LOCUS       NM_000176               6778 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 3 group C member 1 (NR3C1),
            transcript variant 1, mRNA.
ACCESSION   NM_000176 XM_374144
VERSION     NM_000176.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6778)
  AUTHORS   Vos,S., Van den Bergh,B.R.H., Martens,D.S., Bijnens,E., Shkedy,Z.,
            Kindermans,H., Platzer,M., Schwab,M. and Nawrot,T.S.
  TITLE     Maternal perceived stress and green spaces during pregnancy are
            associated with adult offspring gene (NR3C1 and IGF2/H19)
            methylation patterns in adulthood: A pilot study
  JOURNAL   Psychoneuroendocrinology 167, 107088 (2024)
   PUBMED   38924829
  REMARK    GeneRIF: Maternal perceived stress and green spaces during
            pregnancy are associated with adult offspring gene (NR3C1 and
            IGF2/H19) methylation patterns in adulthood: A pilot study.
REFERENCE   2  (bases 1 to 6778)
  AUTHORS   Lockett,J., Inder,W.J. and Clifton,V.L.
  TITLE     The Glucocorticoid Receptor: Isoforms, Functions, and Contribution
            to Glucocorticoid Sensitivity
  JOURNAL   Endocr Rev 45 (4), 593-624 (2024)
   PUBMED   38551091
  REMARK    GeneRIF: The Glucocorticoid Receptor: Isoforms, Functions, and
            Contribution to Glucocorticoid Sensitivity.
            Review article
REFERENCE   3  (bases 1 to 6778)
  AUTHORS   Stroud,L.R., Jao,N.C., Ward,L.G., Lee,S.Y. and Marsit,C.J.
  TITLE     Differential impact of prenatal PTSD symptoms and preconception
            trauma exposure on placental NR3C1 and FKBP5 methylation
  JOURNAL   Stress 27 (1), 2321595 (2024)
   PUBMED   38676353
  REMARK    GeneRIF: Differential impact of prenatal PTSD symptoms and
            preconception trauma exposure on placental NR3C1 and FKBP5
            methylation.
REFERENCE   4  (bases 1 to 6778)
  AUTHORS   Lu,N.Z., Collins,J.B., Grissom,S.F. and Cidlowski,J.A.
  TITLE     Selective regulation of bone cell apoptosis by translational
            isoforms of the glucocorticoid receptor
  JOURNAL   Mol Cell Biol 27 (20), 7143-7160 (2007)
   PUBMED   17682054
  REMARK    GeneRIF: Results suggest that translational glucocorticoid receptor
            isoforms can elicit distinct glucocorticoid responses.
REFERENCE   5  (bases 1 to 6778)
  AUTHORS   Lu,N.Z. and Cidlowski,J.A.
  TITLE     Translational regulatory mechanisms generate N-terminal
            glucocorticoid receptor isoforms with unique transcriptional target
            genes
  JOURNAL   Mol Cell 18 (3), 331-342 (2005)
   PUBMED   15866175
  REMARK    GeneRIF: Results suggest that cell-type specific glucocorticoid
            receptor isoforms generate specificity in glucocorticoid control of
            transcription in different tissues.
REFERENCE   6  (bases 1 to 6778)
  AUTHORS   de Lange,P., Segeren,C.M., Koper,J.W., Wiemer,E., Sonneveld,P.,
            Brinkmann,A.O., White,A., Brogan,I.J., de Jong,F.H. and
            Lamberts,S.W.
  TITLE     Expression in hematological malignancies of a glucocorticoid
            receptor splice variant that augments glucocorticoid
            receptor-mediated effects in transfected cells
  JOURNAL   Cancer Res 61 (10), 3937-3941 (2001)
   PUBMED   11358809
REFERENCE   7  (bases 1 to 6778)
  AUTHORS   Krett,N.L., Pillay,S., Moalli,P.A., Greipp,P.R. and Rosen,S.T.
  TITLE     A variant glucocorticoid receptor messenger RNA is expressed in
            multiple myeloma patients
  JOURNAL   Cancer Res 55 (13), 2727-2729 (1995)
   PUBMED   7796394
REFERENCE   8  (bases 1 to 6778)
  AUTHORS   Subramaniam,M., Colvard,D., Keeting,P.E., Rasmussen,K., Riggs,B.L.
            and Spelsberg,T.C.
