LOCUS       NM_000908               7454 bp    mRNA    linear   PRI 27-AUG-2023
DEFINITION  Homo sapiens natriuretic peptide receptor 3 (NPR3), transcript
            variant 2, mRNA.
ACCESSION   NM_000908
VERSION     NM_000908.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7454)
  AUTHORS   Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao
            Y, Xi B, Yu X, Xu F, Yang J, Zhang Y and Zhang C.
  TITLE     NPRC deletion mitigated atherosclerosis by inhibiting oxidative
            stress, inflammation and apoptosis in ApoE knockout mice
  JOURNAL   Signal Transduct Target Ther 8 (1), 290 (2023)
   PUBMED   37553374
  REMARK    GeneRIF: NPRC deletion mitigated atherosclerosis by inhibiting
            oxidative stress, inflammation and apoptosis in ApoE knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7454)
  AUTHORS   Liu J, He S, Ma B, Li X, Wang Y and Xiong J.
  TITLE     TMT-based quantitative proteomic analysis revealed that FBLN2 and
            NPR3 are involved in the early osteogenic differentiation of
            mesenchymal stem cells (MSCs)
  JOURNAL   Aging (Albany NY) 15 (15), 7637-7654 (2023)
   PUBMED   37543430
  REMARK    GeneRIF: TMT-based quantitative proteomic analysis revealed that
            FBLN2 and NPR3 are involved in the early osteogenic differentiation
            of mesenchymal stem cells (MSCs).
REFERENCE   3  (bases 1 to 7454)
  AUTHORS   Cronje HT, Karhunen V, Hovingh GK, Coppieters K, Lagerstedt JO,
            Nyberg M and Gill D.
  TITLE     Genetic evidence implicating natriuretic peptide receptor-3 in
            cardiovascular disease risk: a Mendelian randomization study
  JOURNAL   BMC Med 21 (1), 158 (2023)
   PUBMED   37101178
  REMARK    GeneRIF: Genetic evidence implicating natriuretic peptide
            receptor-3 in cardiovascular disease risk: a Mendelian
            randomization study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7454)
  AUTHORS   Ryan RM, Paintlia MK, Newton DA, Spyropoulos DD, Kemp M, Jobe AH
            and Baatz JE.
  TITLE     Oxygen and steroids affect the regulatory role of natriuretic
            peptide receptor-C on surfactant secretion by type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (1), L13-L22 (2022)
   PUBMED   34668435
  REMARK    GeneRIF: Oxygen and steroids affect the regulatory role of
            natriuretic peptide receptor-C on surfactant secretion by type II
            cells.
REFERENCE   5  (bases 1 to 7454)
  AUTHORS   Li S, Guo R, Peng Z, Quan B, Hu Y, Wang Y and Wang Y.
  TITLE     NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma
            cell growth through blocking the PI3K/AKT pathway
  JOURNAL   Cell Signal 86, 110074 (2021)
   PUBMED   34229087
  REMARK    GeneRIF: NPR3, transcriptionally regulated by POU2F1, inhibits
            osteosarcoma cell growth through blocking the PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 7454)
  AUTHORS   Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai
            H, Saito Y, Kambayashi Y, Inouye K et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   7  (bases 1 to 7454)
  AUTHORS   Bennett BD, Bennett GL, Vitangcol RV, Jewett JR, Burnier J, Henzel
            W and Lowe DG.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 7454)
  AUTHORS   Lowe DG, Klisak I, Sparkes RS, Mohandas T and Goeddel DV.
  TITLE     Chromosomal distribution of three members of the human natriuretic
            peptide receptor/guanylyl cyclase gene family
  JOURNAL   Genomics 8 (2), 304-312 (1990)
   PUBMED   1979052
REFERENCE   9  (bases 1 to 7454)
  AUTHORS   Porter JG, Arfsten A, Fuller F, Miller JA, Gregory LC and Lewicki
            JA.
  TITLE     Isolation and functional expression of the human atrial natriuretic
            peptide clearance receptor cDNA
  JOURNAL   Biochem Biophys Res Commun 171 (2), 796-803 (1990)
   PUBMED   2169733
REFERENCE   10 (bases 1 to 7454)
  AUTHORS   Lowe DG, Camerato TR and Goeddel DV.
