LOCUS       NM_176880               1290 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nuclear receptor 2C2 associated protein (NR2C2AP),
            transcript variant 2, mRNA.
ACCESSION   NM_176880
VERSION     NM_176880.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Fang,F., Zheng,Q., Zhang,J., Dong,B., Zhu,S., Huang,X., Wang,Y.,
            Zhao,B., Li,S., Xiong,H., Chen,J., Wu,N., Song,S.W., Chang,C. and
            Yang,Y.
  TITLE     Testicular orphan nuclear receptor 4-associated protein 16 promotes
            non-small cell lung carcinoma by activating estrogen receptor beta
            and blocking testicular orphan nuclear receptor 2
  JOURNAL   Oncol Rep 29 (1), 297-305 (2013)
   PUBMED   23129017
  REMARK    GeneRIF: High TRA16 expression promotes small cell lung carcinoma
            by activating estrogen receptor beta and blocking testicular orphan
            nuclear receptor 2
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   Towsley,G., Neradilek,M.B., Snow,A.L. and Ersek,M.
  TITLE     Evaluating the Cornell Scale for Depression in Dementia as a proxy
            measure in nursing home residents with and without dementia
  JOURNAL   Aging Ment Health 16 (7), 892-901 (2012)
   PUBMED   22486638
REFERENCE   5  (bases 1 to 1290)
  AUTHORS   Wang,C.P., Lee,Y.F., Chang,C. and Lee,H.J.
  TITLE     Transactivation of the proximal promoter of human oxytocin gene by
            TR4 orphan receptor
  JOURNAL   Biochem Biophys Res Commun 351 (1), 204-208 (2006)
   PUBMED   17054912
  REMARK    GeneRIF: Taken together, these results suggested that TR4 should be
            one of important regulators of OXT gene expression.
REFERENCE   6  (bases 1 to 1290)
  AUTHORS   Lee,Y.F., Bao,B.Y. and Chang,C.
  TITLE     Modulation of the retinoic acid-induced cell apoptosis and
            differentiation by the human TR4 orphan nuclear receptor
  JOURNAL   Biochem Biophys Res Commun 323 (3), 876-883 (2004)
   PUBMED   15381082
  REMARK    GeneRIF: Together, these findings provide the first in vivo
            evidence that an orphan nuclear receptor, such as TR4, may play
            major roles in the RA-mediated apoptosis or differentiation in P19
            cells.
REFERENCE   7  (bases 1 to 1290)
  AUTHORS   Yang,Y., Wang,X., Dong,T., Kim,E., Lin,W.J. and Chang,C.
  TITLE     Identification of a novel testicular orphan receptor-4
            (TR4)-associated protein as repressor for the selective suppression
            of TR4-mediated transactivation
  JOURNAL   J Biol Chem 278 (9), 7709-7717 (2003)
   PUBMED   12486131
  REMARK    GeneRIF: TRA16 may function as a novel repressor to selectively
            suppress the TR4-mediated transactivation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY088736.1, BC057837.1 and AA588235.1.
            
            On Jun 2, 2019 this sequence version replaced NM_176880.5.
            
            Transcript Variant: This variant (2) uses alternate splice sites in
            the 3' terminal exon, resulting in a novel 3' coding region and 3'
            UTR. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.14120.1,
                                           SRR7346977.493702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331552.12/ ENSP00000332823.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 HY088736.1         17-24
            9-1284              BC057837.1         3-1278
            1285-1290           AA588235.1         18-23               c
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1290
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /note="nuclear receptor 2C2 associated protein"
                     /db_xref="GeneID:126382"
                     /db_xref="HGNC:HGNC:30763"
                     /db_xref="MIM:608719"
     exon            1..392
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..774
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     repressor for TR4 transactivation; TR4 orphan receptor
                     associated protein TRA16; TR4 orphan receptor-associated
                     16 kDa protein"
                     /codon_start=1
                     /product="nuclear receptor 2C2-associated protein isoform
                     2"
                     /protein_id="NP_795361.1"
                     /db_xref="CCDS:CCDS32967.1"
                     /db_xref="GeneID:126382"
                     /db_xref="HGNC:HGNC:30763"
                     /db_xref="MIM:608719"
                     /translation="MTHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQG
                     PSQWVTLEFPQLIRVSQLQIQFQGGFSSRRGCLEGSQGTQALHKIVDFYPEDNNSLQT
                     FPIPAAEVDRLKVTFEDATDFFGRVVIYHLRVLGEKV"
     exon            393..483
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /inference="alignment:Splign:2.1.0"
     exon            484..589
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /inference="alignment:Splign:2.1.0"
     exon            590..657
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1290
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /note="hexamer: TATAAA"
     polyA_site      1290
                     /gene="NR2C2AP"
                     /gene_synonym="TRA16"
                     /note="major polyA site"
ORIGIN      
        1 gcggttccgg gtcccaagat ttggctccaa gagctattcg cagagaaaca gcctcgcaca
       61 aaaagccacc gcccccgaaa cccgcgggaa atctgtttcc tgtgaaaggc ctggcctccg
      121 ggcattggcg gtttccctga tcctctctcc caaattttcc ggcaggggat tgatcgaggc
      181 gacatttagg actggggtgg gcgagggagt ggcggttctc gtcccaagtt acaggtgagg
      241 acgttcaggc caaggcgtag ccaagatcgc gccgccctgt agcttgagga ggcgccggga
      301 ttcgaaccaa ggctgtgccc aatcctaagc cctgcgaggt cttgtggaac cgacatgacc
      361 cactctttgg tttgtccaga gacagtgagc agggtgagtt cagtgctgaa tcgcaacact
      421 cggcagtttg gaaaaaaaca tcttttcgac caggatgagg agacatgttg gaactcagac
      481 cagggcccct cccagtgggt gacgctggag tttccccagc tcatccgtgt ctcccagctg
      541 cagatccagt ttcagggtgg cttctccagt cgccggggct gcctggaagg ttcacagggc
      601 actcaggctc tccacaagat tgtagatttc taccctgagg acaacaactc gcttcagact
      661 ttccccatac cagctgctga agtggaccgg ctgaaggtga cgtttgagga tgccactgac
      721 ttttttggcc gtgtggtcat ctaccacctg cgggtgcttg gggagaaggt gtgagacctc
      781 taggggctgt ctcctccagg aagccctccg ggaagcacag caaagtccct cattctgcac
      841 agaaggttta ttggttcctc ttgggaaggg tcccctccca ccacctgtcc agaagctgcc
      901 tttgaagtca gttctgggtt tccccagctc tggctgacca ttttgttccc tgagtgtctg
      961 agtccccggc aggcggcctt cactcagggt cagcgggcac caggttgctc tggaagagct
     1021 tgaggatgtg gttctcgatc acctgttgca ctgagatggg gcagggaaaa ggtgggctgt
     1081 gagcttgaat cgggagtggg gtggaggcac aggccaacct gcgctctccc cttaggggac
     1141 aaacagggac ccttgcagag acctgcatta cagagcaaag ctgggagaac cgaggactca
     1201 ccccaggaac ctcaacttcc cctaagtttg taaaaatgca cttttgtagc ttttcagaat
     1261 taatataaaa atatttccta ccaagcaaaa
//
