LOCUS       NM_003995               4248 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens natriuretic peptide receptor 2 (NPR2), transcript
            variant 1, mRNA.
ACCESSION   NM_003995
VERSION     NM_003995.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4248)
  AUTHORS   Chen,H., Zhang,S., Sun,Y., Chen,J., Yuan,K., Zhang,Y., Yang,X.,
            Lin,X. and Chen,R.
  TITLE     Novel pathogenic NPR2 variants in short stature patients and the
            therapeutic response to rhGH
  JOURNAL   Orphanet J Rare Dis 18 (1), 221 (2023)
   PUBMED   37501190
  REMARK    GeneRIF: Novel pathogenic NPR2 variants in short stature patients
            and the therapeutic response to rhGH.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4248)
  AUTHORS   Zhu,J., Meng,R., Zhao,H., Cai,L., Wen,X., Zeng,W., Luo,Y. and Qi,H.
  TITLE     Identification of Diagnostic Variants in FGFR2 and NPR2 Genes in a
            Chinese Family Affected by Crouzon Syndrome and Acromesomelic
            Dysplasia, Type Maroteaux
  JOURNAL   DNA Cell Biol 41 (11), 996-1006 (2022)
   PUBMED   36322898
  REMARK    GeneRIF: Identification of Diagnostic Variants in FGFR2 and NPR2
            Genes in a Chinese Family Affected by Crouzon Syndrome and
            Acromesomelic Dysplasia, Type Maroteaux.
REFERENCE   3  (bases 1 to 4248)
  AUTHORS   Stavber,L., Gaia,M.J., Hovnik,T., Jenko Bizjan,B., Debeljak,M.,
            Kovac,J., Omladic,J.S., Battelino,T., Kotnik,P. and Dovc,K.
  TITLE     Heterozygous NPR2 Variants in Idiopathic Short Stature
  JOURNAL   Genes (Basel) 13 (6), 1065 (2022)
   PUBMED   35741827
  REMARK    GeneRIF: Heterozygous NPR2 Variants in Idiopathic Short Stature.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4248)
  AUTHORS   Li,Q., Fan,X., Lu,W., Sun,C., Pei,Z., Zhang,M., Ni,J., Wu,J.,
            Yu,F.X. and Luo,F.
  TITLE     Novel NPR2 Gene Mutations Affect Chondrocytes Function via ER
            Stress in Short Stature
  JOURNAL   Cells 11 (8), 1265 (2022)
   PUBMED   35455946
  REMARK    GeneRIF: Novel NPR2 Gene Mutations Affect Chondrocytes Function via
            ER Stress in Short Stature.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4248)
  AUTHORS   Yuan,K., Chen,J., Chen,Q., Chen,H., Zhu,J., Fang,Y. and Wang,C.
  TITLE     NPR2 gene variants in familial short stature: a single-center study
  JOURNAL   J Pediatr Endocrinol Metab 35 (2), 185-190 (2021)
   PUBMED   34565054
  REMARK    GeneRIF: NPR2 gene variants in familial short stature: a
            single-center study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4248)
  AUTHORS   Koller,K.J. and Goeddel,D.V.
  TITLE     Molecular biology of the natriuretic peptides and their receptors
  JOURNAL   Circulation 86 (4), 1081-1088 (1992)
   PUBMED   1327579
  REMARK    Review article
REFERENCE   7  (bases 1 to 4248)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 4248)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   9  (bases 1 to 4248)
  AUTHORS   Lowe,D.G., Klisak,I., Sparkes,R.S., Mohandas,T. and Goeddel,D.V.
  TITLE     Chromosomal distribution of three members of the human natriuretic
            peptide receptor/guanylyl cyclase gene family
  JOURNAL   Genomics 8 (2), 304-312 (1990)
   PUBMED   1979052
REFERENCE   10 (bases 1 to 4248)
  AUTHORS   Chang,M.S., Lowe,D.G., Lewis,M., Hellmiss,R., Chen,E. and
            Goeddel,D.V.
  TITLE     Differential activation by atrial and brain natriuretic peptides of
            two different receptor guanylate cyclases
  JOURNAL   Nature 341 (6237), 68-72 (1989)
   PUBMED   2570358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133410.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 17, 2019 this sequence version replaced NM_003995.3.
            
            Summary: This gene encodes natriuretic peptide receptor B, one of
            two integral membrane receptors for natriuretic peptides. Both NPR1
            and NPR2 contain five functional domains: an extracellular
            ligand-binding domain, a single membrane-spanning region, and
            intracellularly a protein kinase homology domain, a helical hinge
            region involved in oligomerization, and a carboxyl-terminal
            guanylyl cyclase catalytic domain. The protein is the primary
            receptor for C-type natriuretic peptide (CNP), which upon ligand
            binding exhibits greatly increased guanylyl cyclase activity.
