LOCUS       NM_173157               2485 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1),
            transcript variant 2, mRNA.
ACCESSION   NM_173157
VERSION     NM_173157.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2485)
  AUTHORS   Wernig-Zorc,S., Schwartz,U., Martinez-Rodriguez,P., Inalef,J.,
            Pavicic,F., Ehrenfeld,P., Langst,G. and Maldonado,R.
  TITLE     The Long Non-Coding RNA MALAT1 Modulates NR4A1 Expression through a
            Downstream Regulatory Element in Specific Cancer Cell Types
  JOURNAL   Int J Mol Sci 25 (10), 5515 (2024)
   PUBMED   38791553
  REMARK    GeneRIF: The Long Non-Coding RNA MALAT1 Modulates NR4A1 Expression
            through a Downstream Regulatory Element in Specific Cancer Cell
            Types.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2485)
  AUTHORS   Chen,J., Zhang,Z., Liu,Y., Huang,L., Liu,Y., Yang,D., Bao,X.,
            Liu,P., Ge,Y., Li,Q., Shu,X., Xu,L., Shi,Y.S., Zhu,X. and Xu,Y.
  TITLE     Progressive reduction of nuclear receptor Nr4a1 mediates
            age-dependent cognitive decline
  JOURNAL   Alzheimers Dement 20 (5), 3504-3524 (2024)
   PUBMED   38605605
  REMARK    GeneRIF: Progressive reduction of nuclear receptor Nr4a1 mediates
            age-dependent cognitive decline.
REFERENCE   3  (bases 1 to 2485)
  AUTHORS   Zhu,J., Li,J., Yang,K., Chen,Y., Wang,J., He,Y., Shen,K., Wang,K.,
            Shi,T. and Chen,W.
  TITLE     NR4A1 depletion inhibits colorectal cancer progression by promoting
            necroptosis via the RIG-I-like receptor pathway
  JOURNAL   Cancer Lett 585, 216693 (2024)
   PUBMED   38301909
  REMARK    GeneRIF: NR4A1 depletion inhibits colorectal cancer progression by
            promoting necroptosis via the RIG-I-like receptor pathway.
REFERENCE   4  (bases 1 to 2485)
  AUTHORS   Jin,X., Hu,Q., Qin,M., Yin,Y. and Xia,Z.
  TITLE     SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and
            Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic
            Organ Prolapse
  JOURNAL   Balkan Med J 41 (2), 105-112 (2024)
   PUBMED   38229336
  REMARK    GeneRIF: SOCS3, Transcriptionally Activated by NR4A1, Induces
            Apoptosis and Extracellular Matrix Degradation of Vaginal
            Fibroblasts in Pelvic Organ Prolapse.
REFERENCE   5  (bases 1 to 2485)
  AUTHORS   Jiang,N.X., Zhao,W.J., Shen,H.R., Du,D.F. and Li,X.L.
  TITLE     Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling:
            new insight into polycystic ovary syndrome (PCOS)-related
            infertility
  JOURNAL   J Ovarian Res 17 (1), 31 (2024)
   PUBMED   38310251
  REMARK    GeneRIF: Hyperinsulinemia impairs decidualization via AKT-NR4A1
            signaling: new insight into polycystic ovary syndrome
            (PCOS)-related infertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2485)
  AUTHORS   Uemura,H., Mizokami,A. and Chang,C.
  TITLE     Identification of a new enhancer in the promoter region of human
            TR3 orphan receptor gene. A member of steroid receptor superfamily
  JOURNAL   J Biol Chem 270 (10), 5427-5433 (1995)
   PUBMED   7890657
REFERENCE   7  (bases 1 to 2485)
  AUTHORS   Bondy,G.P.
  TITLE     Phorbol ester, forskolin, and serum induction of a human colon
            nuclear hormone receptor gene related to the NUR 77/NGFI-B genes
  JOURNAL   Cell Growth Differ 2 (4), 203-208 (1991)
   PUBMED   1651101
REFERENCE   8  (bases 1 to 2485)
  AUTHORS   Nakai,A., Kartha,S., Sakurai,A., Toback,F.G. and DeGroot,L.J.
