LOCUS       NM_005122               1371 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 1 group I member 3 (NR1I3),
            transcript variant 3, mRNA.
ACCESSION   NM_005122
VERSION     NM_005122.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Shizu,R., Makida,N., Sobe,K., Ishimura,M., Takeshita,A., Hosaka,T.,
            Kanno,Y., Sasaki,T. and Yoshinari,K.
  TITLE     Interaction with YAP underlies the species differences between
            humans and rodents in CAR-dependent hepatocyte proliferation
  JOURNAL   Toxicol Sci 198 (1), 101-112 (2024)
   PUBMED   38128062
  REMARK    GeneRIF: Interaction with YAP underlies the species differences
            between humans and rodents in CAR-dependent hepatocyte
            proliferation.
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Yoshinari,K. and Shizu,R.
  TITLE     Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver
            Cancer Development
  JOURNAL   Drug Metab Dispos 50 (7), 1019-1026 (2022)
   PUBMED   35184041
  REMARK    GeneRIF: Distinct Roles of the Sister Nuclear Receptors PXR and CAR
            in Liver Cancer Development.
            Review article
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Li,Z., Kwon,S.M., Li,D., Li,L., Peng,X., Zhang,J., Sueyoshi,T.,
            Raufman,J.P., Negishi,M., Wang,X.W. and Wang,H.
  TITLE     Human constitutive androstane receptor represses liver cancer
            development and hepatoma cell proliferation by inhibiting
            erythropoietin signaling
  JOURNAL   J Biol Chem 298 (5), 101885 (2022)
   PUBMED   35367211
  REMARK    GeneRIF: Human constitutive androstane receptor represses liver
            cancer development and hepatoma cell proliferation by inhibiting
            erythropoietin signaling.
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Bwayi,M.N., Garcia-Maldonado,E., Chai,S.C., Xie,B., Chodankar,S.,
            Huber,A.D., Wu,J., Annu,K., Wright,W.C., Lee,H.M., Seetharaman,J.,
            Wang,J., Buchman,C.D., Peng,J. and Chen,T.
  TITLE     Molecular basis of crosstalk in nuclear receptors:
            heterodimerization between PXR and CAR and the implication in gene
            regulation
  JOURNAL   Nucleic Acids Res 50 (6), 3254-3275 (2022)
   PUBMED   35212371
  REMARK    GeneRIF: Molecular basis of crosstalk in nuclear receptors:
            heterodimerization between PXR and CAR and the implication in gene
            regulation.
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   de Almeida Velozo,C., de Almeida,T.B., de Azevedo,M.C.V.M.,
            Espasandin,I., da Cunha Pinto,J.F., Lopez,S., Pizzatti,L.,
            Tanuri,A., da Silva Santos,S., Ribeiro-Alves,M. and Cardoso,C.C.
  TITLE     Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with
            virologic response to antiretroviral therapy in Brazilian
            HIV-positive individuals
  JOURNAL   Pharmacogenomics J 22 (1), 33-38 (2022)
   PUBMED   34504302
  REMARK    GeneRIF: Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in
            association with virologic response to antiretroviral therapy in
            Brazilian HIV-positive individuals.
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Seol,W., Hanstein,B., Brown,M. and Moore,D.D.
  TITLE     Inhibition of estrogen receptor action by the orphan receptor SHP
            (short heterodimer partner)
  JOURNAL   Mol Endocrinol 12 (10), 1551-1557 (1998)
   PUBMED   9773978
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Choi,H.S., Chung,M., Tzameli,I., Simha,D., Lee,Y.K., Seol,W. and
            Moore,D.D.
  TITLE     Differential transactivation by two isoforms of the orphan nuclear
            hormone receptor CAR
  JOURNAL   J Biol Chem 272 (38), 23565-23571 (1997)
   PUBMED   9295294
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     An orphan nuclear hormone receptor that lacks a DNA binding domain
            and heterodimerizes with other receptors
  JOURNAL   Science 272 (5266), 1336-1339 (1996)
   PUBMED   8650544
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Choi,H.S., Seol,W. and Moore,D.D.
  TITLE     A component of the 26S proteasome binds on orphan member of the
            nuclear hormone receptor superfamily
  JOURNAL   J Steroid Biochem Mol Biol 56 (1-6 Spec No), 23-30 (1996)
   PUBMED   8603043
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Baes,M., Gulick,T., Choi,H.S., Martinoli,M.G., Simha,D. and
            Moore,D.D.
  TITLE     A new orphan member of the nuclear hormone receptor superfamily
            that interacts with a subset of retinoic acid response elements
  JOURNAL   Mol Cell Biol 14 (3), 1544-1552 (1994)
   PUBMED   8114692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB124867.1 and Z30425.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_005122.4.
