LOCUS       NM_000909               2762 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neuropeptide Y receptor Y1 (NPY1R), mRNA.
ACCESSION   NM_000909
VERSION     NM_000909.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Feng,X., Ding,Y., Zhou,M., Song,N. and Ding,Y.
  TITLE     Integrative Analysis of Exosomal miR-452 and miR-4713
            Downregulating NPY1R for the Prevention of Childhood Obesity
  JOURNAL   Dis Markers 2022, 2843353 (2022)
   PUBMED   35401881
  REMARK    GeneRIF: Integrative Analysis of Exosomal miR-452 and miR-4713
            Downregulating NPY1R for the Prevention of Childhood Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Medeiros,P.J., Pascetta,S.A., Kirsh,S.M., Al-Khazraji,B.K. and
            Uniacke,J.
  TITLE     Expression of hypoxia inducible factor-dependent neuropeptide Y
            receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation
  JOURNAL   J Biol Chem 298 (3), 101645 (2022)
   PUBMED   35093384
  REMARK    GeneRIF: Expression of hypoxia inducible factor-dependent
            neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY
            stimulation.
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Park,C., Kim,J., Ko,S.B., Choi,Y.K., Jeong,H., Woo,H., Kang,H.,
            Bang,I., Kim,S.A., Yoon,T.Y., Seok,C., Im,W. and Choi,H.J.
  TITLE     Structural basis of neuropeptide Y signaling through Y1 receptor
  JOURNAL   Nat Commun 13 (1), 853 (2022)
   PUBMED   35165283
  REMARK    GeneRIF: Structural basis of neuropeptide Y signaling through Y1
            receptor.
            Erratum:[Nat Commun. 2022 Feb 25;13(1):1126. doi:
            10.1038/s41467-022-28837-0.. PMID: 35217654]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Bhat,R., Thangavel,H., Abdulkareem,N.M., Vasaikar,S., De
            Angelis,C., Bae,L., Cataldo,M.L., Nanda,S., Fu,X., Zhang,B.,
            Schiff,R. and Trivedi,M.V.
  TITLE     NPY1R exerts inhibitory action on estradiol-stimulated growth and
            predicts endocrine sensitivity and better survival in ER-positive
            breast cancer
  JOURNAL   Sci Rep 12 (1), 1972 (2022)
   PUBMED   35121782
  REMARK    GeneRIF: NPY1R exerts inhibitory action on estradiol-stimulated
            growth and predicts endocrine sensitivity and better survival in
            ER-positive breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Winning,L., El Karim,I.A., Linden,G.J., Irwin,C.R., Killough,S.A.
            and Lundy,F.T.
  TITLE     Differential regulation of NPY and SP receptor expression in
            STRO-1+ve PDLSCs by inflammatory cytokines
  JOURNAL   J Periodontal Res 57 (1), 186-194 (2022)
   PUBMED   34773642
  REMARK    GeneRIF: Differential regulation of NPY and SP receptor expression
            in STRO-1+ve PDLSCs by inflammatory cytokines.
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Rose,P.M., Fernandes,P., Lynch,J.S., Frazier,S.T., Fisher,S.M.,
            Kodukula,K., Kienzle,B. and Seethala,R.
  TITLE     Cloning and functional expression of a cDNA encoding a human type 2
            neuropeptide Y receptor
  JOURNAL   J Biol Chem 270 (39), 22661-22664 (1995)
   PUBMED   7559383
  REMARK    Erratum:[J Biol Chem. 1995 Dec 1;270(48):29038.. PMID: 7499438]
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Herzog,H., Baumgartner,M., Vivero,C., Selbie,L.A., Auer,B. and
            Shine,J.
  TITLE     Genomic organization, localization, and allelic differences in the
            gene for the human neuropeptide Y Y1 receptor
  JOURNAL   J Biol Chem 268 (9), 6703-6707 (1993)
   PUBMED   8095935
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Herzog,H., Hort,Y.J., Ball,H.J., Hayes,G., Shine,J. and Selbie,L.A.