  TITLE     cDNA sequence of the human atrial natriuretic peptide clearance
            receptor
  JOURNAL   Nucleic Acids Res 18 (11), 3412 (1990)
   PUBMED   2162522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008766.4, AF025998.1 and
            AC026703.4.
            
            On May 31, 2019 this sequence version replaced NM_000908.3.
            
            Summary: This gene encodes one of three natriuretic peptide
            receptors. Natriutetic peptides are small peptides which regulate
            blood volume and pressure, pulmonary hypertension, and cardiac
            function as well as some metabolic and growth processes. The
            product of this gene encodes a natriuretic peptide receptor
            responsible for clearing circulating and extracellular natriuretic
            peptides through endocytosis of the receptor. Multiple transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            resulting protein (isoform 2) is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52282.1, AF025998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AC008766.4         109302-109757
            457-2079            AF025998.1         1-1623
            2080-7454           AC026703.4         63940-69314         c
FEATURES             Location/Qualifiers
     source          1..7454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..7454
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="natriuretic peptide receptor 3"
                     /db_xref="GeneID:4883"
                     /db_xref="HGNC:HGNC:7945"
                     /db_xref="MIM:108962"
     exon            1..1225
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2079
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; atrial natriuretic peptide receptor 3; atrial
                     natriuretic peptide receptor type C; atrial natriuretic
                     peptide clearance receptor; natriuretic peptide receptor
                     C/guanylate cyclase C (atrionatriuretic peptide receptor
                     C)"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 3 isoform 2
                     precursor"
                     /protein_id="NP_000899.1"
                     /db_xref="CCDS:CCDS47196.1"
                     /db_xref="GeneID:4883"
                     /db_xref="HGNC:HGNC:7945"
                     /db_xref="MIM:108962"
                     /translation="MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQE
                     REALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVA
                     YEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGAL
                     AAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLE
                     GVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHR
                     HGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEK
                     FSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQT
                     WNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKY
                     PWGPLKLRIDENRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYR
                     ITIERRTQQEESNLGKHRELREDSIRSHFSVA"
     exon            1226..1348
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1515
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1651
