LOCUS       NM_000903               2521 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript
            variant 1, mRNA.
ACCESSION   NM_000903
VERSION     NM_000903.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   Chen,H., Li,H., He,M., Lai,Z., Huang,L., Wen,D., Shi,M. and Kan,A.
  TITLE     UBA2 SUMOylates NQO1 and promotes the proliferation of
            hepatocellular carcinoma by modulating the MAPK pathway
  JOURNAL   Cancer Sci 115 (9), 2998-3012 (2024)
   PUBMED   39013843
  REMARK    GeneRIF: UBA2 SUMOylates NQO1 and promotes the proliferation of
            hepatocellular carcinoma by modulating the MAPK pathway.
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Wang,M., Shen,Y., Gao,Y., Chen,H., Duan,F., Li,S. and Wang,G.
  TITLE     NQO1 polymorphism and susceptibility to ischemic stroke in a
            Chinese population
  JOURNAL   BMC Med Genomics 17 (1), 219 (2024)
   PUBMED   39174970
  REMARK    GeneRIF: NQO1 polymorphism and susceptibility to ischemic stroke in
            a Chinese population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Zhang,X., Yang,Y., Zhao,H., Tian,Z., Cao,Q., Li,Y., Gu,Y., Song,Q.,
            Hu,X., Jin,M. and Jiang,X.
  TITLE     Correlation of PD-L1 expression with CD8+ T cells and oxidative
            stress-related molecules NRF2 and NQO1 in esophageal squamous cell
            carcinoma
  JOURNAL   J Pathol Clin Res 10 (4), e12390 (2024)
   PUBMED   38992928
  REMARK    GeneRIF: Correlation of PD-L1 expression with CD8+ T cells and
            oxidative stress-related molecules NRF2 and NQO1 in esophageal
            squamous cell carcinoma.
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Matsumoto,H., Sasai,H., Kawamoto,N., Katsuyama,M., Minamiyama,M.,
            Kuru,S., Fukao,T. and Ohnishi,H.
  CONSRTM   SMON Research Group Members
  TITLE     Loss-of-function polymorphisms in NQO1 are not associated with the
            development of subacute myelo-optico-neuropathy
  JOURNAL   Mol Genet Genomic Med 12 (6), e2470 (2024)
   PUBMED   38860482
  REMARK    GeneRIF: Loss-of-function polymorphisms in NQO1 are not associated
            with the development of subacute myelo-optico-neuropathy.
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   Li,Y. and Jaiswal,A.K.
  TITLE     Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of
            AP1 binding site contained within human antioxidant response
            element
  JOURNAL   J Biol Chem 267 (21), 15097-15104 (1992)
   PUBMED   1340765
  REMARK    Erratum:[J Biol Chem. 1993 Oct 5;268(28):21454.. PMID: 8407991]
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Traver,R.D., Horikoshi,T., Danenberg,K.D., Stadlbauer,T.H.,
            Danenberg,P.V., Ross,D. and Gibson,N.W.
  TITLE     NAD(P)H:quinone oxidoreductase gene expression in human colon
            carcinoma cells: characterization of a mutation which modulates
            DT-diaphorase activity and mitomycin sensitivity
  JOURNAL   Cancer Res 52 (4), 797-802 (1992)
   PUBMED   1737339
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Jaiswal,A.K.
  TITLE     Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and
            induction by dioxin
  JOURNAL   Biochemistry 30 (44), 10647-10653 (1991)
   PUBMED   1657151
REFERENCE   9  (bases 1 to 2521)
  AUTHORS   Chen,L.Z., Harris,P.C., Apostolou,S., Baker,E., Holman,K.,
            Lane,S.A., Nancarrow,J.K., Whitmore,S.A., Stallings,R.L.,
            Hildebrand,C.E. et al.