  TITLE     A human early response gene homologous to murine nur77 and rat
            NGFI-B, and related to the nuclear receptor superfamily
  JOURNAL   Mol Endocrinol 4 (10), 1438-1443 (1990)
   PUBMED   2283997
REFERENCE   9  (bases 1 to 2485)
  AUTHORS   Ryseck,R.P., Macdonald-Bravo,H., Mattei,M.G., Ruppert,S. and
            Bravo,R.
  TITLE     Structure, mapping and expression of a growth factor inducible gene
            encoding a putative nuclear hormonal binding receptor
  JOURNAL   EMBO J 8 (11), 3327-3335 (1989)
   PUBMED   2555161
REFERENCE   10 (bases 1 to 2485)
  AUTHORS   Chang,C., Kokontis,J., Liao,S.S. and Chang,Y.
  TITLE     Isolation and characterization of human TR3 receptor: a member of
            steroid receptor superfamily
  JOURNAL   J Steroid Biochem 34 (1-6), 391-395 (1989)
   PUBMED   2626032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025259.49, L13740.1 and
            BG057763.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173157.2.
            
            Summary: This gene encodes a member of the steroid-thyroid
            hormone-retinoid receptor superfamily. Expression is induced by
            phytohemagglutinin in human lymphocytes and by serum stimulation of
            arrested fibroblasts. The encoded protein acts as a nuclear
            transcription factor. Translocation of the protein from the nucleus
            to mitochondria induces apoptosis. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (2) differs in the 5' structure,
            lacks a portion of the 5' coding region, and initiates translation
            at a downstream start codon, compared to variant 4. The encoded
            isoform (1) has a shorter N-terminus compared to isoform 3.
            Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.244591.1,
                                           SRR3476690.784150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394825.6/ ENSP00000378302.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC025259.49        32259-32279         c
            22-118              L13740.1           3-99
            119-120             AC025259.49        32160-32161         c
            121-293             L13740.1           102-274
            294-914             AC025259.49        28608-29228         c
            915-1237            L13740.1           896-1218
            1238-1251           AC025259.49        27112-27125         c
            1252-1382           L13740.1           1233-1363
            1383-1383           AC025259.49        26569-26569         c
            1384-2314           L13740.1           1365-2295
            2315-2482           L13740.1           2297-2464
            2483-2485           BG057763.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..2485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2485
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /note="nuclear receptor subfamily 4 group A member 1"
                     /db_xref="GeneID:3164"
                     /db_xref="HGNC:HGNC:7980"
                     /db_xref="MIM:139139"
     exon            1..127
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            128..1005
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1926
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     growth factor-inducible nuclear protein N10; early
                     response protein NAK1; orphan nuclear receptor HMR; TR3
                     orphan receptor; steroid receptor TR3; hormone receptor;
                     nuclear hormone receptor NUR/77; ST-59; testicular
                     receptor 3; orphan nuclear receptor TR3; nuclear receptor
                     subfamily 4immunitygroup A member 1"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4immunitygroup A
                     member 1 isoform 1"
                     /protein_id="NP_775180.1"
                     /db_xref="CCDS:CCDS8818.1"
                     /db_xref="GeneID:3164"
                     /db_xref="HGNC:HGNC:7980"
                     /db_xref="MIM:139139"
                     /translation="MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAP
                     AAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFK
                     FEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGH
                     FSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQL
                     GEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASC
                     QHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVK
                     EVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVL
                     PHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILR
                     LAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSA
                     LVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLC
                     TQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF"
     exon            1006..1135
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1287
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1490
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1669
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..2485
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /note="hexamer: AATAAA"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /note="hexamer: AATAGA"
     polyA_site      2478
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /note="major polyA site"
     polyA_site      2485
                     /gene="NR4A1"
                     /gene_synonym="GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77;
                     TR3"
                     /note="major polyA site"
ORIGIN      
        1 agtcccagtg gcggaggcta cgaaacttgg gggagtgcac agaagaactt cgggagcgca
       61 cgcgggacca gggaccaggc tgagactcgg ggcgccagtc cgggcagggg cagcgggagc
      121 cggccggaga tgccctgtat ccaagcccaa tatgggacac cagcaccgag tccgggaccc
      181 cgtgaccacc tggcaagcga ccccctgacc cctgagttca tcaagcccac catggacctg
      241 gccagccccg aggcagcccc cgctgccccc actgccctgc ccagcttcag caccttcatg
      301 gacggctaca caggagagtt tgacaccttc ctctaccagc tgccaggaac agtccagcca
      361 tgctcctcag cctcctcctc ggcctcctcc acatcctcgt cctcagccac ctcccctgcc
      421 tctgcctcct tcaagttcga ggacttccag gtgtacggct gctaccccgg ccccctgagc
      481 ggcccagtgg atgaggccct gtcctccagt ggctctgact actatggcag cccctgctcg
      541 gccccgtcgc cctccacgcc cagcttccag ccgccccagc tctctccctg ggatggctcc
      601 ttcggccact tctcgcccag ccagacttac gaaggcctgc gggcatggac agagcagctg
      661 cccaaagcct ctgggccccc acagcctcca gccttctttt ccttcagtcc tcccaccggc
      721 cccagcccca gcctggccca gagccccctg aagttgttcc cctcacaggc cacccaccag
      781 ctgggggagg gagagagcta ttccatgcct acggccttcc caggtttggc acccacttct
      841 ccacaccttg agggctcggg gatactggat acacccgtga cctcaaccaa ggcccggagc
      901 ggggccccag gtggaagtga aggccgctgt gctgtgtgtg gggacaacgc ttcatgccag
      961 cattatggtg tccgcacatg tgagggctgc aagggcttct tcaagcgcac agtgcagaaa
     1021 aacgccaagt acatctgcct ggctaacaag gactgccctg tggacaagag gcggcgaaac
     1081 cgctgccagt tctgccgctt ccagaagtgc ctggcggtgg gcatggtgaa ggaagttgtc
     1141 cgaacagaca gcctgaaggg gcggcggggc cggctacctt caaaacccaa gcagccccca
     1201 gatgcctccc ctgccaatct cctcacttcc ctggtccgtg cacacctgga ctcagggccc
     1261 agcactgcca aactggacta ctccaagttc caggagctgg tgctgcccca ctttgggaag
     1321 gaagatgctg gggatgtaca gcagttctac gacctgctct ccggttctct ggaggtcatc
     1381 cgcaagtggg cggagaagat ccctggcttt gctgagctgt caccggctga ccaggacctg
     1441 ttgctggagt cggccttcct ggagctcttc atcctccgcc tggcgtacag gtctaagcca
     1501 ggcgagggca agctcatctt ctgctcaggc ctggtgctac accggctgca gtgtgcccgt
     1561 ggcttcgggg actggattga cagtatcctg gccttctcaa ggtccctgca cagcttgctt
     1621 gtcgatgtcc ctgccttcgc ctgcctctct gcccttgtcc tcatcaccga ccggcatggg
     1681 ctgcaggagc cgcggcgggt ggaggagctg cagaaccgca tcgccagctg cctgaaggag
     1741 cacgtggcag ctgtggcggg cgagccccag ccagccagct gcctgtcacg tctgttgggc
     1801 aaactgcccg agctgcggac cctgtgcacc cagggcctgc agcgcatctt ctacctcaag
     1861 ctggaggact tggtgccccc tccacccatc attgacaaga tcttcatgga cacgctgccc
     1921 ttctgacccc tgcctgggaa cacgtgtgca catgcgcact ctcatatgcc accccatgtg
     1981 cctttagtcc acggaccccc agagcacccc caagcctggg cttgagctgc agaatgactc
     2041 caccttctca cctgctccag gaggtttgca gggagctcaa gcccttgggg agggggatgc
     2101 cttcatgggg gtgaccccac gatttgtctt atccccccca gcctggcccc ggcctttatg
     2161 ttttttgtaa gataaaccgt ttttaacaca tagcgccgtg ctgtaaataa gcccagtgct
     2221 gctgtaaata caggaagaaa gagcttgagg tgggagcggg gctgggagga agggatgggc
     2281 cccgccttcc tgggcagcct ttccagcctc ctgctggctc tctcttccta ccctccttcc
     2341 acatgtacat aaactgtcac tctaggaaga agacaaatga cagattctga catttatatt
     2401 tgtgtatttt cctggattta tagtatgtga cttttctgat taatatattt aatatattga
     2461 ataaaaaata gacatgtagt tggaa
//
