LOCUS       NM_001291694            8419 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 2 group C member 2 (NR2C2),
            transcript variant 2, mRNA.
ACCESSION   NM_001291694 XM_005265428
VERSION     NM_001291694.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8419)
  AUTHORS   Hu,H., Ma,J., Peng,Y., Feng,R., Luo,C., Zhang,M., Tao,Z., Chen,L.,
            Zhang,T., Chen,W., Yin,Q., Zhai,J., Chen,J., Yin,A., Wang,C.C. and
            Zhong,M.
  TITLE     Thrombospondin-1 Regulates Trophoblast Necroptosis via
            NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia
  JOURNAL   Adv Sci (Weinh) 11 (21), e2309002 (2024)
   PUBMED   38569496
  REMARK    GeneRIF: Thrombospondin-1 Regulates Trophoblast Necroptosis via
            NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
REFERENCE   2  (bases 1 to 8419)
  AUTHORS   Wang,H., Zhu,S., Zhou,Z., Wang,Z., Zhuang,W., Xue,D., Lu,Z.,
            Zheng,Q., Ding,L., Ren,L., Luo,W., Wang,R., Ge,G., Xia,L., Li,G.
            and Wu,H.
  TITLE     TR4 worsen urosepsis by regulating GSDMD
  JOURNAL   Eur J Med Res 29 (1), 151 (2024)
   PUBMED   38429762
  REMARK    GeneRIF: TR4 worsen urosepsis by regulating GSDMD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8419)
  AUTHORS   Liu,Y., Ma,L., Li,M., Tian,Z., Yang,M., Wu,X., Wang,X., Shang,G.,
            Xie,M., Chen,Y., Liu,X., Jiang,L., Wu,W., Xu,C., Xia,L., Li,G.,
            Dai,S. and Chen,Z.
  TITLE     Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal
            the molecular basis of transcriptional regulation
  JOURNAL   Nucleic Acids Res 51 (3), 1443-1457 (2023)
   PUBMED   36651297
  REMARK    GeneRIF: Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes
            reveal the molecular basis of transcriptional regulation.
REFERENCE   4  (bases 1 to 8419)
  AUTHORS   Xu,G., Niu,L., Wang,Y., Yang,G., Zhu,X., Yao,Y., Zhao,G., Wang,S.
            and Li,H.
  TITLE     HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to
            promote macrophage M2 polarization in colon cancer
  JOURNAL   Cell Death Dis 13 (10), 888 (2022)
   PUBMED   36270986
  REMARK    GeneRIF: HDAC6-dependent deacetylation of TAK1 enhances sIL-6R
            release to promote macrophage M2 polarization in colon cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8419)
  AUTHORS   Lee,C.H., Chinpaisal,C. and Wei,L.N.
  TITLE     A novel nuclear receptor heterodimerization pathway mediated by
            orphan receptors TR2 and TR4
  JOURNAL   J Biol Chem 273 (39), 25209-25215 (1998)
   PUBMED   9737983
REFERENCE   6  (bases 1 to 8419)
  AUTHORS   Yan,Z.H., Karam,W.G., Staudinger,J.L., Medvedev,A., Ghanayem,B.I.
            and Jetten,A.M.
  TITLE     Regulation of peroxisome proliferator-activated receptor
            alpha-induced transactivation by the nuclear orphan receptor
            TAK1/TR4
  JOURNAL   J Biol Chem 273 (18), 10948-10957 (1998)
   PUBMED   9556573
REFERENCE   7  (bases 1 to 8419)
  AUTHORS   Young,W.J., Smith,S.M. and Chang,C.
  TITLE     Induction of the intronic enhancer of the human ciliary
            neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan
            receptor. A member of steroid receptor superfamily
  JOURNAL   J Biol Chem 272 (5), 3109-3116 (1997)
   PUBMED   9006963
REFERENCE   8  (bases 1 to 8419)
  AUTHORS   Yoshikawa,T., DuPont,B.R., Leach,R.J. and Detera-Wadleigh,S.D.