            
            Summary: This gene encodes a member of the nuclear receptor
            superfamily, and is a key regulator of xenobiotic and endobiotic
            metabolism. The protein binds to DNA as a monomer or a heterodimer
            with the retinoid X receptor and regulates the transcription of
            target genes involved in drug metabolism and bilirubin clearance,
            such as cytochrome P450 family members. Unlike most nuclear
            receptors, this transcriptional regulator is constitutively active
            in the absence of ligand but is regulated by both agonists and
            inverse agonists. Ligand binding results in translocation of this
            protein to the nucleus, where it activates or represses target gene
            transcription. These ligands include bilirubin, a variety of
            foreign compounds, steroid hormones, and prescription drugs. In
            addition to drug metabolism, the CAR protein is also reported to
            regulate genes involved in glucose metabolism, lipid metabolism,
            cell proliferation, and circadian clock regulation. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (3), also known as WT or REF, uses
            two alternate splice sites in the 3' coding region, compared to
            variant 1. The resulting protein (isoform 3) is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.63873.1,
                                           DRR138522.123980.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367983.9/ ENSP00000356962.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CB124867.1         8-47
            41-1371             Z30425.1           117-1447
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1371
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="nuclear receptor subfamily 1 group I member 3"
                     /db_xref="GeneID:9970"
                     /db_xref="HGNC:HGNC:7969"
                     /db_xref="MIM:603881"
     exon            1..163
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            164..303
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1243
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="isoform 3 is encoded by transcript variant 3;
                     constitutive activator of retinoid response; constitutive
                     active receptor; constitutive androstane receptor; orphan
                     nuclear hormone receptor; constitutive active response;
                     orphan nuclear receptor MB67"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group I member 3
                     isoform 3"
                     /protein_id="NP_005113.1"
                     /db_xref="CCDS:CCDS1228.1"
                     /db_xref="GeneID:9970"
                     /db_xref="HGNC:HGNC:7969"
                     /db_xref="MIM:603881"
                     /translation="MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIG
                     PTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT
                     PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTH
                     FADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFL
                     CGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVT
                     QRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ
                     GLSAMMPLLQEICS"
     exon            304..434
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            435..604
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            605..744
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            745..890
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1007
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1113
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1371
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="hexamer: AATGAA"
     polyA_site      1371
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="major polyA site"
ORIGIN      
        1 agacatctct tgttttccag atactacggg tcataatccc taactccaat cactggcaac
       61 tcctgagatc agaggaaaac cagcaacagc gtgggagttt ggggagaggc attccatacc
      121 agattctgtg gcctgcaggt gacatgctgc ctaagagaag caggagtctg tgacagccac
      181 cccaacacgt gacgtcatgg ccagtaggga agatgagctg aggaactgtg tggtatgtgg
      241 ggaccaagcc acaggctacc actttaatgc gctgacttgt gagggctgca agggtttctt
      301 caggagaaca gtcagcaaaa gcattggtcc cacctgcccc tttgctggaa gctgtgaagt
      361 cagcaagact cagaggcgcc actgcccagc ctgcaggttg cagaagtgct tagatgctgg
      421 catgaggaaa gacatgatac tgtcggcaga agccctggca ttgcggcgag caaagcaggc
      481 ccagcggcgg gcacagcaaa cacctgtgca actgagtaag gagcaagaag agctgatccg
      541 gacactcctg ggggcccaca cccgccacat gggcaccatg tttgaacagt ttgtgcagtt
      601 taggcctcca gctcatctgt tcatccatca ccagcccttg cccaccctgg cccctgtgct
      661 gcctctggtc acacacttcg cagacatcaa cactttcatg gtactgcaag tcatcaagtt
      721 tactaaggac ctgcccgtct tccgttccct gcccattgaa gaccagatct cccttctcaa
      781 gggagcagct gtggaaatct gtcacatcgt actcaatacc actttctgtc tccaaacaca
      841 aaacttcctc tgcgggcctc ttcgctacac aattgaagat ggagcccgtg tggggttcca
      901 ggtagagttt ttggagttgc tctttcactt ccatggaaca ctacgaaaac tgcagctcca
      961 agagcctgag tatgtgctct tggctgccat ggccctcttc tctcctgacc gacctggagt
     1021 tacccagaga gatgagattg atcagctgca agaggagatg gcactgactc tgcaaagcta
     1081 catcaagggc cagcagcgaa ggccccggga tcggtttctg tatgcgaagt tgctaggcct
     1141 gctggctgag ctccggagca ttaatgaggc ctacgggtac caaatccagc acatccaggg
     1201 cctgtctgcc atgatgccgc tgctccagga gatctgcagc tgaggccatg ctcacttcct
     1261 tccccagctc acctggaaca ccctggatac actggagtgg gaaaatgctg ggaccaaaga
     1321 ttgggccggg ttcaaaggga gcccagtggt tgcaatgaaa gactaaagca a
//
