LOCUS       NM_002522               5439 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens neuronal pentraxin 1 (NPTX1), mRNA.
ACCESSION   NM_002522 XM_941257
VERSION     NM_002522.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5439)
  AUTHORS   Sun,Y., Xie,L., Ren,X., Ran,L., He,H., Kong,F., Yang,S. and
            Zhang,M.
  TITLE     miR-148a-3p regulates proliferation and apoptosis of idiopathic
            gingival fibroma by targeting NPTX1
  JOURNAL   Oral Dis 30 (4), 2136-2149 (2024)
   PUBMED   37357360
  REMARK    GeneRIF: miR-148a-3p regulates proliferation and apoptosis of
            idiopathic gingival fibroma by targeting NPTX1.
REFERENCE   2  (bases 1 to 5439)
  AUTHORS   Warth Perez Arias,C.C., Silbern,I., Caldi Gomes,L., Wartmann,H.,
            Dambeck,V., Fanz,J., Neuenroth,L., Bahr,M., Outeiro,T.F., Bonn,S.,
            Stadelmann-Nessler,C., Rizzoli,S.O., Lenz,C., Urlaub,H. and
            Lingor,P.
  TITLE     Proteomic analysis of the human hippocampus identifies neuronal
            pentraxin 1 (NPTX1) as synapto-axonal target in late-stage
            Parkinson's disease
  JOURNAL   J Neurochem 166 (5), 862-874 (2023)
   PUBMED   37515330
  REMARK    GeneRIF: Proteomic analysis of the human hippocampus identifies
            neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage
            Parkinson's disease.
REFERENCE   3  (bases 1 to 5439)
  AUTHORS   Coutelier,M., Jacoupy,M., Janer,A., Renaud,F., Auger,N.,
            Saripella,G.V., Ancien,F., Pucci,F., Rooman,M., Gilis,D.,
            Lariviere,R., Sgarioto,N., Valter,R., Guillot-Noel,L., Le Ber,I.,
            Sayah,S., Charles,P., Numann,A., Pauly,M.G., Helmchen,C.,
            Deininger,N., Haack,T.B., Brais,B., Brice,A., Tregouet,D.A., El
            Hachimi,K.H., Shoubridge,E.A., Durr,A. and Stevanin,G.
  TITLE     NPTX1 mutations trigger endoplasmic reticulum stress and cause
            autosomal dominant cerebellar ataxia
  JOURNAL   Brain 145 (4), 1519-1534 (2022)
   PUBMED   34788392
  REMARK    GeneRIF: NPTX1 mutations trigger endoplasmic reticulum stress and
            cause autosomal dominant cerebellar ataxia.
REFERENCE   4  (bases 1 to 5439)
  AUTHORS   Vial,R., Poitevin,S., McKay,N., Burtey,S. and Cerini,C.
  TITLE     Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in
            Endothelial Cells
  JOURNAL   Int J Mol Sci 23 (4), 2369 (2022)
   PUBMED   35216489
  REMARK    GeneRIF: Tryptophan Metabolites Regulate Neuropentraxin 1
            Expression in Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5439)
  AUTHORS   Ye,R.Y., Kuang,X.Y., Shao,N., Wang,S.M. and Lin,Y.
  TITLE     Downregulation of NPTX1 induces cell cycle progression through
            Wnt/beta-catenin signaling in breast cancer
  JOURNAL   J Biol Regul Homeost Agents 35 (3), 1177-1183 (2021)
   PUBMED   34212686
  REMARK    GeneRIF: Downregulation of NPTX1 induces cell cycle progression
            through Wnt/beta-catenin signaling in breast cancer.
REFERENCE   6  (bases 1 to 5439)
  AUTHORS   Guzeloglu-Kayisli,O., Basar,M., Shapiro,J.P., Semerci,N.,
            Huang,J.S., Schatz,F., Lockwood,C.J. and Kayisli,U.A.
  TITLE     Long-acting progestin-only contraceptives enhance human endometrial
            stromal cell expressed neuronal pentraxin-1 and reactive oxygen
            species to promote endothelial cell apoptosis
  JOURNAL   J Clin Endocrinol Metab 99 (10), E1957-E1966 (2014)
   PUBMED   25029423
  REMARK    GeneRIF: Long acting progestin contraceptive-enhanced NPTX1
            secretion and reactive oxygen species generation in endometrial
            stromal cells impair endometrial endothelial cells survival
            resulting in a loss in vascular integrity.
REFERENCE   7  (bases 1 to 5439)
  AUTHORS   Abad,M.A., Enguita,M., DeGregorio-Rocasolano,N., Ferrer,I. and
            Trullas,R.