  TITLE     New variants of the human and rat nuclear hormone receptor, TR4:
            expression and chromosomal localization of the human gene
  JOURNAL   Genomics 35 (2), 361-366 (1996)
   PUBMED   8661150
REFERENCE   9  (bases 1 to 8419)
  AUTHORS   Hirose,T., Fujimoto,W., Tamaai,T., Kim,K.H., Matsuura,H. and
            Jetten,A.M.
  TITLE     TAK1: molecular cloning and characterization of a new member of the
            nuclear receptor superfamily
  JOURNAL   Mol Endocrinol 8 (12), 1667-1680 (1994)
   PUBMED   7708055
REFERENCE   10 (bases 1 to 8419)
  AUTHORS   Chang,C., Da Silva,S.L., Ideta,R., Lee,Y., Yeh,S. and Burbach,J.P.
  TITLE     Human and rat TR4 orphan receptors specify a subclass of the
            steroid receptor superfamily
  JOURNAL   Proc Natl Acad Sci U S A 91 (13), 6040-6044 (1994)
   PUBMED   8016112
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090937.2, AK290590.1,
            AC090954.3 and AI986459.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001291694.1.
            
            Summary: This gene encodes a protein that belongs to the nuclear
            hormone receptor family. Members of this family act as
            ligand-activated transcription factors and function in many
            biological processes such as development, cellular differentiation
            and homeostasis. The activated receptor/ligand complex is
            translocated to the nucleus where it binds to hormone response
            elements of target genes. The protein encoded by this gene plays a
            role in protecting cells from oxidative stress and damage induced
            by ionizing radiation. The lack of a similar gene in mouse results
            in growth retardation, severe spinal curvature, subfertility,
            premature aging, and prostatic intraepithelial neoplasia (PIN)
            development. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Apr
            2014].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            5' coding region compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290590.1, DRR138511.11246.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425241.6/ ENSP00000388387.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC090937.2         77821-77821
            2-242               AK290590.1         1-241
            243-245             AC090937.2         78063-78065
            246-2483            AK290590.1         245-2482
            2484-7941           AC090954.3         148495-153952       c
            7942-8419           AI986459.1         11-488              c
FEATURES             Location/Qualifiers
     source          1..8419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..8419
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /note="nuclear receptor subfamily 2 group C member 2"
                     /db_xref="GeneID:7182"
                     /db_xref="HGNC:HGNC:7972"
                     /db_xref="MIM:601426"
     exon            1..324
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            325..435
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2154
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Nuclear hormone receptor TR4; testicular nuclear receptor
