LOCUS       NM_006981               5604 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 4 group A member 3 (NR4A3),
            transcript variant 1, mRNA.
ACCESSION   NM_006981
VERSION     NM_006981.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5604)
  AUTHORS   Wu,Y., Jing,H., Li,Y., Li,M., Zheng,Y., Lin,Y., Ma,G., Cao,H. and
            Yang,H.
  TITLE     NOR1 promotes the osteoblastic differentiation of human periodontal
            ligament stem cells via TGF-beta signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 338 (2024)
   PUBMED   39120703
  REMARK    GeneRIF: NOR1 promotes the osteoblastic differentiation of human
            periodontal ligament stem cells via TGF-beta signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5604)
  AUTHORS   He,S., Jiang,W., Jiang,B., Yu,C., Zhao,G., Li,Y., Qi,L., Zhang,J.
            and Wang,D.
  TITLE     Potential Roles of Nr4a3-Mediated Inflammation in Immunological and
            Neurological Diseases
  JOURNAL   Mol Neurobiol 61 (8), 5958-5973 (2024)
   PUBMED   38261254
  REMARK    GeneRIF: Potential Roles of Nr4a3-Mediated Inflammation in
            Immunological and Neurological Diseases.
            Review article
REFERENCE   3  (bases 1 to 5604)
  AUTHORS   Ma,W., Jia,K., Cheng,H., Xu,H., Li,Z., Zhang,H., Xie,H., Sun,H.,
            Yi,L., Chen,Z., Duan,S., Sano,M., Fukuda,K., Lu,L., Gao,F.,
            Zhang,R. and Yan,X.
  TITLE     Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via
            Histone Lactylation
  JOURNAL   Circ Res 134 (11), 1427-1447 (2024)
   PUBMED   38629274
  REMARK    GeneRIF: Orphan Nuclear Receptor NR4A3 Promotes Vascular
            Calcification via Histone Lactylation.
REFERENCE   4  (bases 1 to 5604)
  AUTHORS   Phelan,D.E., Reddan,B., Shigemura,M., Sznajder,J.I., Crean,D. and
            Cummins,E.P.
  TITLE     Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3
            Selectively Modulate Elements of the Monocyte Response to Buffered
            Hypercapnia
  JOURNAL   Int J Mol Sci 25 (5), 2852 (2024)
   PUBMED   38474099
  REMARK    GeneRIF: Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and
            NR4A3 Selectively Modulate Elements of the Monocyte Response to
            Buffered Hypercapnia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5604)
  AUTHORS   Wang,J., Chen,S., Xiang,W., Zhu,Q. and Ren,N.
  TITLE     NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by
            Regulating NOR1
  JOURNAL   Folia Biol (Praha) 69 (1), 13-21 (2023)
   PUBMED   37962027
  REMARK    GeneRIF: NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by
            Regulating NOR1.
REFERENCE   6  (bases 1 to 5604)
  AUTHORS   Labelle,Y., Bussieres,J., Courjal,F. and Goldring,M.B.
  TITLE     The EWS/TEC fusion protein encoded by the t(9;22) chromosomal
            translocation in human chondrosarcomas is a highly potent
            transcriptional activator
  JOURNAL   Oncogene 18 (21), 3303-3308 (1999)
   PUBMED   10359536
REFERENCE   7  (bases 1 to 5604)
  AUTHORS   Ohkura,N., Ito,M., Tsukada,T., Sasaki,K., Yamaguchi,K. and Miki,K.
  TITLE     Alternative splicing generates isoforms of human neuron-derived
            orphan receptor-1 (NOR-1) mRNA
  JOURNAL   Gene 211 (1), 79-85 (1998)
   PUBMED   9573341
REFERENCE   8  (bases 1 to 5604)
  AUTHORS   Ohkura,N., Ito,M., Tsukada,T., Sasaki,K., Yamaguchi,K. and Miki,K.
  TITLE     Structure, mapping and expression of a human NOR-1 gene, the third
            member of the Nur77/NGFI-B family
  JOURNAL   Biochim Biophys Acta 1308 (3), 205-214 (1996)
   PUBMED   8809112
REFERENCE   9  (bases 1 to 5604)
  AUTHORS   Hedvat,C.V. and Irving,S.G.
  TITLE     The isolation and characterization of MINOR, a novel
            mitogen-inducible nuclear orphan receptor
  JOURNAL   Mol Endocrinol 9 (12), 1692-1700 (1995)
   PUBMED   8614405
REFERENCE   10 (bases 1 to 5604)
  AUTHORS   Ohkura,N., Hijikuro,M., Yamamoto,A. and Miki,K.
