LOCUS       NM_001204375            7457 bp    mRNA    linear   PRI 27-AUG-2023
DEFINITION  Homo sapiens natriuretic peptide receptor 3 (NPR3), transcript
            variant 1, mRNA.
ACCESSION   NM_001204375
VERSION     NM_001204375.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7457)
  AUTHORS   Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao
            Y, Xi B, Yu X, Xu F, Yang J, Zhang Y and Zhang C.
  TITLE     NPRC deletion mitigated atherosclerosis by inhibiting oxidative
            stress, inflammation and apoptosis in ApoE knockout mice
  JOURNAL   Signal Transduct Target Ther 8 (1), 290 (2023)
   PUBMED   37553374
  REMARK    GeneRIF: NPRC deletion mitigated atherosclerosis by inhibiting
            oxidative stress, inflammation and apoptosis in ApoE knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7457)
  AUTHORS   Liu J, He S, Ma B, Li X, Wang Y and Xiong J.
  TITLE     TMT-based quantitative proteomic analysis revealed that FBLN2 and
            NPR3 are involved in the early osteogenic differentiation of
            mesenchymal stem cells (MSCs)
  JOURNAL   Aging (Albany NY) 15 (15), 7637-7654 (2023)
   PUBMED   37543430
  REMARK    GeneRIF: TMT-based quantitative proteomic analysis revealed that
            FBLN2 and NPR3 are involved in the early osteogenic differentiation
            of mesenchymal stem cells (MSCs).
REFERENCE   3  (bases 1 to 7457)
  AUTHORS   Cronje HT, Karhunen V, Hovingh GK, Coppieters K, Lagerstedt JO,
            Nyberg M and Gill D.
  TITLE     Genetic evidence implicating natriuretic peptide receptor-3 in
            cardiovascular disease risk: a Mendelian randomization study
  JOURNAL   BMC Med 21 (1), 158 (2023)
   PUBMED   37101178
  REMARK    GeneRIF: Genetic evidence implicating natriuretic peptide
            receptor-3 in cardiovascular disease risk: a Mendelian
            randomization study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7457)
  AUTHORS   Ryan RM, Paintlia MK, Newton DA, Spyropoulos DD, Kemp M, Jobe AH
            and Baatz JE.
  TITLE     Oxygen and steroids affect the regulatory role of natriuretic
            peptide receptor-C on surfactant secretion by type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (1), L13-L22 (2022)
   PUBMED   34668435
  REMARK    GeneRIF: Oxygen and steroids affect the regulatory role of
            natriuretic peptide receptor-C on surfactant secretion by type II
            cells.
REFERENCE   5  (bases 1 to 7457)
  AUTHORS   Li S, Guo R, Peng Z, Quan B, Hu Y, Wang Y and Wang Y.
  TITLE     NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma
            cell growth through blocking the PI3K/AKT pathway
  JOURNAL   Cell Signal 86, 110074 (2021)
   PUBMED   34229087
  REMARK    GeneRIF: NPR3, transcriptionally regulated by POU2F1, inhibits
            osteosarcoma cell growth through blocking the PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 7457)
  AUTHORS   Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai
            H, Saito Y, Kambayashi Y, Inouye K et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   7  (bases 1 to 7457)
  AUTHORS   Bennett BD, Bennett GL, Vitangcol RV, Jewett JR, Burnier J, Henzel
            W and Lowe DG.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 7457)
  AUTHORS   Lowe DG, Klisak I, Sparkes RS, Mohandas T and Goeddel DV.
  TITLE     Chromosomal distribution of three members of the human natriuretic
            peptide receptor/guanylyl cyclase gene family
  JOURNAL   Genomics 8 (2), 304-312 (1990)
   PUBMED   1979052
REFERENCE   9  (bases 1 to 7457)
  AUTHORS   Porter JG, Arfsten A, Fuller F, Miller JA, Gregory LC and Lewicki
            JA.
  TITLE     Isolation and functional expression of the human atrial natriuretic
            peptide clearance receptor cDNA
  JOURNAL   Biochem Biophys Res Commun 171 (2), 796-803 (1990)
   PUBMED   2169733
REFERENCE   10 (bases 1 to 7457)
  AUTHORS   Lowe DG, Camerato TR and Goeddel DV.