  TITLE     Neuronal pentraxin 1 contributes to the neuronal damage evoked by
            amyloid-beta and is overexpressed in dystrophic neurites in
            Alzheimer's brain
  JOURNAL   J Neurosci 26 (49), 12735-12747 (2006)
   PUBMED   17151277
  REMARK    GeneRIF: Neuronal pentraxin 1 transgene is a key factor for the
            synapse loss, the neurite damage, and the apoptotic neuronal death
            evoked by amyloid-beta protein, which regulates NP1 expression.
REFERENCE   8  (bases 1 to 5439)
  AUTHORS   Poulsen,T.T., Pedersen,N., Perin,M.S., Hansen,C.K. and Poulsen,H.S.
  TITLE     Specific sensitivity of small cell lung cancer cell lines to the
            snake venom toxin taipoxin
  JOURNAL   Lung Cancer 50 (3), 329-337 (2005)
   PUBMED   16115696
  REMARK    GeneRIF: The purpose of the present study was to assess the toxic
            effect of taipoxin in SCLC-cell lines and to determine if toxicity
            correlates to NPR and NP1 and NP2 expression levels.
REFERENCE   9  (bases 1 to 5439)
  AUTHORS   Kirkpatrick,L.L., Matzuk,M.M., Dodds,D.C. and Perin,M.S.
  TITLE     Biochemical interactions of the neuronal pentraxins. Neuronal
            pentraxin (NP) receptor binds to taipoxin and taipoxin-associated
            calcium-binding protein 49 via NP1 and NP2
  JOURNAL   J Biol Chem 275 (23), 17786-17792 (2000)
   PUBMED   10748068
REFERENCE   10 (bases 1 to 5439)
  AUTHORS   Omeis,I.A., Hsu,Y.C. and Perin,M.S.
  TITLE     Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic
            structure, and chromosomal localization
  JOURNAL   Genomics 36 (3), 543-545 (1996)
   PUBMED   8884281
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120024.22, AK127335.1 and
            DA188847.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002522.3.
            
            Summary: NPTX1 is a member of the neuronal pentraxin gene family.
            Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a
            binding protein for the snake venom toxin taipoxin. Human NPTX1
            mRNA is exclusively localized to the nervous system. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127335.1, U61849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306773.5/ ENSP00000307549.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC120024.22        65534-65536
            4-1067              AK127335.1         1-1064
            1068-1382           DA188847.1         196-510
            1383-5439           AC120024.22        71251-75307
FEATURES             Location/Qualifiers
     source          1..5439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..5439
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /note="neuronal pentraxin 1"
                     /db_xref="GeneID:4884"
                     /db_xref="HGNC:HGNC:7952"
                     /db_xref="MIM:602367"
     exon            1..605
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1460
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /note="NP-I; neuronal pentraxin I"
                     /codon_start=1
                     /product="neuronal pentraxin-1 precursor"
                     /protein_id="NP_002513.2"
                     /db_xref="CCDS:CCDS32762.1"
                     /db_xref="GeneID:4884"
                     /db_xref="HGNC:HGNC:7952"
                     /db_xref="MIM:602367"
                     /translation="MPAGRAARTCALLALCLLGAGAQDFGPTRFICTSVPVDADMCAA
                     SVAAGGAEELRSSVLQLRETVLQQKETILSQKETIRELTAKLGRCESQSTLDPGAGEA
                     RAGGGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTN
                     SLKDLLQSKIDELERQVLSRVNTLEEGKGGPRNDTEERVKIETALTSLHQRISELEKG
                     QKDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKSSATPGVGTPFSYAVP
                     GQANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQ
                     GGSGENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVY
                     NLATCSTKALSGNVIAWAESHIEIYGGATKWTFEACRQIN"
     exon            606..813
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1058
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1238
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..5439
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5420..5425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /note="hexamer: AGTAAA"
     polyA_site      5439
                     /gene="NPTX1"
                     /gene_synonym="NP1; SCA50"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtgggg gcctgatagc gcggcggtgt ggaccgcgcg gccgaagagc gcggcgccca
       61 gagcgcgggc cgctcgcgga gccacagccc gagccgggtc ccagccggag ccgagcccca
      121 gccgagccga gccgggcccg gagcgcccgg tgcccgcagc catgccggcc ggccgcgccg
      181 cgcgcacctg tgcgctgctc gccctctgcc tcctgggcgc cggggcccag gatttcgggc
      241 cgacgcgctt catctgcacc tcggtgcccg tggacgccga catgtgcgcc gcgtccgtgg
      301 ccgccggcgg cgccgaggag ctccggagca gcgtgctgca gctccgcgag acggtgctgc
      361 agcagaagga gaccatcctg agccagaagg agaccatccg cgagctgacc gccaagctgg
      421 gccgctgcga gagccagagc acgctggacc ccggagccgg cgaggcccgg gcgggcggcg
      481 gccgcaagca gcccggctcg ggcaagaaca ccatgggcga cctgtcccgg acaccggccg
      541 ccgagacgct cagccaactc gggcaaactt tgcaatcgct caaaacccgc ctggagaacc
      601 tcgagcagta cagccgcctc aattcctcca gccagaccaa cagcctcaag gatctgctgc
      661 agagcaagat cgatgagctg gagaggcagg tgctgtcccg ggtgaacacc ctggaggagg
      721 gcaagggggg ccccaggaac gacaccgagg agagggtcaa gatcgagacc gccctgacct
      781 ccctgcacca gcggatcagc gagctcgaga aaggtcagaa agacaaccgc cctggagaca
      841 agttccagct cacattccca ctgcggacca actatatgta tgccaaggtg aagaagagcc
      901 tgccagagat gtacgccttc actgtctgca tgtggctcaa gtccagcgcc acgccaggtg
      961 tgggcacgcc cttctcctac gctgtgcccg gccaggccaa cgagctggtc ctcattgagt
     1021 ggggcaacaa ccccatggag atcctcatca atgacaaggt ggccaagttg ccttttgtca
     1081 tcaatgatgg caagtggcac cacatctgtg tcacctggac cacccgggac ggggtctggg
     1141 aggcctacca ggatggcacg cagggtggca gtggcgagaa cttggcgccc tatcacccca
     1201 tcaagcccca gggcgtgctg gtgctgggcc aggagcagga cactctgggt ggtgggtttg
     1261 atgccaccca ggcatttgtg ggtgagctgg cccacttcaa catctgggac cgcaagctga
     1321 cccccgggga ggtgtacaac ctggccacct gcagcaccaa ggctctgtcc ggcaatgtca
     1381 tcgcctgggc tgaatcccac atcgagatct acggaggggc caccaagtgg accttcgagg
     1441 cctgtcgcca gatcaactga gcacggcagg ccaggctgag cccgcccgcc ctcgccccct
     1501 gcttgtgcgg cgatgatctg ttttgtgcgt ctcttctctc ccttttcccc aggaatgaac
     1561 cgaggccgtc gcccctgcac acgcacacgc acacagcctg gttttgtcct catgcacacg
     1621 aagcagcccc tgctcccatc tgtccctgag gaagccccac ttctctgtag gagcccggac
     1681 tctctcaggc atgccccatt cacagctgaa gtgggtgctg caacgtcttg aacaaggcag
     1741 aagttggtga gaggatctgt gtgtgcgtgt ctacatgtgt gtgtctacgt gtgtgcgtgc
     1801 gtggctgggg gaggcctttt ctttgaggac gtacctcatt tccttctttc ttctggcttt
     1861 ggaaaaatct catgatgaaa attcatattt gccaactttg ttagctgcgt gcgtgctttg
     1921 gggttggtgc aacctcagta cacgcatttg tctttgtttg caaacctttc tcagagcgac
     1981 atatctttat attgatgtaa taaatgtctt ttagtggttt gtcaaaggcc gggggcgggg
     2041 gctctctaca gagaattttt attttgtaat agaagtgaac tgtctctgaa gggtgaaggc
     2101 aggccgtcct gggatggtac cctgtgctct cccgtggagg agaggggatg gctgaggaca
     2161 ctggccctta ccccagggcc agacagcatc catccctgct gtttgcatct gagagcagca
     2221 tggggcctgg gaggtcggcc tgtgtgccca gctcagctag ctctgcccca ggacggccct
     2281 gccctcgacc ttcccacctc ctcagatcct gcaaggctgg ggtctgcccc tcccttctca
     2341 cctctggagc tgtgctgcac tgcttcagcc cagagggccc tgagagagga gcgtgccacc
     2401 cacagcccgg gaagccgggc cccagcaccc ctctcctttg gcctccggca gtgcagacca