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1746
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1882
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1967
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..7454
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7438..7443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="hexamer: AATACA"
     polyA_site      7454
                     /gene="NPR3"
                     /gene_synonym="ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23;
                     GUCY2B; NPR-C; NPRC"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgaatc aatgagatca aatgcgaggg agatgcaccg tcaattacaa acacttggac
       61 aagtctaact ttttttttct tctacaaaaa cgctttcaaa agcaacctta gcaacgccca
      121 aataagaagc cacctctaag caaaatagta tatgtataaa cggagggcga atatatacaa
      181 gtatatatat atgtatatta cagacgcaca ggtttacacc cggtgaactt tttctttttc
      241 tttttctttt ttttttaaga aaaactagtg acattgcaga gaaggacgct tcctctctat
      301 cttttggcgc attagtgaag ggggtattct attttgttaa agcgcccaag ggggcgcagg
      361 gaccttggag agaagagtgg ggaggaaaga ggaagggtgg gtggggggca gagggcgagt
      421 cggcggcggc gagggcaagc tctttcttgc ggcacgatgc cgtctctgct ggtgctcact
      481 ttctccccgt gcgtactact cggctgggcg ttgctggccg gcggcaccgg tggcggtggc
      541 gttggcggcg gcggcggtgg cgcgggcata ggcggcggac gccaggagag agaggcgctg
      601 ccgccacaga agatcgaggt gctggtgtta ctgccccagg atgactcgta cttgttttca
      661 ctcacccggg tgcggccggc catcgagtat gctctgcgca gcgtggaggg caacgggact
      721 gggaggcggc ttctgccgcc gggcactcgc ttccaggtgg cttacgagga ttcagactgt
      781 gggaaccgtg cgctcttcag cttggtggac cgcgtggcgg cggcgcgggg cgccaagcca
      841 gaccttatcc tggggccagt gtgcgagtat gcagcagcgc cagtggcccg gcttgcatcg
      901 cactgggacc tgcccatgct gtcggctggg gcgctggccg ctggcttcca gcacaaggac
      961 tctgagtact cgcacctcac gcgcgtggcg cccgcctacg ccaagatggg cgagatgatg
     1021 ctcgccctgt tccgccacca ccactggagc cgcgctgcac tggtctacag cgacgacaag
     1081 ctggagcgga actgctactt caccctcgag ggggtccacg aggtcttcca ggaggagggt
     1141 ttgcacacgt ccatctacag tttcgacgag accaaagact tggatctgga agacatcgtg
     1201 cgcaatatcc aggccagtga gagagtggtg atcatgtgtg cgagcagtga caccatccgg
     1261 agcatcatgc tggtggcgca caggcatggc atgaccagtg gagactacgc cttcttcaac
     1321 attgagctct tcaacagctc ttcctatgga gatggctcat ggaagagagg agacaaacac
     1381 gactttgaag ctaagcaagc atactcgtcc ctccagacag tcactctact gaggacagtg
     1441 aaacctgagt ttgagaagtt ttccatggag gtgaaaagtt cagttgagaa acaagggctc
     1501 aatatggagg attacgttaa catgtttgtt gaaggattcc acgatgccat cctcctctac
     1561 gtcttggctc tacatgaagt actcagagct ggttacagca aaaaggatgg agggaaaatt
     1621 atacagcaga cttggaacag aacatttgaa ggtatcgccg ggcaggtgtc catagatgcc
     1681 aacggagacc gatatgggga tttctctgtg attgccatga ctgatgtgga ggcgggcacc
     1741 caggaggtta ttggtgatta ttttggaaaa gaaggtcgtt ttgaaatgcg gccgaatgtc
     1801 aaatatcctt ggggcccttt aaaactgaga atagatgaaa accgaattgt agagcataca
     1861 aacagctctc cctgcaaatc atgtggccta gaagaatcgg cagtgacagg aattgtcgtg
     1921 ggggctttac taggagctgg cttgctaatg gccttctact ttttcaggaa gaaatacaga
     1981 ataaccattg agaggcgaac ccagcaagaa gaaagtaacc ttggaaaaca tcgggaatta
     2041 cgggaagatt ccatcagatc ccatttttca gtagcttaaa ggaagccccc cacttttttt
     2101 ttttctgcct gagattcttt aaggagatag acgggttgaa agacatcaat gaaacagaag