  TITLE     cDNA sequence of the human atrial natriuretic peptide clearance
            receptor
  JOURNAL   Nucleic Acids Res 18 (11), 3412 (1990)
   PUBMED   2162522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008766.4, AK290870.1 and
            AC026703.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001204375.1.
            
            Summary: This gene encodes one of three natriuretic peptide
            receptors. Natriutetic peptides are small peptides which regulate
            blood volume and pressure, pulmonary hypertension, and cardiac
            function as well as some metabolic and growth processes. The
            product of this gene encodes a natriuretic peptide receptor
            responsible for clearing circulating and extracellular natriuretic
            peptides through endocytosis of the receptor. Multiple transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290870.1, BC131540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265074.13/ ENSP00000265074.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC008766.4         109302-109312
            12-251              AK290870.1         1-240
            252-1721            AK290870.1         246-1715
            1722-1722           AC026703.4         74868-74868         c
            1723-2019           AK290870.1         1717-2013
            2020-2020           AC026703.4         69377-69377         c
            2021-2361           AK290870.1         2015-2355
            2362-7457           AC026703.4         63940-69035         c
FEATURES             Location/Qualifiers
     source          1..7457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..7457
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="natriuretic peptide receptor 3"
                     /db_xref="GeneID:4883"
                     /db_xref="HGNC:HGNC:7945"
                     /db_xref="MIM:108962"
     exon            1..1225
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2082
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; atrial natriuretic peptide receptor 3; atrial
                     natriuretic peptide receptor type C; atrial natriuretic
                     peptide clearance receptor; natriuretic peptide receptor
                     C/guanylate cyclase C (atrionatriuretic peptide receptor
                     C)"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 3 isoform 1
                     precursor"
                     /protein_id="NP_001191304.1"
                     /db_xref="CCDS:CCDS56357.1"
                     /db_xref="GeneID:4883"
                     /db_xref="HGNC:HGNC:7945"
                     /db_xref="MIM:108962"
                     /translation="MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQE
                     REALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVA
                     YEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGAL
                     AAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLE
                     GVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHR
                     HGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEK
                     FSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQT
                     WNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKY
                     PWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKY
