LOCUS       NM_001077476            1092 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 1 group I member 3 (NR1I3),
            transcript variant 13, mRNA.
ACCESSION   NM_001077476
VERSION     NM_001077476.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Shizu,R., Makida,N., Sobe,K., Ishimura,M., Takeshita,A., Hosaka,T.,
            Kanno,Y., Sasaki,T. and Yoshinari,K.
  TITLE     Interaction with YAP underlies the species differences between
            humans and rodents in CAR-dependent hepatocyte proliferation
  JOURNAL   Toxicol Sci 198 (1), 101-112 (2024)
   PUBMED   38128062
  REMARK    GeneRIF: Interaction with YAP underlies the species differences
            between humans and rodents in CAR-dependent hepatocyte
            proliferation.
REFERENCE   2  (bases 1 to 1092)
  AUTHORS   Yoshinari,K. and Shizu,R.
  TITLE     Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver
            Cancer Development
  JOURNAL   Drug Metab Dispos 50 (7), 1019-1026 (2022)
   PUBMED   35184041
  REMARK    GeneRIF: Distinct Roles of the Sister Nuclear Receptors PXR and CAR
            in Liver Cancer Development.
            Review article
REFERENCE   3  (bases 1 to 1092)
  AUTHORS   Li,Z., Kwon,S.M., Li,D., Li,L., Peng,X., Zhang,J., Sueyoshi,T.,
            Raufman,J.P., Negishi,M., Wang,X.W. and Wang,H.
  TITLE     Human constitutive androstane receptor represses liver cancer
            development and hepatoma cell proliferation by inhibiting
            erythropoietin signaling
  JOURNAL   J Biol Chem 298 (5), 101885 (2022)
   PUBMED   35367211
  REMARK    GeneRIF: Human constitutive androstane receptor represses liver
            cancer development and hepatoma cell proliferation by inhibiting
            erythropoietin signaling.
REFERENCE   4  (bases 1 to 1092)
  AUTHORS   Bwayi,M.N., Garcia-Maldonado,E., Chai,S.C., Xie,B., Chodankar,S.,
            Huber,A.D., Wu,J., Annu,K., Wright,W.C., Lee,H.M., Seetharaman,J.,
            Wang,J., Buchman,C.D., Peng,J. and Chen,T.
  TITLE     Molecular basis of crosstalk in nuclear receptors:
            heterodimerization between PXR and CAR and the implication in gene
            regulation
  JOURNAL   Nucleic Acids Res 50 (6), 3254-3275 (2022)
   PUBMED   35212371
  REMARK    GeneRIF: Molecular basis of crosstalk in nuclear receptors:
            heterodimerization between PXR and CAR and the implication in gene
            regulation.
REFERENCE   5  (bases 1 to 1092)
  AUTHORS   de Almeida Velozo,C., de Almeida,T.B., de Azevedo,M.C.V.M.,
            Espasandin,I., da Cunha Pinto,J.F., Lopez,S., Pizzatti,L.,
            Tanuri,A., da Silva Santos,S., Ribeiro-Alves,M. and Cardoso,C.C.
  TITLE     Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with
            virologic response to antiretroviral therapy in Brazilian
            HIV-positive individuals
  JOURNAL   Pharmacogenomics J 22 (1), 33-38 (2022)
   PUBMED   34504302
  REMARK    GeneRIF: Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in
            association with virologic response to antiretroviral therapy in
            Brazilian HIV-positive individuals.
REFERENCE   6  (bases 1 to 1092)
  AUTHORS   Seol,W., Hanstein,B., Brown,M. and Moore,D.D.
  TITLE     Inhibition of estrogen receptor action by the orphan receptor SHP
            (short heterodimer partner)
  JOURNAL   Mol Endocrinol 12 (10), 1551-1557 (1998)
   PUBMED   9773978
REFERENCE   7  (bases 1 to 1092)
  AUTHORS   Choi,H.S., Chung,M., Tzameli,I., Simha,D., Lee,Y.K., Seol,W. and
            Moore,D.D.
  TITLE     Differential transactivation by two isoforms of the orphan nuclear
            hormone receptor CAR
  JOURNAL   J Biol Chem 272 (38), 23565-23571 (1997)
   PUBMED   9295294
REFERENCE   8  (bases 1 to 1092)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     An orphan nuclear hormone receptor that lacks a DNA binding domain
            and heterodimerizes with other receptors
  JOURNAL   Science 272 (5266), 1336-1339 (1996)
   PUBMED   8650544
REFERENCE   9  (bases 1 to 1092)
  AUTHORS   Choi,H.S., Seol,W. and Moore,D.D.
  TITLE     A component of the 26S proteasome binds on orphan member of the
            nuclear hormone receptor superfamily
  JOURNAL   J Steroid Biochem Mol Biol 56 (1-6 Spec No), 23-30 (1996)
   PUBMED   8603043
REFERENCE   10 (bases 1 to 1092)
  AUTHORS   Baes,M., Gulick,T., Choi,H.S., Martinoli,M.G., Simha,D. and
            Moore,D.D.
