LOCUS       NM_001364458            6294 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens natriuretic peptide receptor 3 (NPR3), transcript
            variant 5, mRNA.
ACCESSION   NM_001364458 XM_011514048
VERSION     NM_001364458.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6294)
  AUTHORS   Cheng,C., Zhang,J., Li,X., Xue,F., Cao,L., Meng,L., Sui,W.,
            Zhang,M., Zhao,Y., Xi,B., Yu,X., Xu,F., Yang,J., Zhang,Y. and
            Zhang,C.
  TITLE     NPRC deletion mitigated atherosclerosis by inhibiting oxidative
            stress, inflammation and apoptosis in ApoE knockout mice
  JOURNAL   Signal Transduct Target Ther 8 (1), 290 (2023)
   PUBMED   37553374
  REMARK    GeneRIF: NPRC deletion mitigated atherosclerosis by inhibiting
            oxidative stress, inflammation and apoptosis in ApoE knockout mice.
            Erratum:[Signal Transduct Target Ther. 2023 Sep 4;8(1):329. doi:
            10.1038/s41392-023-01599-x.. PMID: 37666826]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6294)
  AUTHORS   Liu,J., He,S., Ma,B., Li,X., Wang,Y. and Xiong,J.
  TITLE     TMT-based quantitative proteomic analysis revealed that FBLN2 and
            NPR3 are involved in the early osteogenic differentiation of
            mesenchymal stem cells (MSCs)
  JOURNAL   Aging (Albany NY) 15 (15), 7637-7654 (2023)
   PUBMED   37543430
  REMARK    GeneRIF: TMT-based quantitative proteomic analysis revealed that
            FBLN2 and NPR3 are involved in the early osteogenic differentiation
            of mesenchymal stem cells (MSCs).
REFERENCE   3  (bases 1 to 6294)
  AUTHORS   Cronje,H.T., Karhunen,V., Hovingh,G.K., Coppieters,K.,
            Lagerstedt,J.O., Nyberg,M. and Gill,D.
  TITLE     Genetic evidence implicating natriuretic peptide receptor-3 in
            cardiovascular disease risk: a Mendelian randomization study
  JOURNAL   BMC Med 21 (1), 158 (2023)
   PUBMED   37101178
  REMARK    GeneRIF: Genetic evidence implicating natriuretic peptide
            receptor-3 in cardiovascular disease risk: a Mendelian
            randomization study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6294)
  AUTHORS   Ryan,R.M., Paintlia,M.K., Newton,D.A., Spyropoulos,D.D., Kemp,M.,
            Jobe,A.H. and Baatz,J.E.
  TITLE     Oxygen and steroids affect the regulatory role of natriuretic
            peptide receptor-C on surfactant secretion by type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (1), L13-L22 (2022)
   PUBMED   34668435
  REMARK    GeneRIF: Oxygen and steroids affect the regulatory role of
            natriuretic peptide receptor-C on surfactant secretion by type II
            cells.
REFERENCE   5  (bases 1 to 6294)
  AUTHORS   Li,S., Guo,R., Peng,Z., Quan,B., Hu,Y., Wang,Y. and Wang,Y.
  TITLE     NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma
            cell growth through blocking the PI3K/AKT pathway
  JOURNAL   Cell Signal 86, 110074 (2021)
   PUBMED   34229087
  REMARK    GeneRIF: NPR3, transcriptionally regulated by POU2F1, inhibits
            osteosarcoma cell growth through blocking the PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 6294)
  AUTHORS   Suga,S., Nakao,K., Hosoda,K., Mukoyama,M., Ogawa,Y., Shirakami,G.,
            Arai,H., Saito,Y., Kambayashi,Y., Inouye,K. et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   7  (bases 1 to 6294)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 6294)
  AUTHORS   Lowe,D.G., Klisak,I., Sparkes,R.S., Mohandas,T. and Goeddel,D.V.
  TITLE     Chromosomal distribution of three members of the human natriuretic
            peptide receptor/guanylyl cyclase gene family
  JOURNAL   Genomics 8 (2), 304-312 (1990)
   PUBMED   1979052
REFERENCE   9  (bases 1 to 6294)
  AUTHORS   Porter,J.G., Arfsten,A., Fuller,F., Miller,J.A., Gregory,L.C. and
            Lewicki,J.A.
  TITLE     Isolation and functional expression of the human atrial natriuretic
            peptide clearance receptor cDNA
  JOURNAL   Biochem Biophys Res Commun 171 (2), 796-803 (1990)
   PUBMED   2169733
REFERENCE   10 (bases 1 to 6294)
  AUTHORS   Lowe,D.G., Camerato,T.R. and Goeddel,D.V.