  TITLE     Molecular cloning of a novel thyroid/steroid receptor superfamily
            gene from cultured rat neuronal cells
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1959-1965 (1994)
   PUBMED   7811288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK226108.1, S81243.1,
            AL358937.16 and U12767.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006981.3.
            
            Summary: This gene encodes a member of the steroid-thyroid
            hormone-retinoid receptor superfamily. The encoded protein may act
            as a transcriptional activator. The protein can efficiently bind
            the NGFI-B Response Element (NBRE). Three different versions of
            extraskeletal myxoid chondrosarcomas (EMCs) are the result of
            reciprocal translocations between this gene and other genes. The
            translocation breakpoints are associated with Nuclear Receptor
            Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing
            Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II,
            TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome
            17), or Transcription factor 12 (on chromosome 15). Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) lacks the exon containing the
            translational start site compared to variant 3. The resulting
            isoform (a) is shorter at the N-terminus compared to isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226108.1, D78579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395097.7/ ENSP00000378531.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AK226108.1         13-460
            449-2797            S81243.1           366-2714
            2798-5580           AL358937.16        25963-28745
            5581-5604           U12767.1           4953-4976
FEATURES             Location/Qualifiers
     source          1..5604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..5604
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="nuclear receptor subfamily 4 group A member 3"
                     /db_xref="GeneID:8013"
                     /db_xref="HGNC:HGNC:7982"
                     /db_xref="MIM:600542"
     exon            1..523
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..697
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1650
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             700..2580
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="isoform a is encoded by transcript variant 1;
                     chondrosarcoma, extraskeletal myxoid, fused to EWS;
                     translocated in extraskeletal chondrosarcoma; nuclear
                     hormone receptor NOR-1; neuron-derived orphan receptor 1;
                     mitogen-induced nuclear orphan receptor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 3
                     isoform a"
                     /protein_id="NP_008912.2"
                     /db_xref="CCDS:CCDS6743.1"
                     /db_xref="GeneID:8013"
                     /db_xref="HGNC:HGNC:7982"
                     /db_xref="MIM:600542"
                     /translation="MPCVQAQYSPSPPGSSYAAQTYSSEYTTEIMNPDYTKLTMDLGS
                     TEITATATTSLPSISTFVEGYSSNYELKPSCVYQMQRPLIKVEEGRAPSYHHHHHHHH
                     HHHHHHQQQHQQPSIPPASSPEDEVLPSTSMYFKQSPPSTPTTPAFPPQAGALWDEAL
                     PSAPGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGHHLGYDPTAA
                     AALSLPLGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPS
                     LPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNC
                     PVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPP
                     SPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEHVQQFYNLLTASIDVSRS
                     WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR
