LOCUS       NM_005126               5231 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 1 group D member 2 (NR1D2),
            transcript variant 1, mRNA.
ACCESSION   NM_005126 XM_940036
VERSION     NM_005126.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5231)
  AUTHORS   Karuga,F.F., Jaromirska,J., Sochal,M., Bialasiewicz,P. and
            Gabryelska,A.
  TITLE     Association between glucose metabolism, the circadian cycle and
            hypoxia: Evaluation of the NPAS2 and Rev-Erb-alpha protein serum
            levels in obstructive sleep apnea patients - a pilot study
  JOURNAL   Dent Med Probl 61 (3), 465-469 (2024)
   PUBMED   38804230
  REMARK    GeneRIF: Association between glucose metabolism, the circadian
            cycle and hypoxia: Evaluation of the NPAS2 and Rev-Erb-alpha
            protein serum levels in obstructive sleep apnea patients - a pilot
            study.
REFERENCE   2  (bases 1 to 5231)
  AUTHORS   Cho,H., Yun,A., Kim,J., Park,E., Jung,J.W., Chung,S. and Son,G.H.
  TITLE     Functional Characterization of Circadian Nuclear Receptors
            REV-ERBalpha and REV-ERBbeta in Human Osteosarcoma Cell Cultures
  JOURNAL   Int J Mol Sci 25 (2), 770 (2024)
   PUBMED   38255844
  REMARK    GeneRIF: Functional Characterization of Circadian Nuclear Receptors
            REV-ERBalpha and REV-ERBbeta in Human Osteosarcoma Cell Cultures.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5231)
  AUTHORS   Hida,A., Iida,A., Ukai,M., Kadotani,H., Uchiyama,M., Ebisawa,T.,
            Inoue,Y., Kitamura,S. and Mishima,K.
  TITLE     Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals
            with non-24-hour sleep-wake rhythm disorder
  JOURNAL   Sleep 46 (6) (2023)
   PUBMED   36897197
  REMARK    GeneRIF: Novel CLOCK and NR1D2 variants in 64 sighted Japanese
            individuals with non-24-hour sleep-wake rhythm disorder.
REFERENCE   4  (bases 1 to 5231)
  AUTHORS   Mittal,N., Davis,C., McLean,P., Calla,J., Godinez-Macias,K.P.,
            Gardner,A., Healey,D., Orjuela-Sanchez,P., Ottilie,S., Chong,Y.,
            Gibson,C. and Winzeler,E.A.
  TITLE     Human nuclear hormone receptor activity contributes to malaria
            parasite liver stage development
  JOURNAL   Cell Chem Biol 30 (5), 486-498 (2023)
   PUBMED   37172592
  REMARK    GeneRIF: Human nuclear hormone receptor activity contributes to
            malaria parasite liver stage development.
REFERENCE   5  (bases 1 to 5231)
  AUTHORS   Raza,G.S., Sodum,N., Kaya,Y. and Herzig,K.H.
  TITLE     Role of Circadian Transcription Factor Rev-Erb in Metabolism and
            Tissue Fibrosis
  JOURNAL   Int J Mol Sci 23 (21), 12954 (2022)
   PUBMED   36361737
  REMARK    GeneRIF: Role of Circadian Transcription Factor Rev-Erb in
            Metabolism and Tissue Fibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5231)
  AUTHORS   Sauve,F., McBroom,L.D., Gallant,J., Moraitis,A.N., Labrie,F. and
            Giguere,V.
  TITLE     CIA, a novel estrogen receptor coactivator with a bifunctional
            nuclear receptor interacting determinant
  JOURNAL   Mol Cell Biol 21 (1), 343-353 (2001)
   PUBMED   11113208
REFERENCE   7  (bases 1 to 5231)
  AUTHORS   Koh,Y.S. and Moore,D.D.
  TITLE     Linkage of the nuclear hormone receptor genes NR1D2, THRB, and
            RARB: evidence for an ancient, large-scale duplication
  JOURNAL   Genomics 57 (2), 289-292 (1999)
   PUBMED   10198169
REFERENCE   8  (bases 1 to 5231)
  AUTHORS   Burke,L.J., Downes,M., Laudet,V. and Muscat,G.E.