  TITLE     cDNA sequence of the human atrial natriuretic peptide clearance
            receptor
  JOURNAL   Nucleic Acids Res 18 (11), 3412 (1990)
   PUBMED   2162522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008766.4 and AC026703.4.
            
            On Jun 1, 2019 this sequence version replaced NM_001364458.1.
            
            Summary: This gene encodes one of three natriuretic peptide
            receptors. Natriutetic peptides are small peptides which regulate
            blood volume and pressure, pulmonary hypertension, and cardiac
            function as well as some metabolic and growth processes. The
            product of this gene encodes a natriuretic peptide receptor
            responsible for clearing circulating and extracellular natriuretic
            peptides through endocytosis of the receptor. Multiple transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (5)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279838.4864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC008766.4         88853-88914
            63-185              AC008766.4         122679-122801
            186-352             AC008766.4         136845-137011
            353-488             AC026703.4         80817-80952         c
            489-583             AC026703.4         74844-74938         c
            584-719             AC026703.4         72632-72767         c
            720-807             AC026703.4         70777-70864         c
            808-6294            AC026703.4         63940-69426         c
FEATURES             Location/Qualifiers
     source          1..6294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..6294
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="natriuretic peptide receptor 3"
                     /db_xref="GeneID:4883"
                     /db_xref="HGNC:HGNC:7945"
                     /db_xref="MIM:108962"
     exon            1..62
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..919
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="isoform 5 is encoded by transcript variant 5;
                     atrial natriuretic peptide receptor 3; atrial natriuretic
                     peptide receptor type C; atrial natriuretic peptide
                     clearance receptor; natriuretic peptide receptor
                     C/guanylate cyclase C (atrionatriuretic peptide receptor
                     C)"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 3 isoform 5"
                     /protein_id="NP_001351387.1"
                     /db_xref="GeneID:4883"
                     /db_xref="HGNC:HGNC:7945"
                     /db_xref="MIM:108962"
                     /translation="MRTEMFQLTTPGILQTLVIMCASSDTIRSIMLVAHRHGMTSGDY
                     AFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSS
                     VEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGI
                     AGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLR
                     IDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRT
                     QQEESNLGKHRELREDSIRSHFSVA"
     exon            63..185
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            186..352
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            353..488
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            489..583
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            584..719
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            720..807
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            808..6294
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6278..6283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="hexamer: AATACA"
     polyA_site      6294
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="major polyA site"
ORIGIN      
        1 agaagccgca tggatgagaa ctgagatgtt ccagctgacc accccgggta ttctccagac