  TITLE     Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and
            proto-oncogenes in normal human osteoblast-like cells
  JOURNAL   J Cell Biochem 50 (4), 411-424 (1992)
   PUBMED   1469072
REFERENCE   9  (bases 1 to 6778)
  AUTHORS   Scherrer,L.C. and Pratt,W.B.
  TITLE     Association of the transformed glucocorticoid receptor with a
            cytoskeletal protein complex
  JOURNAL   J Steroid Biochem Mol Biol 41 (3-8), 719-721 (1992)
   PUBMED   1562545
REFERENCE   10 (bases 1 to 6778)
  AUTHORS   Plotkin,L.L., Labutin,A.L., Lebedev,L.V., Khanukov,L.A. and
            Zelikson,O.S.
  TITLE     [Balloon probe for the removal of emboli and thrombi]
  JOURNAL   Med Tekh (3), 42-43 (1975)
   PUBMED   1152650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091925.3, X03225.1 and
            AC004782.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 7, 2018 this sequence version replaced NM_000176.2.
            
            Summary: This gene encodes glucocorticoid receptor, which can
            function both as a transcription factor that binds to
            glucocorticoid response elements in the promoters of glucocorticoid
            responsive genes to activate their transcription, and as a
            regulator of other transcription factors. This receptor is
            typically found in the cytoplasm, but upon ligand binding, is
            transported into the nucleus. It is involved in inflammatory
            responses, cellular proliferation, and differentiation in target
            tissues. Mutations in this gene are associated with generalized
            glucocorticoid resistance. Alternative splicing of this gene
            results in transcript variants encoding either the same or
            different isoforms. Additional isoforms resulting from the use of
            alternate in-frame translation initiation sites have also been
            described, and shown to be functional, displaying diverse
            cytoplasm-to-nucleus trafficking patterns and distinct
            transcriptional activities (PMID:15866175). [provided by RefSeq,
            Feb 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the predominant physiological isoform
            (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the
            same isoform.
            
            Sequence Note: This RefSeq containing mutliple in-frame translation
            initiation codons, is annotated with a CDS starting from the
            upstream start codon (at nt 493-495). Additional isoforms (alpha-B,
            C1, C2, C3, D1, D2 and D3) result from the use of downstream
            translation initiation codons. These isoforms are functional, and
            display diverse cytoplasm-to-nucleus trafficking patterns and
            distinct transcriptional activities (PMID:15866175). This RefSeq
            record was created from transcript and genomic sequence data to
            make the sequence consistent with the reference genome assembly.
            The genomic coordinates used for the transcript record were based
            on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.31527.1,
                                           SRR1803616.11823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394464.7/ ENSP00000377977.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AC091925.3         120990-121465       c
            477-5145            X03225.1           120-4788
            5146-6778           AC004782.1         21608-23240
FEATURES             Location/Qualifiers
     source          1..6778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..6778
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /note="nuclear receptor subfamily 3 group C member 1"
                     /db_xref="GeneID:2908"
