LOCUS       NM_006174               1890 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neuropeptide Y receptor Y5 (NPY5R), transcript variant
            2, mRNA.
ACCESSION   NM_006174
VERSION     NM_006174.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Liu,B. and Chen,F.
  TITLE     Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and
            secretion through neuropeptide Y Y5 receptor
  JOURNAL   Peptides 154, 170824 (2022)
   PUBMED   35660638
  REMARK    GeneRIF: Neuropeptide Y promotes hepatic apolipoprotein A1
            synthesis and secretion through neuropeptide Y Y5 receptor.
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Medeiros,P.J., Pascetta,S.A., Kirsh,S.M., Al-Khazraji,B.K. and
            Uniacke,J.
  TITLE     Expression of hypoxia inducible factor-dependent neuropeptide Y
            receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation
  JOURNAL   J Biol Chem 298 (3), 101645 (2022)
   PUBMED   35093384
  REMARK    GeneRIF: Expression of hypoxia inducible factor-dependent
            neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY
            stimulation.
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Dietrich,P., Wormser,L., Fritz,V., Seitz,T., De Maria,M.,
            Schambony,A., Kremer,A.E., Gunther,C., Itzel,T., Thasler,W.E.,
            Teufel,A., Trebicka,J., Hartmann,A., Neurath,M.F., von Horsten,S.,
            Bosserhoff,A.K. and Hellerbrand,C.
  TITLE     Molecular crosstalk between Y5 receptor and neuropeptide Y drives
            liver cancer
  JOURNAL   J Clin Invest 130 (5), 2509-2526 (2020)
   PUBMED   31999643
  REMARK    GeneRIF: Molecular crosstalk between Y5 receptor and neuropeptide Y
            drives liver cancer.
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Chatree,S., Sitticharoon,C., Maikaew,P., Uawithya,P. and
            Chearskul,S.
  TITLE     Adipose Y5R mRNA is higher in obese than non-obese humans and is
            correlated with obesity parameters
  JOURNAL   Exp Biol Med (Maywood) 243 (9), 786-795 (2018)
   PUBMED   29763369
  REMARK    GeneRIF: Y1R and Y5R might be the dominant receptors that mediate
            the effect of NPY-induced fat accumulation in both subcutaneous and
            visceral adipose tissues. Y1R and Y5R in visceral adipose tissue
            might be targets of drug development in prevention or treatment of
            obesity.
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Czarnecka,M., Trinh,E., Lu,C., Kuan-Celarier,A., Galli,S.,
            Hong,S.H., Tilan,J.U., Talisman,N., Izycka-Swieszewska,E.,
            Tsuei,J., Yang,C., Martin,S., Horton,M., Christian,D., Everhart,L.,
            Maheswaran,I. and Kitlinska,J.
  TITLE     Neuropeptide Y receptor Y5 as an inducible pro-survival factor in
            neuroblastoma: implications for tumor chemoresistance
  JOURNAL   Oncogene 34 (24), 3131-3143 (2015)
   PUBMED   25132261
  REMARK    GeneRIF: NPY5R is an inducible pro-survival factor that is
            responsible for chemoresistance in neuroblastoma cells.
REFERENCE   6  (bases 1 to 1890)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   7  (bases 1 to 1890)
  AUTHORS   Herzog,H., Darby,K., Ball,H., Hort,Y., Beck-Sickinger,A. and
            Shine,J.
  TITLE     Overlapping gene structure of the human neuropeptide Y receptor
            subtypes Y1 and Y5 suggests coordinate transcriptional regulation
  JOURNAL   Genomics 41 (3), 315-319 (1997)
   PUBMED   9169127
REFERENCE   8  (bases 1 to 1890)
  AUTHORS   Hu,Y., Bloomquist,B.T., Cornfield,L.J., DeCarr,L.B.,
            Flores-Riveros,J.R., Friedman,L., Jiang,P., Lewis-Higgins,L.,
            Sadlowski,Y., Schaefer,J., Velazquez,N. and McCaleb,M.L.
  TITLE     Identification of a novel hypothalamic neuropeptide Y receptor
            associated with feeding behavior
  JOURNAL   J Biol Chem 271 (42), 26315-26319 (1996)
   PUBMED   8824284
REFERENCE   9  (bases 1 to 1890)
  AUTHORS   Gerald,C., Walker,M.W., Criscione,L., Gustafson,E.L.,
            Batzl-Hartmann,C., Smith,K.E., Vaysse,P., Durkin,M.M., Laz,T.M.,
            Linemeyer,D.L., Schaffhauser,A.O., Whitebread,S., Hofbauer,K.G.,
            Taber,R.I., Branchek,T.A. and Weinshank,R.L.
  TITLE     A receptor subtype involved in neuropeptide-Y-induced food intake
  JOURNAL   Nature 382 (6587), 168-171 (1996)
   PUBMED   8700207
REFERENCE   10 (bases 1 to 1890)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI464162.1 and BC042416.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006174.3.
