261254
  REMARK    GeneRIF: Potential Roles of Nr4a3-Mediated Inflammation in
            Immunological and Neurological Diseases.
            Review article
REFERENCE   3  (bases 1 to 5676)
  AUTHORS   Ma,W., Jia,K., Cheng,H., Xu,H., Li,Z., Zhang,H., Xie,H., Sun,H.,
            Yi,L., Chen,Z., Duan,S., Sano,M., Fukuda,K., Lu,L., Gao,F.,
            Zhang,R. and Yan,X.
  TITLE     Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via
            Histone Lactylation
  JOURNAL   Circ Res 134 (11), 1427-1447 (2024)
   PUBMED   38629274
  REMARK    GeneRIF: Orphan Nuclear Receptor NR4A3 Promotes Vascular
            Calcification via Histone Lactylation.
REFERENCE   4  (bases 1 to 5676)
  AUTHORS   Phelan,D.E., Reddan,B., Shigemura,M., Sznajder,J.I., Crean,D. and
            Cummins,E.P.
  TITLE     Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3
            Selectively Modulate Elements of the Monocyte Response to Buffered
            Hypercapnia
  JOURNAL   Int J Mol Sci 25 (5), 2852 (2024)
   PUBMED   38474099
  REMARK    GeneRIF: Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and
            NR4A3 Selectively Modulate Elements of the Monocyte Response to
            Buffered Hypercapnia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5676)
  AUTHORS   Wang,J., Chen,S., Xiang,W., Zhu,Q. and Ren,N.
  TITLE     NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by
            Regulating NOR1
  JOURNAL   Folia Biol (Praha) 69 (1), 13-21 (2023)
   PUBMED   37962027
  REMARK    GeneRIF: NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by
            Regulating NOR1.
REFERENCE   6  (bases 1 to 5676)
  AUTHORS   Labelle,Y., Bussieres,J., Courjal,F. and Goldring,M.B.
  TITLE     The EWS/TEC fusion protein encoded by the t(9;22) chromosomal
            translocation in human chondrosarcomas is a highly potent
            transcriptional activator
  JOURNAL   Oncogene 18 (21), 3303-3308 (1999)
   PUBMED   10359536
REFERENCE   7  (bases 1 to 5676)
  AUTHORS   Ohkura,N., Ito,M., Tsukada,T., Sasaki,K., Yamaguchi,K. and Miki,K.
  TITLE     Alternative splicing generates isoforms of human neuron-derived
            orphan receptor-1 (NOR-1) mRNA
  JOURNAL   Gene 211 (1), 79-85 (1998)
   PUBMED   9573341
REFERENCE   8  (bases 1 to 5676)
  AUTHORS   Ohkura,N., Ito,M., Tsukada,T., Sasaki,K., Yamaguchi,K. and Miki,K.
  TITLE     Structure, mapping and expression of a human NOR-1 gene, the third
            member of the Nur77/NGFI-B family
  JOURNAL   Biochim Biophys Acta 1308 (3), 205-214 (1996)
   PUBMED   8809112
REFERENCE   9  (bases 1 to 5676)
  AUTHORS   Hedvat,C.V. and Irving,S.G.
  TITLE     The isolation and characterization of MINOR, a novel
            mitogen-inducible nuclear orphan receptor
  JOURNAL   Mol Endocrinol 9 (12), 1692-1700 (1995)
   PUBMED   8614405
REFERENCE   10 (bases 1 to 5676)
  AUTHORS   Ohkura,N., Hijikuro,M., Yamamoto,A. and Miki,K.
  TITLE     Molecular cloning of a novel thyroid/steroid receptor superfamily
            gene from cultured rat neuronal cells
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1959-1965 (1994)
   PUBMED   7811288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK226108.1, U12767.1, S81243.1
            and AL358937.16.
            
            On Aug 13, 2020 this sequence version replaced NM_173200.2.