  TITLE     A refined physical map of the long arm of human chromosome 16
  JOURNAL   Genomics 10 (2), 308-312 (1991)
   PUBMED   2071140
REFERENCE   10 (bases 1 to 2521)
  AUTHORS   Jaiswal,A.K., McBride,O.W., Adesnik,M. and Nebert,D.W.
  TITLE     Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase.
            cDNA sequence and localization of gene to chromosome 16
  JOURNAL   J Biol Chem 263 (27), 13572-13578 (1988)
   PUBMED   2843525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM452267.1, BC007659.2,
            BM052991.1, BM787983.1, BM828301.1 and AV729122.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000903.2.
            
            Summary: This gene is a member of the NAD(P)H dehydrogenase
            (quinone) family and encodes a cytoplasmic 2-electron reductase.
            This FAD-binding protein forms homodimers and reduces quinones to
            hydroquinones. This protein's enzymatic activity prevents the one
            electron reduction of quinones that results in the production of
            radical species. Mutations in this gene have been associated with
            tardive dyskinesia (TD), an increased risk of hematotoxicity after
            exposure to benzene, and susceptibility to various forms of cancer.
            Altered expression of this protein has been seen in many tumors and
            is also associated with Alzheimer's disease (AD). Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.15706.1,
                                           SRR1803614.237687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153946, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320623.10/ ENSP00000319788.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BM452267.1         282-299
            19-1081             BC007659.2         15-1077
            1082-1593           BM052991.1         79-590
            1594-1929           BM787983.1         296-631
            1930-2407           BM828301.1         229-706
            2408-2521           AV729122.1         233-346
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2521
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /note="NAD(P)H quinone dehydrogenase 1"
                     /db_xref="GeneID:1728"
                     /db_xref="HGNC:HGNC:2874"
                     /db_xref="MIM:125860"
     exon            1..128
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..946
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /EC_number="1.6.5.2"
                     /note="isoform a is encoded by transcript variant 1;
                     diaphorase (NADH/NADPH) (cytochrome b-5 reductase);
                     NAD(P)H:Quinone acceptor oxidoreductase type 1; quinone
                     reductase 1; DT-diaphorase; azoreductase; phylloquinone
                     reductase; menadione reductase; NAD(P)H:quinone
                     oxireductase; dioxin-inducible 1; NAD(P)H:menadione
                     oxidoreductase 1; diaphorase-4; NAD(P)H dehydrogenase,
                     quinone 1; NAD(P)H:quinone oxidoreductase 1;
                     NAD(P)H-quinone oxidoreductase"
                     /codon_start=1
                     /product="NAD(P)H dehydrogenase [quinone] 1 isoform a"
                     /protein_id="NP_000894.1"
                     /db_xref="CCDS:CCDS10883.1"
                     /db_xref="GeneID:1728"
                     /db_xref="HGNC:HGNC:2874"
                     /db_xref="MIM:125860"
                     /translation="MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYA
                     MNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQF
                     PLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQG
                     IHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDE
                     TPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK"