     2461 gaggggacct tttaaggaaa gaagccgtgt ttcgatgaag acctggccac atggggccac
     2521 tgggacttca acccagccca tcggtgggaa ggtccttttt gggggacttt gacagccata
     2581 tccctcccag cacaccaggc gccaggtgag ctggttcaga cccctccagg ggtactccag
     2641 agacctcacg tgtggagcca ggcctggcca gggcaggggc ctgaaaccca ctcctccatc
     2701 tcatggggct cacggcctac agcagcccac aagctgccac tggccggcga cactgacacc
     2761 tgagcagtgt ccagaacctt tttgcctttt tttgttcccc gtgaaaagca acatggacat
     2821 ttccttctag tccttccaag gaggggagag aagtgtatgt gcatttgtgt gtgtgtgtgt
     2881 gtgttgtgtg tgtgtgtgcg ctaagtgaga aagagagcag gctcgggagg ccctgcccag
     2941 ggtaggagga gcttcctgct ttgcaccatc tggtggtcgc acgccctgag ggcaccccga
     3001 ctctgtctcc aggagtctca tcagcaaacc gctgacaagt ctttctagaa attctactgc
     3061 actgcctggc tcagctgcag ctgcagacat ttctgcagga ggagcaggtg tttctgtctt
     3121 ctgttccttc tagggccacc tgtcccctta aacacaggtc cacgttgtgt caagaaccta
     3181 gtgcatctgt gtgtgtctgt cagtgtctct gtgtcagtgt tctcgtgggt gtctgcacgg
     3241 tacccggccg ccgttctgca atgcatcact cccgcagagg ggggtgcaga tcaggcgccg
     3301 tgctgcgcgt tgttgttcaa cagtggcttt ttcttagata atcgtgcttc ctcagcgccc
     3361 gtcgggttgt ggcatccttg gatctgcagg gatcttctcc gtttgcatgt tcctcggggt
     3421 ggcgtgttcc ttgctccctg ggtccgacat gtgttcccgc acctgcatgg actgccccgg
     3481 ttctgtgttg tgtgccgagt gccgcccagt gttctgtgac cacccgtgta gctactgaaa
     3541 atggctgggt aagcaagtca agggtgttgg aggaggtcaa gagagagctc agtttccctc
     3601 tccccctccc caaacacacc aagaagcatt tttaacgtgt aggttgagaa caagcctaaa
     3661 ggattcccac agctgggagc cagcaagaga gcttggagtc gcctctctag accagatcta
     3721 gccccaccct cactccagcc atctcggagc ccttgtgtag gcaacgcccg gtgcgggctg
     3781 tgtggggtgc tcccctgcca gcacctccgg ccagccccgc ccctgccgat ctactggacc
     3841 gcagaccacc ttctgccccc gtgggccagg tgggagctgt ccgttcagga ccatgagcca
     3901 tcctctgccc tgactagcga ggggcagagc acaccccagt gcttacgcct ccacccctgc
     3961 agcctcctgg cccgctcacc ttcctcaccc ctcctctgac ccacccatgg tgccagggcc
     4021 gaagctgacc tttagctccc tcctgcccct tgctagggtc tgagccaagc ccctcgactc
     4081 cctcactgtg ttgacacttg gcactttgct ggccccgaga aaggtcgatg acacagccgc
     4141 aaatctaatc cacgtagttc ccatttactc cttaatctga ttgatgttcc ctcttgcact
     4201 gaataataca tgcctctctc aggtaagcca ttttataaaa caagaagata aaaagcactg
     4261 ttgaggcagt gtttgctttt gccgagctgg tgtccgacag ctccctgggt gtccggggtg
     4321 ggagagctgt tgacagaagc tctccgggcc ctcaggggct tagatcccac ttgagtcgta
     4381 agccttcttg cttttgataa cacagtatta tttctcttac tgtagaagaa aaagtttatt
     4441 accaaacaag agtattttta tgaaagaaaa ggacaaacct ataaattaac tcaacctata
     4501 tctcccttga aaatactttc aggctccacc aaaacgtaga actgaaagca tgtattttgg
     4561 aagaaagaga tacattttgt atgctttctt ttccttttgt agattcccag tttattttct
     4621 aagactgcaa agatcacttt gtcaccagcc ctgggacctg agaccaaggg ggtgtcttgt
     4681 gggcagtgag ggggtgagga gaggctggca tgaggttcag tcattccagt gagctccaaa
     4741 gaggggccac ctgttctcaa aagcatgttg gggaccagga ggtaaaactg gccatttatg
     4801 gtgaacctgt gtcttggagc tgacttacta agtggaatga gccgaggatt tgaatatcag
     4861 ttctaacctt gatagaagaa ccttgggtta catgtggttc acattaagag gatagaatcc
     4921 tttggaatct tatggcaacc aaatgtggct tgacgaagtc gtggtttcat ctcttaaaca
     4981 cagtgtgtaa atttattcaa ctaacgatgg gaaatgtatt acttctgtac acagtggact
     5041 gaagtgcaat ttgttgaaag ggaacaagtc attgaagaga aaaaaaaagc ccaatactta
     5101 gagtcccaat tttgtctcat ttgccaaaaa aaaaaaaaaa aaaaaagcaa accccctatg
     5161 gttgatattg ttataatgta tatactgtat aatatgaaag agaatcgatg tatctcactt
     5221 tttcattatt tgctaaccaa agctgtacat ttttcatatg atctgcagcc ttttgggtat
     5281 caaatgggtc aaaaccatgg gacctgccac ctcccatcag caattctgga aatgcactat
     5341 ttctactggt attcttgctt tttttttttt tttcattttc ttgctgaaat gacatgaatt
     5401 gttgagttta tttttacaca gtaaagagtg gagaaagac
//