            
            Summary: This gene encodes a member of the steroid-thyroid
            hormone-retinoid receptor superfamily. The encoded protein may act
            as a transcriptional activator. The protein can efficiently bind
            the NGFI-B Response Element (NBRE). Three different versions of
            extraskeletal myxoid chondrosarcomas (EMCs) are the result of
            reciprocal translocations between this gene and other genes. The
            translocation breakpoints are associated with Nuclear Receptor
            Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing
            Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II,
            TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome
            17), or Transcription factor 12 (on chromosome 15). Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3792177.1,
                                           SRR14038195.1070238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-682               AK226108.1         13-694
            683-779             U12767.1           1-97
            780-2869            S81243.1           625-2714
            2870-5652           AL358937.16        25963-28745
            5653-5676           U12767.1           4953-4976
FEATURES             Location/Qualifiers
     source          1..5676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..5676
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="nuclear receptor subfamily 4 group A member 3"
                     /db_xref="GeneID:8013"
                     /db_xref="HGNC:HGNC:7982"
                     /db_xref="MIM:600542"
     exon            1..523
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..697
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..769
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             739..2652
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="isoform b is encoded by transcript variant 3;
                     chondrosarcoma, extraskeletal myxoid, fused to EWS;
                     translocated in extraskeletal chondrosarcoma; nuclear
                     hormone receptor NOR-1; neuron-derived orphan receptor 1;
                     mitogen-induced nuclear orphan receptor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 3
                     isoform b"
                     /protein_id="NP_775292.1"
                     /db_xref="CCDS:CCDS6742.1"
                     /db_xref="GeneID:8013"
                     /db_xref="HGNC:HGNC:7982"
                     /db_xref="MIM:600542"
                     /translation="MHDSIRFGNVDMPCVQAQYSPSPPGSSYAAQTYSSEYTTEIMNP
                     DYTKLTMDLGSTEITATATTSLPSISTFVEGYSSNYELKPSCVYQMQRPLIKVEEGRA
                     PSYHHHHHHHHHHHHHHQQQHQQPSIPPASSPEDEVLPSTSMYFKQSPPSTPTTPAFP
                     PQAGALWDEALPSAPGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAG
                     GHHLGYDPTAAAALSLPLGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSP
                     TASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN
                     AKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSP
                     LQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEHVQQFYN
                     LLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN
                     GLVLHRLQCLRGFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRV
                     EELCNKITSSLKDHQSKGQALEPTESKVLGALVELRKICTLGLQRIFYLKLEDLVSPP
                     SIIDKLFLDTLPF"
     exon            770..1722
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1852
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2025
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2225