                     4; orphan nuclear receptor TR4; orphan nuclear receptor
                     TAK1; orphan receptor TR4"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group C member 2
                     isoform 2"
                     /protein_id="NP_001278623.1"
                     /db_xref="CCDS:CCDS74905.1"
                     /db_xref="GeneID:7182"
                     /db_xref="HGNC:HGNC:7972"
                     /db_xref="MIM:601426"
                     /translation="MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDAS
                     GSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERL
                     LGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCI
                     INKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLR
                     SPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGT
                     LANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADG
                     IDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASR
                     LLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNH
                     LQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGL
                     TSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGL
                     IGNVSIDSIIPYILKMETAEYNGQITGASL"
     exon            436..636
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..739
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            740..919
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1067
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1161
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1295
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1473
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1595
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1735
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1873
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1979
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..8419
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8397..8402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /note="hexamer: ATTAAA"
     polyA_site      8419
                     /gene="NR2C2"
                     /gene_synonym="TAK1; TR4"
                     /note="major polyA site"
ORIGIN      
        1 gaacattcgc cctcctccta ccagcgcgcg ggcggcggcg gcggcggcac cggggtcacg
       61 aactctgacc tttcactgac aaaaacaata acaaaccccc ccttctccgc gaccccggcg
      121 gcgcccccgg gcccgtcccc gccaccccgc tcccacctcg gcgtctcgtc tctcgcccgc
      181 tgccccgcga gcccgcggcc cccgggctcc cgccatccgc cgacaccggg agcccgggct
      241 ccccgcgccc tgccctccgc gccgggggcc gcccgccgca gacacgggac ccgcttcgag
      301 gccgctttgg cgccaaatcc tgaggtaaca cgtacacaga cctctcggcc ggaatctcca
      361 gggatgacca gcccctcccc acgcatccag ataatctcca ccgactctgc tgtagcctca
      421 cctcagcgca ttcagattgt cacagaccag cagacaggac agaaaatcca gatagtcacc
      481 gcagtggacg cctccggatc ccccaaacag cagttcatcc tgaccagccc agatggagct
      541 ggaactggga aggtgatcct ggcttcccca gagacatcca gcgccaagca actcatattc
      601 accacctcag acaacctcgt ccctggcagg atccagattg tcacggattc tgcctctgtg
      661 gagcgtttac tggggaagac ggacgtccag cggccccagg tggtagagta ctgtgtggtc
