LOCUS       NM_006186               3472 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 4 group A member 2 (NR4A2),
            transcript variant 1, mRNA.
ACCESSION   NM_006186
VERSION     NM_006186.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3472)
  AUTHORS   Jin,X., Liu,L., Liu,D., Wu,J., Wang,C., Wang,S., Wang,F., Yu,G.,
            Jin,X., Xue,Y.W., Jiang,D., Ni,Y., Yang,X., Wang,M.S., Wang,Z.W.,
            Orlov,Y.L., Jia,W., Melino,G., Liu,J.B. and Chen,W.L.
  TITLE     Unveiling the methionine cycle: a key metabolic signature and NR4A2
            as a methionine-responsive oncogene in esophageal squamous cell
            carcinoma
  JOURNAL   Cell Death Differ 31 (5), 558-573 (2024)
   PUBMED   38570607
  REMARK    GeneRIF: Unveiling the methionine cycle: a key metabolic signature
            and NR4A2 as a methionine-responsive oncogene in esophageal
            squamous cell carcinoma.
REFERENCE   2  (bases 1 to 3472)
  AUTHORS   Phelan,D.E., Reddan,B., Shigemura,M., Sznajder,J.I., Crean,D. and
            Cummins,E.P.
  TITLE     Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3
            Selectively Modulate Elements of the Monocyte Response to Buffered
            Hypercapnia
  JOURNAL   Int J Mol Sci 25 (5), 2852 (2024)
   PUBMED   38474099
  REMARK    GeneRIF: Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and
            NR4A3 Selectively Modulate Elements of the Monocyte Response to
            Buffered Hypercapnia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3472)
  AUTHORS   Solis-Barbosa,M.A., Santana,E., Munoz-Torres,J.R.,
            Segovia-Gamboa,N.C., Patino-Martinez,E., Meraz-Rios,M.A.,
            Samaniego,R., Sanchez-Mateos,P. and Sanchez-Torres,C.
  TITLE     The nuclear receptor Nurr1 is preferentially expressed in human
            pro-inflammatory macrophages and limits their inflammatory profile
  JOURNAL   Int Immunol 36 (3), 111-128 (2024)
   PUBMED   38066638
  REMARK    GeneRIF: The nuclear receptor Nurr1 is preferentially expressed in
            human pro-inflammatory macrophages and limits their inflammatory
            profile.
REFERENCE   4  (bases 1 to 3472)
  AUTHORS   Zhao,S., Wang,X., Huang,F., Zhou,Y., Meng,D., Zhao,D., Wang,J.,
            Zhang,H., Wu,L., Zhang,Y., Zhao,L., Zhang,L., Song,Y. and Wang,Q.
  TITLE     A role of NR4A2 in Graves' disease: regulation of Th17/Treg
  JOURNAL   Endocrine 83 (2), 432-441 (2024)
   PUBMED   37651006
  REMARK    GeneRIF: A role of NR4A2 in Graves' disease: regulation of
            Th17/Treg.
REFERENCE   5  (bases 1 to 3472)
  AUTHORS   Mohammadi,M., Asgarian-Omran,H., Najafi,B., Najafi,A., Valadan,R.,
            Karami,H., Naderisoraki,M., Alizadeforoutan,M., Shekarriz,R. and
            Tehrani,M.
  TITLE     Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in
            Acute Leukemia
  JOURNAL   Iran J Immunol 20 (4), 438-445 (2023)
   PUBMED   37961948
  REMARK    GeneRIF: Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T
            cells in Acute Leukemia.
REFERENCE   6  (bases 1 to 3472)
  AUTHORS   Forman,B.M., Umesono,K., Chen,J. and Evans,R.M.
  TITLE     Unique response pathways are established by allosteric interactions
            among nuclear hormone receptors
  JOURNAL   Cell 81 (4), 541-550 (1995)
   PUBMED   7758108
REFERENCE   7  (bases 1 to 3472)
  AUTHORS   Okabe,T., Takayanagi,R., Imasaki,K., Haji,M., Nawata,H. and
            Watanabe,T.
  TITLE     cDNA cloning of a NGFI-B/nur77-related transcription factor from an
            apoptotic human T cell line
  JOURNAL   J Immunol 154 (8), 3871-3879 (1995)
   PUBMED   7706727
REFERENCE   8  (bases 1 to 3472)
  AUTHORS   Perlmann,T. and Jansson,L.
  TITLE     A novel pathway for vitamin A signaling mediated by RXR
            heterodimerization with NGFI-B and NURR1
  JOURNAL   Genes Dev 9 (7), 769-782 (1995)
   PUBMED   7705655
REFERENCE   9  (bases 1 to 3472)
  AUTHORS   Mages,H.W., Rilke,O., Bravo,R., Senger,G. and Kroczek,R.A.
