LOCUS       NM_021969               1165 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2),
            mRNA.
ACCESSION   NM_021969
VERSION     NM_021969.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1165)
  AUTHORS   Li,Z., Xu,L., Huang,D., Li,C., Haenen,G.R.M.M. and Zhang,M.
  TITLE     NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database Analysis
            Combined with Drug-Target Mendelian Randomization
  JOURNAL   Genes (Basel) 15 (9), 1210 (2024)
   PUBMED   39336801
  REMARK    GeneRIF: NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database
            Analysis Combined with Drug-Target Mendelian Randomization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1165)
  AUTHORS   Zang,X., Zhao,Z., Chen,K., Song,W., Ma,J., Fu,H., Wang,X. and
            Zhao,Y.
  TITLE     SHP-1 alleviates atrial fibrosis in atrial fibrillation by
            modulating STAT3 activation
  JOURNAL   Exp Biol Med (Maywood) 248 (11), 979-990 (2023)
   PUBMED   37226737
  REMARK    GeneRIF: SHP-1 alleviates atrial fibrosis in atrial fibrillation by
            modulating STAT3 activation.
REFERENCE   3  (bases 1 to 1165)
  AUTHORS   Bayram,M., Irak,K., Cifci,S., Koksal,A.R., Kazezoglu,C., Acar,Z.,
            Ozari,H.O. and Alkim,H.
  TITLE     The effectiveness of small heterodimer partner and FGF 19 levels in
            prediction of perinatal morbidity in intrahepatic cholestasis of
            pregnancy
  JOURNAL   J Obstet Gynaecol 42 (5), 1174-1178 (2022)
   PUBMED   35156505
  REMARK    GeneRIF: The effectiveness of small heterodimer partner and FGF 19
            levels in prediction of perinatal morbidity in intrahepatic
            cholestasis of pregnancy.
REFERENCE   4  (bases 1 to 1165)
  AUTHORS   Wu,J., Nagy,L.E. and Wang,L.
  TITLE     The long and the small collide: LncRNAs and small heterodimer
            partner (SHP) in liver disease
  JOURNAL   Mol Cell Endocrinol 528, 111262 (2021)
   PUBMED   33781837
  REMARK    GeneRIF: The long and the small collide: LncRNAs and small
            heterodimer partner (SHP) in liver disease.
            Review article
REFERENCE   5  (bases 1 to 1165)
  AUTHORS   Kumar,S., Vijayan,R., Dash,A.K., Gourinath,S. and Tyagi,R.K.
  TITLE     Nuclear receptor SHP dampens transcription function and abrogates
            mitotic chromatin association of PXR and ERalpha via intermolecular
            interactions
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (3), 194683 (2021)
   PUBMED   33444783
  REMARK    GeneRIF: Nuclear receptor SHP dampens transcription function and
            abrogates mitotic chromatin association of PXR and ERalpha via
            intermolecular interactions.
REFERENCE   6  (bases 1 to 1165)
  AUTHORS   Johansson,L., Bavner,A., Thomsen,J.S., Farnegardh,M.,
            Gustafsson,J.A. and Treuter,E.
  TITLE     The orphan nuclear receptor SHP utilizes conserved LXXLL-related
            motifs for interactions with ligand-activated estrogen receptors
  JOURNAL   Mol Cell Biol 20 (4), 1124-1133 (2000)
   PUBMED   10648597
REFERENCE   7  (bases 1 to 1165)
  AUTHORS   Lee,Y.K., Dell,H., Dowhan,D.H., Hadzopoulou-Cladaras,M. and
            Moore,D.D.
  TITLE     The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor
            4 and retinoid X receptor transactivation: two mechanisms for
            repression
  JOURNAL   Mol Cell Biol 20 (1), 187-195 (2000)
   PUBMED   10594021
REFERENCE   8  (bases 1 to 1165)
  AUTHORS   Seol,W., Hanstein,B., Brown,M. and Moore,D.D.
  TITLE     Inhibition of estrogen receptor action by the orphan receptor SHP
            (short heterodimer partner)
  JOURNAL   Mol Endocrinol 12 (10), 1551-1557 (1998)
   PUBMED   9773978
REFERENCE   9  (bases 1 to 1165)
  AUTHORS   Lee,H.K., Lee,Y.K., Park,S.H., Kim,Y.S., Park,S.H., Lee,J.W.,
            Kwon,H.B., Soh,J., Moore,D.D. and Choi,H.S.
