LOCUS       NM_021724               2630 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1),
            mRNA.
ACCESSION   NM_021724
VERSION     NM_021724.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Yang,Y., Zhang,X., Cai,D., Zheng,X., Zhao,X., Zou,J.X., Zhang,J.,
            Borowsky,A.D., Dall'Era,M.A., Corey,E., Mitsiades,N., Kung,H.J.,
            Chen,X., Li,J.J., Downes,M., Evans,R.M. and Chen,H.W.
  TITLE     Functional inversion of circadian regulator REV-ERBalpha leads to
            tumorigenic gene reprogramming
  JOURNAL   Proc Natl Acad Sci U S A 121 (42), e2411321121 (2024)
   PUBMED   39383000
  REMARK    GeneRIF: Functional inversion of circadian regulator REV-ERBalpha
            leads to tumorigenic gene reprogramming.
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Kumar,S., Arora,R., Gupta,S., Ahuja,N., Bhagyaraj,E., Nanduri,R.,
            Kalra,R., Khare,A.K., Kumawat,S., Kaushal,V., Sharma,M. and
            Gupta,P.
  TITLE     Nuclear receptor Rev-erbalpha role in fine-tuning erythropoietin
            gene expression
  JOURNAL   Blood Adv 8 (14), 3705-3717 (2024)
   PUBMED   38748870
  REMARK    GeneRIF: Nuclear receptor Rev-erbalpha role in fine-tuning
            erythropoietin gene expression.
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Baburski,A.Z., Becin,A.P., Travicic,D.Z., Medar,M.L.J., Andric,S.A.
            and Kostic,T.S.
  TITLE     REVERBA couples the circadian clock to Leydig cell steroidogenesis
  JOURNAL   Biofactors 50 (4), 738-749 (2024)
   PUBMED   38147453
  REMARK    GeneRIF: REVERBA couples the circadian clock to Leydig cell
            steroidogenesis.
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Cho,H., Yun,A., Kim,J., Park,E., Jung,J.W., Chung,S. and Son,G.H.
  TITLE     Functional Characterization of Circadian Nuclear Receptors
            REV-ERBalpha and REV-ERBbeta in Human Osteosarcoma Cell Cultures
  JOURNAL   Int J Mol Sci 25 (2), 770 (2024)
   PUBMED   38255844
  REMARK    GeneRIF: Functional Characterization of Circadian Nuclear Receptors
            REV-ERBalpha and REV-ERBbeta in Human Osteosarcoma Cell Cultures.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Yin,L., Wang,J., Klein,P.S. and Lazar,M.A.
  TITLE     Nuclear receptor Rev-erbalpha is a critical lithium-sensitive
            component of the circadian clock
  JOURNAL   Science 311 (5763), 1002-1005 (2006)
   PUBMED   16484495
  REMARK    GeneRIF: findings show that GSK3beta phosphorylates and stabilizes
            Rev-erbalpha, a negative component of the circadian clock; control
            of Rev-erbalpha protein stability is a critical component of the
            peripheral clock and a biological target of lithium therapy
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Downes,M., Burke,L.J., Bailey,P.J. and Muscat,G.E.
  TITLE     Two receptor interaction domains in the corepressor, N-CoR/RIP13,
            are required for an efficient interaction with Rev-erbA alpha and
            RVR: physical association is dependent on the E region of the
            orphan receptors
  JOURNAL   Nucleic Acids Res 24 (22), 4379-4386 (1996)
   PUBMED   8948627
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Adelmant,G., Begue,A., Stehelin,D. and Laudet,V.
  TITLE     A functional Rev-erb alpha responsive element located in the human
            Rev-erb alpha promoter mediates a repressing activity
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3553-3558 (1996)
   PUBMED   8622974
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Laudet,V., Begue,A., Henry-Duthoit,C., Joubel,A., Martin,P.,
            Stehelin,D. and Saule,S.