     2161 gggcgttctt gaagaattca taattttaag cagttagtaa tttcatttta aaatttctgt
     2221 agaagctcag gaattatgat taatcaccat ctgcctccag gcctttcatc tcatgacaaa
     2281 caaatataat aatgatatcg tgtcactctg ttaaatgttc atactgtttc aagcccatat
     2341 gattagattt atgtttttaa aatctgttgt ctccatatct tgatggcttt tgggagcatt
     2401 tcacacaagg atataaaatg cggttttctt aaatgaaatg ttttgtagct agaataaaat
     2461 catttttaca agtacagcat tcttggaaag aatttaacac ccaaaaaggg gaaaatgtaa
     2521 tgaaaaatct caaggttgga aatacagcct tactctctct agagctggag gacaggtttg
     2581 tggttgagga cttctctgtc cgatgtctac attcaggttc tgacttcata tcttgaaaaa
     2641 ggatttcctc cctgtctttt tcagtgtctc ataaacgcta ctctggattg ttgtaaatat
     2701 tagtgagatg ggaggattta cagaagaaaa gcaagtcaaa aatatttcct ttttgatgta
     2761 aaaaaaaaaa gccctatttc gcactaacat tttattttac aagtatttta atcttatatt
     2821 ttggtattag aaaaatttgt ctattttttc attttgaaga ttaaatgttg cttacatttt
     2881 aaaagcatgg gtgaagtgta caacaaacca ataatgataa aaaatacttc tctttttctc
     2941 cctgtttccc tttttccctt ggccacagcc aaatgctaat tgctgcttta attacagaga
     3001 tgtgtaaatg tattcagatt acaaactcta caggaataca tcaacatttt aactcttttg
     3061 cgtttttact gtttaactgt tttaaatgca agttatttta gggtgacact ccttccagtt
     3121 ctggccagat catgagtttc aagatcaaga gtaaaaagtt attagaatta aacagtttta
     3181 taaagggagg cagccctttt ccctcaagaa caactttgtt gagagttact acttgacagc
     3241 aagcacagaa atgacaaatt taaaactttt acacatggca tttaccaaaa ttcccagtga
     3301 ttattttgtt taaaagaggg aacctaaata tctactctat tccctttcag ttaactccac
     3361 agaactttgt aggcatccat gaatacctgt aatagtgggt taggtgtgga gataaggaat
     3421 ttggacaaag ttgagtaagt ttttactggg tatctgcttt gcacccagta gtctgcaaca
     3481 tgagtttaaa ctcaggttac tactttcact tatactttat ggagaagata gacagtgagg
     3541 gaggaatggg aagctgtcat gagagtgcac cgtcttggaa ttacataact ggggtctttc
     3601 ctcaataaca ttttgagcat ctgaaaaata gtttaaaaaa ttgtcttaat atctattaaa
     3661 aggcatgtct agtgaggaaa caggagagtc tgagcaatcc cttggtggcg atgaaggtgg
     3721 tagttcacac aagtaacagt ggaggcaaag gtaagcgcaa gctgcctgtc ccagatgctg
     3781 gcccatgtgt gagtgcttcc ctggagaagt ccgcttctgt tgctcccacc tgagtcacag
     3841 ttaacagatt atttctgtgt gaggcacatt tcccttctgt tgtttaagaa atgggagctg
     3901 ggaggcagct gagagggcgt gataaaagaa ttaagtgtga tcaactgaaa caactatgtt
     3961 gtagttctcc atgctggatg caaaggaaaa agtgtcgaat tccaaaaagg atggaagaag
     4021 aaggcaagaa gggcaaactc cagaagttct agtgcaggaa gagagtttga gaagtaaaat
     4081 ccaggcaagc aaagcgttgt accacttggg actccccaaa gtgaaacagc aaggaaggat
     4141 tgtgtccatc ttacttactt gaattggaga gcttgtttct ctctcatttt tatttttcaa
     4201 tgatgttttc tttatatttt agagatattc attttctctt atcttgtgct tgtaaaaagc
     4261 atttacattt caagtctatg tgcttattac aggggaaaaa taatctacct ggttgcagtc
     4321 tttgagtata aacatttcta acctttttaa aacttctata gcagcccatt aacactaaca
     4381 tttttagagc aaatatattc tattttaact tcaggtagag gaatagtcct aaacttaata
     4441 tgatagctct agataagatc ttagagataa gtgagcattt agtattctaa aagtggcaga
     4501 acaaatcatg aggtttctgg atgctatacc aatttaaaat caattcttat gttaatattg
     4561 attgcttatt tacatgtcag tcatctactt tttttctttg aaatctgcat atgggttaca
     4621 aaaactctgt taggttttga aaattccatt aagttggaaa ccttggttaa aaatgtaggt
     4681 gcctggccca tggttaccct ggattcaggt ctctcatgat tatatttggg gatttacgtt
     4741 cctaactgct aagcaacatc tttgacaact agtaattcat actctactag tagtcacatg
