LOCUS       NM_005972               2033 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neuropeptide Y receptor Y4 (NPY4R), transcript variant
            1, mRNA.
ACCESSION   NM_005972 XM_001129329
VERSION     NM_005972.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Choong,Y.S., Lim,Y.Y., Soong,J.X., Savoo,N., Guida,C., Rhyman,L.,
            Ramracheya,R. and Ramasami,P.
  TITLE     Theoretical study of the interactions between peptide tyrosine
            tyrosine [PYY (1-36)], a newly identified modulator in type 2
            diabetes pathophysiology, with receptors NPY1R and NPY4R
  JOURNAL   Hormones (Athens) 20 (3), 557-569 (2021)
   PUBMED   33782920
  REMARK    GeneRIF: Theoretical study of the interactions between peptide
            tyrosine tyrosine [PYY (1-36)], a newly identified modulator in
            type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Shebanits,K., Andersson-Assarsson,J.C., Larsson,I.,
            Carlsson,L.M.S., Feuk,L. and Larhammar,D.
  TITLE     Copy number of pancreatic polypeptide receptor gene NPY4R
            correlates with body mass index and waist circumference
  JOURNAL   PLoS One 13 (4), e0194668 (2018)
   PUBMED   29621259
  REMARK    GeneRIF: Our results suggest that NPY4R genetic variation
            influences body weight in women, but the exact role of this
            receptor appears to be more complex than previously proposed.
            Erratum:[PLoS One. 2022 Oct 12;17(10):e0276288. doi:
            10.1371/journal.pone.0276288.. PMID: 36223423]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Wanka,L., Babilon,S., Burkert,K., Morl,K., Gurevich,V.V. and
            Beck-Sickinger,A.G.
  TITLE     C-terminal motif of human neuropeptide Y4 receptor determines
            internalization and arrestin recruitment
  JOURNAL   Cell Signal 29, 233-239 (2017)
   PUBMED   27818291
  REMARK    GeneRIF: the internalization motif for the human neuropeptide Y4
            receptor, which regulates arrestin-3 recruitment and receptor
            endocytosis, was identified.
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Aerts,E., Beckers,S., Zegers,D., Van Hoorenbeeck,K., Massa,G.,
            Verrijken,A., Verhulst,S.L., Van Gaal,L.F. and Van Hul,W.
  TITLE     CNV analysis and mutation screening indicate an important role for
            the NPY4R gene in human obesity
  JOURNAL   Obesity (Silver Spring) 24 (4), 970-976 (2016)
   PUBMED   26921218
  REMARK    GeneRIF: A copy number variation (CNV) analysis demonstrated a
            significantly higher frequency of NPY4R containing 10q11.22 CNV
            loss in the patient population, while CNV gain in this region was
            more prevalent in the control population. Mutation analysis
            resulted in the identification of 15 rare non-synonymous
            heterozygous variants. Two variants in the patient population
            demonstrated receptor dysfunction and a pathogenic effect.
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Wang,Z., Ma,B., Li,H., Xiao,X., Zhou,W., Liu,F., Zhang,B., Zhu,M.,
            Yang,Q., Zeng,Y., Sun,Y., Sun,S., Wang,Y., Zhang,Y., Weng,H.,
            Chen,L., Ye,M., An,X. and Liu,J.
  TITLE     Protein 4.1N acts as a potential tumor suppressor linking PP1 to
            JNK-c-Jun pathway regulation in NSCLC
  JOURNAL   Oncotarget 7 (1), 509-523 (2016)
   PUBMED   26575790
  REMARK    GeneRIF: Data suggest that repression of JNK-c-Jun signaling
            through pancreatic polypeptide receptor 1 (PP1) is one of the key
            anti-tumor mechanisms of neuronal membrane cytoskeletal protein 4.1
            (4.1N).
            Erratum:[Oncotarget. 2019 Oct 22;10(58):6285. doi:
            10.18632/oncotarget.27282.. PMID: 31692885]
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Yan,H., Yang,J., Marasco,J., Yamaguchi,K., Brenner,S., Collins,F.
            and Karbon,W.
  TITLE     Cloning and functional expression of cDNAs encoding human and rat
            pancreatic polypeptide receptors
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4661-4665 (1996)
   PUBMED   8643460
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Lundell,I., Blomqvist,A.G., Berglund,M.M., Schober,D.A.,
            Johnson,D., Statnick,M.A., Gadski,R.A., Gehlert,D.R. and
            Larhammar,D.
  TITLE     Cloning of a human receptor of the NPY receptor family with high
            affinity for pancreatic polypeptide and peptide YY
  JOURNAL   J Biol Chem 270 (49), 29123-29128 (1995)
   PUBMED   7493937
REFERENCE   9  (bases 1 to 2033)
  AUTHORS   Bard,J.A., Walker,M.W., Branchek,T.A. and Weinshank,R.L.
  TITLE     Cloning and functional expression of a human Y4 subtype receptor
            for pancreatic polypeptide, neuropeptide Y, and peptide YY
  JOURNAL   J Biol Chem 270 (45), 26762-26765 (1995)
   PUBMED   7592911
REFERENCE   10 (bases 1 to 2033)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244230.3.