      721 tgtggcgaca aagcctccgg ccgtcactat ggggctgtca gttgtgaagg ttgcaaaggt
      781 ttcttcaaaa ggagtgtgag gaaaaatttg acctacagct gccggagcaa ccaagactgc
      841 atcatcaata aacatcaccg gaaccgctgt cagttttgcc ggctgaaaaa atgcttagag
      901 atgggcatga aaatggaatc tgtgcagagt gaacggaagc ccttcgatgt gcaacgggag
      961 aaaccaagca attgtgctgc ttcaactgag aaaatctata tccggaaaga cctgagaagt
     1021 cccctgatag ctactcccac gtttgtggca gacaaagatg gagcaagaca aacaggtctt
     1081 cttgatccag ggatgcttgt gaacatccag cagcctttga tacgtgagga tggtacagtt
     1141 ctcctggcca cggattctaa ggctgaaaca agccagggag ctctgggcac actggcaaat
     1201 gtagtgacct cccttgccaa cctaagtgaa tctttgaaca acggtgacac ttcagaaatc
     1261 cagccagagg accagtctgc aagtgagata actcgggcat ttgatacctt agctaaagca
     1321 cttaatacca cagacagctc ctcttctcca agcttggcag atgggataga caccagtgga
     1381 ggagggagca tccacgtcat cagcagagac cagtcgacac ccatcattga ggttgaaggc
     1441 cccctccttt cagacacaca cgtcacattt aagctaacaa tgcccagtcc aatgccagag
     1501 tacctcaacg tgcactacat ctgtgagtct gcatcccgtc tgcttttcct ctcaatgcac
     1561 tgggctcggt caatcccagc ctttcaggca cttgggcagg actgcaacac cagccttgtg
     1621 cgggcctgct ggaatgagct cttcaccctc ggcctggccc agtgtgccca ggtcatgagt
     1681 ctctccacca tcctggctgc cattgtcaac cacctgcaga acagcatcca ggaagataaa
     1741 ctttctggtg accggataaa gcaagtcatg gagcacatct ggaagctgca ggagttctgt
     1801 aacagcatgg cgaagctgga tatagatggc tatgagtatg cataccttaa agctatagtt
     1861 ctctttagcc ccgatcatcc aggtttgacc agcacaagcc agattgaaaa attccaagaa
     1921 aaggcacaga tggagttgca ggactatgtt cagaaaacct actcagaaga cacctaccga
     1981 ttggcccgga tcctcgttcg cctgccggca ctcaggctga tgagctccaa cataacagaa
     2041 gaactttttt ttactggtct cattggcaat gtttcgatag acagcataat cccctacatc
     2101 ctcaagatgg agacagcaga gtataatggc cagatcaccg gagccagtct atagcgcaaa
     2161 ccacacacct gccaaggagc aacagaatcc ttccaggacc gttcacatac aaagaaaagt
     2221 agtggtattt tggtatgtgc aaatatttcc atatgttagc catttcctgt ctggtttctc
     2281 cttatctgtt aatcccagac aatagcaatt aaaagactag taggatcctt tcctgacata
     2341 agaaatgttt taatgccttt tgatgaagca gcagattttg gaacaatctt ttaactcaat
     2401 ttgtatttag aaattctcaa agggcaaaaa acaaaaaaaa aggttttata atgtcagaga
     2461 ctagtattaa agaaaactga aagaacctga gagaatagta tgtgtgtata tatatatata
     2521 aaaaagtcct tggaattata gatactaatt accagggtaa taatattagc actttctaag
     2581 cacttatcaa tgtgtaacgt tagcaacatc ttgcctgtgg gcagggcaaa tggaaaactg
     2641 tgtatgtctt ttgccgaaat gctaatgatt tctgtgaaaa ctcactaggg tacaggagac
     2701 aatcatttat gtttaagaaa agaaggcatc attcctaatt gtgtgcacat gttgtggagt
     2761 tgagctgaat tctgtgaatg gaaacgtggc tcatttgcat catgcagtaa gtgggagtgt
     2821 ggtagcacag tcggtggtga cccagttcag aagcttctag ccatagagca gacacttgtc
     2881 aggttccctg actacttggt cctggtctct gatgggcatc tgcagactcc tctagaacct
     2941 ggggttctcc tttgatgact ggttatctga attggattgc aactagtcag acattaactg
     3001 ccaaatgaga tgtacagttc ctccagcaag tgaaaacatc cccaagtcac atccgccgct
     3061 cgtggcagat ggagccttgt gaccaaaaag tgcaaggtgg gcattttgag ctcttgacag
     3121 tacttccaat acaattgggg gtgcttgtgt gtttgtccag atggaggagt gtggccttgg
     3181 agtgtgagcg ttaccttccc agggctttcc actccaaatg cccccttgaa aagggctcgt
     3241 gtttctgcag ctccatcata actgtgaggc tggattgggg ctgggcagga gcctgctgcc