  TITLE     Identification and characterization of a novel corepressor
            interaction region in RVR and Rev-erbA alpha
  JOURNAL   Mol Endocrinol 12 (2), 248-262 (1998)
   PUBMED   9482666
REFERENCE   9  (bases 1 to 5231)
  AUTHORS   Downes,M., Burke,L.J., Bailey,P.J. and Muscat,G.E.
  TITLE     Two receptor interaction domains in the corepressor, N-CoR/RIP13,
            are required for an efficient interaction with Rev-erbA alpha and
            RVR: physical association is dependent on the E region of the
            orphan receptors
  JOURNAL   Nucleic Acids Res 24 (22), 4379-4386 (1996)
   PUBMED   8948627
REFERENCE   10 (bases 1 to 5231)
  AUTHORS   Dumas,B., Harding,H.P., Choi,H.S., Lehmann,K.A., Chung,M.,
            Lazar,M.A. and Moore,D.D.
  TITLE     A new orphan member of the nuclear hormone receptor superfamily
            closely related to Rev-Erb
  JOURNAL   Mol Endocrinol 8 (8), 996-1005 (1994)
   PUBMED   7997240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR004486.1, D16815.1,
            AC124914.3 and CA412377.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005126.4.
            
            Summary: This gene encodes a member of the nuclear hormone receptor
            family, specifically the NR1 subfamily of receptors. The encoded
            protein functions as a transcriptional repressor and may play a
            role in circadian rhythms and carbohydrate and lipid metabolism.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.192213.1, BC045613.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312521.9/ ENSP00000310006.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               DR004486.1         32-273
            243-2103            D16815.1           255-2115
            2104-4642           AC124914.3         122667-125205
            4643-5231           CA412377.1         20-608              c
FEATURES             Location/Qualifiers
     source          1..5231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..5231
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /note="nuclear receptor subfamily 1 group D member 2"
                     /db_xref="GeneID:9975"
                     /db_xref="HGNC:HGNC:7963"
                     /db_xref="MIM:602304"
     exon            1..309
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2033
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rev-erb-beta; rev-erba-alpha-related receptor; rev-erb
                     alpha-related receptor; orphan nuclear hormone receptor
                     BD73; V-erbA-related protein 1-related"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group D member 2
                     isoform 1"
                     /protein_id="NP_005117.3"
                     /db_xref="CCDS:CCDS33718.1"
                     /db_xref="GeneID:9975"
                     /db_xref="HGNC:HGNC:7963"
                     /db_xref="MIM:602304"
                     /translation="MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSP
                     NSSNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLL
                     CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCR
                     FKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQ
                     TALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSA
                     ESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGH
                     AICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPMSKSPYV
                     DPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRF
                     ASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTA
                     VVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNN
                     MHSEELLAFKVHP"
     exon            310..576
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            577..665
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            666..810
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1439
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1625
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1836
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..5231
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5213..5218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /note="hexamer: AATAAA"
     polyA_site      5231
                     /gene="NR1D2"
                     /gene_synonym="BD73; EAR-1R; REVERBB; REVERBbeta; RVR"
                     /note="major polyA site"
ORIGIN      
        1 gtcagccgcc ctcgccgccg cggtgcgctg gctgcaggaa gccgccgcgc cgccgctttt
       61 gttgtcaggg acccagcgag gagcgccgct cgccggccgc cgccaccctc tctcgctgca
      121 gcctgctgtg cgctgcacgg cctggggccc gggagccccg cccgctctgc ccatgagggg
      181 gccccgcgac caccgctgct tccagcccgg ggcggcgcgg cgctgaggcg gcggcggcgg
      241 cgctgccccc tctgcgggaa gcgggcggcc ccggccgcct ccgcgagggc accatggagg
      301 tgaatgcagg aggtgtgatt gcctatatca gttcttccag ctcagcctca agccctgcct
      361 cttgtcacag tgagggttct gagaatagtt tccagtcctc ctcctcttct gttccatctt
      421 ctccaaatag ctctaattct gataccaatg gtaatcccaa gaatggtgat ctcgccaata
      481 ttgaaggcat cttgaagaat gatcgaatag attgttctat gaaaacaagc aaatcgagtg
      541 cacctgggat gacaaaaagt catagtggtg tgacaaaatt tagtggcatg gttctactgt
      601 gtaaagtctg tggggatgtg gcgtcaggat tccactatgg agttcatgct tgcgaaggct
      661 gtaagggttt ctttcggaga agtattcaac aaaacatcca gtacaagaag tgcctgaaga
      721 atgaaaactg ttctataatg agaatgaata ggaacagatg tcagcaatgt cgcttcaaaa
      781 agtgtctgtc tgttggaatg tcaagagatg ctgttcggtt tggtcgtatt cctaagcgtg
      841 aaaaacagag gatgctaatt gaaatgcaaa gtgcaatgaa gaccatgatg aacagccagt
      901 tcagtggtca cttgcaaaat gacacattag tagaacatca tgaacagaca gccttgccag
      961 cccaggaaca gctgcgaccc aagccccaac tggagcaaga aaacatcaaa agctcttctc
     1021 ctccatcttc tgattttgca aaggaagaag tgattggcat ggtgaccaga gctcacaagg
     1081 atacctttat gtataatcaa gagcagcaag aaaactcagc tgagagcatg cagccccaga
     1141 gaggagaacg gattcccaag aacatggagc aatataattt aaatcatgat cattgcggca
     1201 atgggcttag cagccatttt ccctgtagtg agagccagca gcatctcaat ggacagttca
     1261 aagggaggaa tataatgcat tacccaaatg gtcatgccat ttgtattgca aatggacatt
     1321 gtatgaactt ctccaatgct tatactcaaa gagtatgtga tagagttccg atagatggat
     1381 tttctcagaa tgagaacaag aatagttacc tgtgcaacac tggaggaaga atgcatctgg
     1441 tttgtccaat gagtaagtct ccatatgtgg atcctcataa atcaggacat gaaatctggg
     1501 aagaattttc gatgagcttc actccagcag tgaaagaagt ggtggaattt gcaaagcgta
     1561 ttcctgggtt cagagatctc tctcagcatg accaggtcaa ccttttaaag gctgggactt
     1621 ttgaggtttt aatggtacgg ttcgcatcat tatttgatgc aaaggaacgt actgtcacct
     1681 ttttaagtgg aaagaaatat agtgtggatg atttacactc aatgggagca ggggatctgc
     1741 taaactctat gtttgaattt agtgagaagc taaatgccct ccaacttagt gatgaagaga
     1801 tgagtttgtt tacagctgtt gtcctggtat ctgcagatcg atctggaata gaaaacgtca
     1861 actctgtgga ggctttgcag gaaactctca ttcgtgcact aaggacctta ataatgaaaa
     1921 accatccaaa tgaggcctct atttttacaa aactgcttct aaagttgcca gatcttcgat
     1981 ctttaaacaa catgcactct gaggagctct tggcctttaa agttcaccct taaggccttt
     2041 gtttatttaa acatgaactg atggtaactg tacattttgt gctaaaatgc atatttatat
     2101 gtgtatacca tatgtggaga tagaaaagac ctttaagaca ataaaagatt gtaggctatc
     2161 tctgtaatca tgcaatagct gttcggattg agaactcttc agccatgatt agacgttgac
     2221 tgcatctccc tgatagacca atcagctgtg tcgcacttaa actggagaag ttacactgaa