            
            Summary: The protein encoded by this gene is a receptor for
            neuropeptide Y and peptide YY. The encoded protein appears to be
            involved in regulating food intake, with defects in this gene being
            associated with eating disorders. Also, the encoded protein is
            involved in a pathway that protects neuroblastoma cells from
            chemotherapy-induced cell death, providing a possible therapeutic
            target against neuroblastoma. Three transcript variants encoding
            the same protein have been found for this gene. [provided by
            RefSeq, Nov 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042416.1, SRR1660809.113734.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338566.8/ ENSP00000339377.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BI464162.1         51-97
            48-1890             BC042416.1         1-1843
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.2"
     gene            1..1890
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /note="neuropeptide Y receptor Y5"
                     /db_xref="GeneID:4889"
                     /db_xref="HGNC:HGNC:7958"
                     /db_xref="MIM:602001"
     exon            1..109
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /inference="alignment:Splign:2.1.0"
     exon            110..149
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /inference="alignment:Splign:2.1.0"
     exon            150..220
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1890
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1567
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /note="Y5 receptor; NPY-Y5 receptor"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 5"
                     /protein_id="NP_006165.1"
                     /db_xref="CCDS:CCDS3804.1"
                     /db_xref="GeneID:4889"
                     /db_xref="HGNC:HGNC:7958"
                     /db_xref="MIM:602001"
                     /translation="MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFL
                     IGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSV
                     LLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLI
                     ATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLV
                     QYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHK
                     WSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVP
                     TCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTD
                     FNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /note="hexamer: AGTAAA"
     polyA_site      1890
                     /gene="NPY5R"
                     /gene_synonym="NPY5-R; NPYR5; NPYY5-R"
                     /note="major polyA site"
ORIGIN      
        1 gcctccaggt cctgctcccg ctgctgccgc caccgccggg gtgcaggagc gatcgcgctg
       61 ggccgcgctc ccgggagccc agggcctgca gcggccgggg cgccccgagg tctgctcatt
      121 gtgtttttca ggaaaaagga agggaaaggg tgttacaagg aaaggctatc ggtaacaact
      181 gacctgccac aaagttagaa gaaaggattg attcaagaaa gactataata tggatttaga
      241 gctcgacgag tattataaca agacacttgc cacagagaat aatactgctg ccactcggaa
      301 ttctgatttc ccagtctggg atgactataa aagcagtgta gatgacttac agtattttct
      361 gattgggctc tatacatttg taagtcttct tggctttatg gggaatctac ttattttaat
      421 ggctctcatg aaaaagcgta atcagaagac tacggtaaac ttcctcatag gcaatctggc
      481 cttttctgat atcttggttg tgctgttttg ctcacctttc acactgacgt ctgtcttgct
      541 ggatcagtgg atgtttggca aagtcatgtg ccatattatg ccttttcttc aatgtgtgtc
      601 agttttggtt tcaactttaa ttttaatatc aattgccatt gtcaggtatc atatgataaa
      661 acatcccata tctaataatt taacagcaaa ccatggctac tttctgatag ctactgtctg
      721 gacactaggt tttgccatct gttctcccct tccagtgttt cacagtcttg tggaacttca
      781 agaaacattt ggttcagcat tgctgagcag caggtattta tgtgttgagt catggccatc
      841 tgattcatac agaattgcct ttactatctc tttattgcta gttcagtata ttctgccctt
      901 agtttgtctt actgtaagtc atacaagtgt ctgcagaagt ataagctgtg gattgtccaa
      961 caaagaaaac agacttgaag aaaatgagat gatcaactta actcttcatc catccaaaaa
     1021 gagtgggcct caggtgaaac tctctggcag ccataaatgg agttattcat tcatcaaaaa
     1081 acacagaaga agatatagca agaagacagc atgtgtgtta cctgctccag aaagaccttc
     1141 tcaagagaac cactccagaa tacttccaga aaactttggc tctgtaagaa gtcagctctc
     1201 ttcatccagt aagttcatac caggggtccc cacttgcttt gagataaaac ctgaagaaaa
     1261 ttcagatgtt catgaattga gagtaaaacg ttctgttaca agaataaaaa agagatctcg
     1321 aagtgttttc tacagactga ccatactgat attagtattt gctgttagtt ggatgccact
     1381 acaccttttc catgtggtaa ctgattttaa tgacaatctt atttcaaata ggcatttcaa
     1441 gttggtgtat tgcatttgtc atttgttggg catgatgtcc tgttgtctta atccaattct
     1501 atatgggttt cttaataatg ggattaaagc tgatttagtg tcccttatac actgtcttca
     1561 tatgtaataa ttctcactgt ttaccaagga aagaacaaat gctggggtca tataaaatat
     1621 atttatgata actatttaca tataataaat agaaattttg ttaacatgga atttaattta
     1681 tgtgaaagag ttctggattc aaatgtcagt tcataatata tggaagataa ttttatgtgt
     1741 tatagtagga ttaatttatt tagttgtgca gtcagtgtca atccaatctg taatttcact
     1801 ttagaaggtt gtattacctt ccacttccat gttgtcttat aaacaaatga attgtatttt
     1861 ttgttgaaag taaaagttat atctaaccaa
//