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2404
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..5676
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5653..5658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="hexamer: ATTAAA"
     polyA_site      5676
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagccgg gagagcggag tctcctgcct cccgcccccc acccctccag ctcctgctcc
       61 tcctccgctc cccatacaca gacgcgctca cacccgctcc ctcactcgca cacacagaca
      121 caagcgcgca cacaggctcc gcacacacac ttcgctctcc cgcgcgctca cacccctctt
      181 gccctgagcc cttgccggtg cagcgcggcg ccgcagctgg acgcccctcc cgggctcact
      241 ttgcaacgct gacggtgccg gcagtggccg tggaggtggg aacagcggcg gcatcctccc
      301 ccctggtcac agcccaagcc aggacgcccg cggaacctct cggctgtgct ctcccatgag
      361 tcgggatcgc agcatccccc accagccgct caccgcctcc gggagccgct gggcttgtac
      421 accgcagccc ttccgggaca gcagctgtga ctccccccca gtgcagattt cgggacagct
      481 ctctagaaac tcgctctaaa gacggaaccg ccacagcact caaagcccac tgcggaagag
      541 ggcagcccgg caagcccggg ccctgagcct ggacccttag cggtgccggg cagcactgcc
      601 ggcgcttcgc ctcgccggac gtccgctcct cctacactct cagcctccgc tggagagacc
      661 cccagcccca ccattcagcg cgcaagatac cctccaggcc ctcatcacct tttttcaagt
      721 caagatttca tcccatacat gcatgactca atcagatttg gaaatgtgga tatgccctgc
      781 gtccaagccc aatatagccc ttcccctcca ggttccagtt atgcggcgca gacatacagc
      841 tcggaataca ccacggagat catgaacccc gactacacca agctgaccat ggaccttggc
      901 agcactgaga tcacggctac agccaccacg tccctgccca gcatcagtac cttcgtggag
      961 ggctactcga gcaactacga actcaagcct tcctgcgtgt accaaatgca gcggcccttg
     1021 atcaaagtgg aggaggggcg ggcgcccagc taccatcacc atcaccacca ccaccaccac
     1081 caccaccacc atcaccagca gcagcatcag cagccatcca ttcctccagc ctccagcccg
     1141 gaggacgagg tgctgcccag cacctccatg tacttcaagc agtccccacc gtccaccccc
     1201 accacgccgg ccttcccccc gcaggcgggg gcgttatggg acgaggcact gccctcggcg
     1261 cccggctgca tcgcacccgg cccgctgctg gacccgccga tgaaggcggt ccccacggtg
     1321 gccggcgcgc gcttcccgct cttccacttc aagccctcgc cgccgcatcc ccccgcgccc
     1381 agcccggccg gcggccacca cctcggctac gacccgacgg ccgctgccgc gctcagcctg
     1441 ccgctgggag ccgcagccgc cgcgggcagc caggccgccg cgcttgagag ccacccgtac
     1501 gggctgccgc tggccaagag ggcggccccg ctggccttcc cgcctctcgg cctcacgccc
     1561 tcccctaccg cgtccagcct gctgggcgag agtcccagcc tgccgtcgcc gcccagcagg
     1621 agctcgtcgt ctggcgaggg cacgtgtgcc gtgtgcgggg acaacgccgc ctgccagcac
     1681 tacggcgtgc gaacctgcga gggctgcaag ggctttttca agagaacagt gcagaaaaat
     1741 gcaaaatatg tttgcctggc aaataaaaac tgcccagtag acaagagacg tcgaaaccga
     1801 tgtcagtact gtcgatttca gaagtgtctc agtgttggaa tggtaaaaga agttgtccgt
     1861 acagatagtc tgaaagggag gagaggtcgt ctgccttcca aaccaaagag cccattacaa
     1921 caggaacctt ctcagccctc tccaccttct cctccaatct gcatgatgaa tgcccttgtc
     1981 cgagctttaa cagactcaac acccagagat cttgattatt ccagatactg tcccactgac
     2041 caggctgctg caggcacaga tgctgagcat gtgcaacaat tctacaacct cctgacagcc
     2101 tccattgatg tatccagaag ctgggcagaa aagattccgg gatttactga tctccccaaa
     2161 gaagatcaga cattacttat tgaatcagcc tttttggagc tgtttgtcct cagactttcc
     2221 atcaggtcaa acactgctga agataagttt gtgttctgca atggacttgt cctgcatcga
     2281 cttcagtgcc ttcgtggatt tggggagtgg ctcgactcta ttaaagactt ttccttaaat
     2341 ttgcagagcc tgaaccttga tatccaagcc ttagcctgcc tgtcagcact gagcatgatc
     2401 acagaaagac atgggttaaa agaaccaaag agagtcgaag agctatgcaa caagatcaca
     2461 agcagtttaa aagaccacca gagtaaggga caggctctgg agcccaccga gtccaaggtc
     2521 ctgggtgccc tggtagaact gaggaagatc tgcaccctgg gcctccagcg catcttctac
     2581 ctgaagctgg aagacttggt gtctccacct tccatcattg acaagctctt cctggacacc
     2641 ctacctttct aatcaggagc agtggagcag tgagctgcct cctctcctag cacctgcttg