                     RITIERRTQQEESNLGKHRELREDSIRSHFSVA"
     exon            1226..1348
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1515
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1651
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1746
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1882
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1970
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..7457
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7441..7446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="hexamer: AATACA"
     polyA_site      7457
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgaatc aatgagatca aatgcgaggg agatgcaccg tcaattacaa acacttggac
       61 aagtctaact ttttttttct tctacaaaaa cgctttcaaa agcaacctta gcaacgccca
      121 aataagaagc cacctctaag caaaatagta tatgtataaa cggagggcga atatatacaa
      181 gtatatatat atgtatatta cagacgcaca ggtttacacc cggtgaactt tttctttttc
      241 tttttctttt ttttttaaga aaaactagtg acattgcaga gaaggacgct tcctctctat
      301 cttttggcgc attagtgaag ggggtattct attttgttaa agcgcccaag ggggcgcagg
      361 gaccttggag agaagagtgg ggaggaaaga ggaagggtgg gtggggggca gagggcgagt
      421 cggcggcggc gagggcaagc tctttcttgc ggcacgatgc cgtctctgct ggtgctcact
      481 ttctccccgt gcgtactact cggctgggcg ttgctggccg gcggcaccgg tggcggtggc
      541 gttggcggcg gcggcggtgg cgcgggcata ggcggcggac gccaggagag agaggcgctg
      601 ccgccacaga agatcgaggt gctggtgtta ctgccccagg atgactcgta cttgttttca
      661 ctcacccggg tgcggccggc catcgagtat gctctgcgca gcgtggaggg caacgggact
      721 gggaggcggc ttctgccgcc gggcactcgc ttccaggtgg cttacgagga ttcagactgt
      781 gggaaccgtg cgctcttcag cttggtggac cgcgtggcgg cggcgcgggg cgccaagcca
      841 gaccttatcc tggggccagt gtgcgagtat gcagcagcgc cagtggcccg gcttgcatcg
      901 cactgggacc tgcccatgct gtcggctggg gcgctggccg ctggcttcca gcacaaggac
      961 tctgagtact cgcacctcac gcgcgtggcg cccgcctacg ccaagatggg cgagatgatg
     1021 ctcgccctgt tccgccacca ccactggagc cgcgctgcac tggtctacag cgacgacaag
     1081 ctggagcgga actgctactt caccctcgag ggggtccacg aggtcttcca ggaggagggt
     1141 ttgcacacgt ccatctacag tttcgacgag accaaagact tggatctgga agacatcgtg
     1201 cgcaatatcc aggccagtga gagagtggtg atcatgtgtg cgagcagtga caccatccgg
     1261 agcatcatgc tggtggcgca caggcatggc atgaccagtg gagactacgc cttcttcaac
     1321 attgagctct tcaacagctc ttcctatgga gatggctcat ggaagagagg agacaaacac
     1381 gactttgaag ctaagcaagc atactcgtcc ctccagacag tcactctact gaggacagtg
     1441 aaacctgagt ttgagaagtt ttccatggag gtgaaaagtt cagttgagaa acaagggctc
     1501 aatatggagg attacgttaa catgtttgtt gaaggattcc acgatgccat cctcctctac
     1561 gtcttggctc tacatgaagt actcagagct ggttacagca aaaaggatgg agggaaaatt
     1621 atacagcaga cttggaacag aacatttgaa ggtatcgccg ggcaggtgtc catagatgcc
     1681 aacggagacc gatatgggga tttctctgtg attgccatga ctgatgtgga ggcgggcacc
     1741 caggaggtta ttggtgatta ttttggaaaa gaaggtcgtt ttgaaatgcg gccgaatgtc
     1801 aaatatcctt ggggcccttt aaaactgaga atagatgaaa accgaattgt agagcataca
     1861 aacagctctc cctgcaaatc atcaggtggc ctagaagaat cggcagtgac aggaattgtc
     1921 gtgggggctt tactaggagc tggcttgcta atggccttct actttttcag gaagaaatac
     1981 agaataacca ttgagaggcg aacccagcaa gaagaaagta accttggaaa acatcgggaa
     2041 ttacgggaag attccatcag atcccatttt tcagtagctt aaaggaagcc ccccactttt
     2101 tttttttctg cctgagattc tttaaggaga tagacgggtt gaaagacatc aatgaaacag