       61 attggtgatc atgtgtgcga gcagtgacac catccggagc atcatgctgg tggcgcacag
      121 gcatggcatg accagtggag actacgcctt cttcaacatt gagctcttca acagctcttc
      181 ctatggagat ggctcatgga agagaggaga caaacacgac tttgaagcta agcaagcata
      241 ctcgtccctc cagacagtca ctctactgag gacagtgaaa cctgagtttg agaagttttc
      301 catggaggtg aaaagttcag ttgagaaaca agggctcaat atggaggatt acgttaacat
      361 gtttgttgaa ggattccacg atgccatcct cctctacgtc ttggctctac atgaagtact
      421 cagagctggt tacagcaaaa aggatggagg gaaaattata cagcagactt ggaacagaac
      481 atttgaaggt atcgccgggc aggtgtccat agatgccaac ggagaccgat atggggattt
      541 ctctgtgatt gccatgactg atgtggaggc gggcacccag gaggttattg gtgattattt
      601 tggaaaagaa ggtcgttttg aaatgcggcc gaatgtcaaa tatccttggg gccctttaaa
      661 actgagaata gatgaaaacc gaattgtaga gcatacaaac agctctccct gcaaatcatc
      721 aggtggccta gaagaatcgg cagtgacagg aattgtcgtg ggggctttac taggagctgg
      781 cttgctaatg gccttctact ttttcaggaa gaaatacaga ataaccattg agaggcgaac
      841 ccagcaagaa gaaagtaacc ttggaaaaca tcgggaatta cgggaagatt ccatcagatc
      901 ccatttttca gtagcttaaa ggaagccccc cacttttttt ttttctgcct gagattcttt
      961 aaggagatag acgggttgaa agacatcaat gaaacagaag gggcgttctt gaagaattca
     1021 taattttaag cagttagtaa tttcatttta aaatttctgt agaagctcag gaattatgat
     1081 taatcaccat ctgcctccag gcctttcatc tcatgacaaa caaatataat aatgatatcg
     1141 tgtcactctg ttaaatgttc atactgtttc aagcccatat gattagattt atgtttttaa
     1201 aatctgttgt ctccatatct tgatggcttt tgggagcatt tcacacaagg atataaaatg
     1261 cggttttctt aaatgaaatg ttttgtagct agaataaaat catttttaca agtacagcat
     1321 tcttggaaag aatttaacac ccaaaaaggg gaaaatgtaa tgaaaaatct caaggttgga
     1381 aatacagcct tactctctct agagctggag gacaggtttg tggttgagga cttctctgtc
     1441 cgatgtctac attcaggttc tgacttcata tcttgaaaaa ggatttcctc cctgtctttt
     1501 tcagtgtctc ataaacgcta ctctggattg ttgtaaatat tagtgagatg ggaggattta
     1561 cagaagaaaa gcaagtcaaa aatatttcct ttttgatgta aaaaaaaaaa gccctatttc
     1621 gcactaacat tttattttac aagtatttta atcttatatt ttggtattag aaaaatttgt
     1681 ctattttttc attttgaaga ttaaatgttg cttacatttt aaaagcatgg gtgaagtgta
     1741 caacaaacca ataatgataa aaaatacttc tctttttctc cctgtttccc tttttccctt
     1801 ggccacagcc aaatgctaat tgctgcttta attacagaga tgtgtaaatg tattcagatt
     1861 acaaactcta caggaataca tcaacatttt aactcttttg cgtttttact gtttaactgt
     1921 tttaaatgca agttatttta gggtgacact ccttccagtt ctggccagat catgagtttc
     1981 aagatcaaga gtaaaaagtt attagaatta aacagtttta taaagggagg cagccctttt
     2041 ccctcaagaa caactttgtt gagagttact acttgacagc aagcacagaa atgacaaatt
     2101 taaaactttt acacatggca tttaccaaaa ttcccagtga ttattttgtt taaaagaggg
     2161 aacctaaata tctactctat tccctttcag ttaactccac agaactttgt aggcatccat
     2221 gaatacctgt aatagtgggt taggtgtgga gataaggaat ttggacaaag ttgagtaagt
     2281 ttttactggg tatctgcttt gcacccagta gtctgcaaca tgagtttaaa ctcaggttac
     2341 tactttcact tatactttat ggagaagata gacagtgagg gaggaatggg aagctgtcat
     2401 gagagtgcac cgtcttggaa ttacataact ggggtctttc ctcaataaca ttttgagcat
     2461 ctgaaaaata gtttaaaaaa ttgtcttaat atctattaaa aggcatgtct agtgaggaaa
     2521 caggagagtc tgagcaatcc cttggtggcg atgaaggtgg tagttcacac aagtaacagt
     2581 ggaggcaaag gtaagcgcaa gctgcctgtc ccagatgctg gcccatgtgt gagtgcttcc
     2641 ctggagaagt ccgcttctgt tgctcccacc tgagtcacag ttaacagatt atttctgtgt
     2701 gaggcacatt tcccttctgt tgtttaagaa atgggagctg ggaggcagct gagagggcgt
     2761 gataaaagaa ttaagtgtga tcaactgaaa caactatgtt gtagttctcc atgctggatg
     2821 caaaggaaaa agtgtcgaat tccaaaaagg atggaagaag aaggcaagaa gggcaaactc
     2881 cagaagttct agtgcaggaa gagagtttga gaagtaaaat ccaggcaagc aaagcgttgt
     2941 accacttggg actccccaaa gtgaaacagc aaggaaggat tgtgtccatc ttacttactt
     3001 gaattggaga gcttgtttct ctctcatttt tatttttcaa tgatgttttc tttatatttt
     3061 agagatattc attttctctt atcttgtgct tgtaaaaagc atttacattt caagtctatg
     3121 tgcttattac aggggaaaaa taatctacct ggttgcagtc tttgagtata aacatttcta