                     /db_xref="HGNC:HGNC:7978"
                     /db_xref="MIM:138040"
     exon            1..476
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            477..1673
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..2823
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /note="isoform alpha is encoded by transcript variant 1;
                     nuclear receptor subfamily 3, group C, member 1
                     (glucocorticoid receptor); nuclear receptor subfamily 3
                     group C member 1 variant hGR-B(54); nuclear receptor
                     subfamily 3 group C member 1 variant hGR-B(77); nuclear
                     receptor subfamily 3 group C member 1 variant hGR-B(93)"
                     /codon_start=1
                     /product="glucocorticoid receptor isoform alpha"
                     /protein_id="NP_000167.1"
                     /db_xref="CCDS:CCDS4278.1"
                     /db_xref="GeneID:2908"
                     /db_xref="HGNC:HGNC:7978"
                     /db_xref="MIM:138040"
                     /translation="MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSAS
                     SPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDL
                     GFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTH
                     SDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLL
                     IDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQV
                     KTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHY
                     DMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNG
                     YSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVE
                     GQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVS
                     QETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNML
                     GGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFA
                     PDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKS
                     QELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTF
                     LDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK"
     exon            1674..1840
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1957
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2236
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2381
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2512
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2670
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..6778
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6757..6762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /note="hexamer: AATAAA"
     polyA_site      6778
                     /gene="NR3C1"
                     /gene_synonym="GCCR; GCR; GCRST; GR; GRL"
                     /note="major polyA site"
ORIGIN      
        1 gccgcctcca cccgctcccc gctcggtccc gctcgctcgc ccaggccggg ctgccctttc
       61 gcgtgtccgc gctctcttcc ctccgccgcc gcctcctcca ttttgcgagc tcgtgtctgt
      121 gacgggagcc cgagtcaccg cctgcccgtc ggggacggat tctgtgggtg gaaggagacg
      181 ccgcagccgg agcggccgaa gcagctggga ccgggacggg gcacgcgcgc ccggaacctc
      241 gacccgcgga gcccggcgcg gggcggaggg ctggcttgtc agctgggcaa tgggagactt
      301 tcttaaatag gggctctccc cccacccatg gagaaagggg cggctgttta cttccttttt
      361 ttagaaaaaa aaaatatatt tccctcctgc tccttctgcg ttcacaagct aagttgttta
      421 tctcggctgc ggcgggaact gcggacggtg gcgggcgagc ggctcctctg ccagagttga
      481 tattcactga tggactccaa agaatcatta actcctggta gagaagaaaa ccccagcagt
      541 gtgcttgctc aggagagggg agatgtgatg gacttctata aaaccctaag aggaggagct
      601 actgtgaagg tttctgcgtc ttcaccctca ctggctgtcg cttctcaatc agactccaag
      661 cagcgaagac ttttggttga ttttccaaaa ggctcagtaa gcaatgcgca gcagccagat