  TITLE     Cloned human neuropeptide Y receptor couples to two different
            second messenger systems
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5794-5798 (1992)
   PUBMED   1321422
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Larhammar,D., Blomqvist,A.G., Yee,F., Jazin,E., Yoo,H. and
            Wahlested,C.
  TITLE     Cloning and functional expression of a human neuropeptide Y/peptide
            YY receptor of the Y1 type
  JOURNAL   J Biol Chem 267 (16), 10935-10938 (1992)
   PUBMED   1317848
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036657.2 and AC079238.7.
            
            On Nov 23, 2018 this sequence version replaced NM_000909.5.
            
            Summary: This gene belongs to the G-protein-coupled receptor
            superfamily. The encoded transmembrane protein mediates the
            function of neuropeptide Y (NPY), a neurotransmitter, and peptide
            YY (PYY), a gastrointestinal hormone. The encoded receptor
            undergoes fast agonist-induced internalization through
            clathrin-coated pits and is subsequently recycled back to the cell
            membrane. Activation of Y1 receptors may result in mobilization of
            intracellular calcium and inhibition of adenylate cyclase activity.
            [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036657.2, SRR1803611.106369.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296533.3/ ENSP00000354652.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1981              BC036657.2         1-1981
            1982-1983           AC079238.7         103155-103156       c
            1984-2212           BC036657.2         1982-2210
            2213-2213           AC079238.7         102925-102925       c
            2214-2759           BC036657.2         2212-2757
            2760-2762           AC079238.7         102376-102378       c
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.2"
     gene            1..2762
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /note="neuropeptide Y receptor Y1"
                     /db_xref="GeneID:4886"
                     /db_xref="HGNC:HGNC:7956"
                     /db_xref="MIM:162641"
     exon            1..115
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /inference="alignment:Splign:2.1.0"
     exon            116..965
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1421
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 1"
                     /protein_id="NP_000900.1"
                     /db_xref="CCDS:CCDS34089.1"
                     /db_xref="GeneID:4886"
                     /db_xref="HGNC:HGNC:7956"
                     /db_xref="MIM:162641"
                     /translation="MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLA
                     LAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL
                     MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIA
                     VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVL
                     QYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCW
                     LPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF
                     FNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI"
     exon            966..2762
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /note="hexamer: TATAAA"
     polyA_site      1701
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
     regulatory      2731..2736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /note="hexamer: ATTAAA"
     polyA_site      2762
                     /gene="NPY1R"
