LOCUS       NM_021005               5287 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 2 group F member 2 (NR2F2),
            transcript variant 1, mRNA.
ACCESSION   NM_021005
VERSION     NM_021005.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5287)
  AUTHORS   Ganapathi,M., Matsuoka,L.S., March,M., Li,D., Brokamp,E.,
            Benito-Sanz,S., White,S.M., Lachlan,K., Ahimaz,P., Sewda,A.,
            Bastarache,L., Thomas-Wilson,A., Stoler,J.M., Bramswig,N.C.,
            Baptista,J., Stals,K., Demurger,F., Cogne,B., Isidor,B.,
            Bedeschi,M.F., Peron,A., Amiel,J., Zackai,E., Schacht,J.P.,
            Iglesias,A.D., Morton,J., Schmetz,A., Seidel,V., Lucia,S.,
            Baskin,S.M., Thiffault,I., Cogan,J.D., Gordon,C.T., Chung,W.K.,
            Bowdin,S. and Bhoj,E.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Heterozygous rare variants in NR2F2 cause a recognizable multiple
            congenital anomaly syndrome with developmental delays
  JOURNAL   Eur J Hum Genet 31 (10), 1117-1124 (2023)
   PUBMED   37500725
  REMARK    GeneRIF: Heterozygous rare variants in NR2F2 cause a recognizable
            multiple congenital anomaly syndrome with developmental delays.
REFERENCE   2  (bases 1 to 5287)
  AUTHORS   Dougherty,E.J., Chen,L.Y., Awad,K.S., Ferreyra,G.A.,
            Demirkale,C.Y., Keshavarz,A., Gairhe,S., Johnston,K.A., Hicks,M.E.,
            Sandler,A.B., Curran,C.S., Krack,J.M., Ding,Y., Suffredini,A.F.,
            Solomon,M.A., Elinoff,J.M. and Danner,R.L.
  TITLE     Inflammation and DKK1-induced AKT activation contribute to
            endothelial dysfunction following NR2F2 loss
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (6), L783-L798 (2023)
   PUBMED   37039367
  REMARK    GeneRIF: Inflammation and DKK1-induced AKT activation contribute to
            endothelial dysfunction following NR2F2 loss.
REFERENCE   3  (bases 1 to 5287)
  AUTHORS   Davalos,V., Lovell,C.D., Von Itter,R., Dolgalev,I., Agrawal,P.,
            Baptiste,G., Kahler,D.J., Sokolova,E., Moran,S., Pique,L.,
            Vega-Saenz de Miera,E., Fontanals-Cirera,B., Karz,A., Tsirigos,A.,
            Yun,C., Darvishian,F., Etchevers,H.C., Osman,I., Esteller,M.,
            Schober,M. and Hernando,E.
  TITLE     An epigenetic switch controls an alternative NR2F2 isoform that
            unleashes a metastatic program in melanoma
  JOURNAL   Nat Commun 14 (1), 1867 (2023)
   PUBMED   37015919
  REMARK    GeneRIF: An epigenetic switch controls an alternative NR2F2 isoform
            that unleashes a metastatic program in melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5287)
  AUTHORS   Di-Luoffo,M., Pierre,K.J., Robert,N.M., Girard,M.J. and
            Tremblay,J.J.
  TITLE     The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3
            promoter in Leydig cells
  JOURNAL   Reproduction 164 (2), 31-40 (2022)
   PUBMED   35666805
  REMARK    GeneRIF: The nuclear receptors SF1 and COUP-TFII cooperate on the
            Insl3 promoter in Leydig cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5287)
  AUTHORS   Li,W., Zhang,Z., Li,Y. and Wang,Z.
  TITLE     Abnormal hsa_circ_0003948 expression affects chronic periodontitis
            development by regulating miR-144-3p/NR2F2/PTEN signaling
  JOURNAL   J Periodontal Res 57 (2), 316-323 (2022)
   PUBMED   34910830
  REMARK    GeneRIF: Abnormal hsa_circ_0003948 expression affects chronic
            periodontitis development by regulating miR-144-3p/NR2F2/PTEN
            signaling.
REFERENCE   6  (bases 1 to 5287)
  AUTHORS   Qiu,Y., Krishnan,V., Zeng,Z., Gilbert,D.J., Copeland,N.G.,
            Gibson,L., Yang-Feng,T., Jenkins,N.A., Tsai,M.J. and Tsai,S.Y.
