LOCUS       NM_001030013            1231 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens neuropeptide S (NPS), mRNA.
ACCESSION   NM_001030013
VERSION     NM_001030013.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1231)
  AUTHORS   Prisinzano,M., Bernacchioni,C., Seidita,I., Rossi,M., Raeispour,M.,
            Cencetti,F., Vannuccini,S., Fambrini,M., Petraglia,F., Bruni,P. and
            Donati,C.
  TITLE     Sphingosine 1-phosphate signaling axis mediates neuropeptide
            S-induced invasive phenotype of endometriotic cells
  JOURNAL   FEBS J 291 (8), 1744-1758 (2024)
   PUBMED   38287231
  REMARK    GeneRIF: Sphingosine 1-phosphate signaling axis mediates
            neuropeptide S-induced invasive phenotype of endometriotic cells.
REFERENCE   2  (bases 1 to 1231)
  AUTHORS   Cherik,F., Lepage,M., Remerand,G., Francannet,C., Delabaere,A.,
            Salaun,G., Pebrel-Richard,C., Gouas,L., Vago,P., Tchirkov,A. and
            Goumy,C.
  TITLE     Further refining the critical region of 10q26 microdeletion
            syndrome: A possible involvement of INSYN2 and NPS in the cognitive
            phenotype
  JOURNAL   Eur J Med Genet 64 (9), 104287 (2021)
   PUBMED   34252586
  REMARK    GeneRIF: Further refining the critical region of 10q26
            microdeletion syndrome: A possible involvement of INSYN2 and NPS in
            the cognitive phenotype.
REFERENCE   3  (bases 1 to 1231)
  AUTHORS   Reinscheid,R.K., Mafessoni,F., Luttjohann,A., Jungling,K.,
            Pape,H.C. and Schulz,S.
  TITLE     Neandertal introgression and accumulation of hypomorphic mutations
            in the neuropeptide S (NPS) system promote attenuated functionality
  JOURNAL   Peptides 138, 170506 (2021)
   PUBMED   33556445
  REMARK    GeneRIF: Neandertal introgression and accumulation of hypomorphic
            mutations in the neuropeptide S (NPS) system promote attenuated
            functionality.
REFERENCE   4  (bases 1 to 1231)
  AUTHORS   Holanda,V.A.D., Oliveira,M.C., Souza,L.S., Lobao-Soares,B.,
            Andre,E., Da Silva Junior,E.D., Guerrini,R., Calo,G., Ruzza,C. and
            Gavioli,E.C.
  TITLE     Dopamine D1 and D2 receptors mediate neuropeptide S-induced
            antinociception in the mouse formalin test
  JOURNAL   Eur J Pharmacol 859, 172557 (2019)
   PUBMED   31326375
  REMARK    GeneRIF: analgesic effects of NPS are linked with dopaminergic
            neurotransmission mainly through dopamine D2-like receptor
            signaling
REFERENCE   5  (bases 1 to 1231)
  AUTHORS   Acevedo,N., Ezer,S., Kebede Merid,S., Gaertner,V.D., Soderhall,C.,
            D'Amato,M., Kabesch,M., Melen,E., Kere,J. and Pulkkinen,V.
  TITLE     Neuropeptide S (NPS) variants modify the signaling and risk effects
            of NPS Receptor 1 (NPSR1) variants in asthma
  JOURNAL   PLoS One 12 (5), e0176568 (2017)
   PUBMED   28463995
  REMARK    GeneRIF: SNPs modify asthma risk
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1231)
  AUTHORS   Reinscheid,R.K. and Xu,Y.L.
  TITLE     Neuropeptide S and its receptor: a newly deorphanized G
            protein-coupled receptor system
  JOURNAL   Neuroscientist 11 (6), 532-538 (2005)
   PUBMED   16282594
  REMARK    Review article
REFERENCE   7  (bases 1 to 1231)
  AUTHORS   Reinscheid,R.K. and Xu,Y.L.
  TITLE     Neuropeptide S as a novel arousal promoting peptide transmitter
  JOURNAL   FEBS J 272 (22), 5689-5693 (2005)
   PUBMED   16279934
  REMARK    Review article
REFERENCE   8  (bases 1 to 1231)
  AUTHORS   Vendelin,J., Pulkkinen,V., Rehn,M., Pirskanen,A.,
            Raisanen-Sokolowski,A., Laitinen,A., Laitinen,L.A., Kere,J. and
            Laitinen,T.
  TITLE     Characterization of GPRA, a novel G protein-coupled receptor
            related to asthma
  JOURNAL   Am J Respir Cell Mol Biol 33 (3), 262-270 (2005)
   PUBMED   15947423
REFERENCE   9  (bases 1 to 1231)
  AUTHORS   Xu,Y.L., Reinscheid,R.K., Huitron-Resendiz,S., Clark,S.D., Wang,Z.,
            Lin,S.H., Brucher,F.A., Zeng,J., Ly,N.K., Henriksen,S.J., de
            Lecea,L. and Civelli,O.
