LOCUS       NM_007121               2416 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens nuclear receptor subfamily 1 group H member 2 (NR1H2),
            transcript variant 1, mRNA.
ACCESSION   NM_007121
VERSION     NM_007121.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   de la Aleja,A.G., Herrero,C., Torres-Torresano,M., Schiaffino,M.T.,
            Del Castillo,A., Alonso,B., Vega,M.A., Puig-Kroger,A., Castrillo,A.
            and Corbi,A.L.
  TITLE     Inhibition of LXR controls the polarization of human inflammatory
            macrophages through upregulation of MAFB
  JOURNAL   Cell Mol Life Sci 80 (4), 96 (2023)
   PUBMED   36930354
  REMARK    GeneRIF: Inhibition of LXR controls the polarization of human
            inflammatory macrophages through upregulation of MAFB.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Shavva,V.S., Babina,A.V., Nekrasova,E.V., Lisunov,A.V., Dizhe,E.B.,
            Oleinikova,G.N. and Orlov,S.V.
  TITLE     Insulin Downregulates the Expression of ATP-binding Cassette
            Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and
            LXR Dependent Manner
  JOURNAL   Cell Biochem Biophys 81 (1), 151-160 (2023)
   PUBMED   36251137
  REMARK    GeneRIF: Insulin Downregulates the Expression of ATP-binding
            Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a
            FOXO1 and LXR Dependent Manner.
            Erratum:[Cell Biochem Biophys. 2023 Mar;81(1):161. doi:
            10.1007/s12013-022-01115-y.. PMID: 36342646]
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Kim,J., Lee,H., Lee,J.E., Choi,G., Chung,H., Kim,D., Park,M.J.,
            Gye,Y.S., Shin,K.S., Kang,C.Y., Kwok,S.K. and Chung,Y.
  TITLE     Liver X receptor controls follicular helper T cell differentiation
            via repression of TCF-1
  JOURNAL   Proc Natl Acad Sci U S A 120 (9), e2213793120 (2023)
   PUBMED   36802434
  REMARK    GeneRIF: Liver X receptor controls follicular helper T cell
            differentiation via repression of TCF-1.
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Liang,Z., Jiao,W., Wang,L., Chen,Y., Li,D., Zhang,Z., Zhang,Z.,
            Liang,Y. and Niu,H.
  TITLE     CYP27A1 inhibits proliferation and migration of clear cell renal
            cell carcinoma via activation of LXRs/ABCA1
  JOURNAL   Exp Cell Res 419 (1), 113279 (2022)
   PUBMED   35810773
  REMARK    GeneRIF: CYP27A1 inhibits proliferation and migration of clear cell
            renal cell carcinoma via activation of LXRs/ABCA1.
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Izumi,A., Hiraguchi,H., Kodaka,M., Ikeuchi,E., Narita,J.,
            Kobayashi,R., Matsumoto,Y., Suzuki,T., Yamamoto,Y., Sato,R. and
            Inoue,J.
  TITLE     MIG12 is involved in the LXR activation-mediated induction of the
            polymerization of mammalian acetyl-CoA carboxylase
  JOURNAL   Biochem Biophys Res Commun 567, 138-142 (2021)
   PUBMED   34153683
  REMARK    GeneRIF: MIG12 is involved in the LXR activation-mediated induction
            of the polymerization of mammalian acetyl-CoA carboxylase.
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Song,C., Hiipakka,R.A., Kokontis,J.M. and Liao,S.
  TITLE     Ubiquitous receptor: structures, immunocytochemical localization,
            and modulation of gene activation by receptors for retinoic acids
            and thyroid hormones
  JOURNAL   Ann N Y Acad Sci 761, 38-49 (1995)
   PUBMED   7625741
  REMARK    Review article
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Le Beau,M.M., Song,C., Davis,E.M., Hiipakka,R.A., Kokontis,J.M. and
            Liao,S.
