LOCUS       NM_000905                555 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens neuropeptide Y (NPY), mRNA.
ACCESSION   NM_000905
VERSION     NM_000905.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 555)
  AUTHORS   Tayran,H., Yilmaz,E., Bhattarai,P., Min,Y., Wang,X., Ma,Y.,
            Wang,N., Jeong,I., Nelson,N., Kassara,N., Cosacak,M.I., Dogru,R.M.,
            Reyes-Dumeyer,D., Stenersen,J.M., Reddy,J.S., Qiao,M., Flaherty,D.,
            Gunasekaran,T.I., Yang,Z., Jurisch-Yaksi,N., Teich,A.F.,
            Kanekiyo,T., Tosto,G., Vardarajan,B.N., Is,O., Ertekin-Taner,N.,
            Mayeux,R. and Kizil,C.
  TITLE     ABCA7-dependent induction of neuropeptide Y is required for
            synaptic resilience in Alzheimer's disease through BDNF/NGFR
            signaling
  JOURNAL   Cell Genom 4 (9), 100642 (2024)
   PUBMED   39216475
  REMARK    GeneRIF: ABCA7-dependent induction of neuropeptide Y is required
            for synaptic resilience in Alzheimer's disease through BDNF/NGFR
            signaling.
REFERENCE   2  (bases 1 to 555)
  AUTHORS   Malva,J.O., Xapelli,S., Baptista,S., Valero,J., Agasse,F.,
            Ferreira,R. and Silva,A.P.
  TITLE     Multifaces of neuropeptide Y in the brain--neuroprotection,
            neurogenesis and neuroinflammation
  JOURNAL   Neuropeptides 46 (6), 299-308 (2012)
   PUBMED   23116540
  REMARK    GeneRIF: In this review, we highlight recent evidences concerning
            paracrine/autocrine actions of NPY involved in neuroprotection,
            neurogenesis and neuroinflammation--{REVIEW}
REFERENCE   3  (bases 1 to 555)
  AUTHORS   Benarroch,E.E.
  TITLE     Neuropeptide Y: its multiple effects in the CNS and potential
            clinical significance
  JOURNAL   Neurology 72 (11), 1016-1020 (2009)
   PUBMED   19289742
  REMARK    GeneRIF: neuropeptide y is widely expressed in the nervous system
            and has been shown to have a role in numerous physiologic
            processes--{REVIEW}
            Review article
REFERENCE   4  (bases 1 to 555)
  AUTHORS   El Karim,I.A., Linden,G.J., Orr,D.F. and Lundy,F.T.
  TITLE     Antimicrobial activity of neuropeptides against a range of
            micro-organisms from skin, oral, respiratory and gastrointestinal
            tract sites
  JOURNAL   J Neuroimmunol 200 (1-2), 11-16 (2008)
   PUBMED   18603306
REFERENCE   5  (bases 1 to 555)
  AUTHORS   Gaszner,B., Korosi,A., Palkovits,M., Roubos,E.W. and Kozicz,T.
  TITLE     Neuropeptide Y activates urocortin 1 neurons in the
            nonpreganglionic Edinger-Westphal nucleus
  JOURNAL   J Comp Neurol 500 (4), 708-719 (2007)
   PUBMED   17154253
  REMARK    GeneRIF: NPY, via NPY Y5 and to a lesser extent via the Y1
            receptors, exerts a stimulatory action on Ucn1 cells in the
            nonpreganglionic Edinger-Westphal nucleus.
REFERENCE   6  (bases 1 to 555)
  AUTHORS   Shimizu,M., Shigeri,Y., Tatsu,Y., Yoshikawa,S. and Yumoto,N.
  TITLE     Enhancement of antimicrobial activity of neuropeptide Y by
            N-terminal truncation
  JOURNAL   Antimicrob Agents Chemother 42 (10), 2745-2746 (1998)
   PUBMED   9756788
  REMARK    GeneRIF: Neuropeptide Y has fungicidal, antimicrobial activity
            against Candida albicans.
REFERENCE   7  (bases 1 to 555)
  AUTHORS   Monks,S.A., Karagianis,G., Howlett,G.J. and Norton,R.S.
