LOCUS       NM_014293               5830 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens neuronal pentraxin receptor (NPTXR), mRNA.
ACCESSION   NM_014293
VERSION     NM_014293.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5830)
  AUTHORS   Lim,B., Fowler,C., Li,Q.X., Rowe,C., Dhiman,K., Gupta,V.B.,
            Masters,C.L., Doecke,J.D., Martins,R.N., Collins,S. and
            Diamandis,E.P.
  TITLE     Decreased cerebrospinal fluid neuronal pentraxin receptor is
            associated with PET-Abeta load and cerebrospinal fluid Abeta in a
            pilot study of Alzheimer's disease
  JOURNAL   Neurosci Lett 731, 135078 (2020)
   PUBMED   32450185
  REMARK    GeneRIF: Decreased cerebrospinal fluid neuronal pentraxin receptor
            is associated with PET-Abeta load and cerebrospinal fluid Abeta in
            a pilot study of Alzheimer's disease.
REFERENCE   2  (bases 1 to 5830)
  AUTHORS   Lee,S.J., Wei,M., Zhang,C., Maxeiner,S., Pak,C., Calado Botelho,S.,
            Trotter,J., Sterky,F.H. and Sudhof,T.C.
  TITLE     Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and
            Inhibitory Synapses
  JOURNAL   J Neurosci 37 (5), 1062-1080 (2017)
   PUBMED   27986928
REFERENCE   3  (bases 1 to 5830)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   4  (bases 1 to 5830)
  AUTHORS   Yin,G.N., Lee,H.W., Cho,J.Y. and Suk,K.
  TITLE     Neuronal pentraxin receptor in cerebrospinal fluid as a potential
            biomarker for neurodegenerative diseases
  JOURNAL   Brain Res 1265, 158-170 (2009)
   PUBMED   19368810
  REMARK    GeneRIF: study suggests that NCAM-120, alpha-dystroglycan, and NPR
            are candidate biomarkers in CSF for neurodegenerative diseases, and
            that the changes in the CSF level of NPR may be specific for
            Alzheimer's disease
REFERENCE   5  (bases 1 to 5830)
  AUTHORS   Andersson,K.B., Florholmen,G., Winer,L.H., Tonnessen,T. and
            Christensen,G.
  TITLE     Regulation of neuronal type genes in congestive heart failure rats
  JOURNAL   Acta Physiol (Oxf) 186 (1), 17-27 (2006)
   PUBMED   16497176
REFERENCE   6  (bases 1 to 5830)
  AUTHORS   Poulsen,T.T., Pedersen,N., Perin,M.S., Hansen,C.K. and Poulsen,H.S.
  TITLE     Specific sensitivity of small cell lung cancer cell lines to the
            snake venom toxin taipoxin
  JOURNAL   Lung Cancer 50 (3), 329-337 (2005)
   PUBMED   16115696
  REMARK    GeneRIF: The purpose of the present study was to assess the toxic
            effect of taipoxin in SCLC-cell lines and to determine if toxicity
            correlates to NPR and NP1 and NP2 expression levels.
REFERENCE   7  (bases 1 to 5830)
  AUTHORS   Kirkpatrick,L.L., Matzuk,M.M., Dodds,D.C. and Perin,M.S.
  TITLE     Biochemical interactions of the neuronal pentraxins. Neuronal
            pentraxin (NP) receptor binds to taipoxin and taipoxin-associated
            calcium-binding protein 49 via NP1 and NP2
  JOURNAL   J Biol Chem 275 (23), 17786-17792 (2000)
   PUBMED   10748068
REFERENCE   8  (bases 1 to 5830)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 5830)
  AUTHORS   Dodds,D.C., Omeis,I.A., Cushman,S.J., Helms,J.A. and Perin,M.S.
  TITLE     Neuronal pentraxin receptor, a novel putative integral membrane
            pentraxin that interacts with neuronal pentraxin 1 and 2 and
            taipoxin-associated calcium-binding protein 49
  JOURNAL   J Biol Chem 272 (34), 21488-21494 (1997)
   PUBMED   9261167
  REMARK    GeneRIF: non-AUG translation initiation site. Comparison of rat
            determined N-terminal amino acid sequence with cDNA sequence
            indicates that a CUG codon is used as an initiator codon and codes
            for a methionine. The CTG is present in cDNAs of mouse, rat, and
            human.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL008583.1, DR007138.1,
            DA321562.1, AL161974.1 and CA423268.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014293.3.
