LOCUS       NM_000904               1073 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens N-ribosyldihydronicotinamide:quinone dehydrogenase 2
            (NQO2), transcript variant 3, mRNA.
ACCESSION   NM_000904
VERSION     NM_000904.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Janda,E., Boutin,J.A., De Lorenzo,C. and Arbitrio,M.
  TITLE     Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future
  JOURNAL   Genes (Basel) 15 (1), 87 (2024)
   PUBMED   38254976
  REMARK    GeneRIF: Polymorphisms and Pharmacogenomics of NQO2: The Past and
            the Future.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Nakashima,C., Fujiwara-Tani,R., Mori,S., Kishi,S., Ohmori,H.,
            Fujii,K., Mori,T., Miyagawa,Y., Yamamoto,K., Kirita,T., Luo,Y. and
            Kuniyasu,H.
  TITLE     An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances
            Metastatic Ability in Oral Squamous Cell Carcinoma
  JOURNAL   Int J Mol Sci 23 (18), 10704 (2022)
   PUBMED   36142607
  REMARK    GeneRIF: An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs
            Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Megarity,C.F. and Timson,D.J.
  TITLE     Cancer-associated variants of human NQO1: impacts on inhibitor
            binding and cooperativity
  JOURNAL   Biosci Rep 39 (9) (2019)
   PUBMED   31431515
  REMARK    GeneRIF: Cancer-associated variants of human NQO1: impacts on
            inhibitor binding and cooperativity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Wu,K., Knox,R., Sun,X.Z., Joseph,P., Jaiswal,A.K., Zhang,D.,
            Deng,P.S. and Chen,S.
  TITLE     Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a
            dihydronicotinamide riboside dependent oxidoreductase
  JOURNAL   Arch Biochem Biophys 347 (2), 221-228 (1997)
   PUBMED   9367528
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Zhao,Q., Yang,X.L., Holtzclaw,W.D. and Talalay,P.
  TITLE     Unexpected genetic and structural relationships of a long-forgotten
            flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
  JOURNAL   Proc Natl Acad Sci U S A 94 (5), 1669-1674 (1997)
   PUBMED   9050836
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1997 May 27;94(11):5979]
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Jaiswal,A.K.
  TITLE     Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity,
            and tissue-specific expression
  JOURNAL   J Biol Chem 269 (20), 14502-14508 (1994)
   PUBMED   8182056
REFERENCE   9  (bases 1 to 1073)
  AUTHORS   Jaiswal,A.K., Burnett,P., Adesnik,M. and McBride,O.W.
  TITLE     Nucleotide and deduced amino acid sequence of a human cDNA (NQO2)
            corresponding to a second member of the NAD(P)H:quinone
            oxidoreductase gene family. Extensive polymorphism at the NQO2 gene
            locus on chromosome 6
  JOURNAL   Biochemistry 29 (7), 1899-1906 (1990)
   PUBMED   1691923
REFERENCE   10 (bases 1 to 1073)
  AUTHORS   Jaiswal,A.K., McBride,O.W., Adesnik,M. and Nebert,D.W.
  TITLE     Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase.
            cDNA sequence and localization of gene to chromosome 16
  JOURNAL   J Biol Chem 263 (27), 13572-13578 (1988)
   PUBMED   2843525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133351.34.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 1, 2019 this sequence version replaced NM_000904.5.
            
            Summary: This gene encodes a member of the thioredoxin family of
            enzymes. It is a cytosolic and ubiquitously expressed flavoprotein
            that catalyzes the two-electron reduction of quinone substrates and
            uses dihydronicotinamide riboside as a reducing coenzyme. Mutations
            in this gene have been associated with neurodegenerative diseases
            and several cancers. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK311746.1, J02888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380455.11/ ENSP00000369822.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL133351.34        135858-136049
            193-284             AL133351.34        142432-142523
            285-449             AL133351.34        145989-146153
            450-580             AL133351.34        148508-148638
            581-694             AL133351.34        151494-151607
            695-796             AL133351.34        152848-152949
            797-1073            AL133351.34        155443-155719
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..1073
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /note="N-ribosyldihydronicotinamide:quinone dehydrogenase
                     2"
                     /db_xref="GeneID:4835"
                     /db_xref="HGNC:HGNC:7856"
                     /db_xref="MIM:160998"
     exon            1..192
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     exon            193..284
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..973
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /EC_number="1.10.5.1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2;
                     NAD(P)H quinone dehydrogenase 2;
                     ribosyldihydronicotinamide dehydrogenase; quinone
                     reductase 2; NAD(P)H dehydrogenase, quinone 2; NRH:quinone
                     oxidoreductase 2; N-ribosyldihydronicotinamide:quinone
                     reductase 2"
                     /codon_start=1
                     /product="ribosyldihydronicotinamide dehydrogenase
                     [quinone] isoform 1"
                     /protein_id="NP_000895.2"
                     /db_xref="CCDS:CCDS4481.1"
                     /db_xref="GeneID:4835"
                     /db_xref="HGNC:HGNC:7856"
                     /db_xref="MIM:160998"
                     /translation="MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYA
                     MNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQF
                     PLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTG
                     VNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKE
                     EPIPCTAHWHFGQ"
     exon            285..449
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..580
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..694
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..796
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1073
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="NQO2"
                     /gene_synonym="DHQV; DIA6; NMOR2; QR2"
                     /note="major polyA site"
ORIGIN      
        1 gcaggttccg ggctgcttag gttggcaccg gtccgtggtc cccgggggcg cagtcgcagc
       61 gctcccgccc tccaggcgtc agcgagtgcg cggtccagtg cggccggaac ctggcgcaac
      121 tcctagagcg gtccttgggg agacgcgggt cccagtcctg cggctcctac tggggagtgc
      181 gctggtcgga agattgctgg actcgctgaa gagagactac gcaggaaagc cccagccacc
      241 catcaaatca gagagaagga atccaccttc ttacgctatg gcaggtaaga aagtactcat
      301 tgtctatgca caccaggaac ccaagtcttt caacggatcc ttgaagaatg tggctgtaga
      361 tgaactgagc aggcagggct gcaccgtcac agtgtctgat ttgtatgcca tgaaccttga
      421 gccgagggcc acagacaaag atatcactgg tactctttct aatcctgagg ttttcaatta
      481 tggagtggaa acccacgaag cctacaagca aaggtctctg gctagcgaca tcactgatga
      541 gcagaaaaag gttcgggagg ctgacctagt gatatttcag ttcccgctgt actggttcag
      601 cgtgccagcc atcctgaagg gctggatgga tagggtgctg tgccagggct ttgcctttga
      661 catcccagga ttctacgatt ccggtttgct ccagggtaaa ctagcgctcc tttccgtaac
      721 cacgggaggc acggccgaga tgtacacgaa gacaggagtc aatggagatt ctcgatactt
      781 cctgtggcca ctccagcatg gcacattaca cttctgtgga tttaaagtcc ttgcccctca
      841 gatcagcttt gctcctgaaa ttgcatccga agaagaaaga aaggggatgg tggctgcgtg
      901 gtcccagagg ctgcagacca tctggaagga agagcccatc ccctgcacag cccactggca
      961 cttcgggcaa taactctgtg gcacgtgggc atcacgtaag cagcacacta ggaggcccag
     1021 gcgcaggcaa agagaagatg gtgctgtcat gaaataaaat tacaacatag cta
//
