LOCUS       NM_005654               3843 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1),
            transcript variant 1, mRNA.
ACCESSION   NM_005654
VERSION     NM_005654.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3843)
  AUTHORS   Zhang,K., Zhang,H., Wang,B., Gao,S., Sun,C., Jia,C. and Cui,J.
  TITLE     NR2F1 overexpression alleviates trophoblast cell dysfunction by
            inhibiting GDF15/MAPK axis in preeclampsia
  JOURNAL   Hum Cell 37 (5), 1405-1420 (2024)
   PUBMED   39007956
  REMARK    GeneRIF: NR2F1 overexpression alleviates trophoblast cell
            dysfunction by inhibiting GDF15/MAPK axis in preeclampsia.
REFERENCE   2  (bases 1 to 3843)
  AUTHORS   Tran,T.T.T. and Hung,J.J.
  TITLE     PTEN decreases NR2F1 expression to inhibit ciliogenesis during
            EGFRL858R-induced lung cancer progression
  JOURNAL   Cell Death Dis 15 (3), 225 (2024)
   PUBMED   38499532
  REMARK    GeneRIF: PTEN decreases NR2F1 expression to inhibit ciliogenesis
            during EGFR[L858R]-induced lung cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3843)
  AUTHORS   Liang,Y., Wan,L., Liu,X., Zhang,J., Zhu,G. and Yang,G.
  TITLE     Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
  JOURNAL   Int J Dev Neurosci 84 (1), 75-83 (2024)
   PUBMED   38010976
  REMARK    GeneRIF: Infantile epileptic spasm syndrome as a new NR2F1 gene
            phenotype.
REFERENCE   4  (bases 1 to 3843)
  AUTHORS   Santo,M., Rigoldi,L., Falcone,C., Tuccillo,M., Calabrese,M.,
            Martinez-Cerdeno,V. and Mallamaci,A.
  TITLE     Spatial control of astrogenesis progression by cortical
            arealization genes
  JOURNAL   Cereb Cortex 33 (6), 3107-3123 (2023)
   PUBMED   35818636
  REMARK    GeneRIF: Spatial control of astrogenesis progression by cortical
            arealization genes.
REFERENCE   5  (bases 1 to 3843)
  AUTHORS   Meng,J., Liu,X., Tang,S., Liu,Y., Zhao,C., Zhou,Q., Li,N. and
            Hou,S.
  TITLE     METTL3 inhibits inflammation of retinal pigment epithelium cells by
            regulating NR2F1 in an m6A-dependent manner
  JOURNAL   Front Immunol 13, 905211 (2022)
   PUBMED   35936005
  REMARK    GeneRIF: METTL3 inhibits inflammation of retinal pigment epithelium
            cells by regulating NR2F1 in an m(6)A-dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3843)
  AUTHORS   Schaaf,C., Yu-Wai-Man,P. and Valentin,I.
  TITLE     NR2F1-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36508512
REFERENCE   7  (bases 1 to 3843)
  AUTHORS   Ing,N.H., Beekman,J.M., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Members of the steroid hormone receptor superfamily interact with
            TFIIB (S300-II)
  JOURNAL   J Biol Chem 267 (25), 17617-17623 (1992)
   PUBMED   1517211
REFERENCE   8  (bases 1 to 3843)
  AUTHORS   Berrodin,T.J., Marks,M.S., Ozato,K., Linney,E. and Lazar,M.A.
  TITLE     Heterodimerization among thyroid hormone receptor, retinoic acid
            receptor, retinoid X receptor, chicken ovalbumin upstream promoter
            transcription factor, and an endogenous liver protein
  JOURNAL   Mol Endocrinol 6 (9), 1468-1478 (1992)
   PUBMED   1331778
REFERENCE   9  (bases 1 to 3843)
  AUTHORS   Kliewer,S.A., Umesono,K., Heyman,R.A., Mangelsdorf,D.J., Dyck,J.A.
            and Evans,R.M.
  TITLE     Retinoid X receptor-COUP-TF interactions modulate retinoic acid
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1448-1452 (1992)
   PUBMED   1311101
REFERENCE   10 (bases 1 to 3843)
  AUTHORS   Wang,L.H., Tsai,S.Y., Cook,R.G., Beattie,W.G., Tsai,M.J. and
            O'Malley,B.W.
  TITLE     COUP transcription factor is a member of the steroid receptor
            superfamily
  JOURNAL   Nature 340 (6229), 163-166 (1989)
   PUBMED   2739739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106818.2, BC017493.1 and
            AF087978.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005654.5.
            
            Summary: The protein encoded by this gene is a nuclear hormone
            receptor and transcriptional regulator. The encoded protein acts as
            a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene
            are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS).