     4801 tcatatagta aaataaatag ggctttagtt cttaagtaat tctataggat tttaccctga
     4861 aatccagggt gttcagattt caaaaaggat aatttatcag tattttctca tccagtcaaa
     4921 cttcagctga cattgataca ggtcaaaatg cgtagatgct ttttggtgtt ggaaataagt
     4981 gtctgtctta tggtcatcat tgtcttctta gatttttggg taggggggcc aggtaggggg
     5041 agactcagaa ataaaagcgt tccccagata acttcaatct ggaaagaatt ttttgtatag
     5101 agtccatctc tccctcaaga ctgaccacag gtttcatgag aaggtccctg aaaacatcac
     5161 atttctctga agaaccatca acttgtcttt tcttgaacca caggaatggt tctacagacc
     5221 ctactataat tcttcacatt tcagaaccca tgtttaatgg agggaagaga gaaatgcatg
     5281 ggaaaagaac acctcctttt ctcctttctc ttaaattcaa agacgtttgc tttggaatgc
     5341 cctcacttct ccctattcac aggcttctaa aatcattaat ttactcaagg cacatgtgcc
     5401 ttctttgccc caaatgcatc actttccttt tagttatggc tgattttggg tgtgtgtgtg
     5461 taagacatgc agtcaacaat gagatgaagg ccattgcata gatctcatgc agatagtgat
     5521 ggattcagaa agtaggttcc agtggcgtca ctaccttctt gtaagccagt atacactggc
     5581 tatttgtgga aatctctttg ggagatcaaa tagagtatta tgccactgtg agtgtttata
     5641 aactggaagg aacaagtacc tgtgtttctt gggacacaaa gcactcagat cctgagtgga
     5701 tgcagacatg agagtaaatg tcagcccaaa ttaggcccct cgacctacag acatttcatg
     5761 ggttttattt aatcacaccc catggtttgg ggctacatga ggaagttggt aatgagctga
     5821 atttcttatt cagtggaaaa aactgaaact gtctaaaaac acgggatata ttttagaggc
     5881 aattgtggaa gcggagagaa tgagatgatg gtgttcagag ggaccagctt ctttttcagt
     5941 tgtctttaga actcaagaat aatcaataat ttagtgcccc ttcaacagcc atactcagca
     6001 agaagaatca gaagcttgat cctctaacag aaatagaaga gggtagcttt gcccattgcc
     6061 actgtcttta ctgccccttc tgcccctcca cccacatcca cattcagcat cactccaagg
     6121 atgtgtcagc atcttgccca tgcaggtaga aatttgtgag taggcctcca tacttcctcg
     6181 ggggaagaaa gagaaactag tgctggtttt aagaatgtag ctggcttttc atcagaaccc
     6241 ttatgctaac ctgaccacac ttgctctcgg ggaagttcaa gcctgtgatg tgcataaact
     6301 ccaacaagcc tggctttggt gttcagcatg cacattccat aaatatctct tgcaggcata
     6361 ccccacagct agactgcagg attaaaataa cttccaaaag gtgctggatt ggagtttgtt
     6421 caaatttctc attaaccact aatgttaatt cataccaaat gcaaagtatt ctaaaccagc
     6481 tgatgctgtc agtgttcaag ttttaagtga cttcaaacac aatggaagtg tttcaatggg
     6541 agccagatct catgagtaaa aatccatttt ataatagctc tgtgatatat cagtgggaga
     6601 tgattcatag gggagagatt tgaacaagca gaattaagtg ttagcaaaaa tgctgcattg
     6661 ctttgattca tgtttaaaga cctaaatttc tatgcacaag gaataaaggg cctacttacc
     6721 aagtgtaaat cacaacatag gctaccaaaa tatttcttat ttgctaggag aacaaagctg
     6781 tcacggtgca tgatagttgg acagagatgg ctaaaaaaga ggcaaattca gatttggaaa
     6841 cagggtggcc tcttcattat ttattgccaa gatctgaaaa tcttcaacat cttataagac
     6901 aacaatgaag tagcccctga acagcatgga gttgctgtga gtttgttcgt tgcagacctt
     6961 tgtgttgggt cctgggaatc tgagctttgt tccctgtgca tggtggataa ttgaaaccaa
     7021 gaggacatgg gatagacctt gtgacagacc aattctgtga cccctgtctt ctgggtcaca
     7081 ttattcattg ttgatttaaa tacaggacta ccaaacagta caaatctatc atgagtctgg
     7141 tagaaaagta aaagtaaaag ctgcacacgt tacatactgt ttattgttct aatgtacaac
     7201 taactatttg catataatgt gatttaattt attgctgttt tgtgtagaaa aggagaacta
     7261 atgactgtgg atataaccca tgttttgtat aatatatttt atttcttgtg cgaactggtc
     7321 atttaaaata tctacttcat ttgatgtttg gatataaatg tgtatgtgtc cttgtaaatg
     7381 tttctatcaa gcaagaatgc cacgtactca gagtataaca atgtgttctc attaaaaaat
     7441 acatcccacg gaaa
//