                     GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSL
                     KDHQSKGQALEPTESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDTL
                     PF"
     exon            1651..1780
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1953
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2153
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2332
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..5604
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5581..5586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="hexamer: ATTAAA"
     polyA_site      5604
                     /gene="NR4A3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagccgg gagagcggag tctcctgcct cccgcccccc acccctccag ctcctgctcc
       61 tcctccgctc cccatacaca gacgcgctca cacccgctcc ctcactcgca cacacagaca
      121 caagcgcgca cacaggctcc gcacacacac ttcgctctcc cgcgcgctca cacccctctt
      181 gccctgagcc cttgccggtg cagcgcggcg ccgcagctgg acgcccctcc cgggctcact
      241 ttgcaacgct gacggtgccg gcagtggccg tggaggtggg aacagcggcg gcatcctccc
      301 ccctggtcac agcccaagcc aggacgcccg cggaacctct cggctgtgct ctcccatgag
      361 tcgggatcgc agcatccccc accagccgct caccgcctcc gggagccgct gggcttgtac
      421 accgcagccc ttccgggaca gcagctgtga ctccccccca gtgcagattt cgggacagct
      481 ctctagaaac tcgctctaaa gacggaaccg ccacagcact caaagcccac tgcggaagag
      541 ggcagcccgg caagcccggg ccctgagcct ggacccttag cggtgccggg cagcactgcc
      601 ggcgcttcgc ctcgccggac gtccgctcct cctacactct cagcctccgc tggagagacc
      661 cccagcccca ccattcagcg cgcaagatac cctccagata tgccctgcgt ccaagcccaa
      721 tatagccctt cccctccagg ttccagttat gcggcgcaga catacagctc ggaatacacc
      781 acggagatca tgaaccccga ctacaccaag ctgaccatgg accttggcag cactgagatc
      841 acggctacag ccaccacgtc cctgcccagc atcagtacct tcgtggaggg ctactcgagc
      901 aactacgaac tcaagccttc ctgcgtgtac caaatgcagc ggcccttgat caaagtggag
      961 gaggggcggg cgcccagcta ccatcaccat caccaccacc accaccacca ccaccaccat
     1021 caccagcagc agcatcagca gccatccatt cctccagcct ccagcccgga ggacgaggtg
     1081 ctgcccagca cctccatgta cttcaagcag tccccaccgt ccacccccac cacgccggcc
     1141 ttccccccgc aggcgggggc gttatgggac gaggcactgc cctcggcgcc cggctgcatc
     1201 gcacccggcc cgctgctgga cccgccgatg aaggcggtcc ccacggtggc cggcgcgcgc
     1261 ttcccgctct tccacttcaa gccctcgccg ccgcatcccc ccgcgcccag cccggccggc
     1321 ggccaccacc tcggctacga cccgacggcc gctgccgcgc tcagcctgcc gctgggagcc
     1381 gcagccgccg cgggcagcca ggccgccgcg cttgagagcc acccgtacgg gctgccgctg
     1441 gccaagaggg cggccccgct ggccttcccg cctctcggcc tcacgccctc ccctaccgcg
     1501 tccagcctgc tgggcgagag tcccagcctg ccgtcgccgc ccagcaggag ctcgtcgtct
     1561 ggcgagggca cgtgtgccgt gtgcggggac aacgccgcct gccagcacta cggcgtgcga
     1621 acctgcgagg gctgcaaggg ctttttcaag agaacagtgc agaaaaatgc aaaatatgtt
     1681 tgcctggcaa ataaaaactg cccagtagac aagagacgtc gaaaccgatg tcagtactgt
     1741 cgatttcaga agtgtctcag tgttggaatg gtaaaagaag ttgtccgtac agatagtctg
     1801 aaagggagga gaggtcgtct gccttccaaa ccaaagagcc cattacaaca ggaaccttct
     1861 cagccctctc caccttctcc tccaatctgc atgatgaatg cccttgtccg agctttaaca
     1921 gactcaacac ccagagatct tgattattcc agatactgtc ccactgacca ggctgctgca
     1981 ggcacagatg ctgagcatgt gcaacaattc tacaacctcc tgacagcctc cattgatgta
     2041 tccagaagct gggcagaaaa gattccggga tttactgatc tccccaaaga agatcagaca
     2101 ttacttattg aatcagcctt tttggagctg tttgtcctca gactttccat caggtcaaac
     2161 actgctgaag ataagtttgt gttctgcaat ggacttgtcc tgcatcgact tcagtgcctt
     2221 cgtggatttg gggagtggct cgactctatt aaagactttt ccttaaattt gcagagcctg
     2281 aaccttgata tccaagcctt agcctgcctg tcagcactga gcatgatcac agaaagacat
     2341 gggttaaaag aaccaaagag agtcgaagag ctatgcaaca agatcacaag cagtttaaaa
     2401 gaccaccaga gtaagggaca ggctctggag cccaccgagt ccaaggtcct gggtgccctg
     2461 gtagaactga ggaagatctg caccctgggc ctccagcgca tcttctacct gaagctggaa