  TITLE     Structure and expression of the orphan nuclear receptor SHP gene
  JOURNAL   J Biol Chem 273 (23), 14398-14402 (1998)
   PUBMED   9603951
REFERENCE   10 (bases 1 to 1165)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     An orphan nuclear hormone receptor that lacks a DNA binding domain
            and heterodimerizes with other receptors
  JOURNAL   Science 272 (5266), 1336-1339 (1996)
   PUBMED   8650544
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI457167.1 and BC030207.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021969.2.
            
            Summary: The protein encoded by this gene is an unusual orphan
            receptor that contains a putative ligand-binding domain but lacks a
            conventional DNA-binding domain. The gene product is a member of
            the nuclear hormone receptor family, a group of transcription
            factors regulated by small hydrophobic hormones, a subset of which
            do not have known ligands and are referred to as orphan nuclear
            receptors. The protein has been shown to interact with retinoid and
            thyroid hormone receptors, inhibiting their ligand-dependent
            transcriptional activation. In addition, interaction with estrogen
            receptors has been demonstrated, leading to inhibition of function.
            Studies suggest that the protein represses nuclear hormone
            receptor-mediated transactivation via two separate steps:
            competition with coactivators and the direct effects of its
            transcriptional repressor function. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030207.1, BU156944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254227.4/ ENSP00000254227.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AI457167.1         92-100
            10-1165             BC030207.1         1-1156
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1165
                     /gene="NR0B2"
                     /gene_synonym="SHP; SHP1"
                     /note="nuclear receptor subfamily 0 group B member 2"
                     /db_xref="GeneID:8431"
                     /db_xref="HGNC:HGNC:7961"
                     /db_xref="MIM:604630"
     exon            1..567
                     /gene="NR0B2"
                     /gene_synonym="SHP; SHP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..809
                     /gene="NR0B2"
                     /gene_synonym="SHP; SHP1"
                     /note="orphan nuclear receptor SHP; small heterodimer
                     partner"
                     /codon_start=1
                     /product="nuclear receptor subfamily 0 group B member 2"
                     /protein_id="NP_068804.1"
                     /db_xref="CCDS:CCDS291.1"
                     /db_xref="GeneID:8431"
                     /db_xref="HGNC:HGNC:7961"
                     /db_xref="MIM:604630"
                     /translation="MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQH
                     RPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQ
                     DAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLE
                     LSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVL
                     LTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR"
     exon            568..1165
                     /gene="NR0B2"
                     /gene_synonym="SHP; SHP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NR0B2"
                     /gene_synonym="SHP; SHP1"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="NR0B2"
                     /gene_synonym="SHP; SHP1"
                     /note="major polyA site"
ORIGIN      
        1 gccagagagc tggaagtgag agcagatccc taaccatgag caccagccaa ccaggggcct
       61 gcccatgcca gggagctgca agccgccccg ccattctcta cgcacttctg agctccagcc
      121 tcaaggctgt cccccgaccc cgtagccgct gcctatgtag gcagcaccgg cccgtccagc
      181 tatgtgcacc tcatcgcacc tgccgggagg ccttggatgt tctggccaag acagtggcct
      241 tcctcaggaa cctgccatcc ttctggcagc tgcctcccca ggaccagcgg cggctgctgc
      301 agggttgctg gggccccctc ttcctgcttg ggttggccca agatgctgtg acctttgagg
      361 tggctgaggc cccggtgccc agcatactca agaagattct gctggaggag cccagcagca
      421 gtggaggcag tggccaactg ccagacagac cccagccctc cctggctgcg gtgcagtggc
      481 ttcaatgctg tctggagtcc ttctggagcc tggagcttag ccccaaggaa tatgcctgcc
      541 tgaaagggac catcctcttc aaccccgatg tgccaggcct ccaagccgcc tcccacattg
      601 ggcacctgca gcaggaggct cactgggtgc tgtgtgaagt cctggaaccc tggtgcccag
      661 cagcccaagg ccgcctgacc cgtgtcctcc tcacggcctc caccctcaag tccattccga
      721 ccagcctgct tggggacctc ttctttcgcc ctatcattgg agatgttgac atcgctggcc
      781 ttcttgggga catgcttttg ctcaggtgac ctgttccagc ccaggcagag atcaggtggg
      841 cagaggctgg cagtgctgat tcagcctggc catccccaga ggtgacccaa tgctcctgga
      901 gggggcaagc ctgtatagac agcacttggc tccttaggaa cagctcttca ctcagccaca
      961 ccccacattg gacttccttg gtttggacac agtgttccag ctgcctggga ggcttttggt
     1021 ggtccccaca gcctctgggc caagactcct gtcccttctt gggatgagaa tgaaagctta
     1081 ggctgcttat tggaccagaa gtcctatcga ctttatacag aactgaatta agttattgat
     1141 ttttgtaata aaaggtatga aacac
//