      721 ctgtccaaag cagtttcact ctcaatggga ctgtatatgg gagagacaga aacaaaagtg
      781 atgggaaatg acctgggatt cccacagcag ggccaaatca gcctttcctc gggggaaaca
      841 gacttaaagc ttttggaaga aagcattgca aacctcaata ggtcgaccag tgttccagag
      901 aaccccaaga gttcagcatc cactgctgtg tctgctgccc ccacagagaa ggagtttcca
      961 aaaactcact ctgatgtatc ttcagaacag caacatttga agggccagac tggcaccaac
     1021 ggtggcaatg tgaaattgta taccacagac caaagcacct ttgacatttt gcaggatttg
     1081 gagttttctt ctgggtcccc aggtaaagag acgaatgaga gtccttggag atcagacctg
     1141 ttgatagatg aaaactgttt gctttctcct ctggcgggag aagacgattc attccttttg
     1201 gaaggaaact cgaatgagga ctgcaagcct ctcattttac cggacactaa acccaaaatt
     1261 aaggataatg gagatctggt tttgtcaagc cccagtaatg taacactgcc ccaagtgaaa
     1321 acagaaaaag aagatttcat cgaactctgc acccctgggg taattaagca agagaaactg
     1381 ggcacagttt actgtcaggc aagctttcct ggagcaaata taattggtaa taaaatgtct
     1441 gccatttctg ttcatggtgt gagtacctct ggaggacaga tgtaccacta tgacatgaat
     1501 acagcatccc tttctcaaca gcaggatcag aagcctattt ttaatgtcat tccaccaatt
     1561 cccgttggtt ccgaaaattg gaataggtgc caaggatctg gagatgacaa cttgacttct
     1621 ctggggactc tgaacttccc tggtcgaaca gttttttcta atggctattc aagccccagc
     1681 atgagaccag atgtaagctc tcctccatcc agctcctcaa cagcaacaac aggaccacct
     1741 cccaaactct gcctggtgtg ctctgatgaa gcttcaggat gtcattatgg agtcttaact
     1801 tgtggaagct gtaaagtttt cttcaaaaga gcagtggaag gacagcacaa ttacctatgt
     1861 gctggaagga atgattgcat catcgataaa attcgaagaa aaaactgccc agcatgccgc
     1921 tatcgaaaat gtcttcaggc tggaatgaac ctggaagctc gaaaaacaaa gaaaaaaata
     1981 aaaggaattc agcaggccac tacaggagtc tcacaagaaa cctctgaaaa tcctggtaac
     2041 aaaacaatag ttcctgcaac gttaccacaa ctcaccccta ccctggtgtc actgttggag
     2101 gttattgaac ctgaagtgtt atatgcagga tatgatagct ctgttccaga ctcaacttgg
     2161 aggatcatga ctacgctcaa catgttagga gggcggcaag tgattgcagc agtgaaatgg
     2221 gcaaaggcaa taccaggttt caggaactta cacctggatg accaaatgac cctactgcag
     2281 tactcctgga tgtttcttat ggcatttgct ctggggtgga gatcatatag acaatcaagt
     2341 gcaaacctgc tgtgttttgc tcctgatctg attattaatg agcagagaat gactctaccc
     2401 tgcatgtacg accaatgtaa acacatgctg tatgtttcct ctgagttaca caggcttcag
     2461 gtatcttatg aagagtatct ctgtatgaaa accttactgc ttctctcttc agttcctaag
     2521 gacggtctga agagccaaga gctatttgat gaaattagaa tgacctacat caaagagcta
     2581 ggaaaagcca ttgtcaagag ggaaggaaac tccagccaga actggcagcg gttttatcaa
     2641 ctgacaaaac tcttggattc tatgcatgaa gtggttgaaa atctccttaa ctattgcttc
     2701 caaacatttt tggataagac catgagtatt gaattccccg agatgttagc tgaaatcatc
     2761 accaatcaga taccaaaata ttcaaatgga aatatcaaaa aacttctgtt tcatcaaaag
     2821 tgactgcctt aataagaatg gttgccttaa agaaagtcga attaatagct tttattgtat
     2881 aaactatcag tttgtcctgt agaggttttg ttgttttatt ttttattgtt ttcatctgtt
     2941 gttttgtttt aaatacgcac tacatgtggt ttatagaggg ccaagacttg gcaacagaag
     3001 cagttgagtc gtcatcactt ttcagtgatg ggagagtaga tggtgaaatt tattagttaa
     3061 tatatcccag aaattagaaa ccttaatatg tggacgtaat ctccacagtc aaagaaggat
     3121 ggcacctaaa ccaccagtgc ccaaagtctg tgtgatgaac tttctcttca tacttttttt
     3181 cacagttggc tggatgaaat tttctagact ttctgttggt gtatcccccc cctgtatagt
     3241 taggatagca tttttgattt atgcatggaa acctgaaaaa aagtttacaa gtgtatatca
     3301 gaaaagggaa gttgtgcctt ttatagctat tactgtctgg ttttaacaat ttcctttata
     3361 tttagtgaac tacgcttgct cattttttct tacataattt tttattcaag ttattgtaca
     3421 gctgtttaag atgggcagct agttcgtagc tttcccaaat aaactctaaa cattaatcaa
     3481 tcatctgtgt gaaaatgggt tggtgcttct aacctgatgg cacttagcta tcagaagacc
     3541 acaaaaattg actcaaatct ccagtattct tgtcaaaaaa aaaaaaaaaa aagctcatat
     3601 tttgtatata tctgcttcag tggagaatta tataggttgt gcaaattaac agtcctaact
     3661 ggtatagagc acctagtcca gtgacctgct gggtaaactg tggatgatgg ttgcaaaaga
     3721 ctaatttaaa aaataactac caagaggccc tgtctgtacc taacgcccta tttttgcaat
