LOCUS       NM_207172               1634 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens neuropeptide S receptor 1 (NPSR1), transcript variant
            1, mRNA.
ACCESSION   NM_207172
VERSION     NM_207172.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Peng,Y., Chen,L., Chen,X., Lin,J., Wei,J., Cheng,J., Zhou,F.,
            Ge,L., Zhou,R., Ding,F. and Wang,X.
  TITLE     NPSR1 promotes chronic colitis through regulating CD4+ T cell
            effector function in inflammatory bowel disease
  JOURNAL   Int Immunopharmacol 142 (Pt B), 113252 (2024)
   PUBMED   39332092
  REMARK    GeneRIF: NPSR1 promotes chronic colitis through regulating CD4[+] T
            cell effector function in inflammatory bowel disease.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Tapmeier,T.T., Rahmioglu,N., Lin,J., De Leo,B., Obendorf,M.,
            Raveendran,M., Fischer,O.M., Bafligil,C., Guo,M., Harris,R.A.,
            Hess-Stumpp,H., Laux-Biehlmann,A., Lowy,E., Lunter,G., Malzahn,J.,
            Martin,N.G., Martinez,F.O., Manek,S., Mesch,S., Montgomery,G.W.,
            Morris,A.P., Nagel,J., Simmons,H.A., Brocklebank,D., Shang,C.,
            Treloar,S., Wells,G., Becker,C.M., Oppermann,U., Zollner,T.M.,
            Kennedy,S.H., Kemnitz,J.W., Rogers,J. and Zondervan,K.T.
  TITLE     Neuropeptide S receptor 1 is a nonhormonal treatment target in
            endometriosis
  JOURNAL   Sci Transl Med 13 (608) (2021)
   PUBMED   34433639
  REMARK    GeneRIF: Neuropeptide S receptor 1 is a nonhormonal treatment
            target in endometriosis.
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Bengoetxea,X., Goedecke,L., Remmes,J., Blaesse,P., Grosch,T.,
            Lesting,J., Pape,H.C. and Jungling,K.
  TITLE     Human-Specific Neuropeptide S Receptor Variants Regulate Fear
            Extinction in the Basal Amygdala of Male and Female Mice Depending
            on Threat Salience
  JOURNAL   Biol Psychiatry 90 (3), 145-155 (2021)
   PUBMED   33902914
  REMARK    GeneRIF: Human-Specific Neuropeptide S Receptor Variants Regulate
            Fear Extinction in the Basal Amygdala of Male and Female Mice
            Depending on Threat Salience.
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Ahmad,A., Almsned,F., Ghazal,P., Ahmed,M.W., Jafri,M.S. and
            Bokhari,H.
  TITLE     Neuropeptide S receptor gene Asn107 polymorphism in obese male
            individuals in Pakistan
  JOURNAL   PLoS One 15 (12), e0243205 (2020)
   PUBMED   33332443
  REMARK    GeneRIF: Neuropeptide S receptor gene Asn107 polymorphism in obese
            male individuals in Pakistan.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Vendelin,J., Pulkkinen,V., Rehn,M., Pirskanen,A.,
            Raisanen-Sokolowski,A., Laitinen,A., Laitinen,L.A., Kere,J. and
            Laitinen,T.
  TITLE     Characterization of GPRA, a novel G protein-coupled receptor
            related to asthma
  JOURNAL   Am J Respir Cell Mol Biol 33 (3), 262-270 (2005)
   PUBMED   15947423
  REMARK    GeneRIF: GPRA might have functional relevance in modulating asthma
            by increased expression levels in the relevant tissues under
            diseased state and by potential inhibitory effect of GPRA-A
            activation on cell growth
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Xu,Y.L., Reinscheid,R.K., Huitron-Resendiz,S., Clark,S.D., Wang,Z.,
            Lin,S.H., Brucher,F.A., Zeng,J., Ly,N.K., Henriksen,S.J., de
            Lecea,L. and Civelli,O.
  TITLE     Neuropeptide S: a neuropeptide promoting arousal and
            anxiolytic-like effects
  JOURNAL   Neuron 43 (4), 487-497 (2004)
   PUBMED   15312648
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Laitinen,T., Polvi,A., Rydman,P., Vendelin,J., Pulkkinen,V.,
            Salmikangas,P., Makela,S., Rehn,M., Pirskanen,A., Rautanen,A.,
            Zucchelli,M., Gullsten,H., Leino,M., Alenius,H., Petays,T.,
            Haahtela,T., Laitinen,A., Laprise,C., Hudson,T.J., Laitinen,L.A.
            and Kere,J.
  TITLE     Characterization of a common susceptibility locus for
            asthma-related traits
  JOURNAL   Science 304 (5668), 300-304 (2004)
   PUBMED   15073379
  REMARK    GeneRIF: properties of GPRA make it a strong candidate for
            involvement in the pathogenesis of asthma and other IgE-mediated
            diseases; GPRA encodes isoforms produced in distinct patterns by
            bronchial epithelial & smooth muscle cells in asthma & healthy
            individuals
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Gupte,J., Cutler,G., Chen,J.L. and Tian,H.
  TITLE     Elucidation of signaling properties of vasopressin receptor-related
            receptor 1 by using the chimeric receptor approach
  JOURNAL   Proc Natl Acad Sci U S A 101 (6), 1508-1513 (2004)
   PUBMED   14757815
  REMARK    GeneRIF: Vasopressin receptor-related receptor 1, also called G
            protein-coupled receptor 154, has dual signaling properties in
            coupling to both G(q) and G(S) pathways.
