LOCUS       NM_000910               3619 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens neuropeptide Y receptor Y2 (NPY2R), transcript variant
            1, mRNA.
ACCESSION   NM_000910
VERSION     NM_000910.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3619)
  AUTHORS   Kang,H., Park,C., Choi,Y.K., Bae,J., Kwon,S., Kim,J., Choi,C.,
            Seok,C., Im,W. and Choi,H.J.
  TITLE     Structural basis for Y2 receptor-mediated neuropeptide Y and
            peptide YY signaling
  JOURNAL   Structure 31 (1), 44-57 (2023)
   PUBMED   36525977
  REMARK    GeneRIF: Structural basis for Y2 receptor-mediated neuropeptide Y
            and peptide YY signaling.
REFERENCE   2  (bases 1 to 3619)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3619)
  AUTHORS   Wickham,J., Ledri,M., Bengzon,J., Jespersen,B., Pinborg,L.H.,
            Englund,E., Woldbye,D.P.D., Andersson,M. and Kokaia,M.
  TITLE     Inhibition of epileptiform activity by neuropeptide Y in brain
            tissue from drug-resistant temporal lobe epilepsy patients
  JOURNAL   Sci Rep 9 (1), 19393 (2019)
   PUBMED   31852985
  REMARK    GeneRIF: Inhibition of epileptiform activity by neuropeptide Y in
            brain tissue from drug-resistant temporal lobe epilepsy patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3619)
  AUTHORS   Derkac,I., Januleviciene,I., Sepetiene,R., Valiauga,R. and
            Velickiene,D.
  TITLE     The Association of CEP135 rs4865047 and NPY2R rs1902491 Single
            Nucleotide Polymorphisms (SNPs) with Rapid Progression of
            Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes
            Mellitus
  JOURNAL   Med Sci Monit 24, 8891-8898 (2018)
   PUBMED   30531682
  REMARK    GeneRIF: The analysis of the distribution of genotypes in CEP135
            rs4865047 and NPY2R rs1902491 detected significant differences only
            in the single nucleotide polymorphism rs4865047 genotype between
            the case and control group in comparison to the reference group.
            No significant association was found for the NPY2R SNP rs1902491
            genotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3619)
  AUTHORS   Aerts,E., Geets,E., Sorber,L., Beckers,S., Verrijken,A., Massa,G.,
            Van Hoorenbeeck,K., Verhulst,S.L., Van Gaal,L.F. and Van Hul,W.
  TITLE     Evaluation of a Role for NPY and NPY2R in the Pathogenesis of
            Obesity by Mutation and Copy Number Variation Analysis in Obese
            Children and Adolescents
  JOURNAL   Ann Hum Genet 82 (1), 1-10 (2018)
   PUBMED   28857123
  REMARK    GeneRIF: genetic variation in NPY and NPY2R is at low frequency and
            thus does not make a major contribution to the obese phenotype in
            the general population
REFERENCE   6  (bases 1 to 3619)
  AUTHORS   Gerald,C., Walker,M.W., Vaysse,P.J., He,C., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Expression cloning and pharmacological characterization of a human
            hippocampal neuropeptide Y/peptide YY Y2 receptor subtype
  JOURNAL   J Biol Chem 270 (45), 26758-26761 (1995)
   PUBMED   7592910
REFERENCE   7  (bases 1 to 3619)
  AUTHORS   Rose,P.M., Fernandes,P., Lynch,J.S., Frazier,S.T., Fisher,S.M.,
            Kodukula,K., Kienzle,B. and Seethala,R.
  TITLE     Cloning and functional expression of a cDNA encoding a human type 2
            neuropeptide Y receptor
  JOURNAL   J Biol Chem 270 (39), 22661-22664 (1995)
   PUBMED   7559383
  REMARK    Erratum:[J Biol Chem. 1995 Dec 1;270(48):29038.. PMID: 7499438]
REFERENCE   8  (bases 1 to 3619)
  AUTHORS   Lynch,J.W., Lemos,V.S., Bucher,B., Stoclet,J.C. and Takeda,K.
  TITLE     A pertussis toxin-insensitive calcium influx mediated by
            neuropeptide Y2 receptors in a human neuroblastoma cell line
  JOURNAL   J Biol Chem 269 (11), 8226-8233 (1994)
   PUBMED   8132547
REFERENCE   9  (bases 1 to 3619)
  AUTHORS   Herzog,H., Hort,Y.J., Ball,H.J., Hayes,G., Shine,J. and Selbie,L.A.