            Mutations in this gene are the cause of acromesomelic dysplasia
            Maroteaux type. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13436.1, SRR18074969.1661216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342694.7/ ENSP00000341083.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1485              AL133410.32        111472-112956
            1486-1691           AL133410.32        113779-113984
            1692-1805           AL133410.32        119499-119612
            1806-1941           AL133410.32        119903-120038
            1942-2036           AL133410.32        120270-120364
            2037-2169           AL133410.32        120590-120722
            2170-2254           AL133410.32        120951-121035
            2255-2375           AL133410.32        121524-121644
            2376-2450           AL133410.32        121807-121881
            2451-2528           AL133410.32        122087-122164
            2529-2633           AL133410.32        122384-122488
            2634-2705           AL133410.32        122613-122684
            2706-2865           AL133410.32        125392-125551
            2866-3021           AL133410.32        125711-125866
            3022-3190           AL133410.32        125946-126114
            3191-3337           AL133410.32        126273-126419
            3338-3461           AL133410.32        126904-127027
            3462-3530           AL133410.32        127211-127279
            3531-3705           AL133410.32        128390-128564
            3706-3804           AL133410.32        128636-128734
            3805-3896           AL133410.32        129037-129128
            3897-4248           AL133410.32        129261-129612
FEATURES             Location/Qualifiers
     source          1..4248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4248
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="natriuretic peptide receptor 2"
                     /db_xref="GeneID:4882"
                     /db_xref="HGNC:HGNC:7944"
                     /db_xref="MIM:108961"
     exon            1..1485
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     CDS             819..3962
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /EC_number="4.6.1.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; atrial natriuretic peptide receptor 2;
                     natriuretic peptide receptor B/guanylate cyclase B
                     (atrionatriuretic peptide receptor B); atrial natriuretic
                     peptide B-type receptor; atrial natriuretic peptide
                     receptor type B; guanylate cyclase 2B; guanylyl cyclase B"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 2 isoform 1
                     precursor"
                     /protein_id="NP_003986.2"
                     /db_xref="CCDS:CCDS6590.1"
                     /db_xref="GeneID:4882"
                     /db_xref="HGNC:HGNC:7944"
                     /db_xref="MIM:108961"
                     /translation="MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPR
                     VGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCV
                     YPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHF
                     NWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIR
                     ANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD
                     NRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIA
                     GCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDF
                     VLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDK
                     TPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYH
                     KGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLF
                     ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLI
                     NDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYA
                     KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKV
                     RNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSIL
                     DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEA
                     FDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMV
                     VSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGL
                     KMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGK
                     MRTYWLLGERKGPPGLL"
     exon            1486..1691
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1805
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1941
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2036
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2169
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2254
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2375
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2450
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2528
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2633
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2705
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2865
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3021
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3190
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3337
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3461
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3530
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3705
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3804