  TITLE     Genomic organization of the human thyroid hormone receptor alpha
            (c-erbA-1) gene
  JOURNAL   Nucleic Acids Res 19 (5), 1105-1112 (1991)
   PUBMED   1850510
REFERENCE   9  (bases 1 to 2630)
  AUTHORS   Lazar,M.A., Jones,K.E. and Chin,W.W.
  TITLE     Isolation of a cDNA encoding human Rev-ErbA alpha: transcription
            from the noncoding DNA strand of a thyroid hormone receptor gene
            results in a related protein that does not bind thyroid hormone
  JOURNAL   DNA Cell Biol 9 (2), 77-83 (1990)
   PUBMED   1971514
REFERENCE   10 (bases 1 to 2630)
  AUTHORS   Miyajima,N., Horiuchi,R., Shibuya,Y., Fukushige,S., Matsubara,K.,
            Toyoshima,K. and Yamamoto,T.
  TITLE     Two erbA homologs encoding proteins with different T3 binding
            capacities are transcribed from opposite DNA strands of the same
            genetic locus
  JOURNAL   Cell 57 (1), 31-39 (1989)
   PUBMED   2539258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC056148.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021724.4.
            
            Summary: This gene encodes a transcription factor that is a member
            of the nuclear receptor subfamily 1. The encoded protein is a
            ligand-sensitive transcription factor that negatively regulates the
            expression of core clock proteins. In particular this protein
            represses the circadian clock transcription factor aryl hydrocarbon
            receptor nuclear translocator-like protein 1 (ARNTL). This protein
            may also be involved in regulating genes that function in
            metabolic, inflammatory and cardiovascular processes. [provided by
            RefSeq, Jan 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056148.1, M24898.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246672.4/ ENSP00000246672.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2630              BC056148.1         28-2657
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..2630
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /note="nuclear receptor subfamily 1 group D member 1"
                     /db_xref="GeneID:9572"
                     /db_xref="HGNC:HGNC:7962"
                     /db_xref="MIM:602408"
     exon            1..526
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..2340
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /note="nuclear receptor Rev-ErbA-alpha; Rev-ErbAalpha;
                     rev-erbA-alpha; V-erbA-related protein 1"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group D member 1"
                     /protein_id="NP_068370.1"
                     /db_xref="CCDS:CCDS11361.1"
                     /db_xref="GeneID:9572"
                     /db_xref="HGNC:HGNC:7962"
                     /db_xref="MIM:602408"
                     /translation="MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSL
                     TQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGS
                     LQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSI
                     QQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLA
                     EMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPP
                     RSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQ
                     GCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTH
                     VYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREV
                     VEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQEL
                     GAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETL
                     LRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ"
     exon            527..865
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     exon            866..954
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1099