  TITLE     Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3
            using fluorescence in situ hybridization
  JOURNAL   Genomics 26 (1), 166-168 (1995)
   PUBMED   7782080
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Song,C., Kokontis,J.M., Hiipakka,R.A. and Liao,S.
  TITLE     Ubiquitous receptor: a receptor that modulates gene activation by
            retinoic acid and thyroid hormone receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 10809-10813 (1994)
   PUBMED   7971966
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Shinar,D.M., Endo,N., Rutledge,S.J., Vogel,R., Rodan,G.A. and
            Schmidt,A.
  TITLE     NER, a new member of the gene family encoding the human steroid
            hormone nuclear receptor
  JOURNAL   Gene 147 (2), 273-276 (1994)
   PUBMED   7926814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA053472.1, BC047750.2, AI252503.1 and AC008655.7.
            
            On May 17, 2019 this sequence version replaced NM_007121.6.
            
            Summary: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB,
            form a subfamily of the nuclear receptor superfamily and are key
            regulators of macrophage function, controlling transcriptional
            programs involved in lipid homeostasis and inflammation. The
            inducible LXRA is highly expressed in liver, adrenal gland,
            intestine, adipose tissue, macrophages, lung, and kidney, whereas
            LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate
            heterodimers with retinoid X receptors (RXRs; see MIM 180245) and
            regulate expression of target genes containing LXR response
            elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied
            by OMIM, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: The coding region was updated to make it identical to
            the current human reference genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.249390.1,
                                           SRR1803611.102460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253727.10/ ENSP00000253727.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA053472.1         35-46
            13-765              BC047750.2         1-753
            766-1964            BC047750.2         757-1955
            1965-2056           AI252503.1         163-254
            2057-2416           AC008655.7         102323-102682
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2416
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="nuclear receptor subfamily 1 group H member 2"
                     /db_xref="GeneID:7376"
                     /db_xref="HGNC:HGNC:7965"
                     /db_xref="MIM:600380"
     exon            1..120
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            121..228
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            229..290
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1630
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitously-expressed nuclear receptor; steroid
                     hormone-nuclear receptor NER; oxysterols receptor
                     LXR-beta; nuclear orphan receptor LXR-beta; LX receptor
                     beta; liver X nuclear receptor beta"
                     /codon_start=1
                     /product="oxysterols receptor LXR-beta isoform 1"
                     /protein_id="NP_009052.4"
                     /db_xref="CCDS:CCDS42593.1"
                     /db_xref="GeneID:7376"
                     /db_xref="HGNC:HGNC:7965"
                     /db_xref="MIM:600380"
                     /translation="MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDP
                     DVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVL
                     SCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVL
                     SEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQ
                     LTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAII
                     SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTY
                     SKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVE
                     ALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPP
                     LLSEIWDVHE"
     exon            291..428
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            429..719
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            720..994
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1174
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1274
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1483
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..2416
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1990..1995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="hexamer: AATAAA"
     polyA_site      2010
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="major polyA site"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="hexamer: GATAAA"
     polyA_site      2294
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
     regulatory      2394..2399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="NR1H2"
                     /gene_synonym="LXR-b; LXRB; NER; NER-I; RIP15; UNR"
ORIGIN      
        1 gtgacgcaag ggcggggttg ccggaagaag tggcgaagtt acttttgagg gtatttgagt
       61 agcggcggtg tgtcaggggc taaagaggag gacgaagaaa agcagagcaa gggaacccag
      121 ggcaacagga gtagttcact ccgcgagagg ccgtccacga gacccccgcg cgcagccatg
      181 agccccgccc cccgctgttg cttggagagg ggcgggacct ggagagaggc tgctccgtga
      241 ccccaccatg tcctctccta ccacgagttc cctggatacc cccctgcctg gaaatggccc
      301 ccctcagcct ggcgcccctt cttcttcacc cactgtaaag gaggagggtc cggagccgtg
      361 gcccgggggt ccggaccctg atgtcccagg cactgatgag gccagctcag cctgcagcac
      421 agactgggtc atcccagatc ccgaagagga accagagcgc aagcgaaaga agggcccagc
      481 cccgaagatg ctgggccacg agctttgccg tgtctgtggg gacaaggcct ccggcttcca
      541 ctacaacgtg ctcagctgcg aaggctgcaa gggcttcttc cggcgcagtg tggtccgtgg
      601 tggggccagg cgctatgcct gccggggtgg cggaacctgc cagatggacg ctttcatgcg
      661 gcgcaagtgc cagcagtgcc ggctgcgcaa gtgcaaggag gcagggatga gggagcagtg
      721 cgtcctttct gaagaacaga tccggaagaa gaagattcgg aaacagcagc aggagtcaca
      781 gtcacagtcg cagtcacctg tggggccgca gggcagcagc agctcagcct ctgggcctgg
      841 ggcttcccct ggtggatctg aggcaggcag ccagggctcc ggggaaggcg agggtgtcca
      901 gctaacagcg gctcaagaac taatgatcca gcagttggtg gcggcccaac tgcagtgcaa
      961 caaacgctcc ttctccgacc agcccaaagt cacgccctgg cccctgggcg cagaccccca
     1021 gtcccgagat gcccgccagc aacgctttgc ccacttcacg gagctggcca tcatctcagt
     1081 ccaggagatc gtggacttcg ctaagcaagt gcctggtttc ctgcagctgg gccgggagga
     1141 ccagatcgcc ctcctgaagg catccactat cgagatcatg ctgctagaga cagccaggcg
     1201 ctacaaccac gagacagagt gtatcacctt cttgaaggac ttcacctaca gcaaggacga
     1261 cttccaccgt gcaggcctgc aggtggagtt catcaacccc atcttcgagt tctcgcgggc
     1321 catgcggcgg ctgggcctgg acgacgctga gtacgccctg ctcatcgcca tcaacatctt
     1381 ctcggccgac cggcccaacg tgcaggagcc gggccgcgtg gaggcgttgc agcagcccta
     1441 cgtggaggcg ctgctgtcct acacgcgcat caagaggccg caggaccagc tgcgcttccc
     1501 gcgcatgctc atgaagctgg tgagcctgcg cacgctgagc tctgtgcact cggagcaggt
     1561 cttcgccttg cggctccagg acaagaagct gccgcctctg ctgtcggaga tctgggacgt
     1621 ccacgagtga ggggctggcc acccagcccc acagccttgc ctgaccaccc tccagcagat
     1681 agacgccggc accccttcct cttcctaggg tggaaggggc cctgggccga gcctgtagac
     1741 ctatcggctc tcatcccttg ggataagccc cagtccaggt ccaggaggct ccctccctgc
     1801 ccagcgagtc ttccagaagg ggtgaaaggg ttgcaggtcc cgaccactga cccttcccgg
     1861 ctgccctccc tccccagctt acacctcaag cccagcacgc agtgcacctt gaacagaggg
     1921 aggggaggac ccatggctct cccccctagc ccgggagacc agggccttcc tcttcctctg
     1981 cttttattta ataaaaacta aaaacagaaa caggaaaata aaatatgaat acaatccagc
     2041 ccggagctgg agtgcaagat ggagagggcg cgggcttcta gggacctcag tgacactggg
     2101 tgcccgaacc tgattgagca ggtgggactg ggtgtcccca ggctgttggg aaaagggtgg
     2161 cacatagggt cccagtgttg ggtggtgtgt cgcctgctgt gaaagttcag gacagaggcc
     2221 tcagcctcag ggtcacctcc ctggacaagg tgaatcagaa ctcacccttg aaggataaac
     2281 aggatttaag tgaatgaggg gacctggact tctgtccgaa caacaagtgt ttgctgaggc
     2341 ctcctgtggg ccaggcactg ggttggccat tctagagatg gagacattca cccaataaat
     2401 gtttccagag cattaa
//