  TITLE     Solution structure of human neuropeptide Y
  JOURNAL   J Biomol NMR 8 (4), 379-390 (1996)
   PUBMED   9008359
REFERENCE   8  (bases 1 to 555)
  AUTHORS   Wan,C.P. and Lau,B.H.
  TITLE     Neuropeptide Y receptor subtypes
  JOURNAL   Life Sci 56 (13), 1055-1064 (1995)
   PUBMED   9001438
  REMARK    Review article
REFERENCE   9  (bases 1 to 555)
  AUTHORS   Herzog,H., Hort,Y.J., Ball,H.J., Hayes,G., Shine,J. and Selbie,L.A.
  TITLE     Cloned human neuropeptide Y receptor couples to two different
            second messenger systems
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5794-5798 (1992)
   PUBMED   1321422
REFERENCE   10 (bases 1 to 555)
  AUTHORS   Minth,C.D., Andrews,P.C. and Dixon,J.E.
  TITLE     Characterization, sequence, and expression of the cloned human
            neuropeptide Y gene
  JOURNAL   J Biol Chem 261 (26), 11974-11979 (1986)
   PUBMED   2427515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from K01911.1 and AI198311.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000905.3.
            
            Summary: This gene encodes a neuropeptide that is widely expressed
            in the central nervous system and influences many physiological
            processes, including cortical excitability, stress response, food
            intake, circadian rhythms, and cardiovascular function. The
            neuropeptide functions through G protein-coupled receptors to
            inhibit adenylyl cyclase, activate mitogen-activated protein kinase
            (MAPK), regulate intracellular calcium levels, and activate
            potassium channels. A polymorphism in this gene resulting in a
            change of leucine 7 to proline in the signal peptide is associated
            with elevated cholesterol levels, higher alcohol consumption, and
            may be a risk factor for various metabolic and cardiovascular
            diseases. The protein also exhibits antimicrobial activity against
            bacteria and fungi. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA330523.1, BC029497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000242152.7/
                                                  ENSP00000242152.2
            Protein has antimicrobial activity :: PMID: 9756788
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               K01911.1           1-551
            552-555             AI198311.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..555
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /note="neuropeptide Y"
                     /db_xref="GeneID:4852"
                     /db_xref="HGNC:HGNC:7955"
                     /db_xref="MIM:162640"
     exon            1..86
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..380
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /note="pro-neuropeptide Y; prepro-neuropeptide Y"
                     /codon_start=1
                     /product="pro-neuropeptide Y preproprotein"
                     /protein_id="NP_000896.1"
                     /db_xref="CCDS:CCDS5387.1"
                     /db_xref="GeneID:4852"
                     /db_xref="HGNC:HGNC:7955"
                     /db_xref="MIM:162640"
                     /translation="MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAED
                     MARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW"
     exon            87..274
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /inference="alignment:Splign:2.1.0"
     exon            275..355
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /inference="alignment:Splign:2.1.0"
     exon            356..555
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      533..538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /note="hexamer: AATAAA"
     polyA_site      555
                     /gene="NPY"
                     /gene_synonym="PYY4"
                     /note="major polyA site"
ORIGIN      
        1 accccatccg ctggctctca cccctcggag acgctcgccc gacagcatag tacttgccgc
       61 ccagccacgc ccgcgcgcca gccaccatgc taggtaacaa gcgactgggg ctgtccggac
      121 tgaccctcgc cctgtccctg ctcgtgtgcc tgggtgcgct ggccgaggcg tacccctcca
      181 agccggacaa cccgggcgag gacgcaccag cggaggacat ggccagatac tactcggcgc
      241 tgcgacacta catcaacctc atcaccaggc agagatatgg aaaacgatcc agcccagaga
      301 cactgatttc agacctcttg atgagagaaa gcacagaaaa tgttcccaga actcggcttg
      361 aagaccctgc aatgtggtga tgggaaatga gacttgctct ctggcctttt cctattttca
      421 gcccatattt catcgtgtaa aacgagaatc cacccatcct accaatgcat gcagccactg
      481 tgctgaattc tgcaatgttt tcctttgtca tcattgtata tatgtgtgtt taaataaagt
      541 atcatgcatt caaaa
//