     3301 gcctggcgag agtggttagg gcctggtaaa gctggatgga aggtttcagg acaatttctt
     3361 cctgttgacc ttaaatacca gagattttaa aaatgtgtat agactcagca tctctgttgg
     3421 caagtctgtt aatgttacca gcacactgtg cactttggtt cccccaggtg tgtgccagcc
     3481 gaccaccccg gagcatttta aatgcaggct gcttgctcct taaaaacaac cctcaatttc
     3541 cagggtgata gtctttctcc tcataaattg tagcaaccag agtttacagc aagaacagta
     3601 tgcgcttaaa aggaagttat gtctaacttc aaacacccgt aaattcccac ggatgtgaat
     3661 atatagcaag cttttcctgt ttgagaacag tggcatgtgg aagacccggt caattgcttt
     3721 gtcttttgct ttttaaatag tccagattaa gaaaatacac cctgttgggt taaatttgcc
     3781 tctcttgatt tgttaatcag atgatatcca aaaagatccc tggacactcc cctgactcac
     3841 aggtgctctg atctggctca ggctggcgcc acatgtgctc cacaggggtg cagtctggcc
     3901 agctacagac gcccctgtgg tgccacattg gacagaatgg aagctgctgc aggctcaagg
     3961 cagaacagga tgcttgatcc tgaagggtta gcagcacttt acgcaagtca gtgttagtag
     4021 ggtaagtggg aacagtgttt ccaacttcta aattcttgtt tggatttaat tatatcattt
     4081 tataattctt gccttggcag caaattttgg agagtagtgg gagtggccat tataaaatga
     4141 tggaaaggat ttaattttgc cagcttaaag taatttttac ttttctaacc ctgatgtgtt
     4201 ttcagtttca aaattaagac aaaaaaccag ctgagacaat ggaattaggg caggtttgtt
     4261 tcatttctgc ttgtgaaggc ttttagtagc aggcatcctg cagctcagtg gtgcctctaa
     4321 cacagattgt tgcctgcctt ccgtcgtttt gatccttgag agtgaccatg agggccatgt
     4381 tgcagttccc tgggaataca agcataacag ctttcagatc ccagttcttg gtgttggtga
     4441 aaaggtctcc accagcccct cctctcattc ccaggtcatt cagtggcagc cagtaggctg
     4501 cttagactca ggctggataa ggaagtgttg ggctgtggtg aaacaacctt gcagaaaacg
     4561 tgattttgct tggaaaggtg ctgattctaa cctggtcctg ctctttaagt ccccttgctg
     4621 gtgatggctg attccaggga ctgttttggg ctttgaacac ctcttggttg gtttctgaga
     4681 tcctcttggc cttactttga agtggccttt tctttaagga tcatgtccac gtaacctgta
     4741 ttcttgctgc tttaactcat ttcaagcctc tgactgcagg tccatttcat ctcctgtcag
     4801 gttggttaag taaagtcagc ccaaagtcaa gaattactta aagagatgca aaccaaatat
     4861 ttgggctcca actttcacag ggcttatagc ccttattagc agtttgtgaa actttgggtt
     4921 tcatgaagtg agacctgtcc tctggctact gaactccatg gagccacgtt catgctccct
     4981 cttctactgg cctggctgct cctccctcaa tgaggagagg cagctggctc agagaggtgg
     5041 gacagacaca tgctgtcatc agttaagtga gctcttttcc agaagtatct cagataatgt
     5101 tgggttaaga cagatagatg ttgaaaatgg tggagatcat tacacattag cataaaacag
     5161 gacaggaaga gattttttga aagaccaaat tagttgagca agtaatactt ttcaagttac
     5221 tcctggaagg tgtttttaag gaagtgtgtt acctaccata ctctcctaat ttgacatttc
     5281 tgtgtcctga ggagttacat ttattgtcta acccttgcca taaggctgtg gtttgaggtt
     5341 cttttgctgt tctgggcttt atatttaatt tcaggtgtag tcacttctaa gatgtgtaat
     5401 tgccctcaag agggactgat ttttagcttg tcattgtcag tattgaatgt ggactcttct
     5461 gaggcagtta ggacaccagc catggtgtta acagtggatg cgttaggctc cttaatctca
     5521 aggcaatatc cacgctacac acatacttat tagctgtctt acttgtttgg gggatagtta
     5581 cggcaaggag caaaaaattc taaggactct agctgtttct agtgctttta ctttcatagt
     5641 cctttgagga catttcctgc agagcactct tgctcacagc ccgccctctg cagggcttcc
     5701 agcccctggc cgcaatcagc agttcatgcc acatgtgtac atccatgttc tgggacctga
     5761 tctcattgga gtccagaagc ttgttgccca ctttccagtg taaatgactt tatgtgcaat
     5821 ggggtcatag gtaacatttt aactcttttc ttagtccagg tcataggaag tctcatcatc
