LOCUS       NM_012428               2420 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neuroplastin (NPTN), transcript variant b, mRNA.
ACCESSION   NM_012428
VERSION     NM_012428.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2420)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2420)
  AUTHORS   Sumardika,I.W., Chen,Y., Tomonobu,N., Kinoshita,R., Ruma,I.M.W.,
            Sato,H., Kondo,E., Inoue,Y., Yamauchi,A., Murata,H., Yamamoto,K.I.,
            Tomida,S., Shien,K., Yamamoto,H., Soh,J., Futami,J., Putranto,E.W.,
            Hibino,T., Nishibori,M., Toyooka,S. and Sakaguchi,M.
  TITLE     Neuroplastin-beta mediates S100A8/A9-induced lung cancer
            disseminative progression
  JOURNAL   Mol Carcinog 58 (6), 980-995 (2019)
   PUBMED   30720226
  REMARK    GeneRIF: Expression profiling of NPTNbeta showed significantly high
            expression levels in lung cancer cell lines. NPTNbeta has strong
            ability to induce cancer-related cellular events, including
            anchorage-independent growth, motility and invasiveness, in lung
            cancer cells in response to extracellular S100A8/A9, eventually
            leading to the expression of a cancer disseminative phenotype in
            lung tissue in vivo.
REFERENCE   4  (bases 1 to 2420)
  AUTHORS   Ilic,K., Mlinac-Jerkovic,K., Jovanov-Milosevic,N., Simic,G.,
            Habek,N., Bogdanovic,N. and Kalanj-Bognar,S.
  TITLE     Hippocampal expression of cell-adhesion glycoprotein neuroplastin
            is altered in Alzheimer's disease
  JOURNAL   J Cell Mol Med 23 (2), 1602-1607 (2019)
   PUBMED   30488668
  REMARK    GeneRIF: Hippocampal expression of neuroplastin is altered in
            Alzheimer's disease.
REFERENCE   5  (bases 1 to 2420)
  AUTHORS   Gong,D., Chi,X., Ren,K., Huang,G., Zhou,G., Yan,N., Lei,J. and
            Zhou,Q.
  TITLE     Structure of the human plasma membrane Ca2+-ATPase 1 in complex
            with its obligatory subunit neuroplastin
  JOURNAL   Nat Commun 9 (1), 3623 (2018)
   PUBMED   30190470
  REMARK    GeneRIF: Cryoelectron microscopy structure offers important insight
            into how the NPTN binds to the PMCA1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2420)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   7  (bases 1 to 2420)
  AUTHORS   Bernstein,H.G., Smalla,K.H., Bogerts,B., Gordon-Weeks,P.R.,
            Beesley,P.W., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     The immunolocalization of the synaptic glycoprotein neuroplastin
            differs substantially between the human and the rodent brain
  JOURNAL   Brain Res 1134 (1), 107-112 (2007)
   PUBMED   17196182
  REMARK    GeneRIF: In human brain np65 is prominently present in cerebellum
            while np55 is the predominant isoform in mouse and rat cerebellum.
REFERENCE   8  (bases 1 to 2420)
  AUTHORS   Saito,A., Fujikura-Ouchi,Y., Kuramasu,A., Shimoda,K., Akiyama,K.,
            Matsuoka,H. and Ito,C.
  TITLE     Association study of putative promoter polymorphisms in the
            neuroplastin gene and schizophrenia
  JOURNAL   Neurosci Lett 411 (3), 168-173 (2007)
   PUBMED   17123723
  REMARK    GeneRIF: NPTN may be involved in genetic susceptibility to
            schizophrenia.
REFERENCE   9  (bases 1 to 2420)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 2420)
  AUTHORS   Langnaese,K., Beesley,P.W. and Gundelfinger,E.D.
  TITLE     Synaptic membrane glycoproteins gp65 and gp55 are new members of
            the immunoglobulin superfamily
  JOURNAL   J Biol Chem 272 (2), 821-827 (1997)
   PUBMED   8995369
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN357076.1, AF109126.1,
            BC067828.1 and AI357728.1.
            
            On May 17, 2019 this sequence version replaced NM_012428.3.
            
            Summary: This gene encodes a type I transmembrane protein belonging
            to the Ig superfamily. The protein is believed to be involved in
            cell-cell interactions or cell-substrate interactions. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, May 2009].
            