  TITLE     NOT, a human immediate-early response gene closely related to the
            steroid/thyroid hormone receptor NAK1/TR3
  JOURNAL   Mol Endocrinol 8 (11), 1583-1591 (1994)
   PUBMED   7877627
REFERENCE   10 (bases 1 to 3472)
  AUTHORS   Cook Shukla,L., Schulze,J., Farlow,J., Pankratz,N.D., Wojcieszek,J.
            and Foroud,T.
  TITLE     Parkinson Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074099.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_006186.3.
            
            Summary: This gene encodes a member of the steroid-thyroid
            hormone-retinoid receptor superfamily. The encoded protein may act
            as a transcription factor. Mutations in this gene have been
            associated with disorders related to dopaminergic dysfunction,
            including Parkinson disease, schizophernia, and manic depression.
            Misregulation of this gene may be associated with rheumatoid
            arthritis. Alternatively spliced transcript variants have been
            described, but their biological validity has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.50815.1, AK223625.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339562.9/ ENSP00000344479.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AC074099.6         102547-102788       c
            243-366             AC074099.6         100735-100858       c
            367-1232            AC074099.6         99390-100255        c
            1233-1362           AC074099.6         98471-98600         c
            1363-1526           AC074099.6         97918-98081         c
            1527-1729           AC074099.6         96785-96987         c
            1730-1908           AC074099.6         96217-96395         c
            1909-3472           AC074099.6         94504-96067         c
FEATURES             Location/Qualifiers
     source          1..3472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.1"
     gene            1..3472
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /note="nuclear receptor subfamily 4 group A member 2"
                     /db_xref="GeneID:4929"
                     /db_xref="HGNC:HGNC:7981"
                     /db_xref="MIM:601828"
     exon            1..242
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            243..366
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            367..1232
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..2165
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /note="isoform a is encoded by transcript variant 1;
                     T-cell nuclear receptor NOT; orphan nuclear receptor
                     NURR1; NGFI-B/nur77 beta-type transcription factor
                     homolog; nur related protein-1, human homolog of;
                     transcriptionally inducible nuclear receptor related 1;
                     intermediate-early receptor protein; orphan nuclear
                     receptor NR4A2; immediate-early response protein NOT;
                     transcriptionally-inducible nuclear receptor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 2
                     isoform a"
                     /protein_id="NP_006177.1"
                     /db_xref="CCDS:CCDS2201.1"
                     /db_xref="GeneID:4929"
                     /db_xref="HGNC:HGNC:7981"
                     /db_xref="MIM:601828"
                     /translation="MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSM
                     DLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQ
                     HSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATT
                     HMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTF
                     AVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYG
                     VRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVR
                     TDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPD
                     YQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLR
                     LAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAA
                     LAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLC
                     TQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF"
     exon            1233..1362
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1526
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1729
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1908
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..3472
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /note="hexamer: AATAAA"