     2281 gtataatcac actgaatgtt agactttttc atctgccaaa accaaaaacc attttgatct
     2341 ccctgtggtt atcaatataa cgcacaatca caagtgtatg aggacttaga aattaatcct
     2401 ttgtggtagg agttctgttg aatgatggaa atcttattac taccacaaga ctatttgatc
     2461 tggtaattgg agacttcggg atttaggaga tctccatgtc tgtatttact ctaccactgc
     2521 taaagtgtgt ggtcctgggt agtttacttg cttgcggaaa atgagaattg atggtgtccc
     2581 caatgcccca cctcacagag ttactaaaaa atgtctgtaa agcatattta cctcttggga
     2641 gataggcact atgtaaataa ggtaaaattt ctgttattac aattattcat aataatattc
     2701 ttttcttatt tctaagcctt tctgggaaat catttcagtc cacaccaacc atattattca
     2761 gggttcctgc catatgtgtg gggtatccta ctgatacaca cgtattcaaa gtttatgggt
     2821 acaacaaaga catagtacat gtacataata tgtatgtgaa tatagttaaa tatatttctt
     2881 cacaatattt taaactgtga agaactttat catacaggaa acttaaaaca agaggtgtca
     2941 aaagacccaa attaggtgca ttttacttgt ttatgatggc ataaccattg ctttaaaatg
     3001 tttagacagt agaatattga atttatgctc tatttttgtt tatttaagca acacttaatg
     3061 taaaagtgca acaggcaatt gaatccaaat ttcaacgaca aaaaaaaaaa acatgtattt
     3121 tagagttcat ctttggcaaa atctttggtt cagggtacta gttgtttaaa agttgattca
     3181 tattcttacc ttgtgctgag aaaggttgca ttgctgcccc ttatacacat gctgcagctt
     3241 gatgttaaag aatttttatt ctttctgaag aactaattaa tgtttaaagc aactgtttaa
     3301 tatgatggca tgtgtgtgtg tgcgtgcgtg tgtatgttct gagtccactt cttttttcct
     3361 aaataacact acagggattt tgtcatatta gatttaattt ataatttgaa aaatcatcta
     3421 gtgtgtgacc tacaggctta gaaatggtat agtcaaagac attttatcca catttctaat
     3481 agtggacttg attaagtaga taagatcagc atctgtttat ggtagtagga gaaatagcca
     3541 aagttgagga ttttatgtat gttttcctgt ttacctggaa aatagcaatt aattggattt
     3601 tttggtaaag attgccttct gtataatgtt tggattatat aaaattgcaa aaatgataac
     3661 agcccgcttt actgtactaa gcctgttact ttcatgacgt gtgagcagaa tgccttattt
     3721 tgtaatcttg tttaacttgt tgctactggg acttgattta ctgtggcact agttaagtaa
     3781 gttaaaaaaa agttaaaccc tctcattatt aaagaggaaa ggcgatggtg atgtctgtag
     3841 tacaatataa accataattg tgatttacct taagtaggta taactcttat gggatataca
     3901 gtatagtttt tgtgaatctt tacatgatag cattatcttt ttataatttt ttttcctaag
     3961 ataaacaaat gcatagtttt cttctatggg tgatagaaac agctttttga agtaatgaaa
     4021 acctcaaaag atcatgttga ttcttaattt ttgccttttg cataagcctc tttataacat
     4081 gtatctttaa aacaattaag tctttaggaa tgtgtaacca gaactatgtt agtattgctt
     4141 ataaaacttt agttaggttc aatatataca tatatacatc tctatatagg tatatagatt
     4201 tgcattttgt cttgtaaaat tttatttgaa taaattcttc ctgtaggtaa tgggaaacaa
     4261 aattaatagt tcatatgtca ctcatagcat ttctatattt gaaagtagcc caatataaaa
     4321 cttttgattc taaaattaaa ccagcagcct attacaagca cattctttga ttgagtcatt
     4381 ggttataaac ttactaaatg cagagaaagc agccaattta ggaaacttct gagttggtgg
     4441 gacactgttg attaataatg tactgtatga attaagtgat gctttaactt tgattttaca
     4501 ttttaaagtt aaaatgtggg cattatgtca gcaaacttaa gggcattatg tcagcaagct
     4561 aaaacatttt ttttcctgtg cttttaatgt atctctttac atgatctgag agaggattca
     4621 agttgataga aatagctgag gggaaaaggg ggaacatctt gggatgaagc ttgtccttat
     4681 ggtgatggtt taattacaga ttaaaaaatt agaaggaaat ttcagtggat taagtgtata
     4741 gctttcatat ctacatttca agaaattacc attgtaactt gataagagat gatttatttt
     4801 atgtaaacat ctttgcaaag caaggtgtag cagctcagct agatttatta ctgtgcacga
     4861 aagtaaatac ctatctcaat tattcttttt cttttccaat ataaagtttg ctgaatgtac
     4921 aagaagagtt tatcacttag gatatagaat ttttttaggg gttgggggag gggatctgtt
     4981 aggaaactgt tacctataaa caaagattga ctggattcga tccaaaagat aaaacttgaa
     5041 gctattctgg aactaacatg gaaaaatgaa atggctattg tttaaaaaaa tgatagaaat
     5101 acattgttga tgggatatga gttaagttta ttttctacaa actgtaattg atgaggacat
     5161 ggataatatc ttcatgtttc tgagaagtaa tctgtatgtg gggggagggg ataataaata
     5221 tttctaacca a
//
