LOCUS       NM_022150               1190 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens neuropeptide VF precursor (NPVF), mRNA.
ACCESSION   NM_022150
VERSION     NM_022150.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Koller,J., Herzog,H. and Zhang,L.
  TITLE     The distribution of Neuropeptide FF and Neuropeptide VF in central
            and peripheral tissues and their role in energy homeostasis control
  JOURNAL   Neuropeptides 90, 102198 (2021)
   PUBMED   34534716
  REMARK    GeneRIF: The distribution of Neuropeptide FF and Neuropeptide VF in
            central and peripheral tissues and their role in energy homeostasis
            control.
            Review article
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Lima,C.J., Cardoso,S.C., Lemos,E.F., Zingler,E., Capanema,C.,
            Menezes,L.D., Vogado,G., Dos Santos,B.T., de Moraes,O.L.,
            Duarte,E.F., de Brito,V.N., Latronico,A.C. and Lofrano-Porto,A.
  TITLE     Mutational analysis of the genes encoding RFamide-related
            peptide-3, the human orthologue of gonadotrophin-inhibitory
            hormone, and its receptor (GPR147) in patients with
            gonadotrophin-releasing hormone-dependent pubertal disorders
  JOURNAL   J Neuroendocrinol 26 (11), 817-824 (2014)
   PUBMED   25180599
  REMARK    GeneRIF: RFRP-3/GPR147 may play secondary, modulatory roles on the
            regulation of pubertal development; a restraining modulatory effect
            of the NPVF p.I71_K72 variant on the activation of the
            gonadotrophic axis cannot be ruled out
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Zhao,L., Bracken,M.B. and DeWan,A.T.
  TITLE     Genome-wide association study of pre-eclampsia detects novel
            maternal single nucleotide polymorphisms and copy-number variants
            in subsets of the Hyperglycemia and Adverse Pregnancy Outcome
            (HAPO) study cohort
  JOURNAL   Ann Hum Genet 77 (4), 277-287 (2013)
   PUBMED   23551011
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Ubuka,T., Morgan,K., Pawson,A.J., Osugi,T., Chowdhury,V.S.,
            Minakata,H., Tsutsui,K., Millar,R.P. and Bentley,G.E.
  TITLE     Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the
            cognate receptor, GPR147 in the human hypothalamic pituitary axis
  JOURNAL   PLoS One 4 (12), e8400 (2009)
   PUBMED   20027225
  REMARK    GeneRIF: GnIH homologs in the human hypothalamus and were
            identified and human GnIH receptor (GPR147) mRNA expression in the
            hypothalamus as well as in the pituitary, was characterized.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   Schulz,H.L., Stoehr,H., White,K., van Driel,M.A., Hoyng,C.B.,
            Cremers,F. and Weber,B.H.
  TITLE     Genomic structure and assessment of the retinally expressed
            RFamide-related peptide gene in dominant cystoid macular dystrophy
  JOURNAL   Mol Vis 8, 67-71 (2002)
   PUBMED   11951088
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Liu,Q., Guan,X.M., Martin,W.J., McDonald,T.P., Clements,M.K.,
            Jiang,Q., Zeng,Z., Jacobson,M., Williams,D.L. Jr., Yu,H.,
            Bomford,D., Figueroa,D., Mallee,J., Wang,R., Evans,J., Gould,R. and
            Austin,C.P.
  TITLE     Identification and characterization of novel mammalian neuropeptide
            FF-like peptides that attenuate morphine-induced antinociception
  JOURNAL   J Biol Chem 276 (40), 36961-36969 (2001)
   PUBMED   11481330
REFERENCE   9  (bases 1 to 1190)
  AUTHORS   Hinuma,S., Shintani,Y., Fukusumi,S., Iijima,N., Matsumoto,Y.,
            Hosoya,M., Fujii,R., Watanabe,T., Kikuchi,K., Terao,Y., Yano,T.,
            Yamamoto,T., Kawamata,Y., Habata,Y., Asada,M., Kitada,C.,
            Kurokawa,T., Onda,H., Nishimura,O., Tanaka,M., Ibata,Y. and
            Fujino,M.
  TITLE     New neuropeptides containing carboxy-terminal RFamide and their
            receptor in mammals
  JOURNAL   Nat Cell Biol 2 (10), 703-708 (2000)
   PUBMED   11025660
REFERENCE   10 (bases 1 to 1190)
  AUTHORS   Stohr,H., Mah,N., Schulz,H.L., Gehrig,A., Frohlich,S. and
            Weber,B.H.