  TITLE     Isolation, characterization, and chromosomal localization of mouse
            and human COUP-TF I and II genes
  JOURNAL   Genomics 29 (1), 240-246 (1995)
   PUBMED   8530078
REFERENCE   7  (bases 1 to 5287)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   8  (bases 1 to 5287)
  AUTHORS   Mietus-Snyder,M., Sladek,F.M., Ginsburg,G.S., Kuo,C.F.,
            Ladias,J.A., Darnell,J.E. Jr. and Karathanasis,S.K.
  TITLE     Antagonism between apolipoprotein AI regulatory protein 1,
            Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates
            apolipoprotein CIII gene expression in liver and intestinal cells
  JOURNAL   Mol Cell Biol 12 (4), 1708-1718 (1992)
   PUBMED   1312668
REFERENCE   9  (bases 1 to 5287)
  AUTHORS   Ladias,J.A. and Karathanasis,S.K.
  TITLE     Regulation of the apolipoprotein AI gene by ARP-1, a novel member
            of the steroid receptor superfamily
  JOURNAL   Science 251 (4993), 561-565 (1991)
   PUBMED   1899293
REFERENCE   10 (bases 1 to 5287)
  AUTHORS   Wang,L.H., Ing,N.H., Tsai,S.Y., O'Malley,B.W. and Tsai,M.J.
  TITLE     The COUP-TFs compose a family of functionally related transcription
            factors
  JOURNAL   Gene Expr 1 (3), 207-216 (1991)
   PUBMED   1820218
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016251.9 and BC042897.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021005.3.
            
            Summary: This gene encodes a member of the steroid thyroid hormone
            superfamily of nuclear receptors. The encoded protein is a ligand
            inducible transcription factor that is involved in the regulation
            of many different genes. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62760.1, SRR1660809.174579.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394166.8/ ENSP00000377721.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1266              AC016251.9         10185-11450         c
            1267-2818           BC042897.1         442-1993
            2819-5287           AC016251.9         1892-4360           c
FEATURES             Location/Qualifiers
     source          1..5287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.2"
     gene            1..5287
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /note="nuclear receptor subfamily 2 group F member 2"
                     /db_xref="GeneID:7026"
                     /db_xref="HGNC:HGNC:7976"
                     /db_xref="MIM:107773"
     exon            1..1848
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1407..2651
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /note="isoform a is encoded by transcript variant 1;
                     ADP-ribosylation factor related protein 1; chicken
                     ovalbumin upstream promoter transcription factor 2;
                     chicken ovalbumin upstream promoter-transcription factor
                     I; COUP transcription factor II; apolipoprotein AI
                     regulatory protein 1; apolipoprotein A-I regulatory
                     protein 1"
                     /codon_start=1
                     /product="COUP transcription factor 2 isoform a"
                     /protein_id="NP_066285.1"
                     /db_xref="CCDS:CCDS10375.1"
                     /db_xref="GeneID:7026"
                     /db_xref="HGNC:HGNC:7976"
                     /db_xref="MIM:107773"
                     /translation="MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPG
                     QGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSF
                     FKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPT
                     HGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAAR
                     MLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLH
                     ASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHV
                     ESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPI
                     ETLIRDMLLSGSSFNWPYMAIQ"
     exon            1849..2376
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..5287
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3844
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /note="major polyA site"
     regulatory      5260..5265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
                     /note="hexamer: ATTATA"
     polyA_site      5287
                     /gene="NR2F2"
                     /gene_synonym="ARP-1; ARP1; CHTD4; COUPTF2; COUPTFB;
                     COUPTFII; NF-E3; SRXX5; SVP40; TFCOUP2"
ORIGIN      
        1 gagaagccac ttctgccagc cccggcgcct ataaatcgca ttccctcccg cgcccccctt
       61 tttagcatat ttgatcactt tgattctctg ttcttttctc tccgcggtgt gtgtgtgcgt
      121 gcgcgcgtgt gtgttttctt cttctcctcc tcctctcccc gagttgcctc ctttctccgg
      181 gtgccgtact gccttttttc ccctctttca ttctttctct ccgtcttttt ctcccccctc
      241 tgcgcacgaa ggatgtgctt ctaggtggtg atctgccctc ctctctctct tttatcattt
      301 ctcccccgcc gccggcgagt tgactctttc cctatgtgtg tgaggcggcg gcggcagcag
      361 cagcagcagc ggctccggcg gcggcagcag cggcagcagc gacttcagcg gcggcggcgg
      421 cgctagacgc agcggctccg ggcccgaccc ggcggcttcg gcggcggctc cggcggcagc
      481 ggcggcccgg gcggcccgca gggaacggcg agcggcctcc acccagcgac tgcgggcggc
      541 ggcggccgga gagagcgagg cgcgcgccgg acgcccgggg caggcggcgg cggcggcggc
      601 ccagcgccag gacgacgccg cgcagcgccc gacgcggacc actttcatgc tgattccccc
      661 ggacccgggc agcgctccgg ccactccgcg ggccgccggc ctccgccccg gcctgcctgg
      721 ctccctgggc gcgcccgcac ccggcgcctc cgatctccta gtcctcctga tttcgatggc
      781 tttcctgaat ggctgactgt gggctgccct ggacttggcc cccggacagt cgcctctcct
      841 cctcctctac ctcctccttc accaccacct cctcttcctc ctcctcctcc tcctcctcct
      901 ccgccaactc ctcggctgca caccagctct aagagcgaga gtgaacgaga gagggaggga
      961 gagagtgaga gcgagcgaga tctttggaga gatttttttt tttgcctcct acttctgtct
     1021 tgaagccaga caatcgactt cagctctccc tcccctccct ctttctccac gttctgctcc
     1081 cactcgctct cctgtcccct tcccctcccc tcccggcgga aagccccccg aaaccaacaa
     1141 agctgagccg agagaaacaa acaaaacaaa cacaccgggc cagacaagcc atcgacaaaa
     1201 ctttgcaaaa gcaaaaacaa aaaaggaaaa actaaccaac ctcaaccaac cagcccccga
     1261 gccacccggg gcgccctccc gcgccctctt gcaccctcgc acacacaaaa ggcggcgcgc
     1321 cggagcccga gacccgggga gccgccgccg ccccgccgcc gcccgcagcc aggggagcag
     1381 gaagtccgga cgcagccccc atagatatgg caatggtagt cagcacgtgg cgcgaccccc
     1441 aggacgaggt gcccggctca cagggcagcc aggcctcgca ggcgccgccc gtgcccggcc
     1501 cgccgcccgg cgccccgcac acgccacaga cgcccggcca agggggccca gccagcacgc
     1561 cagcccagac ggcggccggt ggccagggcg gccctggcgg cccgggtagc gacaagcagc
     1621 agcagcagca acacatcgag tgcgtggtgt gcggagacaa gtcgagcggc aagcactacg
     1681 gccagttcac gtgcgagggc tgcaagagct tcttcaagcg cagcgtgcgg aggaacctga
     1741 gctacacgtg ccgcgccaac cggaactgtc ccatcgacca gcaccatcgc aaccagtgcc
     1801 agtactgccg cctcaaaaag tgcctcaaag tgggcatgag acgggaagcg gtgcagaggg
     1861 gcaggatgcc gccgacccag ccgacccacg ggcagttcgc gctgaccaac ggggatcccc
     1921 tcaactgcca ctcgtacctg tccggatata tttccctgct gttgcgcgcg gagccctatc
     1981 ccacgtcgcg cttcggcagc caatgcatgc agcccaacaa catcatgggt atcgagaaca
     2041 tttgcgaact ggccgcgagg atgctcttca gcgccgtcga gtgggcccgg aacatcccct
     2101 tcttccccga cctgcagatc acggaccagg tggccctgct tcgcctcacc tggagcgagc
     2161 tgtttgtgtt gaatgcggcg cagtgctcca tgcccctcca cgtcgccccg ctcctggccg
     2221 ccgccggcct gcatgcttcg cccatgtccg ccgaccgggt ggtcgccttt atggaccaca
     2281 tacggatctt ccaagagcaa gtggagaagc tcaaggcgct gcacgttgac tcagccgagt