            
            Summary: This gene encodes a protein similar to the rat neuronal
            pentraxin receptor. The rat pentraxin receptor is an integral
            membrane protein that is thought to mediate neuronal uptake of the
            snake venom toxin, taipoxin, and its transport into the synapses.
            Studies in rat indicate that translation of this mRNA initiates at
            a non-AUG (CUG) codon. This may also be true for mouse and human,
            based on strong sequence conservation amongst these species.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL161974.1, BF528869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000333039.4/ ENSP00000327545.3
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL008583.1         71466-71481         c
            17-410              DR007138.1         9-402
            411-702             DA321562.1         1-292
            703-1548            AL161974.1         1-846
            1549-5471           AL008583.1         46264-50186         c
            5472-5830           CA423268.1         18-376              c
FEATURES             Location/Qualifiers
     source          1..5830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..5830
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /note="neuronal pentraxin receptor"
                     /db_xref="GeneID:23467"
                     /db_xref="HGNC:HGNC:7954"
                     /db_xref="MIM:609474"
     exon            1..794
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1673
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="neuronal pentraxin receptor precursor"
                     /protein_id="NP_055108.2"
                     /db_xref="CCDS:CCDS33647.1"
                     /db_xref="GeneID:23467"
                     /db_xref="HGNC:HGNC:7954"
                     /db_xref="MIM:609474"
                     /translation="MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNAS
                     VASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAA
                     CPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGR
                     CESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLS
                     AAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQG
                     RVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQ
                     GTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGL
                     WSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWD
                     HALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA"
     exon            795..1020
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1268
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1448
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..5830
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5808..5813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /note="hexamer: AATAAA"
     polyA_site      5830
                     /gene="NPTXR"
                     /gene_synonym="NPR"
                     /note="major polyA site"
ORIGIN      
        1 agagcggcgg cagcagcggc cgcggcgaca gctccagctc cggctccggc tccggctccg
       61 gctccggctc ccgcgcctgc cccgctcggc ccagcgcgcc cgggctccgc gccccgaccc
      121 cgccgccgcg cctgccgggg gcctcgggcg cccccgccgc ccgcctcacg ctgaagttcc
      181 tggccgtgct gctggccgcg ggcatgctgg cgttcctcgg tgccgtcatc tgcatcatcg
      241 ccagcgtgcc cctggcggcc agcccggcgc gggcgctgcc cggcggcgcc gacaatgctt