            [provided by RefSeq, Apr 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017493.1, SRR3476690.165042.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327111.8/ ENSP00000325819.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC106818.2         50597-50711
            116-304             BC017493.1         1-189
            305-305             AC106818.2         50901-50901
            306-3314            BC017493.1         191-3199
            3315-3843           AF087978.1         67-595
FEATURES             Location/Qualifiers
     source          1..3843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..3843
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /note="nuclear receptor subfamily 2 group F member 1"
                     /db_xref="GeneID:7025"
                     /db_xref="HGNC:HGNC:7975"
                     /db_xref="MIM:132890"
     exon            1..2265
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1803..3074
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor COUP 1 (chicken ovalbumin upstream
                     promoter 1, v-erb-a homolog-like 3); COUP-TF1; COUP-TF I;
                     V-erbA-related protein 3; COUP transcription factor I;
                     chicken ovalbumin upstream promoter-transcription factor
                     I"
                     /codon_start=1
                     /product="COUP transcription factor 1 isoform 1"
                     /protein_id="NP_005645.1"
                     /db_xref="CCDS:CCDS4068.1"
                     /db_xref="GeneID:7025"
                     /db_xref="HGNC:HGNC:7975"
                     /db_xref="MIM:132890"
                     /translation="MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQA
                     GSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFT
                     CEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGR
                     MPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIEN
                     ICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPL
                     LAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACG
                     LSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVR
                     LVGKTPIETLIRDMLLSGSSFNWPYMSIQCS"
     exon            2266..2793
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3843
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3824..3829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /note="hexamer: AATAAA"
     polyA_site      3843
                     /gene="NR2F1"
                     /gene_synonym="BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3;
                     EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1"
                     /note="major polyA site"
ORIGIN      
        1 ggaaacattg ctctgcgagt cctcccgttt aaacgcattc aatttttggg tctctctctc
       61 tctctctctc tctcttcttc tcttctctct ctctctctct ctcctctctc tctctcctct
      121 ttctcccccc tctctccctc ctctcctctc tctctcctct cttctctgaa cctctcttct
      181 ctttctcttt tcttacatat tctactagtt gttttcccct tcttcttctc ctttctctcc
      241 tttttctccc tcctccttgt ctcttttact ccattcctgc agaagagaga gggctaaact
      301 taaagaaaaa aaaaaggagg aggaggagga ggaggcaccc ccttcgtatt cttcttatcg
      361 ttattttata catatatgat tttttttgga gggagggtgt tggttgccgg ctgaagagca
      421 cttatttaaa atactaaaaa aagaacattt ttgggcgatc tccagggttt ttttaactag
      481 ctctgtgtgt tatagcagaa gaagcagaag aaggagcaag aaagaggaaa agaagaggat
      541 tatttattcg acctactttg gatgtctctc tcgcttttcc tttttccttt ttttggcaat
      601 tattttcttc tgatttttat tttttctatt tcgctgtgat ttcgtcgccg gcgtgaatta
      661 tcccgtattt ttctccccct tccgtcacct cccgaaagaa gaaggcagcg agagcccggc
      721 gccaccggca caacaaaaag agcaaagtgt gtgatcttcc tcgccggctg cctcccgctc
      781 tccagcgctg ccttcctgaa tggctggctg cgtccggccc tggacctggc cccccgacac