  TITLE     Cloned human neuropeptide Y receptor couples to two different
            second messenger systems
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5794-5798 (1992)
   PUBMED   1321422
REFERENCE   10 (bases 1 to 3619)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U42766.1 and U36269.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000910.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U42766.1, SRR1803612.265344.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329476.4/ ENSP00000332591.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1066              U42766.1           14-1079
            1067-1418           U36269.1           605-956
            1419-3619           U42766.1           1432-3632
FEATURES             Location/Qualifiers
     source          1..3619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..3619
                     /gene="NPY2R"
                     /gene_synonym="NPY2-R"
                     /note="neuropeptide Y receptor Y2"
                     /db_xref="GeneID:4887"
                     /db_xref="HGNC:HGNC:7957"
                     /db_xref="MIM:162642"
     exon            1..434
                     /gene="NPY2R"
                     /gene_synonym="NPY2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            435..3619
                     /gene="NPY2R"
                     /gene_synonym="NPY2-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1628
                     /gene="NPY2R"
                     /gene_synonym="NPY2-R"
                     /note="NPY-Y2 receptor"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 2"
                     /protein_id="NP_000901.1"
                     /db_xref="CCDS:CCDS3791.1"
                     /db_xref="GeneID:4887"
                     /db_xref="HGNC:HGNC:7957"
                     /db_xref="MIM:162642"
                     /translation="MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDST
                     KLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTL
                     CLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKI
                     SKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTV
                     YSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVV
                     FAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK
                     AFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV"
     regulatory      3599..3604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPY2R"
                     /gene_synonym="NPY2-R"
                     /note="hexamer: ATTAAA"
     polyA_site      3619
                     /gene="NPY2R"
                     /gene_synonym="NPY2-R"
                     /note="major polyA site"
ORIGIN      
        1 gagagaccct ggacactgtt cctgctccct cgccaccaaa acttctcctc cagtcccctc
       61 ccctgcagga ccatcgcccg cagcctctgc acctgttttc ttgtgtttaa gggtggggtt
      121 tgcccccctc cccacgctcc catctctgat cctcccacct tcacccgccc accccgcgag
      181 tgagtgcggt gcccaggcgc gcttggcctg agaggtcggc agcagacccg gcagcgccaa
      241 ccgcccagcc gctctgactg ctccggctgc ccgcccgcgc ggcgcgggct gtcctggacc
      301 ctaggagggg acggaaccgg acttgccttt gggcaccttc cagggccctc tccaggtcgg
      361 ctggctaatc atcggacaga cggactgcac acatcttgtt tccgcgtctc cgcaaaaacg
      421 cgaggtccag gtcagttgta gactcttgtg ctggttgcag gccaagtgga cctgtactga
      481 aaatgggtcc aataggtgca gaggctgatg agaaccagac agtggaagaa atgaaggtgg
      541 aacaatacgg gccacaaaca actcctagag gtgaactggt ccctgaccct gagccagagc
      601 ttatagatag taccaagctg attgaggtac aagttgttct catattggcc tactgctcca
      661 tcatcttgct tggggtaatt ggcaactcct tggtgatcca tgtggtgatc aaattcaaga