     2161 aaggggcgtt cttgaagaat tcataatttt aagcagttag taatttcatt ttaaaatttc
     2221 tgtagaagct caggaattat gattaatcac catctgcctc caggcctttc atctcatgac
     2281 aaacaaatat aataatgata tcgtgtcact ctgttaaatg ttcatactgt ttcaagccca
     2341 tatgattaga tttatgtttt taaaatctgt tgtctccata tcttgatggc ttttgggagc
     2401 atttcacaca aggatataaa atgcggtttt cttaaatgaa atgttttgta gctagaataa
     2461 aatcattttt acaagtacag cattcttgga aagaatttaa cacccaaaaa ggggaaaatg
     2521 taatgaaaaa tctcaaggtt ggaaatacag ccttactctc tctagagctg gaggacaggt
     2581 ttgtggttga ggacttctct gtccgatgtc tacattcagg ttctgacttc atatcttgaa
     2641 aaaggatttc ctccctgtct ttttcagtgt ctcataaacg ctactctgga ttgttgtaaa
     2701 tattagtgag atgggaggat ttacagaaga aaagcaagtc aaaaatattt cctttttgat
     2761 gtaaaaaaaa aaagccctat ttcgcactaa cattttattt tacaagtatt ttaatcttat
     2821 attttggtat tagaaaaatt tgtctatttt ttcattttga agattaaatg ttgcttacat
     2881 tttaaaagca tgggtgaagt gtacaacaaa ccaataatga taaaaaatac ttctcttttt
     2941 ctccctgttt ccctttttcc cttggccaca gccaaatgct aattgctgct ttaattacag
     3001 agatgtgtaa atgtattcag attacaaact ctacaggaat acatcaacat tttaactctt
     3061 ttgcgttttt actgtttaac tgttttaaat gcaagttatt ttagggtgac actccttcca
     3121 gttctggcca gatcatgagt ttcaagatca agagtaaaaa gttattagaa ttaaacagtt
     3181 ttataaaggg aggcagccct tttccctcaa gaacaacttt gttgagagtt actacttgac
     3241 agcaagcaca gaaatgacaa atttaaaact tttacacatg gcatttacca aaattcccag
     3301 tgattatttt gtttaaaaga gggaacctaa atatctactc tattcccttt cagttaactc
     3361 cacagaactt tgtaggcatc catgaatacc tgtaatagtg ggttaggtgt ggagataagg
     3421 aatttggaca aagttgagta agtttttact gggtatctgc tttgcaccca gtagtctgca
     3481 acatgagttt aaactcaggt tactactttc acttatactt tatggagaag atagacagtg
     3541 agggaggaat gggaagctgt catgagagtg caccgtcttg gaattacata actggggtct
     3601 ttcctcaata acattttgag catctgaaaa atagtttaaa aaattgtctt aatatctatt
     3661 aaaaggcatg tctagtgagg aaacaggaga gtctgagcaa tcccttggtg gcgatgaagg
     3721 tggtagttca cacaagtaac agtggaggca aaggtaagcg caagctgcct gtcccagatg
     3781 ctggcccatg tgtgagtgct tccctggaga agtccgcttc tgttgctccc acctgagtca
     3841 cagttaacag attatttctg tgtgaggcac atttcccttc tgttgtttaa gaaatgggag
     3901 ctgggaggca gctgagaggg cgtgataaaa gaattaagtg tgatcaactg aaacaactat
     3961 gttgtagttc tccatgctgg atgcaaagga aaaagtgtcg aattccaaaa aggatggaag
     4021 aagaaggcaa gaagggcaaa ctccagaagt tctagtgcag gaagagagtt tgagaagtaa
     4081 aatccaggca agcaaagcgt tgtaccactt gggactcccc aaagtgaaac agcaaggaag
     4141 gattgtgtcc atcttactta cttgaattgg agagcttgtt tctctctcat ttttattttt
     4201 caatgatgtt ttctttatat tttagagata ttcattttct cttatcttgt gcttgtaaaa
     4261 agcatttaca tttcaagtct atgtgcttat tacaggggaa aaataatcta cctggttgca
     4321 gtctttgagt ataaacattt ctaacctttt taaaacttct atagcagccc attaacacta
     4381 acatttttag agcaaatata ttctatttta acttcaggta gaggaatagt cctaaactta
     4441 atatgatagc tctagataag atcttagaga taagtgagca tttagtattc taaaagtggc
     4501 agaacaaatc atgaggtttc tggatgctat accaatttaa aatcaattct tatgttaata
     4561 ttgattgctt atttacatgt cagtcatcta ctttttttct ttgaaatctg catatgggtt
     4621 acaaaaactc tgttaggttt tgaaaattcc attaagttgg aaaccttggt taaaaatgta
     4681 ggtgcctggc ccatggttac cctggattca ggtctctcat gattatattt ggggatttac
     4741 gttcctaact gctaagcaac atctttgaca actagtaatt catactctac tagtagtcac