     exon            129..293
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..424
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..538
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..640
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2521
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1057..1062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /note="hexamer: AATAAA"
     polyA_site      1081
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /note="major polyA site"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="NQO1"
                     /gene_synonym="DHQU; DIA4; DTD; NMOR1; NMORI; QR1"
ORIGIN      
        1 acacgcgact cccacaaggt tgcagccgga gccgcccagc tcaccgagag cctagttccg
       61 gccagggtcg ccccggcaac cacgagccca gccaatcagc gccccggact gcaccagagc
      121 catggtcggc agaagagcac tgatcgtact ggctcactca gagaggacgt ccttcaacta
      181 tgccatgaag gaggctgctg cagcggcttt gaagaagaaa ggatgggagg tggtggagtc
      241 ggacctctat gccatgaact tcaatcccat catttccaga aaggacatca caggtaaact
      301 gaaggaccct gcgaactttc agtatcctgc cgagtctgtt ctggcttata aagaaggcca
      361 tctgagccca gatattgtgg ctgaacaaaa gaagctggaa gccgcagacc ttgtgatatt
      421 ccagttcccc ctgcagtggt ttggagtccc tgccattctg aaaggctggt ttgagcgagt
      481 gttcatagga gagtttgctt acacttacgc tgccatgtat gacaaaggac ccttccggag
      541 taagaaggca gtgctttcca tcaccactgg tggcagtggc tccatgtact ctctgcaagg
      601 gatccacggg gacatgaatg tcattctctg gccaattcag agtggcattc tgcatttctg
      661 tggcttccaa gtcttagaac ctcaactgac atatagcatt gggcacactc cagcagacgc
      721 ccgaattcaa atcctggaag gatggaagaa acgcctggag aatatttggg atgagacacc
      781 actgtatttt gctccaagca gcctctttga cctaaacttc caggcaggat tcttaatgaa
      841 aaaagaggta caggatgagg agaaaaacaa gaaatttggc ctttctgtgg gccatcactt
      901 gggcaagtcc atcccaactg acaaccagat caaagctaga aaatgagatt ccttagcctg
      961 gatttccttc taacatgtta tcaaatctgg gtatctttcc aggcttccct gacttgcttt
     1021 agtttttaag atttgtgttt ttctttttcc acaaggaata aatgagaggg aatcgactgt
     1081 attcgtgcat ttttggatca tttttaactg attcttatga ttactatcat ggcatataac
     1141 caaaatccga ctgggctcaa gaggccactt agggaaagat gtagaaagat gctagaaaaa
     1201 tgttctttaa aggcatctac acaatttaat tcctcttttt agggctaaag ttttagggta
     1261 cagtttggct aggtatcatt caactctcca atgttctatt aatcacctct ctgtagttta
     1321 tggcagaagg gaattgctca gagaaggaaa agactgaatc tacctgccct aagggactta
     1381 acttgtttgg tagttagcca tctaatgctt gtttatgata tttcttgctt tcaattacaa
     1441 agcagttact aatatgccta gcacaagtac cactcttggt cagcttttgt tgtttatata
     1501 cagtacacag ataccttgaa aggaagagct aataaatctc ttctttgctg cagtcatcta
     1561 cttttttttt aattaaaaaa aatttttttt tgaagcagtc ttgctctgtt acccaggctg
     1621 gagtgcagtg gtgtgatctc ggctcactgc aacctctgcc tcccaggttc cagcaattct
     1681 cctgcctcag cctccctagt agctgggatg acaggcgcct gccatcatgc ctgactaatt
     1741 tttgtatttt tagtagagac ggcgtttcac catgttggcc aggctggtct caaactcctg
     1801 acctcaggtg atccgcctac ctcagcctcc caaagtgctg ggattacagg cgtgatccac
     1861 cacacctggc ccttgcaatc ttctacttta aggtttgcag agataaacca ataaatccac
     1921 accgtacatc tgcaatatga attcaagaaa ggaaatagta ccttcaatac ttaaaaatag
     1981 tcttccacaa aaaatacttt atttctgatc tatacaaatt ttcagaaggt tattttcttt
     2041 atcattgcta aactgatgac ttactatggg atggggtcca gtcccatgac cttggggtac
     2101 aattgtaaac ctagagtttt atcaactttg gtgaacagtt ttggcataat agtcaatttc
     2161 tacttctgga agtcatctca ttccactgtt ggtattatat aattcaagga gaatatgata
     2221 aaacactgcc ctcttgtggt gcattgaaag aagagatgag aaatgatgaa aaggttgcct
     2281 gaaaaatggg agacagcctc ttacttgcca agaaaatgaa gggattggac cgagctggaa
     2341 aacctccttt accagatgct gactggcact ggtggttttt gctctcgaca gtatccacaa
     2401 tagctgacgg ctgggtgttt cagtttgaaa atattttgtt gccttcatct tcactgcaat
     2461 tttgtgtaaa tttctcaaag atctgaatta aataaataaa attcatttct acagacccac
     2521 a
//
