LOCUS       NM_003269               3244 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 2 group E member 1 (NR2E1),
            transcript variant 2, mRNA.
ACCESSION   NM_003269
VERSION     NM_003269.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Hu,R., Hameed,U.F.S., Sun,X., Moorthy,B.S., Zhang,W., Jeffrey,P.D.,
            Zhou,L., Ma,X., Chen,F., Pei,J., Giri,P.K., Mou,Y., Swaminathan,K.
            and Yuan,P.
  TITLE     A NR2E1-interacting peptide of LSD1 inhibits the proliferation of
            brain tumour initiating cells
  JOURNAL   Cell Prolif 56 (1), e13350 (2023)
   PUBMED   36321378
  REMARK    GeneRIF: A NR2E1-interacting peptide of LSD1 inhibits the
            proliferation of brain tumour initiating cells.
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Nelczyk,A.T., Ma,L., Gupta,A.D., Gamage,H.E.V., McHenry,M.T.,
            Henn,M.A., Kadiri,M., Wang,Y., Krawczynska,N., Bendre,S., He,S.,
            Shahoei,S.H., Madak-Erdogan,Z., Hsiao,S.H., Saleh,T., Carpenter,V.,
            Gewirtz,D.A., Spinella,M.J. and Nelson,E.R.
  TITLE     The nuclear receptor TLX (NR2E1) inhibits growth and progression of
            triple- negative breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (11), 166515 (2022)
   PUBMED   35932893
  REMARK    GeneRIF: The nuclear receptor TLX (NR2E1) inhibits growth and
            progression of triple- negative breast cancer.
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Nelson,A.T., Wang,Y. and Nelson,E.R.
  TITLE     TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology
            and Disease
  JOURNAL   Endocrinology 162 (11) (2021)
   PUBMED   34463725
  REMARK    GeneRIF: TLX, an Orphan Nuclear Receptor With Emerging Roles in
            Physiology and Disease.
            Review article
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Zhou,J., Pei,X., Yang,Y., Wang,Z., Gao,W., Ye,R., Zhang,X., Liu,J.,
            Liu,Z., Yang,X., Tao,J., Gu,C., Hu,W., Chan,F.L., Li,X., Mao,J. and
            Wu,D.
  TITLE     Orphan nuclear receptor TLX promotes immunosuppression via its
            transcriptional activation of PD-L1 in glioma
  JOURNAL   J Immunother Cancer 9 (4) (2021)
   PUBMED   33858847
  REMARK    GeneRIF: Orphan nuclear receptor TLX promotes immunosuppression via
            its transcriptional activation of PD-L1 in glioma.
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Wang,Y.Y., Hsu,S.H., Tsai,H.Y. and Cheng,M.C.
  TITLE     Genetic analysis of the NR2E1 gene as a candidate gene of
            schizophrenia
  JOURNAL   Psychiatry Res 293, 113386 (2020)
   PUBMED   32805587
  REMARK    GeneRIF: Genetic analysis of the NR2E1 gene as a candidate gene of
            schizophrenia.
REFERENCE   6  (bases 1 to 3244)
  AUTHORS   Abrahams,B.S., Mak,G.M., Berry,M.L., Palmquist,D.L., Saionz,J.R.,
            Tay,A., Tan,Y.H., Brenner,S., Simpson,E.M. and Venkatesh,B.
  TITLE     Novel vertebrate genes and putative regulatory elements identified
            at kidney disease and NR2E1/fierce loci
  JOURNAL   Genomics 80 (1), 45-53 (2002)
   PUBMED   12079282
  REMARK    GeneRIF: compared sequence from human, mouse, and the puffer fish
            Fugu rubripes
REFERENCE   7  (bases 1 to 3244)
  AUTHORS   Kobayashi,M., Yu,R.T., Yasuda,K. and Umesono,K.
  TITLE     Cell-type-specific regulation of the retinoic acid receptor
            mediated by the orphan nuclear receptor TLX
  JOURNAL   Mol Cell Biol 20 (23), 8731-8739 (2000)
   PUBMED   11073974
REFERENCE   8  (bases 1 to 3244)
  AUTHORS   Jackson,A., Panayiotidis,P. and Foroni,L.
  TITLE     The human homologue of the Drosophila tailless gene (TLX):
            characterization and mapping to a region of common deletion in
            human lymphoid leukemia on chromosome 6q21
  JOURNAL   Genomics 50 (1), 34-43 (1998)
   PUBMED   9628820
REFERENCE   9  (bases 1 to 3244)
  AUTHORS   Yu,R.T., McKeown,M., Evans,R.M. and Umesono,K.