  TITLE     EST mining of the UniGene dataset to identify retina-specific genes
  JOURNAL   Cytogenet Cell Genet 91 (1-4), 267-277 (2000)
   PUBMED   11173868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF440392.1, AB040290.1 and BM714303.1.
            
            On Apr 22, 2006 this sequence version replaced NM_022150.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF440392.1, BM714303.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222674.2/ ENSP00000222674.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AF440392.1         1-139
            140-146             AB040290.1         93-99
            147-371             AF440392.1         147-371
            372-435             BM714303.1         317-380
            436-1190            AF440392.1         436-1190
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1190
                     /gene="NPVF"
                     /gene_synonym="C7orf9; RFRP"
                     /note="neuropeptide VF precursor"
                     /db_xref="GeneID:64111"
                     /db_xref="HGNC:HGNC:13782"
                     /db_xref="MIM:616984"
     exon            1..185
                     /gene="NPVF"
                     /gene_synonym="C7orf9; RFRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..638
                     /gene="NPVF"
                     /gene_synonym="C7orf9; RFRP"
                     /note="RFamide-related peptide; neuropeptide NPVF;
                     FMRFamide-related peptides; pro-FMRFamide-related
                     neuropeptide VF"
                     /codon_start=1
                     /product="pro-FMRFamide-related neuropeptide VF precursor"
                     /protein_id="NP_071433.3"
                     /db_xref="CCDS:CCDS5395.1"
                     /db_xref="GeneID:64111"
                     /db_xref="HGNC:HGNC:13782"
                     /db_xref="MIM:616984"
                     /translation="MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKY
                     SEPRGYPKGERSLNFEELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSA
                     GATANLPLRSGRNMEVSLVRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDL
                     FYSMTCQHQEIQNPDQKQSRRLLFKKIDDAELKQEK"
     exon            186..586
                     /gene="NPVF"
                     /gene_synonym="C7orf9; RFRP"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1190
                     /gene="NPVF"
                     /gene_synonym="C7orf9; RFRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaacattg ggctgcacat agagacttaa ttttagattt agacaaaatg gaaattattt
       61 catcaaaact attcatttta ttgactttag ccacttcaag cttgttaaca tcaaacattt
      121 tttgtgcaga tgaattagtg atgtccaatc ttcacagcaa agaaaattat gacaaatatt
      181 ctgagcctag aggataccca aaaggggaaa gaagcctcaa ttttgaggaa ttaaaagatt
      241 ggggaccaaa aaatgttatt aagatgagta cacctgcagt caataaaatg ccacactcct
      301 tcgccaactt gccattgaga tttgggagga acgttcaaga agaaagaagt gctggagcaa
      361 cagccaacct gcctctgaga tctggaagaa atatggaggt gagcctcgtg agacgtgttc
      421 ctaacctgcc ccaaaggttt gggagaacaa caacagccaa aagtgtctgc aggatgctga
      481 gtgatttgtg tcaaggatcc atgcattcac catgtgccaa tgacttattt tactccatga
      541 cctgccagca ccaagaaatc cagaatcccg atcaaaaaca gtcaaggaga ctgctattca
      601 agaaaataga tgatgcagaa ttgaaacaag aaaaataaga aacctggagc ctgtccctaa
      661 agctgtggcc tgtaatctac aaatggctct atagcgaaga ccacacggaa gagtagctac
      721 atacacttca tcagctatgg atcatcaacg gcaatttttc cttgtcagta cagctataat
      781 agtatcttga aagttgtaaa aaaattaaag catatttgtt acgtaaagtt aaaatgattt
      841 ttgtctgaat aaaaaaaaag cattgcaaat gctttagaaa tctctgataa tggagagaga
      901 gacagaggac cctcctcact accctatata aaaatcattg gcacagttac acttaataaa
      961 aaaaattaaa cagaagagca ccctgaaaaa cattatgatg gaaattaaat agtatgccag
     1021 aataacatgg ttgacaaata agtgaacaag gattaaaaat cacttacaaa cgtgtttctg
     1081 tacacccttt ctatcgtgtc aaatgttaat gaatctgtga tcaattgaaa tgtaaatgtc
     1141 tgtgtaaaac tacaaaataa aaactcttag actttaggga gaaaagaaaa
//