      721 gcatgcgcac agtaaccaac tttttcattg ccaatctggc tgtggcagat cttttggtga
      781 acactctgtg tctaccgttc actcttacct ataccttaat gggggagtgg aaaatgggtc
      841 ctgtcctgtg ccacctggtg ccctatgccc agggcctggc agtacaagta tccacaatca
      901 ccttgacagt aattgccctg gaccggcaca ggtgcatcgt ctaccaccta gagagcaaga
      961 tctccaagcg aatcagcttc ctgattattg gcttggcctg gggcatcagt gccctgctgg
     1021 caagtcccct ggccatcttc cgggagtatt cgctgattga gatcatcccg gactttgaga
     1081 ttgtggcctg tactgaaaag tggcctggcg aggagaagag catctatggc actgtctata
     1141 gtctttcttc cttgttgatc ttgtatgttt tgcctctggg cattatatca ttttcctaca
     1201 ctcgcatttg gagtaaattg aagaaccatg tcagtcctgg agctgcaaat gaccactacc
     1261 atcagcgaag gcaaaaaacc accaaaatgc tggtgtgtgt ggtggtggtg tttgcggtca
     1321 gctggctgcc tctccatgcc ttccagcttg ccgttgacat tgacagccag gtcctggacc
     1381 tgaaggagta caaactcatc ttcacagtgt tccacatcat cgccatgtgc tccacttttg
     1441 ccaatcccct tctctatggc tggatgaaca gcaactacag aaaggctttc ctctcggcct
     1501 tccgctgtga gcagcggttg gatgccattc actctgaggt gtccgtgaca ttcaaggcta
     1561 aaaagaacct ggaggtcaga aagaacagtg gccccaatga ctctttcaca gaggctacca
     1621 atgtctaagg aagctgtggt gtgaaaatgt atggatgaat tctgaccaga gctatgaatc
     1681 tggttgatgg cggctcacaa gtgaaaactg atttcccatt ttaaagaaga agtggatcta
     1741 aatggaagca tctgctgttt aattcctgga aaactggctg ggcagagcct gtgtgaaaat
     1801 actggaattc aaagataagg caacaaaatg gtttacttaa cagttggttg ggtagtaggt
     1861 tgcattatga gtaaaagcag agagaagtac ttttgattat tttcctggag tgaagaaaac
     1921 ttgaacaaga aattggtatt atcaaagcat tgctgagaga cggtgggaaa ataagttgac
     1981 tttcaaatca cgttaggacc tggattgagg aggtgtgcag ttcgctgctc cctgcttggc
     2041 ttatgaaaac accactgaac agaaatttct ccagggagcc acaggctctc cttcatcgca
     2101 ttttgatttt tttgttcatt ctctagacaa aatccatcag ggaatgctgc aggaaacgat
     2161 tgccaactat acgaatggct tcgaggagat aaactgaaat ttgctatata attaatattt
     2221 tggcagatga taggggaact cctcaacact cagtgggcca attgttctta aaaccaattg
     2281 cacgtttggt gaaagtttct tcaactctga atcaaaagct gaaattctca gaattacagg
     2341 aaatgcaaac catcatttaa tttctaattt caagttacat ccgctttatg gagatactat
     2401 ttagataaca agaatacaac ttgatacttt tattgttata cctttttgaa catgtatgat
     2461 ttctgttgtt attcctattg gagctaagtt tgtctacact aaaatttaaa tcagactaga
     2521 gaataatttt tgtggcatgt tgtaacattt cacagtattt acaagctatt tttgcacagg
     2581 tacatagctc tcatgtattt aaagaacact gcagtgttat tttctttgaa attcatcctc
     2641 cacggaccca ttcatactaa ataaaacaat gtaattacat taaaatggac ctatctgtaa
     2701 gaggtactaa aaacactgga ttcatttcat cttgcaaatg ttgtatttca aaccagtttc
     2761 acataagtta tttgtcttct tttcaaaata attagctata tttttatata atatgaatat
     2821 atacataaaa attgtttcta taaattgtag aacatagatg ctacagtatt ttttatttaa
     2881 ttatattatg aataaaattg ttatttcaat agtacccaac caaagatgct taaaaacctt
     2941 ctatgttcat aaaaaataac aactgagatg ttaaaatagt catacgtctt tagatgctat
     3001 taaagtttca ttagtcatat ttttgtaaat atgacagaat ttgtgaatat atttttaaag
     3061 caaaaaactt caacatgcat atgatatata gttacaacat taattttatg aactggagag
     3121 ctttactttg tggatatatt taaaattcat attatagctc ctattaaatt ccttccatga
     3181 tagatataaa ggactggttt ttaagtgcac tgcacttctg gaatactgaa aaagaatgaa
     3241 aacaatatgt tagattaggt gtaagacttt aagaagcgaa caaaaagtaa tgtatatctg
     3301 taatatataa tcaaatgatt catttttctg ttagactagg caaattgttc aaaaataacc
     3361 tttttgtctt ttaagtagca gtcactttgc ttaagatgct aatagaaaac tgtggttaaa
     3421 gatttaccct ccctcttggt gaattattac actgtaagaa atgtatatgc tactgtgtta
     3481 catgttgtat tagtaaatta ttagaatcca attaatgatt caattaacat atatcttatc
     3541 caattcatta tgtcaattca ttaataaaat accttttatg tagaggcttt atgttgcaat
     3601 taaaaagttg ggaaaatga
//