     2341 acagctgcct caaggccata gtcctgttca cctcagatgc ctgtggtctc tctgatgtag
     2401 cccatgtgga aagcttgcag gaaaagtctc agtgtgcttt ggaagaatac gttaggagcc
     2461 agtaccccaa ccagccgacg agattcggaa agcttttgct tcgcctccct tccctccgca
     2521 ccgtctcctc ctcagtcata gagcaattgt ttttcgtccg tttggtaggt aaaaccccca
     2581 tcgaaaccct catccgggat atgttactgt ccggcagcag ttttaactgg ccgtatatgg
     2641 caattcaata aataaataaa ataagaaggg ggagtgaaac agagaaagaa aaggcaaaag
     2701 actggtttgt ttgcttaatt tccttctgtt aagaaaggat ataaaaggat gttacaagtt
     2761 tgctaaaaga agagagggga agaatttaat ggactgtgaa tttcaaaaaa aaaaaaaaag
     2821 actgtcaaat gaacttttac agaatgcatt aaaaaaaaaa aaaaactcct gtgtcggtca
     2881 gaacaacttg ctacttatca tttttgtata aaaaggaaat tagtcttttt ctttttttgg
     2941 taaatttttg aaaaatattg ctaaaagtgc atttaaggag attgggagac aattagcaga
     3001 atggagaaag taagtctttt ttttttccaa attattaatt gtcctgtgtc tatgtacctc
     3061 tagctgttct tttttgtact tttctggttc caaaccagtt tattctgtgg ttctataata
     3121 agttttgata taatcttggc ttcttaaaaa ctgtgtatca ttaaaatata tgttctgcaa
     3181 gaattaaaac tgagtccatg aaaataccat aggaagacat aaaactttaa aaggcaactc
     3241 aaagatgatg gaaacgcact tacaagtggt gaccaaaatt tttaggtgaa gtcgagcact
     3301 ctaattagag aactggagga accacatata acacttaact tcccctaccc tgcccctccc
     3361 caaaagaaac catgacaaac ctagctttta aaaaatattt taagaaagag aatgaactgt
     3421 ggaatttatt ggcagccaag gaatgtgtcc aagacacatg ctgaggtttt gaataaaaag
     3481 tgaacttttg taatttgaat tgggtcccgc ttagttcttg aattgttatg aaaatcctat
     3541 atctgtttgt atatttgcaa accctttgta ttataattgt tgatattttc cctttttaaa
     3601 aaataccatt gaaatcagca tgacaaaaat aacactgttg gcacttatag gtaacgtgat
     3661 tgattcagta tcttagagtt tacagtttgt gttttaaaaa aactgaaggt ttttttttta
     3721 agtgcaacat ttctgtatac tgtaaaagtt ataataactg aactgtttgg tcgagtcttt
     3781 gtgtgttata ttccaaggaa aattgaaagt attcagaaat taaaatatta tttgatatct
     3841 gaaacctggc tgtccccact cactgtcttt acatctagaa gagcccctgt gagctctcgc
     3901 ttagctggcc gggcgggggg tggtgggggg gggcatttgt ttactcccct cagtcagttt
     3961 gttcaaaggt ggactactgt atttgcctgt ttaatttggg tgtgtgtgtg ttgggggggg
     4021 agctgaagtt aatggtttat ctatggttta ggaagtgcca tactgatata gtaaaccacc
     4081 cccattcacc taatcctcct tttaattaaa aatggatttt ccaggaaaaa aaaaaaggcc
     4141 cttatatttg tcacacttaa gtgcctgctt agggaaggta ttgtgaaaaa gtattagaaa
     4201 tcttgagatc agtatctatt ttatgatcag aaaaaaatac tcttttgtac atttctgaca
     4261 gttactcaga agatcgttca agcaagctaa tcacagcatt gtaactagag gacagttgtt
     4321 tgcagtgagt ttttccttaa gtaggtacga ttttttaaaa tattctgtga ttctactcta
     4381 gcgtggttgt tgagagagtt tcaaattcag tgatacaggt tctaagactg aaaggtctac
     4441 ttttaatgta tatatgataa cttgcagttg gtttccctct cccctccccc cctttacctt
     4501 cagtctgtga gagcatgacc acagggtcaa gggaatcttt tccattggag ttatgtacat
     4561 aaaaacacat cgacattttg acatttcaga ttgtgtggct acaatctgta ctgctcttgg
     4621 gatcctttgt ccttagaagc caaattaagg aagagaaagc aggacagaga aaaagaaaga
     4681 aggaaggagg gaaactttac agggtgtgct gatttggaag tagtaactat ttcttttgga
     4741 gtcttttttt catttttcct ctttctcttt tcctggtttg gaggaagctc ggtgctggga
     4801 gcttgcaatt ttgttcttat tcaaggtttc caacccaccc ccccaccgcc agtacttcat
     4861 catgttgtgg tttaattcta attggtgggg gggggggagg actagtgagg gaggtgaaag
     4921 aacagggata attttgtaaa gtgtattaaa cgttaatatt cagatccagt caatacatgc
     4981 agaccagtaa aatctgattt gtgcagagtt ctccatctga ctctcactta tttctgtaga
     5041 tatatacata tataaataca agtatgttct tacggcacag tattgctgac ctttagttcg
     5101 aggttttgtc ggttgttgtt gattttcttc ctcttgcaag tgctatccat gtgagtgtgt
     5161 gaagtttctc taataagtaa aacacaggcc cttttccttg tttgttttgt gttagtttat
     5221 tgtaaacagc catttgttgt aaattattat tggcattaaa ttataattta tgattttcaa
     5281 agcaaaa
//