     5881 tgacagccac ttttctccca gggaaggcgg tgcccactgg gccctgggaa tgcctgagcc
     5941 agcagagcag atgccccacg tgcttccttt atccagcttc cattctctca gttatgaggc
     6001 tctttgaaaa tgtcttaact ttgatgtaaa tttttaaagc caacccctca tcaagacagg
     6061 gttggtttgg gtcttttgta cacagggtct ggaccttctc attgtgtgcc tcccaccagc
     6121 gtgcacttcg tatgtccagc cctgggtccc ttcagcagca ttgtgcgtgt acaggtttct
     6181 aggctgtaag actgaatgaa tgtacatgtg tttatatcct ctccatatgt acagtgtata
     6241 tagtgtgtgt atgtgtacat agatgtatat tatgtataca gacatgtatc caaactttcc
     6301 tttaaagaga gtttttcata aagttgctaa tgtaaactga tatgggtgtt ccaaggtccc
     6361 tcggcaggga agatttgctg gtgattttct tcactccatt ttcctttggg tgagcctgcc
     6421 tgggaagggc catgaagtca gaatctccac tctgcaaaag gaagaattcc aggcagaaga
     6481 ggttctgaca gggtgacatt tccgtatatt ctctaggttc ggacaagagc caggaagctg
     6541 gaagacagtt tatcttaata tccaaaacta agtgggaatt tttaaccttt tcatgcacct
     6601 attcatggcc ctacctggaa ggaacttggc agttgggttg agccatcagc cttcccagct
     6661 attcagctct gttgagtagc ccagagacag gcgtcacggt cagagattca gaacggtctg
     6721 tgtcagtgag gcctgactcc caaagatggt agcaatttcc caggcttgcg ctgtgctcag
     6781 tcagcaagat gtggggcact gtcctatgac tgaataaata gtaattccca tctttctatc
     6841 gccagttaaa aataaacaac ctaccaagta ttattcttta aaactaagca tggatgttga
     6901 tggctaactt ctgcggcata taagctacag atctcaagtt acttctctaa ctgtaagcat
     6961 gtaaatgact ttaactcctt tctataagtt atgattttaa attttcagat aagaattgca
     7021 ttttaatatg gatatgtgtg cccttaaaag ctacagatac caaattttcc tcgtccaggt
     7081 ctactcggac gaattttccc ccttaatctg gccttaaact gagactcggc ccttgagagc
     7141 cagggcctgg cccagcagta gttgctcata gacctgggaa gcaggggcct gctggaagga
     7201 atcactagat tgctgcaaaa actcacataa tccacagttt cctctttttc tttttaaaat
     7261 aagttatcaa aatgttttaa aaacacttta tgagaccata gtactcagtg ccttttgtga
     7321 gacagtgggt catttagcct tcagcttccc tgtttttgat gtagagaaag cttctatttc
     7381 actggcctca tcccacaaga ttgtgcgacc tttccccgtc atagcctgtc gtgacaatca
     7441 cgctattgaa agtggctttc tagttaaaat gcaattggaa acttgacagt ctctaaatga
     7501 attaaaagtt tcctttgggg ctatttagct taacagcagt ctacaaataa ttaaagtgtg
     7561 agcttaagaa aagtatcttt gcggggagaa aaatgtcaga tatttttaat gcccagctat
     7621 aaataatttt ggtgtcttga tatttataca tgcaaaatag aaaaaaaatg ttcaacattt
     7681 attgattgat agactgttaa aatttaatgt ttggaataac atttggaagt agtagacttt
     7741 gcattaaaaa atggcttttc tttaggaaag tataatcaat tattttaatg accatagcat
     7801 tcatggactc aaatgctgct gccacacaca actcaagtgc tggaatattt ttctacagtc
     7861 tctctgttct acggattatc ttgtaaacca gtgttcaact agttttataa ctgaaaagct
     7921 gcacattttt cacagtacaa gccgtagttt ttacctgtag tttggacttc tctgttagaa
     7981 tgtaactgca ttaccagccc ttttaaaggc atctatctat caaaggaaaa tttgggtgtt
     8041 agattttctt gggaccgttt ctgtaacctt tgcccttcac aatatagaaa atattggttt
     8101 tgccattaca ttttaatgcc aggtttaaaa cctgttgaaa gctgcagctt tatacagctt
     8161 tcttctccct gtgaaatcac tttgtttatg tgatggcatt taaaaaatag catgttcttt
     8221 ttaaactgaa ttttatatct aatcaatgtc ttcagtcttg aagaagaatt tgcattgttg
     8281 tgtttgtata tagagtattg cagtgcatga attagcttta tgcattttat taaatgctgt
     8341 ttcaatgtgg cattattgtt gtggcttaat actactacct aaatgaggtt tatactatta
     8401 aaagtgaatt aaagactaa
//