      301 cggtcgcctc gggcgccgcc gcgtccccgg gcccgcagcg gagcctgagc gcgctgcacg
      361 gcgcgggcgg ttcagccggg ccccccgcgc tgcccggggc acccgcggcc agcgcgcacc
      421 cgctgccgcc cgggcccctg ttcagccgct tcctgtgcac gccgctggct gctgcctgcc
      481 cgtcgggggc ccagcagggg gacgcggcgg gcgctgcgcc gggcgagcgc gaagagctgc
      541 tgctgctgca gagcacggcc gagcagctgc gccagacggc gctgcagcag gaggcgcgca
      601 tccgcgccga ccaggacacc atccgtgagc tcaccggcaa gctgggccgc tgcgagagcg
      661 gcctgccgcg cggcctccag ggcgccgggc cccgccgcga caccatggcc gacgggccct
      721 gggactcgcc tgcgctcatt ctggagctgg aggacgccgt gcgcgccctg cgggaccgca
      781 tcgaccgcct ggagcaggag cttccagccc gtgtgaacct ctcagctgcc ccagccccag
      841 tctctgctgt gcccaccggc ctacactcca agatggacca gctggagggg cagctgctgg
      901 cccaggtgct ggcactggag aaggagcgtg tggccctcag ccacagcagc cgccggcaga
      961 ggcaggaagt ggaaaaggag ttggacgtcc tgcagggtcg tgtggctgag ctggagcacg
     1021 ggtcctcagc ctacagtcct ccagatgcct tcaagatcag catccccatc cgtaacaact
     1081 acatgtacgc ccgcgtgcgg aaggctctgc ccgagctcta cgcattcacc gcctgcatgt
     1141 ggctgcggtc caggtccagc ggcaccggcc agggcacccc cttctcctac tcagtgcccg
     1201 ggcaggccaa cgagattgta ctgctagagg cgggccatga gcccatggag ctgctgatca
     1261 acgacaaggt ggcccagctg cccctgagcc tgaaggacaa tggctggcac cacatctgca
     1321 tcgcctggac cacaagggat ggcctatggt ctgcctacca ggacggggag ctgcagggct
     1381 ccggtgagaa cctggctgcc tggcacccca tcaagcctca tgggatcctt atcttgggcc
     1441 aggagcagga taccctgggt ggccggtttg atgccaccca ggcctttgtc ggtgacattg
     1501 cccagtttaa cctgtgggac cacgccctga caccagccca ggtcctgggc attgccaact
     1561 gcactgcgcc actgctgggc aacgtccttc cctgggaaga caagttggtg gaggcctttg
     1621 ggggtgcaac aaaggctgcc ttcgatgtct gcaaggggag ggccaaggca tgaggggcca
     1681 cctcatccag ggcccctccc ttgcctgcca ctttggggac ttgagggggg tcatattccc
     1741 tcctcagcct gcccacgcac tggccttccc tcctgcccca ctcctggctg tgcctcccat
     1801 ttcccctcac ctgtacccac acctccagaa tgccctgccc tgcgagtgtg tcccctgtcc
     1861 ccacctgagt ggggaggagc gtctcaagtg aacagtggga gcctgcccac ctggcactgc
     1921 actggagttg tctcttaccc caccctccct gcccatcaac tgtatctgat ttcactaatt
     1981 ttgacagcac ccccagtagg gtaggattgt gtatgagggg gaccccacta tctcagtggt
     2041 gggggtggcc gcccgccccc ttgtccccca tgcaacaggc ccagtggctt ccccttcagg
     2101 gccacaacag gctgtagaag gggatgacga ggacatcaga ggttagactt accctcctcc
     2161 ctctttccac cagctgccag tcaagggcag tgggatctcg atggagcctc cccccccccc
     2221 cacccatgcc tccctcttcc tcctctttcc tcctctcttt gtgtgtagcg gtttgaatgt
     2281 tggttccatg cctggcccag ccccacctca gtctccagga cattcctttc ccagctccag
     2341 cctggaggga aggggacaaa gaccccagga ggccaaaggg ctgcagtcac cccttgtgct
     2401 cacccatagt gatggccact ggtatagtca tcgctctccc tccatgccaa ggacaggact
     2461 tggaccgctt cagcctgggc tgggagcagc cctaaggtag aggcctcatg gcccaggaga
     2521 ccccacctct ggcagagcca cattacctac cctgtgcatg gtcctggggc agcaaggaag
     2581 aagctcagag ggtggggaga agcatgaagc agtgagcaga gcactgggtg agagggagaa
     2641 gaccttggtt cctagccagc cctgctaatg tgctgtgtgg ccttctgtaa gtccctgccc
     2701 tctctgggcc tggccttcct cattcgtgag ctgaggccct cgctttggtc atttgctctc
     2761 cagattgggt gtgagcttct ctgtgattcc aggtggatat gtggggaaag ctctggtgac
     2821 cctgggcttc gcaggggtag atcccaggac tcggcagtgg atgggatgca gccagtcatg
     2881 ggttagggtc agcagagact cagagtccag ggcaaggttc aaggcagact aacctcatgc
     2941 atggattgta aaaaaccagc tccctttgga tcaacccagc ctggcaccct tgcctgtctg
     3001 agagtgtctc aaagggctga tggcttcctg gtccccttga gtcatcacca gcttccccaa