  TITLE     Relationship between Drosophila gap gene tailless and a vertebrate
            nuclear receptor Tlx
  JOURNAL   Nature 370 (6488), 375-379 (1994)
   PUBMED   8047143
REFERENCE   10 (bases 1 to 3244)
  AUTHORS   Lynch,M.A., Errington,M.L. and Bliss,T.V.
  TITLE     Nordihydroguaiaretic acid blocks the synaptic component of
            long-term potentiation and the associated increases in release of
            glutamate and arachidonate: an in vivo study in the dentate gyrus
            of the rat
  JOURNAL   Neuroscience 30 (3), 693-701 (1989)
   PUBMED   2570372
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL078596.8, AF220532.1,
            AF411525.1 and BC028031.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003269.4.
            
            Summary: The protein encoded by this gene is an orphan receptor
            involved in retinal development. The encoded protein also regulates
            adult neural stem cell proliferation and may be involved in control
            of aggressive behavior. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (2) contains an alternate 5' exon
            and it thus differs in the 5' UTR and 5' coding region, compared to
            variant 1. The encoded isoform (b) has a distinct N-terminus and is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028031.1, SRR1660807.156772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368986.9/ ENSP00000357982.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL078596.8         11074-11109
            37-651              AF220532.1         1-615
            652-1970            AF411525.1         149-1467
            1971-3244           BC028031.1         1432-2705
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3244
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /note="nuclear receptor subfamily 2 group E member 1"
                     /db_xref="GeneID:7101"
                     /db_xref="HGNC:HGNC:7973"
                     /db_xref="MIM:603849"
     exon            1..769
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     CDS             745..1902
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /note="isoform b is encoded by transcript variant 2;
                     tailes-related receptor; nuclear receptor TLX; protein
                     tailless homolog"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group E member 1
                     isoform b"
                     /protein_id="NP_003260.1"
                     /db_xref="CCDS:CCDS5063.1"
                     /db_xref="GeneID:7101"
                     /db_xref="HGNC:HGNC:7973"
                     /db_xref="MIM:603849"
                     /translation="MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSI
                     RRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQ
                     VALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLA
                     QPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLL
                     EDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFR
                     QLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYP
                     TQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI"
     exon            770..915
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1003
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1239
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1386
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1483
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1633
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1739
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..3244
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /note="hexamer: AATATA"
     polyA_site      3244
                     /gene="NR2E1"
                     /gene_synonym="TLL; TLX; XTLL"
                     /note="major polyA site"
ORIGIN      
        1 attcccctcc ccgcggctgc ctgtcagagc gcttctggag atattacagg ggacccagcc