     2701 ctacgcagca aagggatagg tttggaaacc tatcatttcc tgtccttcct taagaggaaa
     2761 agcagctcct gtagaaagca aagactttct tttttttctg gctcttttcc ttacaaccta
     2821 aagccagaaa acttgcagag tattgtgttg gggttgtgtt ttatatttag gcattggggg
     2881 atggggtggg agggggttat agttcatgag ggttttctaa gaaattgcta acaaagcact
     2941 tttggacaat gctatcccag caggaaaaaa aaggataata taactgtttt aaaactcttt
     3001 ctggggaatc caattatagt tgctttgtat ttaaaaacaa gaacagccaa gggttgttcg
     3061 ccagggtagg atgtgtctta aagattggtc ccttgaaaat atgcttcctg tatcaaaggt
     3121 acgtatgtgg tgcaaacaag gcagaaactt ccttttaatt tccttcttcc tttattttaa
     3181 caaatggtga aagatggagg attacctaca aatcagacat ggcaaaacaa taatggctgt
     3241 ttgcttccat aaacaagtgc aattttttaa agtgctgtct tactaagtct tgtttattaa
     3301 ctctccttta ttctatatgg aaataaaaag gaggcagtca tgttagcaaa tgacacgtta
     3361 atatccctag cagaggctgt gttcaccttc cctgtcgatc ccttctgagg tatggcccat
     3421 ccaagacttt taggccattc ttgatggaac cagatccctg ccctgactgt ccagctatcc
     3481 tgaaagtgga tcagattata aactggatta catgtaactg ttttggttgt gttctatcaa
     3541 ccccaccaga gttccctaaa cttgcttcag ttatagtaac tgactggtat attcattcag
     3601 aagcgccata agtcagttga gtatttgatc cctagataag aacatgcaaa tcagcaggaa
     3661 ctggtcatac agggtaagca ccagggacaa taaggatttt tatagatata atttaatttt
     3721 tgttattggt taaggagaca attttggaga gcaagcaaat ctttttaaaa aatagtatga
     3781 atgtgaatac tagaaaagat ttaaaaaata gtatgagtgt gagtactagg aaggattagt
     3841 gggctgcgtt tcaacattcc gtgttcgtac tcccttttgt atgtttctac tgttaatgcc
     3901 atattactat gagataattt gttgcatagt gtccttattt gtataaacat ttgtatgcac
     3961 gttatattgt aatagctttg cctgtattta ttgcaagacc accagctcct ggaagctgag
     4021 ttacagagta attaaatggg gtgttcacag tgacttggat acaccaatta gaaattaaat
     4081 aagcaaatat atatatatat ataaatatag caggttacat atatatattt ataatgtgtc
     4141 tttttattaa ccatttgtac aataaatgtc acttcccatg ccgttatttt atggttcatt
     4201 tgcagtgact tttaaggcag tactgtttag cactttgata ttaaaatttt gcttatgttt
     4261 tgctaaattc gaataatgtt tgaagatttt taggtctaaa agtctttata ttatatactc
     4321 tgtatcaagt caaaatatct ttggccattt tgctaagaaa caaactttga atgtcaaact
     4381 gatgtcacag tagtttttgt tagctttaaa tcatttttgc tttagtcttt ttaaaggaaa
     4441 ataacaaaac tatgctgttt atattgtcat taaattatac aatcaaacaa atgccaaatg
     4501 aattgcctaa ttgctgcaaa gtataaccca gataggaaat catatgtttt tttccaagag
     4561 tcattctaat atttgattat gttatgtgtg cttttatgaa agattgttat ttttatatat
     4621 caagatgata gaacctggaa tgttaggatt ttgaaatgtt agacttggaa ggggcctggt
     4681 ctgtcaacta gtccaacccc ttaaaattca tagaggagca aactggggcc cattgaaggg
     4741 tgaagagtta ctcaaggtca aacagctggt aacagaatca agactaagac ctaatttacc
     4801 tttccatact cttttttttt ctcaacttca tctatataaa atcaggcttt taaacataac
     4861 cactaatatt tacctgaaga taaccatgag taaagtatac ttttgcatta attttttgag
     4921 cttatatgca aacataataa atattattaa atatcaggaa agctaacatt tcatacaaga
     4981 tagcttcaga ccaaattcaa attgaatttg aataaattag aaatactgtg catacataac
     5041 cttcttgtgc accatgagta tttggaaagt taatccttgt ttttgtcgtg tctataaagg
     5101 aagaacaaaa caaaataaaa acagagccct agagaaatgc tgttactttt tatttttaca
     5161 cccatcagat ttaaggaaaa gactttttag ccattataat ctagtggttg gaaggaatga
     5221 agaagctttt ttagtaatag gtccagatat gagtgctaaa aataaagatg atagcatgtt
     5281 cttctgtctt ccatagttat tacaactatg agagcctccc aagtcatctt atcaactcaa
     5341 ctcccttttt tttgtcttaa tgttgcacat aagtttatac agagtggatg accacactag
     5401 cacagaagag aacaacatgt attaaagcag gtgattcctc cccttggcgg gagagctctc
     5461 tcagtgtgaa catgccttct gtgggcggaa atcaggaagc caccagctgt taatggagag
     5521 tgccttgctt ttatttcaga cagcagagtt ttccaaagtt tctctgctcc tctaacagca
     5581 ttgctcttta gtgtgtgtta acctgtggtt tgaaagaaat gctcttgtac attaacaatg
     5641 taaatttaaa tgattaaatt acattttatc aatggc
//