      841 ccgcgcgccc tgatcgccgg cggcagcctc gcccagcgcc ctgctcggct caccgcgctc
      901 cccgcactcc cgagcccggc gagggctccc gccgggacag cggcggcgcc gcgggcggcc
      961 ccggcctccg ctcgcgctcc ggctgcggcc ccgactcctg ctcggactcc ggcccgggtc
     1021 ccggctcctc cagcggcgct cgccgcagca gctccggcgg cagctccagc ggcgcctgca
     1081 gccgcgacct cctcctcctc cgccgccgcc gccgcctccg ccctcgccgg cttcctctat
     1141 gtcggctcag cccgcgcgct gcgcgtagcc cgagcggccg gcgggcgggc gcccggcgcg
     1201 ggtgagcgac tgtgtgtgcg agtgtgtgtg tgcgcggggg tgcgggcgag gcggagggcg
     1261 agtgtgtgcg cgcgccgtgg cccatgcccg ccgcccccgg cgctgcgccc cgcgccgctc
     1321 ccggctgccg cctgtgccat ttctgatttt gcaacttggg gaagaagaaa aaagcgagag
     1381 aagggagctt gctcgccggg gggtggggag gggggaagga gagcgcggcc cccccaggaa
     1441 cggagcgcgg ggggagcggg cgaggggagc aggggtgttg gggggggagc ctgagagcct
     1501 gggggggctg caaaaagaga gaaagaaaac agcaggaacc acaacaaaac gccagcaggg
     1561 cgggcgggcg cgcagcagca gcggggcggc cgaggcagta gcggcggcag cggcggcggc
     1621 ggcggaggca gcggccggtg tccggctcgg gctcggctcc tgcgaccccg gggcgcccgg
     1681 cgggcccccc gccccctccc cctcccccct tccccttccc cttcccctcc cagcgcgccc
     1741 gcgcgccccg cggccctcgg cgagcagctc ggctcccccc agcgctcccc gggcccaaag
     1801 atatggcaat ggtagttagc agctggcgag atccgcagga cgacgtggcc gggggcaacc
     1861 ccggcggccc caaccccgca gcgcaggcgg cccgcggcgg cggcggcggc gccggcgagc
     1921 agcagcagca ggcgggctcg ggcgcgccgc acacgccgca gaccccgggc cagcccggag
     1981 cgcccgccac ccccggcacg gcgggggaca agggccaggg cccgcccggt tcgggccaga
     2041 gccagcagca catcgagtgc gtggtgtgcg gggacaagtc gagcggcaag cactacggcc
     2101 aattcacctg cgagggctgc aaaagtttct tcaagaggag cgtccgcagg aacttaactt
     2161 acacatgccg tgccaacagg aactgtccca tcgaccagca ccaccgcaac cagtgccaat
     2221 actgccgcct caagaagtgc ctcaaagtgg gcatgaggcg ggaagcggtt cagcgaggaa
     2281 gaatgcctcc aacccagccc aatccaggcc agtacgcact caccaacggg gaccccctca
     2341 acggccactg ctacctgtcc ggctacatct cgctgctgct gcgcgccgag ccctacccca
     2401 cgtcgcgcta cggcagccag tgcatgcagc ccaacaacat tatgggcatc gagaacatct
     2461 gcgagctggc cgcgcgcctg ctcttcagcg ccgtcgagtg ggcccgcaac atccccttct
     2521 tcccggatct gcagatcacc gaccaggtgt ccctgctacg cctcacctgg agcgagctgt
     2581 tcgtgctcaa cgcggcccag tgctctatgc cgctgcacgt ggcgccgttg ctggccgccg
     2641 ccggcctgca tgcctcgccc atgtctgccg accgcgtcgt ggccttcatg gaccacatcc
     2701 gcatcttcca ggagcaggtg gagaagctca aggcgctaca cgtcgactca gccgagtaca
     2761 gctgcctcaa agccatcgtg ctgttcacgt cagacgcctg tggcctgtcg gatgcggccc
     2821 acatcgagag cctgcaggag aagtcgcagt gcgcactgga ggagtacgtg aggagccagt
     2881 accccaacca gcccagccgt tttggcaaac tgctgctgcg actgccctcg ctgcgcaccg
     2941 tgtcctcctc cgtcatcgag cagctcttct tcgtccgttt ggtaggtaaa acccccatcg
     3001 aaactctcat ccgcgatatg ttactgtctg ggagcagctt caactggcct tacatgtcca
     3061 tccagtgctc ctagaccttg ggcgcttccc acctgccccg tccccctaga gactcagagg
     3121 acccacctgg gccaaggact ccaaagccgc ggggacaccg ggaagtgcag cgggccaggc
     3181 aggctgggtg ggagggagga gggccgagac aggagcagcc cacccagcag aaatacaatc
     3241 cgagctacaa agcatgggaa aaagagactc ttttaggatc agatctgtga gcacgttggc
     3301 gaggaaaaac aaaacaaaca aaaaaaagaa ccttgtgtct gtctggtgaa aaaaagaaaa
     3361 acaaattgga agagaggacc atgagaattt taataaaaca gaaggaaact aatggacctt
     3421 ccaggattta ttgtggacgg atgtggatat attctgtaca ggaacaacac atatggaagt
     3481 ggactgaagc ctatgtagaa acacacacac actgaacatt gttattcatt ttgtaaaata
     3541 ctagtcttta ttttcatttt ttgtaaaatt taaacatcgt atgcgcataa agaaaaagga
     3601 aacaagaatt aggggaaaat aacattttcc aaataattat aaaaaattgt cctgtgtcta
     3661 tgtatctata tctgttttgt atttttttct ggttccaaac cagatttcct gtgattctat
     3721 actaataatt tttgatataa ccctttgctt cttataatga gtgcgatata tgttgtcgag
     3781 gctgttcttc aagaattaaa attgaagtga aaatttaaac aaaaataaaa gaatttagca
     3841 aaa
//