     3061 gagagtgtca gaatcttaag agctgagagg ccgggcacgg tggctcacgc ctgtaatccc
     3121 agcactttgg gaggctgaga caggcagatc acttgaggtc aggagttcga agtcagcctg
     3181 gccaacgtgg tgaaacccca tcttcactaa aaatacaaaa cttagctggt taggtggtgc
     3241 atgcctgtag tcccagctac tcgggaggcc gaggcagaag aatctcttga actgaggagg
     3301 tggaggttgc agtgagccga gatcacgcca ttgcactcca gcctgggcaa cagagcaaga
     3361 ctccatctca aaaaaataat aataatctta aagatgagaa aagccacccc atctggcacc
     3421 acagctgcat cttgcttgtg agaaatgggg aagagttcag ggaggacacg tgacctgcac
     3481 aggatcacag agcatggggc agagccagga ctagagctca gggcatctga ctccctcttc
     3541 agtgttcttc cccctccatg ttgcctgccc ctgaagacct ttgagttcag tctacaccta
     3601 agcaggtaga catccgcgag gtcagatgct ttccaacatg acacctgaac atcttccttt
     3661 atgcaacacc caaacatctt ggcatcccca ccccaggaag tgcggggagg aggttatgat
     3721 ccctgggcgc ttcggcagaa tggagagctg aggtgtccct cccctgctag tcacctacca
     3781 ggtgtctgag cagctgcatg ctccctggct caagtgggca ctgtaccttt tgcctgcctt
     3841 tttgttccct atctccactc cctgaggcca cttagcctga gacatgatgc aagagctgca
     3901 ggccgggggg ctcagtgcca tggaagctac tccaagttgc attgcctccc gcgcccagat
     3961 cctgctttcc atttcgagaa cataaataga ttgcccagcc cctccagtac aatcccactg
     4021 gaagaaaagg caatggcggg cttcagccag acctgctgag acctaggttg ccacggtaac
     4081 agccaaagac atcaacccaa gtgctgggtc aagtgtctca tcatactggc actgttgctg
     4141 gggtgacggc agaattcaga acttcaattt cagtgacgcc aagcttgatg tgtttctgtt
     4201 attgttttga agaaggtagc tcttgtggag gacttgggag aaggatgggg tcttaggaag
     4261 gaggtgacag cacttgcatg gtcacttgag cccacacaca cgctcaaccc caagtccttt
     4321 atgctttgtc acagtgaaga tgagacctct gacgtccaag ccttgttcct gtgctgcatc
     4381 acccactcag ccttccaaag ggaacaggaa caaatttccc cagcaccact gtttgggtcc
     4441 cgcttttcct atcttctgct gcccctgagc acatccaagc agacagggaa agaggagtca
     4501 gacatggccc agtcacatcc tgagctgctc ctggctgata accacgatgg agcccgtgtt
     4561 tgtcctgcca tctggcactg cactgagtgt ggcacaggca ccgtcctgtt gatctcacaa
     4621 cacagttcta agttaggacg ttcttggctc cgttagacag gtgaggaaac tggggcacag
     4681 agaggtgatg tcatctgcct ggtgtcaatc agctagcaag tgatggagcc cagatttcaa
     4741 accaaagggg gttacgtcca ggggctgagt tcccactcac ctgtgtagag tgccatctgg
     4801 gcaccattgc tccagacgtg ttccgacccc tttcccagcc cacagggctt gaagtgaagg
     4861 aacagaggca gggggtgggc cagccccagg gccagggtcc ccttggtgaa gccgtgccag
     4921 ggggctcagc tgcttcaggg aatgtgtccc tcccaccatg ggccagagct tcagcccttc
     4981 tttagctcag ctagagttca caggagagcc aaaaaagaaa aggaagctga gcatctcccg
     5041 agtcctgggc agggaagggg agggaaattg ctgcttctcc aactcttgct tggggccaag
     5101 ccctgcacca gttgcttccc agctgttatc tgccagatct tcccatcttg tggcatgtgg
     5161 tgcccccacc aacatcccaa ggggaccaat ccccttgcca ccactttgca tcacctggga
     5221 ccacagattt ggacaggaag ggctctgaga agaggccaaa gccctcattt tacagatgag
     5281 gaagctgaag cccggggagg ggagcgaccc tcaaggccac ccagctggac acgggagact
     5341 tgagcccagc cttctgactg cattcagccc tctctaggac gcagcagcct ctccccagca
     5401 ctgagtcccc cctcctttgt gtgtcccagc acccttggcc tgagtaaact tggaaagggg
     5461 ctccctccca gagaagggac tactctcttc acccctttat tccagctgcc tgccacccca
     5521 gacccccacc tcccaccctg acccccgacc cctgggtggg gaaggggctc acatgggccc
     5581 aggctgagtg tgagtgagca tgtcaagttg tctgacactg tgacattagt gcaccctact
     5641 gacaacccct ccccagcctt gcccctttct cctctccctg ttttgtacat aaattgacat
     5701 gagctgcaac atgtgtgcgt gtgtgtgcgt gtgtgtgtgt gtgtatgtgt gtgtgatctg
     5761 tgtcatggtt ttgttacctt tttgtttttg taaacttgaa tgttcaaaat aaacatgctg
     5821 tttactctga
//