     2521 gacttggtgt ctccaccttc catcattgac aagctcttcc tggacaccct acctttctaa
     2581 tcaggagcag tggagcagtg agctgcctcc tctcctagca cctgcttgct acgcagcaaa
     2641 gggataggtt tggaaaccta tcatttcctg tccttcctta agaggaaaag cagctcctgt
     2701 agaaagcaaa gactttcttt tttttctggc tcttttcctt acaacctaaa gccagaaaac
     2761 ttgcagagta ttgtgttggg gttgtgtttt atatttaggc attgggggat ggggtgggag
     2821 ggggttatag ttcatgaggg ttttctaaga aattgctaac aaagcacttt tggacaatgc
     2881 tatcccagca ggaaaaaaaa ggataatata actgttttaa aactctttct ggggaatcca
     2941 attatagttg ctttgtattt aaaaacaaga acagccaagg gttgttcgcc agggtaggat
     3001 gtgtcttaaa gattggtccc ttgaaaatat gcttcctgta tcaaaggtac gtatgtggtg
     3061 caaacaaggc agaaacttcc ttttaatttc cttcttcctt tattttaaca aatggtgaaa
     3121 gatggaggat tacctacaaa tcagacatgg caaaacaata atggctgttt gcttccataa
     3181 acaagtgcaa ttttttaaag tgctgtctta ctaagtcttg tttattaact ctcctttatt
     3241 ctatatggaa ataaaaagga ggcagtcatg ttagcaaatg acacgttaat atccctagca
     3301 gaggctgtgt tcaccttccc tgtcgatccc ttctgaggta tggcccatcc aagactttta
     3361 ggccattctt gatggaacca gatccctgcc ctgactgtcc agctatcctg aaagtggatc
     3421 agattataaa ctggattaca tgtaactgtt ttggttgtgt tctatcaacc ccaccagagt
     3481 tccctaaact tgcttcagtt atagtaactg actggtatat tcattcagaa gcgccataag
     3541 tcagttgagt atttgatccc tagataagaa catgcaaatc agcaggaact ggtcatacag
     3601 ggtaagcacc agggacaata aggattttta tagatataat ttaatttttg ttattggtta
     3661 aggagacaat tttggagagc aagcaaatct ttttaaaaaa tagtatgaat gtgaatacta
     3721 gaaaagattt aaaaaatagt atgagtgtga gtactaggaa ggattagtgg gctgcgtttc
     3781 aacattccgt gttcgtactc ccttttgtat gtttctactg ttaatgccat attactatga
     3841 gataatttgt tgcatagtgt ccttatttgt ataaacattt gtatgcacgt tatattgtaa
     3901 tagctttgcc tgtatttatt gcaagaccac cagctcctgg aagctgagtt acagagtaat
     3961 taaatggggt gttcacagtg acttggatac accaattaga aattaaataa gcaaatatat
     4021 atatatatat aaatatagca ggttacatat atatatttat aatgtgtctt tttattaacc
     4081 atttgtacaa taaatgtcac ttcccatgcc gttattttat ggttcatttg cagtgacttt
     4141 taaggcagta ctgtttagca ctttgatatt aaaattttgc ttatgttttg ctaaattcga
     4201 ataatgtttg aagattttta ggtctaaaag tctttatatt atatactctg tatcaagtca
     4261 aaatatcttt ggccattttg ctaagaaaca aactttgaat gtcaaactga tgtcacagta
     4321 gtttttgtta gctttaaatc atttttgctt tagtcttttt aaaggaaaat aacaaaacta
     4381 tgctgtttat attgtcatta aattatacaa tcaaacaaat gccaaatgaa ttgcctaatt
     4441 gctgcaaagt ataacccaga taggaaatca tatgtttttt tccaagagtc attctaatat
     4501 ttgattatgt tatgtgtgct tttatgaaag attgttattt ttatatatca agatgataga
     4561 acctggaatg ttaggatttt gaaatgttag acttggaagg ggcctggtct gtcaactagt
     4621 ccaacccctt aaaattcata gaggagcaaa ctggggccca ttgaagggtg aagagttact
     4681 caaggtcaaa cagctggtaa cagaatcaag actaagacct aatttacctt tccatactct
     4741 ttttttttct caacttcatc tatataaaat caggctttta aacataacca ctaatattta
     4801 cctgaagata accatgagta aagtatactt ttgcattaat tttttgagct tatatgcaaa
     4861 cataataaat attattaaat atcaggaaag ctaacatttc atacaagata gcttcagacc
     4921 aaattcaaat tgaatttgaa taaattagaa atactgtgca tacataacct tcttgtgcac
     4981 catgagtatt tggaaagtta atccttgttt ttgtcgtgtc tataaaggaa gaacaaaaca
     5041 aaataaaaac agagccctag agaaatgctg ttacttttta tttttacacc catcagattt
     5101 aaggaaaaga ctttttagcc attataatct agtggttgga aggaatgaag aagctttttt
     5161 agtaataggt ccagatatga gtgctaaaaa taaagatgat agcatgttct tctgtcttcc
     5221 atagttatta caactatgag agcctcccaa gtcatcttat caactcaact cccttttttt
     5281 tgtcttaatg ttgcacataa gtttatacag agtggatgac cacactagca cagaagagaa
     5341 caacatgtat taaagcaggt gattcctccc cttggcggga gagctctctc agtgtgaaca
     5401 tgccttctgt gggcggaaat caggaagcca ccagctgtta atggagagtg ccttgctttt
     5461 atttcagaca gcagagtttt ccaaagtttc tctgctcctc taacagcatt gctctttagt
     5521 gtgtgttaac ctgtggtttg aaagaaatgc tcttgtacat taacaatgta aatttaaatg
     5581 attaaattac attttatcaa tggc
//