     3781 ggctatatgg caagaaagct ggtaaactat ttgtctttca ggaccttttg aagtagtttg
     3841 tataacttct taaaagttgt gattccagat aaccagctgt aacacagctg agagactttt
     3901 aatcagacaa agtaattcct ctcactaaac tttacccaaa aactaaatct ctaatatggc
     3961 aaaaatggct agacacccat tttcacattc ccatctgtca ccaattggtt aatctttcct
     4021 gatggtacag gaaagctcag ctactgattt ttgtgattta gaactgtatg tcagacatcc
     4081 atgtttgtaa aactacacat ccctaatgtg tgccatagag tttaacacaa gtcctgtgaa
     4141 tttcttcact gttgaaaatt attttaaaca aaatagaagc tgtagtagcc ctttctgtgt
     4201 gcaccttacc aactttctgt aaactcaaaa cttaacatat ttactaagcc acaagaaatt
     4261 tgatttctat tcaaggtggc caaattattt gtgtaataga aaactgaaaa tctaatatta
     4321 aaaatatgga acttctaata tatttttata tttagttata gtttcagata tatatcatat
     4381 tggtattcac taatctggga agggaagggc tactgcagct ttacatgcaa tttattaaaa
     4441 tgattgtaaa atagcttgta tagtgtaaaa taagaatgat ttttagatga gattgtttta
     4501 tcatgacatg ttatatattt tttgtagggg tcaaagaaat gctgatggat aacctatatg
     4561 atttatagtt tgtacatgca ttcatacagg cagcgatggt ctcagaaacc aaacagtttg
     4621 ctctagggga agagggagat ggagactggt cctgtgtgca gtgaaggttg ctgaggctct
     4681 gacccagtga gattacagag gaagttatcc tctgcctccc attctgacca cccttctcat
     4741 tccaacagtg agtctgtcag cgcaggttta gtttactcaa tctccccttg cactaaagta
     4801 tgtaaagtat gtaaacagga gacaggaagg tggtgcttac atccttaaag gcaccatcta
     4861 atagcgggtt actttcacat acagccctcc cccagcagtt gaatgacaac agaagcttca
     4921 gaagtttggc aatagtttgc atagaggtac cagcaatatg taaatagtgc agaatctcat
     4981 aggttgccaa taatacacta attcctttct atcctacaac aagagtttat ttccaaataa
     5041 aatgaggaca tgtttttgtt ttctttgaat gctttttgaa tgttatttgt tattttcagt
     5101 attttggaga aattatttaa taaaaaaaca atcatttgct ttttgaatgc tctctaaaag
     5161 ggaatgtaat attttaagat ggtgtgtaac ccggctggat aaatttttgg tgcctaagaa
     5221 aactgcttga atattcttat caatgacagt gttaagtttc aaaaagagct tctaaaacgt
     5281 agattatcat tcctttatag aatgttatgt ggttaaaacc agaaagcaca tctcacacat
     5341 taatctgatt ttcatcccaa caatcttggc gctcaaaaaa tagaactcaa tgagaaaaag
     5401 aagattatgt gcacttcgtt gtcaataata agtcaactga tgctcatcga caactatagg
     5461 aggcttttca ttaaatggga aaagaagctg tgccctttta ggatacgtgg gggaaaagaa
     5521 agtcatctta attatgttta attgtggatt taagtgctat atggtggtgc tgtttgaaag
     5581 cagatttatt tcctatgtat gtgttatctg gccatcccaa cccaaactgt tgaagtttgt
     5641 agtaacttca gtgagagttg gttactcaca acaaatcctg aaaagtattt ttagtgtttg
     5701 taggtattct gtgggatact atacaagcag aactgaggca cttaggacat aacacttttg
     5761 gggtatatat atccaaatgc ctaaaactat gggaggaaac cttggccacc ccaaaaggaa
     5821 aactaacatg atttgtgtct atgaagtgct ggataattag catgggatga gctctgggca
     5881 tgccatgaag gaaagccacg ctcccttcag aattcagagg cagggagcaa ttccagtttc
     5941 acctaagtct cataatttta gttccctttt aaaaaccctg aaaactacat caccatggaa
     6001 tgaaaaatat tgttatacaa tacattgatc tgtcaaactt ccagaaccat ggtagccttc
     6061 agtgagattt ccatcttggc tggtcactcc ctgactgtag ctgtaggtga atgtgttttt
     6121 gtgtgtgtgt gtctggtttt agtgtcagaa gggaaataaa agtgtaagga ggacacttta
     6181 aaccctttgg gtggagtttc gtaatttccc agactatttt caagcaacct ggtccaccca
     6241 ggattagtga ccaggttttc aggaaaggat ttgcttctct ctagaaaatg tctgaaagga
     6301 ttttattttc tgatgaaagg ctgtatgaaa ataccctcct caaataactt gcttaactac
     6361 atatagattc aagtgtgtca atattctatt ttgtatatta aatgctatat aatggggaca
     6421 aatctatatt atactgtgta tggcattatt aagaagcttt ttcattattt tttatcacag
     6481 taattttaaa atgtgtaaaa attaaaacca gtgactcctg tttaaaaata aaagttgtag
     6541 ttttttattc atgctgaata ataatctgta gttaaaaaaa aagtgtcttt ttacctacgc
     6601 agtgaaatgt cagactgtaa aaccttgtgt ggaaatgttt aacttttatt ttttcattta
     6661 aatttgctgt tctggtatta ccaaaccaca catttgtacc gaattggcag taaatgttag
     6721 ccatttacag caatgccaaa tatggagaaa catcataata aaaaaatctg ctttttca
//