       61 cgcagcgaca ggcacaaagt cacggggtaa tgaacttcgg ggacccttcg ccgctgcgtg
      121 cgcggctctc cccggaaacc cggacctggc cgcctcttcc ctcggaagat ttcccagcaa
      181 tctagttttc ccactctgcg cttgggttcc ggcagcgcgg agcccgtctg cctctgagac
      241 tgcggtagtg ttttccttct ttccttggga gaccagcggt cggcagagat tgcccacact
      301 ctgcatgcct atgtagaggg agagatcgaa gactgagtga caggaatggg gaaaaagagg
      361 gatttcgctc cgtaggaagg ccattttcgt gtctccatct ctgtctttca acatccctct
      421 cttgctgttc ttccttcttc ctcagtcttc ctgtccatct ctccatctgt ctgtccatgt
      481 gtgtgtccat atcaagcagc attcccagca gctgcggttt tgcaagagcc gggaagaaac
      541 ttaaggatgc ttaaatttcc actgttggac gaattctgag cgcccaggga gcagcgcagc
      601 gcgcgactga cacccacctg tcccgcccag gagccttgca ggctggaggg cagctggaga
      661 gcggcggcgc ccggcggcga ggcgggcgct gccggccggg actcgggcag cgcccaccaa
      721 ccgctccgcc ccgggacagc cagcatgagc aagccagccg gatcaacaag ccgcatttta
      781 gatatcccct gcaaagtgtg tggcgaccgc agctcgggga agcactacgg ggtctacgcc
      841 tgcgacggct gctcaggttt tttcaaacgg agcatccgaa ggaataggac ctatgtctgc
      901 aaatctggaa accagggagg ctgtccggtg gacaagacgc acagaaacca gtgcagggcg
      961 tgtcggctga agaagtgttt ggaagtcaac atgaacaaag acgccgtgca gcacgagcgg
     1021 gggcctcgga cgtccaccat ccgcaagcaa gtggccctct acttccgtgg acacaaggag
     1081 gagaacgggg ccgccgcgca ctttccctcg gcggcgctcc ctgcgccggc cttcttcacc
     1141 gcggtcacgc agctggagcc gcacggcctg gagctggccg cggtgtccac cactccagag
     1201 cggcagaccc tcgtgagcct ggctcagccc acgcccaagt acccccatga agtgaatggg
     1261 accccaatgt atctctatga agtggccacg gagtcggtgt gtgaatcagc tgccagactt
     1321 ctcttcatga gcatcaagtg ggctaagagt gtgccagcct tctccacgct gtctttgcaa
     1381 gaccagctga tgcttttgga agatgcttgg agagaactgt ttgttctagg aatagcacaa
     1441 tgggccattc cggttgatgc taacactcta ctggctgtat ctggcatgaa cggtgacaac
     1501 acagattccc agaagctgaa caagatcata tctgaaatac aggctttaca agaggtggtg
     1561 gctcgattta gacaactccg gttagatgct actgaatttg cctgtctaaa atgcatcgtc
     1621 actttcaaag ccgttcctac acatagtggt tctgaactga gaagtttccg gaatgctgcc
     1681 gccattgcag cccttcaaga tgaggctcag ctaacgctca acagctacat ccataccaga
     1741 tatcccactc aaccctgtcg ctttggaaaa ctcctgttgc ttttgccagc tttacgttct
     1801 attagcccat caactataga agaagtgttt ttcaaaaaaa ccatcggcaa tgtgccaatt
     1861 acaagactgc tttcagatat gtacaaatcc agtgatatct aagctcacaa gatacccact
     1921 tttcaggatg ggacagtatc agatgaactt caacccatgg agaacaagcc tcaactaaca
     1981 aacccttcag gaagcatata ccggggaatg tgtagccttc aggaaaaaaa tgccaattga
     2041 cacaaagcat tccagtagct atgacctgcc gccctgacca ggatagggcg ggtgggaagg
     2101 agaggggtgc aacaggaccg cctgcactga aaactcactg ctgccatgcc ctgggagggg
     2161 gcaaactggg ggttgccaca ggccgtgcca ttctgcctct tacctggaag atcaggctga
     2221 acgatcaaaa gctgaaacat aagtagtgct ttctcttcct ttttagcata caaagtttgg
     2281 taaccaaata tagctctgtg tataacatcg tactgcggcc ttcaaaacta cgttatgttg
     2341 gagcatttat tttaaaaata atggtaggtt ttaaattaaa agtgttatca aaagtttccc
     2401 ctctattgta atacattatt aagtggcctt cagaactgag ttaataagtg aaaagtagct
     2461 tatgccatgt gatttgcttt ttctctatct tcttttttct tttctttctc tttcttttgt
     2521 tctttcttct tcttttttaa taccataggc caggcaacct tgtcaaagga attgatggac
     2581 aaaatgagat tctcaccagg acttcaggtt ggataacatg tcaaaaagag aagagcttta
     2641 ctaaaagaac ataagtcaag ggaggatgaa taaaaacagc aaaaccaaat aaagtggaga
     2701 tgagtgattg agtgaggtag attgctgtcc cgttaacata gtgctgaaac caaaggcagt
     2761 gggggtccaa actcgtggtg cagcaagtca caccagacag gaaacgaata tggacgtaat
     2821 tgcagaagga acttcaagga gatgaatgaa tgctaaaagg gttcttgact gatccattgc
     2881 taacagcctg agactcttca atgcctttcc gaaaactggt ttctagtaaa gccttgaatg
     2941 aacacacaca cacacacaca cacacacaca cacacacaca cacacacaca ccgtcctaca
     3001 ctttaagctg ctcctttggt atgactctat acttatggaa atgtagaaac aaacattttt
     3061 aaatagctgc tgtacttttc acattttgat ttattaggta ctagcactga ggaaaaaaaa
     3121 ttcagcactt ggactatcat aggatgagta aaacttttct tgtacaaagt gaattaactg
     3181 atttgtgaag ttaaaaggtt gtactcattg tatttacaaa gaataaaaat atattgaatt
     3241 taaa
//