     3181 acctttttaa aacttctata gcagcccatt aacactaaca tttttagagc aaatatattc
     3241 tattttaact tcaggtagag gaatagtcct aaacttaata tgatagctct agataagatc
     3301 ttagagataa gtgagcattt agtattctaa aagtggcaga acaaatcatg aggtttctgg
     3361 atgctatacc aatttaaaat caattcttat gttaatattg attgcttatt tacatgtcag
     3421 tcatctactt tttttctttg aaatctgcat atgggttaca aaaactctgt taggttttga
     3481 aaattccatt aagttggaaa ccttggttaa aaatgtaggt gcctggccca tggttaccct
     3541 ggattcaggt ctctcatgat tatatttggg gatttacgtt cctaactgct aagcaacatc
     3601 tttgacaact agtaattcat actctactag tagtcacatg tcatatagta aaataaatag
     3661 ggctttagtt cttaagtaat tctataggat tttaccctga aatccagggt gttcagattt
     3721 caaaaaggat aatttatcag tattttctca tccagtcaaa cttcagctga cattgataca
     3781 ggtcaaaatg cgtagatgct ttttggtgtt ggaaataagt gtctgtctta tggtcatcat
     3841 tgtcttctta gatttttggg taggggggcc aggtaggggg agactcagaa ataaaagcgt
     3901 tccccagata acttcaatct ggaaagaatt ttttgtatag agtccatctc tccctcaaga
     3961 ctgaccacag gtttcatgag aaggtccctg aaaacatcac atttctctga agaaccatca
     4021 acttgtcttt tcttgaacca caggaatggt tctacagacc ctactataat tcttcacatt
     4081 tcagaaccca tgtttaatgg agggaagaga gaaatgcatg ggaaaagaac acctcctttt
     4141 ctcctttctc ttaaattcaa agacgtttgc tttggaatgc cctcacttct ccctattcac
     4201 aggcttctaa aatcattaat ttactcaagg cacatgtgcc ttctttgccc caaatgcatc
     4261 actttccttt tagttatggc tgattttggg tgtgtgtgtg taagacatgc agtcaacaat
     4321 gagatgaagg ccattgcata gatctcatgc agatagtgat ggattcagaa agtaggttcc
     4381 agtggcgtca ctaccttctt gtaagccagt atacactggc tatttgtgga aatctctttg
     4441 ggagatcaaa tagagtatta tgccactgtg agtgtttata aactggaagg aacaagtacc
     4501 tgtgtttctt gggacacaaa gcactcagat cctgagtgga tgcagacatg agagtaaatg
     4561 tcagcccaaa ttaggcccct cgacctacag acatttcatg ggttttattt aatcacaccc
     4621 catggtttgg ggctacatga ggaagttggt aatgagctga atttcttatt cagtggaaaa
     4681 aactgaaact gtctaaaaac acgggatata ttttagaggc aattgtggaa gcggagagaa
     4741 tgagatgatg gtgttcagag ggaccagctt ctttttcagt tgtctttaga actcaagaat
     4801 aatcaataat ttagtgcccc ttcaacagcc atactcagca agaagaatca gaagcttgat
     4861 cctctaacag aaatagaaga gggtagcttt gcccattgcc actgtcttta ctgccccttc
     4921 tgcccctcca cccacatcca cattcagcat cactccaagg atgtgtcagc atcttgccca
     4981 tgcaggtaga aatttgtgag taggcctcca tacttcctcg ggggaagaaa gagaaactag
     5041 tgctggtttt aagaatgtag ctggcttttc atcagaaccc ttatgctaac ctgaccacac
     5101 ttgctctcgg ggaagttcaa gcctgtgatg tgcataaact ccaacaagcc tggctttggt
     5161 gttcagcatg cacattccat aaatatctct tgcaggcata ccccacagct agactgcagg
     5221 attaaaataa cttccaaaag gtgctggatt ggagtttgtt caaatttctc attaaccact
     5281 aatgttaatt cataccaaat gcaaagtatt ctaaaccagc tgatgctgtc agtgttcaag
     5341 ttttaagtga cttcaaacac aatggaagtg tttcaatggg agccagatct catgagtaaa
     5401 aatccatttt ataatagctc tgtgatatat cagtgggaga tgattcatag gggagagatt
     5461 tgaacaagca gaattaagtg ttagcaaaaa tgctgcattg ctttgattca tgtttaaaga
     5521 cctaaatttc tatgcacaag gaataaaggg cctacttacc aagtgtaaat cacaacatag
     5581 gctaccaaaa tatttcttat ttgctaggag aacaaagctg tcacggtgca tgatagttgg
     5641 acagagatgg ctaaaaaaga ggcaaattca gatttggaaa cagggtggcc tcttcattat
     5701 ttattgccaa gatctgaaaa tcttcaacat cttataagac aacaatgaag tagcccctga
     5761 acagcatgga gttgctgtga gtttgttcgt tgcagacctt tgtgttgggt cctgggaatc
     5821 tgagctttgt tccctgtgca tggtggataa ttgaaaccaa gaggacatgg gatagacctt
     5881 gtgacagacc aattctgtga cccctgtctt ctgggtcaca ttattcattg ttgatttaaa
     5941 tacaggacta ccaaacagta caaatctatc atgagtctgg tagaaaagta aaagtaaaag
     6001 ctgcacacgt tacatactgt ttattgttct aatgtacaac taactatttg catataatgt
     6061 gatttaattt attgctgttt tgtgtagaaa aggagaacta atgactgtgg atataaccca
     6121 tgttttgtat aatatatttt atttcttgtg cgaactggtc atttaaaata tctacttcat
     6181 ttgatgtttg gatataaatg tgtatgtgtc cttgtaaatg tttctatcaa gcaagaatgc
     6241 cacgtactca gagtataaca atgtgttctc attaaaaaat acatcccacg gaaa
//