     4801 atgtcatata gtaaaataaa tagggcttta gttcttaagt aattctatag gattttaccc
     4861 tgaaatccag ggtgttcaga tttcaaaaag gataatttat cagtattttc tcatccagtc
     4921 aaacttcagc tgacattgat acaggtcaaa atgcgtagat gctttttggt gttggaaata
     4981 agtgtctgtc ttatggtcat cattgtcttc ttagattttt gggtaggggg gccaggtagg
     5041 gggagactca gaaataaaag cgttccccag ataacttcaa tctggaaaga attttttgta
     5101 tagagtccat ctctccctca agactgacca caggtttcat gagaaggtcc ctgaaaacat
     5161 cacatttctc tgaagaacca tcaacttgtc ttttcttgaa ccacaggaat ggttctacag
     5221 accctactat aattcttcac atttcagaac ccatgtttaa tggagggaag agagaaatgc
     5281 atgggaaaag aacacctcct tttctccttt ctcttaaatt caaagacgtt tgctttggaa
     5341 tgccctcact tctccctatt cacaggcttc taaaatcatt aatttactca aggcacatgt
     5401 gccttctttg ccccaaatgc atcactttcc ttttagttat ggctgatttt gggtgtgtgt
     5461 gtgtaagaca tgcagtcaac aatgagatga aggccattgc atagatctca tgcagatagt
     5521 gatggattca gaaagtaggt tccagtggcg tcactacctt cttgtaagcc agtatacact
     5581 ggctatttgt ggaaatctct ttgggagatc aaatagagta ttatgccact gtgagtgttt
     5641 ataaactgga aggaacaagt acctgtgttt cttgggacac aaagcactca gatcctgagt
     5701 ggatgcagac atgagagtaa atgtcagccc aaattaggcc cctcgaccta cagacatttc
     5761 atgggtttta tttaatcaca ccccatggtt tggggctaca tgaggaagtt ggtaatgagc
     5821 tgaatttctt attcagtgga aaaaactgaa actgtctaaa aacacgggat atattttaga
     5881 ggcaattgtg gaagcggaga gaatgagatg atggtgttca gagggaccag cttctttttc
     5941 agttgtcttt agaactcaag aataatcaat aatttagtgc cccttcaaca gccatactca
     6001 gcaagaagaa tcagaagctt gatcctctaa cagaaataga agagggtagc tttgcccatt
     6061 gccactgtct ttactgcccc ttctgcccct ccacccacat ccacattcag catcactcca
     6121 aggatgtgtc agcatcttgc ccatgcaggt agaaatttgt gagtaggcct ccatacttcc
     6181 tcgggggaag aaagagaaac tagtgctggt tttaagaatg tagctggctt ttcatcagaa
     6241 cccttatgct aacctgacca cacttgctct cggggaagtt caagcctgtg atgtgcataa
     6301 actccaacaa gcctggcttt ggtgttcagc atgcacattc cataaatatc tcttgcaggc
     6361 ataccccaca gctagactgc aggattaaaa taacttccaa aaggtgctgg attggagttt
     6421 gttcaaattt ctcattaacc actaatgtta attcatacca aatgcaaagt attctaaacc
     6481 agctgatgct gtcagtgttc aagttttaag tgacttcaaa cacaatggaa gtgtttcaat
     6541 gggagccaga tctcatgagt aaaaatccat tttataatag ctctgtgata tatcagtggg
     6601 agatgattca taggggagag atttgaacaa gcagaattaa gtgttagcaa aaatgctgca
     6661 ttgctttgat tcatgtttaa agacctaaat ttctatgcac aaggaataaa gggcctactt
     6721 accaagtgta aatcacaaca taggctacca aaatatttct tatttgctag gagaacaaag
     6781 ctgtcacggt gcatgatagt tggacagaga tggctaaaaa agaggcaaat tcagatttgg
     6841 aaacagggtg gcctcttcat tatttattgc caagatctga aaatcttcaa catcttataa
     6901 gacaacaatg aagtagcccc tgaacagcat ggagttgctg tgagtttgtt cgttgcagac
     6961 ctttgtgttg ggtcctggga atctgagctt tgttccctgt gcatggtgga taattgaaac
     7021 caagaggaca tgggatagac cttgtgacag accaattctg tgacccctgt cttctgggtc
     7081 acattattca ttgttgattt aaatacagga ctaccaaaca gtacaaatct atcatgagtc
     7141 tggtagaaaa gtaaaagtaa aagctgcaca cgttacatac tgtttattgt tctaatgtac
     7201 aactaactat ttgcatataa tgtgatttaa tttattgctg ttttgtgtag aaaaggagaa
     7261 ctaatgactg tggatataac ccatgttttg tataatatat tttatttctt gtgcgaactg
     7321 gtcatttaaa atatctactt catttgatgt ttggatataa atgtgtatgt gtccttgtaa
     7381 atgtttctat caagcaagaa tgccacgtac tcagagtata acaatgtgtt ctcattaaaa
     7441 aatacatccc acggaaa
//