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1743
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1929
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2140
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2630
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2630
                     /gene="NR1D1"
                     /gene_synonym="ear-1; EAR1; hRev; REVERBA; REVERBalpha;
                     THRA1; THRAL"
                     /note="major polyA site"
ORIGIN      
        1 agagtgaaat attactgccg agggaacgta gcagggcaca cgtctcgcct ctttgcgact
       61 cggtgccccg tttctcccca tcacctactt acttcctggt tgcaacctct cttcctctgg
      121 gacttttgca ccgggagctc cagattcgcc accccgcagc gctgcggagc cggcaggcag
      181 aggcaccccg tacactgcag agacccgacc ctccttgcta ccttctagcc agaactactg
      241 caggctgatt ccccctacac actctctctg ctcttcccat gcaaagcaga actccgttgc
      301 ctcaacgtcc aacccttctg cagggctgca gtccggccac cccaagacct tgctgcaggg
      361 tgcttcggat cctgatcgtg agtcgcgggg tccactcccc gcccttagcc agtgcccagg
      421 gggcaacagc ggcgatcgca acctctagtt tgagtcaagg tccagtttga atgaccgctc
      481 tcagctggtg aagacatgac gaccctggac tccaacaaca acacaggtgg cgtcatcacc
      541 tacattggct ccagtggctc ctccccaagc cgcaccagcc ctgaatccct ctatagtgac
      601 aactccaatg gcagcttcca gtccctgacc caaggctgtc ccacctactt cccaccatcc
      661 cccactggct ccctcaccca agacccggct cgctcctttg ggagcattcc acccagcctg
      721 agtgatgacg gctccccttc ttcctcatct tcctcgtcgt catcctcctc ctccttctat
      781 aatgggagcc cccctgggag tctacaagtg gccatggagg acagcagccg agtgtccccc
      841 agcaagagca ccagcaacat caccaagctg aatggcatgg tgttactgtg taaagtgtgt
      901 ggggacgttg cctcgggctt ccactacggt gtgcacgcct gcgagggctg caagggcttt
      961 ttccgtcgga gcatccagca gaacatccag tacaaaaggt gtctgaagaa tgagaattgc
     1021 tccatcgtcc gcatcaatcg caaccgctgc cagcaatgtc gcttcaagaa gtgtctctct
     1081 gtgggcatgt ctcgagacgc tgtgcgtttt gggcgcatcc ccaaacgaga gaagcagcgg
     1141 atgcttgctg agatgcagag tgccatgaac ctggccaaca accagttgag cagccagtgc
     1201 ccgctggaga cttcacccac ccagcacccc accccaggcc ccatgggccc ctcgccaccc
     1261 cctgctccgg tcccctcacc cctggtgggc ttctcccagt ttccacaaca gctgacgcct
     1321 cccagatccc caagccctga gcccacagtg gaggatgtga tatcccaggt ggcccgggcc
     1381 catcgagaga tcttcaccta cgcccatgac aagctgggca gctcacctgg caacttcaat
     1441 gccaaccatg catcaggtag ccctccagcc accaccccac atcgctggga aaatcagggc
     1501 tgcccacctg cccccaatga caacaacacc ttggctgccc agcgtcataa cgaggcccta
     1561 aatggtctgc gccaggctcc ctcctcctac cctcccacct ggcctcctgg ccctgcacac
     1621 cacagctgcc accagtccaa cagcaacggg caccgtctat gccccaccca cgtgtatgca
     1681 gccccagaag gcaaggcacc tgccaacagt ccccggcagg gcaactcaaa gaatgttctg
     1741 ctggcatgtc ctatgaacat gtacccgcat ggacgcagtg ggcgaacggt gcaggagatc
     1801 tgggaggatt tctccatgag cttcacgccc gctgtgcggg aggtggtaga gtttgccaaa
     1861 cacatcccgg gcttccgtga cctttctcag catgaccaag tcaccctgct taaggctggc
     1921 acctttgagg tgctgatggt gcgctttgct tcgttgttca acgtgaagga ccagacagtg
     1981 atgttcctaa gccgcaccac ctacagcctg caggagcttg gtgccatggg catgggagac
     2041 ctgctcagtg ccatgttcga cttcagcgag aagctcaact ccctggcgct taccgaggag
     2101 gagctgggcc tcttcaccgc ggtggtgctt gtctctgcag accgctcggg catggagaat
     2161 tccgcttcgg tggagcagct ccaggagacg ctgctgcggg ctcttcgggc tctggtgctg
     2221 aagaaccggc ccttggagac ttcccgcttc accaagctgc tgctcaagct gccggacctg
     2281 cggaccctga acaacatgca ttccgagaag ctgctgtcct tccgggtgga cgcccagtga
     2341 cccgcccggc cggccttctg ccgctgcccc cttgtacaga atcgaactct gcacttctct
     2401 ctcctttacg agacgaaaag gaaaagcaaa ccagaatctt atttatattg ttataaaata
     2461 ttccaagatg agcctctggc cccctgagcc ttcttgtaaa tacctgcctc cctcccccat
     2521 caccgaactt cccctcctcc cctatttaaa ccactctgtc tcccccacaa ccctcccctg
     2581 gccctctgat ttgttctgtt cctgtctcaa atccaatagt tcacagctga
//