            Transcript Variant: This variant (b), alternatively known as beta,
            represents the longest transcript and encodes the longest isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF109126.1, SRR1660809.231379.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345330.9/ ENSP00000290401.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               CN357076.1         30-294
            266-1775            AF109126.1         230-1739
            1776-2418           BC067828.1         1443-2085
            2419-2420           AI357728.1         12-13               c
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2420
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /note="neuroplastin"
                     /db_xref="GeneID:27020"
                     /db_xref="HGNC:HGNC:17867"
                     /db_xref="MIM:612820"
     exon            1..265
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1371
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /note="isoform b precursor is encoded by transcript
                     variant b; stromal cell derived factor receptor 1; SDR-1;
                     stromal cell-derived receptor 1"
                     /codon_start=1
                     /product="neuroplastin isoform b precursor"
                     /protein_id="NP_036560.1"
                     /db_xref="CCDS:CCDS10249.1"
                     /db_xref="GeneID:27020"
                     /db_xref="HGNC:HGNC:17867"
                     /db_xref="MIM:612820"
                     /translation="MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLT
                     GDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLR
                     ITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRD
                     SPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHC
                     VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKEN
                     GMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR
                     SHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNL
                     RQRNTN"
     exon            266..613
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..785
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..880
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1014
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1288
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1310
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1385
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..2420
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2399..2404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /note="hexamer: AATAAA"
     polyA_site      2420
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /note="major polyA site"
ORIGIN      
        1 gaggcctggg cgctgcggcg gcaggaggag gacggggaag gacggagccg agccgcggct
       61 gcctccctcg ctcactccct cgcgcactcg cccgccccct ccctccctcc cctcccttcc
      121 ccggccccgg ctctggcccc ggcccattcg ctgttgggtc ttctgctagg gaggatgtcg
      181 ggttcgtcgc tgcccagcgc cctggccctc tcgctgttgc tggtctctgg ctccctcctc
      241 ccagggccag gcgccgctca gaacgctggg tttgtcaagt cgcccatgtc agaaactaag
      301 ctcacggggg acgcctttga gctgtactgt gacgtggtcg ggagccccac gccagagatc
      361 cagtggtggt acgcagaagt caaccgggca gagtctttca gacagctgtg ggacggtgct
      421 cggaagcgcc gtgtcaccgt aaacaccgcc tacgggtcaa acggcgtgag tgtgctgaga
      481 ataacccggc tcaccttgga ggactctggg acttacgagt gcagggccag caacgacccc
      541 aagaggaatg acttgaggca aaacccctcc ataacatgga ttcgagccca ggccaccata
      601 agcgtccttc agaagccaag gattgtcacc agtgaagagg tcattattcg agacagccct
      661 gttctccctg tcaccctgca gtgtaacctc acctccagct ctcacaccct tacatacagc
      721 tactggacaa agaatggggt ggaactgagt gccactcgta agaatgccag caacatggag
      781 tacaggatca ataagccgag agctgaggat tcaggcgaat accactgcgt atatcacttt
      841 gtcagcgctc ctaaagcaaa cgccaccatt gaagtgaaag ccgctcctga catcactggc
      901 cataaacgga gtgagaacaa gaatgaaggg caggatgcca ctatgtattg caagtcagtt
      961 ggctaccccc acccagactg gatatggcgc aagaaggaga acgggatgcc catggacatt
     1021 gtcaatacct ctggccgctt cttcatcatc aacaaggaaa attacactga gttgaacatt
     1081 gtgaacctgc agatcacgga agaccctggc gagtatgaat gtaatgccac caacgccatt
     1141 ggctccgcct ctgttgtcac tgtcctcagg gtgcggagcc acctggcccc actctggcct
     1201 ttcttgggaa ttctggctga aattatcatc cttgtggtga tcattgttgt gtatgagaag
     1261 aggaagaggc cagatgaggt tcctgacgat gatgaaccag ctggaccaat gaaaaccaac
     1321 tctaccaaca atcacaaaga taaaaacttg cgccagagaa acacaaatta agtactgctt
     1381 acaatatctt taggttcctg aaactggtgg caacatgacc tgctaaaatt ttctgcttgg
     1441 acctctttgg ttctctcccc tttcaagtga gcaacaccac aatgactgtc taaagcatgc
     1501 cttatttagc ctctcctgta agggtgatct agccaggtac attttaaaca atgcttcagt
     1561 gtagaaggtg taaactattt tgggcttgat gtgctgtgaa tgttgctttt ttttttcctt
     1621 tgttaaaata tttaaataga agtgaaaagg tcctctgagg atcagatcat gcatgcgcca
     1681 ttttttactt aatgcagctg ttaaattggc aaagctctaa aatgcactgc tgccatctag
     1741 tgatacactt ttgtaaagta cagcaaaacc tacagatata tacagtatat aaatatatat
     1801 atatatatat ttatattttt gggggtggga gaaatccaaa ataaagtaaa tgcttgtttc
     1861 atttttaagc tgctgatatt cattccttat tgtatgttgt cagatgagga aattgtgcag
     1921 ttctggtaca taaagatgag taatataaac tgaaatctat aattttaagg gcttaacctg
     1981 tgactttaat aagctggaac agtccactga atgggtataa tgaattgcag tatatacgta
     2041 tgattgcttt ttaagtgatt atcttttctt ctgttaagtc atgtaaattc ataaatcctt
     2101 ttgcactgat gtgttgaacc ttattcttgt acattcattc aatcaaggca aacttttata
     2161 atttttcttt tgtttccaat gaccttgaaa tgttatagca tggtaatatt ctatgcaact
     2221 atagttatac tttttggttt gacactgtat tttttcacat tgatttactg gttgatgata
     2281 gattttataa cctaacggtt ctcatgcggt gcgtaattgt agatgcatgt acttgtgtgt
     2341 tttgtgtaat tattgaagtg caatgatgta taaaaaagtg gattcacctg tttttaaaaa
     2401 taaaacattg ataaaaggtg
//