  TITLE     Neuropeptide S: a neuropeptide promoting arousal and
            anxiolytic-like effects
  JOURNAL   Neuron 43 (4), 487-497 (2004)
   PUBMED   15312648
REFERENCE   10 (bases 1 to 1231)
  AUTHORS   Feldman,D.S., Zamah,A.M., Pierce,K.L., Miller,W.E., Kelly,F.,
            Rapacciuolo,A., Rockman,H.A., Koch,W.J. and Luttrell,L.M.
  TITLE     Selective inhibition of heterotrimeric Gs signaling. Targeting the
            receptor-G protein interface using a peptide minigene encoding the
            Galpha(s) carboxyl terminus
  JOURNAL   J Biol Chem 277 (32), 28631-28640 (2002)
   PUBMED   12036966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355316.12.
            
            On Nov 27, 2019 this sequence version replaced NM_001030013.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398023.3/ ENSP00000381105.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL355316.12        112504-112571
            69-150              AL355316.12        112684-112765
            151-1231            AL355316.12        115655-116735
FEATURES             Location/Qualifiers
     source          1..1231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..1231
                     /gene="NPS"
                     /note="neuropeptide S"
                     /db_xref="GeneID:594857"
                     /db_xref="HGNC:HGNC:33940"
                     /db_xref="MIM:609513"
     exon            1..68
                     /gene="NPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..330
                     /gene="NPS"
                     /note="prepro-neuropeptide S"
                     /codon_start=1
                     /product="neuropeptide S precursor"
                     /protein_id="NP_001025184.1"
                     /db_xref="CCDS:CCDS41577.1"
                     /db_xref="GeneID:594857"
                     /db_xref="HGNC:HGNC:33940"
                     /db_xref="MIM:609513"
                     /translation="MISSVKLNLILVLSLSTMHVFWCYPVPSSKVSGKSDYFLILLNS
                     CPTRLDRSKELAFLKPILEKMFVKRSFRNGVGTGMKKTSFQRAKS"
     exon            69..150
                     /gene="NPS"
                     /inference="alignment:Splign:2.1.0"
     exon            151..1231
                     /gene="NPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPS"
                     /note="hexamer: AATATA"
     polyA_site      938
                     /gene="NPS"
                     /note="major polyA site"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPS"
                     /note="hexamer: AATAAA"
     polyA_site      1231
                     /gene="NPS"
ORIGIN      
        1 gtaagtgtga gaaatttggc aataaaacca cctatcttta cagattttgg gaagtccaaa
       61 atgattagct cagtaaaact caatctcatc ctagttctgt cgctgtccac aatgcatgtg
      121 ttttggtgtt atccagttcc atcttctaag gtgtctggaa aatctgatta ctttctcatt
      181 ctgctgaaca gctgcccaac cagattggac aggagcaaag aactagcttt tctaaagcca
      241 attttggaga agatgtttgt gaaaaggtcc tttcgcaatg gagttggcac agggatgaaa
      301 aaaacttcct ttcaaagagc aaaatcatga ctaagtgtgc aaaggactcg gggaattaat
      361 ctaactgtag agtgtgactg acgtactcaa agtccatcgt ctctttatca ttgagtgttg
      421 gcatgctctc tattctcaaa tatctttcct ctcctgactg gtacagagta aattgagtaa
      481 aaaaagaaaa aaaatgtaaa catgtctcaa acctgtctca aacttccact tgtgagagaa
      541 aaaacaattt atgtggtcca ttagtaactt tttcctgaat gggatggaca cttttgcttt
      601 gcttttaact tggccagaaa gcatgagcat gttgacagtc atcacgatag tatgattttt
      661 tttttcctgc ctgtaatatc ataacacgaa tactgtgata tttgtttttc tttttaatac
      721 cgttttctca aatgacttaa caggctcaat tcttggggtg gggggatgtg ctatttctgt
      781 ttctaagggg cttgtgaagt taaccaaaat taaggtgaat ggtacagctg tatcaattga
      841 ttaattaatt gataccaaga acaaacatcc ctggagcact ctagatgtaa ttcttgtctc
      901 ccttttccta ttccaaatat acttagctat agggtgttgt tttgttgtct tgtcttggaa
      961 atttgttgcc ttttaaaatc tttaagcaca gaaatgctgc cagtaacaac aacaacagag
     1021 agactgagag tgccctgtgt tgtcagggca gccatttgga aacctgttcc ccaaactatg
     1081 ctgattaatg ccctctcctt tcccccatcc ttccaggaaa gactgcccac tctttgcact
     1141 gaaactcctg acactccttt tttaaaagga taatgcgaca ttggttgacg tgttatttca
     1201 aatgcataat gttaataaat ctgttcacgc a
//