     polyA_site      3472
                     /gene="NR4A2"
                     /gene_synonym="HZF-3; IDLDP; NOT; NURR1; RNR1; TINUR"
                     /note="major polyA site"
ORIGIN      
        1 aagccacata aacaaaggca cattggcggc cagggccagt ccgcccggcg gctcgcgcac
       61 ggctccgcgg tcccttttgc ctgtccagcc ggccgcctgt ccctgctccc tccctccgtg
      121 aggtgtccgg gttcccttcg cccagctctc ccacccctac ccgaccccgg cgcccgggct
      181 cccagaggga actgcacttc ggcagagttg aatgaatgaa gacagacgcg gagaactcct
      241 aaggaggaga ttggacaggc tggactcccc attgcttttc taaaaatctt ggaaactttg
      301 tccttcattg aattacgaca ctgtccacct ttaatttcct cgaaaacgcc tgtaactcgg
      361 ctgaagccat gccttgtgtt caggcgcagt atgggtcctc gcctcaagga gccagccccg
      421 cttctcagag ctacagttac cactcttcgg gagaatacag ctccgatttc ttaactccag
      481 agtttgtcaa gtttagcatg gacctcacca acactgaaat cactgccacc acttctctcc
      541 ccagcttcag tacctttatg gacaactaca gcacaggcta cgacgtcaag ccaccttgct
      601 tgtaccaaat gcccctgtcc ggacagcagt cctccattaa ggtagaagac attcagatgc
      661 acaactacca gcaacacagc cacctgcccc cccagtctga ggagatgatg ccgcactccg
      721 ggtcggttta ctacaagccc tcctcgcccc cgacgcccac caccccgggc ttccaggtgc
      781 agcacagccc catgtgggac gacccgggat ctctccacaa cttccaccag aactacgtgg
      841 ccactacgca catgatcgag cagaggaaaa cgccagtctc ccgcctctcc ctcttctcct
      901 ttaagcaatc gccccctggc accccggtgt ctagttgcca gatgcgcttc gacgggcccc
      961 tgcacgtccc catgaacccg gagcccgccg gcagccacca cgtggtggac gggcagacct
     1021 tcgctgtgcc caaccccatt cgcaagcccg cgtccatggg cttcccgggc ctgcagatcg
     1081 gccacgcgtc tcagctgctc gacacgcagg tgccctcacc gccgtcgcgg ggctccccct
     1141 ccaacgaggg gctgtgcgct gtgtgtgggg acaacgcggc ctgccaacac tacggcgtgc
     1201 gcacctgtga gggctgcaaa ggcttcttta agcgcacagt gcaaaaaaat gcaaaatacg
     1261 tgtgtttagc aaataaaaac tgcccagtgg acaagcgtcg ccggaatcgc tgtcagtact
     1321 gccgatttca gaagtgcctg gctgttggga tggtcaaaga agtggttcgc acagacagtt
     1381 taaaaggccg gagaggtcgt ttgccctcga aaccgaagag cccacaggag ccctctcccc
     1441 cttcgccccc ggtgagtctg atcagtgccc tcgtcagggc ccatgtcgac tccaacccgg
     1501 ctatgaccag cctggactat tccaggttcc aggcgaaccc tgactatcaa atgagtggag
     1561 atgacaccca gcatatccag caattctatg atctcctgac tggctccatg gagatcatcc
     1621 ggggctgggc agagaagatc cctggcttcg cagacctgcc caaagccgac caagacctgc
     1681 tttttgaatc agctttctta gaactgtttg tccttcgatt agcatacagg tccaacccag
     1741 tggagggtaa actcatcttt tgcaatgggg tggtcttgca caggttgcaa tgcgttcgtg
     1801 gctttgggga atggattgat tccattgttg aattctcctc caacttgcag aatatgaaca
     1861 tcgacatttc tgccttctcc tgcattgctg ccctggctat ggtcacagag agacacgggc
     1921 tcaaggaacc caagagagtg gaagaactgc aaaacaagat tgtaaattgt ctcaaagacc
     1981 acgtgacttt caacaatggg gggttgaacc gccccaatta tttgtccaaa ctgttgggga
     2041 agctcccaga acttcgtacc ctttgcacac aggggctaca gcgcattttc tacctgaaat
     2101 tggaagactt ggtgccaccg ccagcaataa ttgacaaact tttcctggac actttacctt
     2161 tctaagacct cctcccaagc acttcaaagg aactggaatg ataatggaaa ctgtcaagag
     2221 ggggcaagtc acatgggcag agatagccgt gtgagcagtc tcagctcaag ctgcccccca
     2281 tttctgtaac cctcctagcc cccttgatcc ctaaagaaaa caaacaaaca aacaaaaact
     2341 gttgctattt cctaacctgc aggcagaacc tgaaagggca ttttggctcc ggggcatcct
     2401 ggatttagaa catggactac acacaataca gtggtataaa ctttttattc tcagtttaaa
     2461 aatcagtttg ttgttcagaa gaaagattgc tataatgtat aatgggaaat gtttggccat
     2521 gcttggttgt tgcagttcag acaaatgtaa cacacacaca catacacaca cacacacaca
     2581 cacagagaca catcttaagg ggacccacaa gtattgccct ttaacaagac ttcaaagttt
     2641 tctgctgtaa agaaagctgt aatatatagt aaaactaaat gttgcgtggg tggcatgagt
     2701 tgaagaaggc aaaggcttgt aaatttaccc aatgcagttt ggctttttaa attattttgt
     2761 gcctatttat gaataaatat tacaaattct aaaagataag tgtgtttgca aaaaaaaaga
     2821 aaataaatac ataaaaaagg gacaagcatg ttgattctag gttgaaaatg ttataggcac
     2881 ttgctacttc agtaatgtct atattatata aatagtattt cagacactat gtagtctgtt
     2941 agattttata aagattggta gttatctgag cttaaacatt ttctcaattg taaaataggt
     3001 gggcacaagt attacacatc agaaaatcct gacaaaaggg acacatagtg tttgtaacac
     3061 cgtccaacat tccttgtttg taagtgttgt atgtaccgtt gatgttgata aaaagaaagt
     3121 ttatatcttg attattttgt tgtctaaagc taaacaaaac ttgcatgcag cagcttttga
     3181 ctgtttccag agtgcttata atatacataa ctccctggaa ataactgagc actttgaatt
     3241 ttttttatgt ctaaaattgt cagttaattt attattttgt ttgagtaaga attttaatat
     3301 tgccatattc tgtagtattt ttctttgtat atttctagta tggcacatga tatgagtcac
     3361 tgcctttttt tctatggtgt atgacagtta gagatgctga ttttttttct gataaattct
     3421 ttctttgaga aagacaattt taatgtttac aacaataaac catgtaaatg aa
//