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Feldman,D.S., Zamah,A.M., Pierce,K.L., Miller,W.E., Kelly,F.,
            Rapacciuolo,A., Rockman,H.A., Koch,W.J. and Luttrell,L.M.
  TITLE     Selective inhibition of heterotrimeric Gs signaling. Targeting the
            receptor-G protein interface using a peptide minigene encoding the
            Galpha(s) carboxyl terminus
  JOURNAL   J Biol Chem 277 (32), 28631-28640 (2002)
   PUBMED   12036966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005493.1 and AY310326.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_207172.1.
            
            Summary: This gene encodes a member of the vasopressin/oxytocin
            subfamily of G protein-coupled receptors. The encoded membrane
            protein acts as a receptor for neuropeptide S and affects a variety
            of cellular processes through its signaling. Increased expression
            of this gene in ciliated cells of the respiratory epithelium and in
            bronchial smooth muscle cells is associated with asthma.
            Polymorphisms in this gene have also been associated with asthma
            susceptibility, panic disorders, inflammatory bowel disease, and
            rheumatoid arthritis. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes isoform A (PMID:
            15947423).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY310326.1, SRR3476690.879040.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360581.6/ ENSP00000353788.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC005493.1         25182-25248
            68-1634             AY310326.1         1-1567
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..1634
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /note="neuropeptide S receptor 1"
                     /db_xref="GeneID:387129"
                     /db_xref="HGNC:HGNC:23631"
                     /db_xref="MIM:608595"
     exon            1..342
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1311
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /note="isoform A is encoded by transcript variant 1;
                     vasopressin receptor-related receptor 1; G-protein coupled
                     receptor 154; G-protein coupled receptor PGR14; G-protein
                     coupled receptor for asthma susceptibility"
                     /codon_start=1
                     /product="neuropeptide S receptor isoform A"
                     /protein_id="NP_997055.1"
                     /db_xref="CCDS:CCDS5444.1"
                     /db_xref="GeneID:387129"
                     /db_xref="HGNC:HGNC:23631"
                     /db_xref="MIM:608595"
                     /translation="MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSF
                     YYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNI
                     LTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGE
                     KQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLV
                     YFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYS
                     IIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFS
                     SSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI"
     exon            343..475
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..579
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..673
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..875
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..952
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1039
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1220
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1634
                     /gene="NPSR1"
                     /gene_synonym="ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaattgcc aaggagagag cagcacgtag atcctccctg tcatcaggca gagctcttca
       61 gtgaggtggg ctcagggagg gctctgtgcc tccgttcagc agagctgcag ctgctgccca
      121 gctctcagga ggcaagctgg actccctcac tcagctgcag gagcaaggac agtgaggctc
      181 aaccccgcct gagccatgcc agccaacttc acagagggca gcttcgattc cagtgggacc
      241 gggcagacgc tggattcttc cccagtggct tgcactgaaa cagtgacttt tactgaagtg
      301 gtggaaggaa aggaatgggg ttccttctac tactccttta agactgagca attgataact
      361 ctgtgggtcc tctttgtttt taccattgtt ggaaactccg ttgtgctttt ttccacatgg
      421 aggagaaaga agaagtcaag aatgaccttc tttgtgactc agctggccat cacagattct
      481 ttcacaggac tggtcaacat cttgacagat attaattggc gattcactgg agacttcacg
      541 gcacctgacc tggtttgccg agtggtccgc tatttgcagg ttgtgctgct ctacgcctct
      601 acctacgtcc tggtgtccct cagcatagac agataccatg ccatcgtcta ccccatgaag
      661 ttccttcaag gagaaaagca agccagggtc ctcattgtga tcgcctggag cctgtctttt
      721 ctgttctcca ttcccaccct gatcatattt gggaagagga cactgtccaa cggtgaagtg
      781 cagtgctggg ccctgtggcc tgacgactcc tactggaccc catacatgac catcgtggcc
      841 ttcctggtgt acttcatccc tctgacaatc atcagcatca tgtatggcat tgtgatccga
      901 actatttgga ttaaaagcaa aacctacgaa acagtgattt ccaactgctc agatgggaaa
      961 ctgtgcagca gctataaccg aggactcatc tcaaaggcaa aaatcaaggc tatcaagtat
     1021 agcatcatca tcattcttgc cttcatctgc tgttggagtc catacttcct gtttgacatt
     1081 ttggacaatt tcaacctcct tccagacacc caggagcgtt tctatgcctc tgtgatcatt
     1141 cagaacctgc cagcattgaa tagtgccatc aaccccctca tctactgtgt cttcagcagc
     1201 tccatctctt tcccctgcag ggagcaaaga tcacaggatt ccagaatgac gttccgggag
     1261 agaactgaga ggcatgagat gcagattctg tccaagccag aattcatcta gaccctaggg
     1321 cagtgccagt gctaggctga gcaccatcag ctctcccagg tccttgtcac ctgcttgggc
     1381 acgtgcatgg aacccgagcc aacttcaccc caccctcgtc attacctggg agatgcacaa
     1441 gacaaatgtt ctaatgactg catgcactgc ttaagtattg gccaacacga actccccagt
     1501 tattcatgcc agccaggaag gaaacgcctt ccttccccac cattcccagc cctccttccc
     1561 actggccagc acctgaaccc agtgaacaca ggcattagtg gtccagggtc ctggcttgga
     1621 gccagtgagt agac
//