            
            On May 17, 2019 this sequence version replaced NM_005972.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY649985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374312.5/ ENSP00000363431.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AC244230.3         178671-178951       c
            282-437             AC244230.3         176723-176878       c
            438-2033            AC244230.3         174092-175687       c
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..2033
                     /gene="NPY4R"
                     /gene_synonym="NPY4-R; PP1; PPYR1; Y4"
                     /note="neuropeptide Y receptor Y4"
                     /db_xref="GeneID:5540"
                     /db_xref="HGNC:HGNC:9329"
                     /db_xref="MIM:601790"
     exon            1..281
                     /gene="NPY4R"
                     /gene_synonym="NPY4-R; PP1; PPYR1; Y4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..437
                     /gene="NPY4R"
                     /gene_synonym="NPY4-R; PP1; PPYR1; Y4"
                     /inference="alignment:Splign:2.1.0"
     exon            438..2033
                     /gene="NPY4R"
                     /gene_synonym="NPY4-R; PP1; PPYR1; Y4"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..1624
                     /gene="NPY4R"
                     /gene_synonym="NPY4-R; PP1; PPYR1; Y4"
                     /note="pancreatic polypeptide receptor 1"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 4"
                     /protein_id="NP_005963.4"
                     /db_xref="CCDS:CCDS73100.1"
                     /db_xref="GeneID:5540"
                     /db_xref="HGNC:HGNC:9329"
                     /db_xref="MIM:601790"
                     /translation="MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFI
                     VTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYT
                     IMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGI
                     VLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFL
                     LLFQYCLPLGFILVCYARIYRCLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAV
                     LWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIK
                     ALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI"
ORIGIN      
        1 actccgcacg caggcagcat cggggcagca ggagcaggtg aagcaggcgc ggctctgccc
       61 cgcgcctggt gccccctggg cacaggagtg cggccggggg cggggccgag tgggccccgg
      121 tacgaaccct ccgggaagcc gggcgcgctg cctgcccttg gcccggggcg cagagcgtca
      181 cactggatct ggggagcatc ctacccccac tgtggacctc agtctcctca cctgagacat
      241 gggcggcccc atccgcaccc tgtaagccgc aagccaagga gattcctggc ccccatcctg
      301 gattcactta actacatctc ctggtggaag ggccctggga tctgcacttt caacatgctt
      361 ctagaatgat tctgatgttt actgaaggtt gagaactgca accctgtggg attaataatg
      421 actagagaat ctgagaggcg tcatccctca agtgtatcac ttagttcaag agtcctggaa
      481 tcttttcaca tccactatga acacctctca cctcctggcc ttgctgctcc caaaatctcc
      541 acaaggtgaa aacagaagca aacccctggg caccccatac aacttctctg aacattgcca
      601 ggattccgtg gacgtgatgg tcttcatcgt cacttcctac agcattgaga ctgtcgtggg
      661 ggtcctgggt aacctctgcc tgatgtgtgt gactgtgagg cagaaggaga aagccaacgt
      721 gaccaacctg cttatcgcca acctggcctt ctctgacttc ctcatgtgcc tcctctgcca
      781 gccgctgacc gccgtctaca ccatcatgga ctactggatc tttggagaga ccctctgcaa
      841 gatgtcggcc ttcatccagt gcatgtcggt gacggtctcc atcctctcgc tcgtcctcgt
      901 ggccctggag aggcatcagc tcatcatcaa cccaacaggc tggaagccca gcatctcaca
      961 ggcctacctg gggattgtgc tcatctgggt cattgcctgt gtcctctccc tgcccttcct
     1021 ggccaacagc atcctggaga atgtcttcca caagaaccac tccaaggctc tggagttcct
     1081 ggcggataag gtggtctgta ccgagtcctg gccactggct caccaccgca ccatctacac
     1141 caccttcctg ctcctcttcc agtactgcct cccactgggc ttcatcttgg tctgttatgc
     1201 acgcatctac cggtgcctgc agaggcaggg gcgcgtgttt cacaagggca cctacagctt
     1261 gcgagctggg cacatgaagc aggtcaatgt ggtgctggtg gtgatggtgg tggcctttgc
     1321 cgtgctctgg ctgcctctgc atgtgttcaa cagcctggaa gactggcacc atgaggccat
     1381 ccccatctgc catgggaacc tcatcttctt agtgtgccac ttgcttgcca tggcctccac
     1441 ctgtgtcaac ccattcatct atggctttct caacaccaac ttcaagaagg agatcaaggc
     1501 cctggtgctg acttgccagc agagcgcccc cctggaggag tcagagcatc tgcccctgtc
     1561 cacagtacat acggaagtct ccaaagggtc cctgaggcta agtggcaggt ccaatcccat
     1621 ttaaccaggt ctaggtcttc tccctgccat gtcccttgcc aggctcttcc acttagctaa
     1681 gtgggcacac tgcaagctgg ggtggcaccc cagcattcct ggctttctgg ggtccagata
     1741 ggctggcaag agctgttttt gcatccattt gcatcgtgaa gactggcatt ttgatacttc
     1801 agctgtttgt tcctgggaga attctgagca cagattccag aggtcacagt aagccttgca
     1861 gcttgagctg aaagatgcca gagccggaga tgtctgctgg cagcaggcag ggttcattct
     1921 ggtgacacag caacagatgc ctggcctggg aacccaggga tttcacctcc accagtgaga
     1981 ccacggggcc actgtggggt gagggaagga gcgcttggag tcagagctct aga
//