  TITLE     A new orphan member of the nuclear hormone receptor superfamily
            that interacts with a subset of retinoic acid response elements
  JOURNAL   Mol Cell Biol 14 (3), 1544-1552 (1994)
   PUBMED   8114692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB124867.1, AY572817.1 and
            AA918394.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001077476.2.
            
            Summary: This gene encodes a member of the nuclear receptor
            superfamily, and is a key regulator of xenobiotic and endobiotic
            metabolism. The protein binds to DNA as a monomer or a heterodimer
            with the retinoid X receptor and regulates the transcription of
            target genes involved in drug metabolism and bilirubin clearance,
            such as cytochrome P450 family members. Unlike most nuclear
            receptors, this transcriptional regulator is constitutively active
            in the absence of ligand but is regulated by both agonists and
            inverse agonists. Ligand binding results in translocation of this
            protein to the nucleus, where it activates or represses target gene
            transcription. These ligands include bilirubin, a variety of
            foreign compounds, steroid hormones, and prescription drugs. In
            addition to drug metabolism, the CAR protein is also reported to
            regulate genes involved in glucose metabolism, lipid metabolism,
            cell proliferation, and circadian clock regulation. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (13), also known as SV-12, lacks
            an alternate in-frame exon in the 5' coding region and uses two
            alternate splice sites in the 3' coding region, compared to variant
            1. The resulting protein (isoform 13) is shorter, uses an upstream
            start codon, and has distinct N- and C-termini, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY572817.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               CB124867.1         8-109
            103-1024            AY572817.1         1-922
            1025-1092           AA918394.1         10-77               c
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1092
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="nuclear receptor subfamily 1 group I member 3"
                     /db_xref="GeneID:9970"
                     /db_xref="HGNC:HGNC:7969"
                     /db_xref="MIM:603881"
     exon            1..163
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1079
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="isoform 13 is encoded by transcript variant 13;
                     constitutive activator of retinoid response; constitutive
                     active receptor; constitutive androstane receptor; orphan
                     nuclear hormone receptor; constitutive active response;
                     orphan nuclear receptor MB67"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group I member 3
                     isoform 13"
                     /protein_id="NP_001070944.1"
                     /db_xref="CCDS:CCDS53410.1"
                     /db_xref="GeneID:9970"
                     /db_xref="HGNC:HGNC:7969"
                     /db_xref="MIM:603881"
                     /translation="MLPKRSRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLD
                     AGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQ
                     FVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIED
                     QISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHG
                     TLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQ
                     RRPRDRSPGTPWIHWSGKMLGPKIGPGSKGAQWLQ"
     exon            164..294
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            295..464
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            465..604
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            605..750
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            751..867
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            868..988
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1092
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="hexamer: AATGAA"
     polyA_site      1092
                     /gene="NR1I3"
                     /gene_synonym="CAR; CAR1; MB67"
                     /note="major polyA site"
ORIGIN      
        1 agacatctct tgttttccag atactacggg tcataatccc taactccaat cactggcaac
       61 tcctgagatc agaggaaaac cagcaacagc gtgggagttt ggggagaggc attccatacc
      121 agattctgtg gcctgcaggt gacatgctgc ctaagagaag caggagaaca gtcagcaaaa
      181 gcattggtcc cacctgcccc tttgctggaa gctgtgaagt cagcaagact cagaggcgcc
      241 actgcccagc ctgcaggttg cagaagtgct tagatgctgg catgaggaaa gacatgatac
      301 tgtcggcaga agccctggca ttgcggcgag caaagcaggc ccagcggcgg gcacagcaaa
      361 cacctgtgca actgagtaag gagcaagaag agctgatccg gacactcctg ggggcccaca
      421 cccgccacat gggcaccatg tttgaacagt ttgtgcagtt taggcctcca gctcatctgt
      481 tcatccatca ccagcccttg cccaccctgg cccctgtgct gcctctggtc acacacttcg
      541 cagacatcaa cactttcatg gtactgcaag tcatcaagtt tactaaggac ctgcccgtct
      601 tccgttccct gcccattgaa gaccagatct cccttctcaa gggagcagct gtggaaatct
      661 gtcacatcgt actcaatacc actttctgtc tccaaacaca aaacttcctc tgcgggcctc
      721 ttcgctacac aattgaagat ggagcccgtg tggggttcca ggtagagttt ttggagttgc
      781 tctttcactt ccatggaaca ctacgaaaac tgcagctcca agagcctgag tatgtgctct
      841 tggctgccat ggccctcttc tctcctgctc cctatcttac agaccgacct ggagttaccc
      901 agagagatga gattgatcag ctgcaagagg agatggcact gactctgcaa agctacatca
      961 agggccagca gcgaaggccc cgggatcgct cacctggaac accctggata cactggagtg
     1021 ggaaaatgct gggaccaaag attgggccgg gttcaaaggg agcccagtgg ttgcaatgaa
     1081 agactaaagc aa
//