                     /gene_synonym="NPY1-R; NPYR"
                     /note="major polyA site"
ORIGIN      
        1 aatctttagg atctgagcag gagaaatacc agcggatctt ccccactctg ctcccttcca
       61 ttcccaccct tccttcttta ataagcagga gcgaaaaaga caaattccaa agaggattgt
      121 tcagttcaag ggaatgaaga attcagaata attttggtaa atggattcca atatggggaa
      181 taagaataag ctgaacagtt gacctgcttt gaagaaacat actgtccatt tgtctaaaat
      241 aatctataac aaccaaacca atcaaaatga attcaacatt attttcccag gttgaaaatc
      301 attcagtcca ctctaatttc tcagagaaga atgcccagct tctggctttt gaaaatgatg
      361 attgtcatct gcccttggcc atgatattta ccttagctct tgcttatgga gctgtgatca
      421 ttcttggtgt ctctggaaac ctggccttga tcataatcat cttgaaacaa aaggagatga
      481 gaaatgttac caacatcctg attgtgaacc tttccttctc agacttgctt gttgccatca
      541 tgtgtctccc ctttacattt gtctacacat taatggacca ctgggtcttt ggtgaggcga
      601 tgtgtaagtt gaatcctttt gtgcaatgtg tttcaatcac tgtgtccatt ttctctctgg
      661 ttctcattgc tgtggaacga catcagctga taatcaaccc tcgagggtgg agaccaaata
      721 atagacatgc ttatgtaggt attgctgtga tttgggtcct tgctgtggct tcttctttgc
      781 ctttcctgat ctaccaagta atgactgatg agccgttcca aaatgtaaca cttgatgcgt
      841 acaaagacaa atacgtgtgc tttgatcaat ttccatcgga ctctcatagg ttgtcttata
      901 ccactctcct cttggtgctg cagtattttg gtccactttg ttttatattt atttgctact
      961 tcaagatata tatacgccta aaaaggagaa acaacatgat ggacaagatg agagacaata
     1021 agtacaggtc cagtgaaacc aaaagaatca atatcatgct gctctccatt gtggtagcat
     1081 ttgcagtctg ctggctccct cttaccatct ttaacactgt gtttgattgg aatcatcaga
     1141 tcattgctac ctgcaaccac aatctgttat tcctgctctg ccacctcaca gcaatgatat
     1201 ccacttgtgt caaccccata ttttatgggt tcctgaacaa aaacttccag agagacttgc
     1261 agttcttctt caacttttgt gatttccggt ctcgggatga tgattatgaa acaatagcca
     1321 tgtccacgat gcacacagat gtttccaaaa cttctttgaa gcaagcaagc ccagtcgcat
     1381 ttaaaaaaat caacaacaat gatgataatg aaaaaatctg aaactactta tagcctatgg
     1441 tcccggatga catctgttta aaaacaagca caacctgcaa catactttga ttacctgttc
     1501 tcccaaggaa tggggttgaa atcatttgaa aatgactaag attttcttgt cttgcttttt
     1561 actgcttttg ttgtagttgt cataattaca tttggaacaa aaggtgtggg ctttggggtc
     1621 ttctggaaat agttttgacc agacatcttt gaagtgcttt ttgtgaattt atgcatataa
     1681 tataaagact tttatactgt acttattgga atgaaatttc tttaaagtat tactattaac
     1741 tgacttcaga agtacctgcc atccaatacg gtcattagat tgggtcatct tgattagatt
     1801 agattagatt agattgtcaa cagattgggc catccttact ttatgatagg catcatttta
     1861 gtgtgttaca atagtaacag tatgcaaaag cagcattcag gagccgaaag atagtctgaa
     1921 gtcattcaga agtggtttga ggtttctgtt ttttggtggt ttttgtttgt tttttttttt
     1981 tttcacctta agggaggatt taatttgctc ccaactgatt gtcacttaaa tgaaaattta
     2041 aaaatgaata aaaagacata cttctcagct gcaaatatta tggagaattg gggcacccac
     2101 aggaatgaag agagaaagca gctccctaac ttcaaaacca ttttggtacc tgacaacaag
     2161 agcattttag agtaattaat ttaataaagt aaattagtat tgctgcaaat agttaaatta
     2221 tatttatttg aattgatggt caagagattt tccatttttt ttacagactg ttcagtgttt
     2281 gtcaagcttt ctggcataaa tatgtactca aaaggcattt ccgcttacaa tttgtagaaa
     2341 cacaaaatgc gttttccata cagcagtgcc tatatagtga ctgattttta actttcaatg
     2401 tccatctttc aaaggaagta acaccaaggt acaatgttaa aggaatattc actttaccta
     2461 gcagggaaaa atacacaaaa actgcagata cttcatatag cccattttaa cttgtataaa
     2521 ctgtgtgact tgtggcgtct tataaataat gcactgtaaa gattactgaa tagttgtgtc
     2581 atgttaatgt gcctaatttc atgtatcttg taatcatgat tgagcctcag aatcatttgg
     2641 agaaactata ttttaaagaa caagacatac ttcaatgtat tatacagata aagtattaca
     2701 tgtgtttgat tttaaaaggg cggacatttt attaaaatca atattgtttt tgctttttct
     2761 ga
//