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3896
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4248
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4216..4221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="hexamer: TATAAA"
     regulatory      4227..4232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="hexamer: AATAAA"
     polyA_site      4236
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="major polyA site"
     polyA_site      4248
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
ORIGIN      
        1 gggagtcgca ctcggccgcc ggcgcagcga gcggagacgg gccgggccga ggcgacctga
       61 cccggacgag cggcgcgcgc ggggcccagg cggggggcgg gaggaagcgc cgggcagcgc
      121 cggccgccag ggcccaggag aagcggagca gagaggagcg gggacacggg cggggccgcc
      181 gtagctccgg atgggaccag cgcccgggcc cgttagtcca agcaggagct ccgggagaat
      241 ccttcacagg gagatttacc cctgccttcc cctgccctcc ggcccaggcc tcgcttcgct
      301 ccccgcctgc ccatgatccc agtccttccg cggcgcgggc accctcccac cttaccccct
      361 tggtcctatg tggcgcagcg ccctcctgcc ctcccggccc tttcagctgt gaggttcccc
      421 caggccgttt ctttgtacca cccgcccccc acccccaccc catcccagtc ccagatcccc
      481 ttttccttct cagctttaga tttatcaggc ttcttcacct cgcactgtcc ccatcctggc
      541 cgcaggcccc ctcggtccct ccctccccct gccaccccgt tctcagtcct cagtccttgc
      601 cctaggctgg tagcccactc cttgcccgcc ccccgccttc ctcccatctc cccctcctct
      661 ccccggcccc cagcaccttc tgcatcccag cctacctagc ctactcctcc tcttcctggc
      721 cctcttcccc aggctccagg ctggggggtg ctcgcgtctc ccctgtaggc cagagcagcc
      781 ccaagttctg ggggcggtgg ggctgctgct ttatccccat ggcgctgcca tcacttctgc
      841 tgttggtggc agccctggca ggtggggtgc gtcctcccgg ggcgcggaac ctgacgctgg
      901 cggtggtgct gccagaacac aacctgagct atgcctgggc ctggccacgg gtgggacccg
      961 ctgtggcact agctgtggag gctctgggcc gggcactgcc cgtggacctg cggtttgtca
     1021 gctccgaact ggaaggcgcc tgctctgagt acctggcacc gctgagcgct gtggacctca
     1081 agctgtacca tgaccccgac ctgctgttag gtcccggttg cgtgtaccct gctgcctctg
     1141 tggcccgctt tgcctcccac tggcgccttc ccctgctgac tgcgggtgct gtggcctctg
     1201 gtttttcggc taagaatgac cattatcgta ccctggttcg cactggcccc tctgctccca
     1261 agctgggtga gtttgtggtg acactacacg ggcacttcaa ttggactgcc cgtgctgcct
     1321 tgctgtacct ggatgctcgc acagatgacc ggcctcacta cttcaccatc gagggcgtct
     1381 ttgaggccct gcagggcagc aacctcagtg tgcagcacca ggtgtatgcc cgagagccag
     1441 ggggccccga gcaggccacc cacttcatcc gggccaacgg gcgcattgtg tatatctgcg
     1501 gccctctgga gatgctgcat gagatcctgc ttcaggccca gagggagaat ctgaccaatg
     1561 gggattatgt cttcttttac ctggatgtct ttggggagag tctccgtgca ggccccacac
     1621 gtgctacagg ccggccctgg caggacaatc gcacccggga acaggcccag gccctcagag
     1681 aggcctttca gactgtattg gtgatcacgt accgagaacc cccaaatcct gagtatcagg
     1741 aattccagaa tcgtctgctg ataagagccc gggaagactt tggtgtggag ctgggccctt
     1801 ccctgatgaa cctcatcgct ggctgcttct atgatgggat cctgctatat gctgaagtcc
     1861 tgaatgagac aatacaggaa ggaggcaccc gggaggatgg acttcgaatt gtggaaaaga
     1921 tgcagggacg aagatatcac ggtgtaactg ggctggttgt catggacaag aacaatgacc
     1981 gagagactga ctttgtcctc tgggccatgg gagacctgga ttctggggac tttcagcctg
     2041 cagcccacta ctcgggagct gagaagcaga tttggtggac gggacggcct attccctggg
     2101 tgaagggggc tcctccctcg gacaatcccc cctgtgcctt tgacttggac gacccatcct
     2161 gtgataaaac tccactttca accctggcaa ttgtggctct gggcacagga atcaccttca
     2221 tcatgtttgg tgtttccagc ttcctaattt tccgaaagct gatgctggag aaggagctgg
     2281 ctagcatgtt gtggcgtatt cgctgggaag aactgcagtt tggcaactca gagcgttatc
     2341 acaaaggtgc aggcagtcgc ctcacactgt cgctgcgggg atccagttac ggctcgctca
     2401 tgacagccca tgggaaatac cagatctttg ccaacaccgg tcacttcaag ggaaatgttg
     2461 tcgccatcaa acatgtgaat aagaagcgca ttgagctgac ccggcaggtt ctgtttgaac
     2521 tcaaacatat gagagatgtt cagttcaacc atctcactcg cttcattggc gcctgcatag
     2581 accctcccaa catttgcatt gtcactgaat actgtcctcg tgggagttta caggatattc
     2641 tagaaaatga cagcatcaac ttggactgga tgtttcgtta ttcactcatt aatgaccttg
     2701 ttaagggcat ggcctttctc cacaacagca ttatttcatc gcatgggagt ctcaagtcct
     2761 ccaactgtgt ggtggatagt cgttttgtgc tcaaaatcac agactatggc ctggccagct
     2821 tccgatcaac tgctgaacct gatgacagcc atgccctcta tgccaagaag ctgtggactg
     2881 ccccagaact gctcagtggg aaccccttgc caaccacagg catgcagaag gctgacgtct
     2941 atagctttgg gatcatcctg caggagatag cacttcgcag tggtcctttc tacttggagg
     3001 gcctggacct cagccccaaa gagattgtcc agaaggtacg aaatggtcag cggccatatt
     3061 tccggccaag cattgaccgg acccaactga atgaagagct agttttgctg atggagcgat
     3121 gttgggctca ggacccagct gagcggccag actttggaca gattaagggc ttcattcggc
     3181 gctttaacaa ggagggtggc accagcatat tggacaacct cctgctgcgc atggaacagt
     3241 atgccaataa cttggagaag ctggtggagg aacgcacaca ggcctatctg gaggaaaaac
     3301 gcaaggctga agctctgctc taccaaatcc taccccattc agtggcagag cagttaaaac
     3361 ggggagagac tgtacaggct gaggcctttg acagtgttac catctacttc agtgacattg
     3421 ttggcttcac agcattgtca gcagagagca cccccatgca ggtagtgaca cttcttaatg
     3481 acctgtatac ctgctttgat gccataattg acaactttga tgtctacaag gtggagacga
     3541 ttggggatgc ttacatggtg gtatctggcc tcccaggccg aaatggtcaa cgccatgcac
     3601 cagaaattgc tcgtatggcc ctagcattac tagatgcagt ttcttccttt cgcatccgcc
     3661 accgacccca tgaccagctg aggctacgca taggggtcca tactgggcca gtctgtgctg
     3721 gggttgttgg cctgaagatg ccccgttatt gtctttttgg agacacagtg aacactgctt
     3781 ctcgaatgga gtctaatggt caagcgctga agatccatgt ctcctctacc accaaggatg
     3841 ccctagatga gctaggatgc ttccagctag agcttcgggg ggatgtggaa atgaagggaa
     3901 aaggaaagat gcgaacatac tggctcttag gagagcggaa aggacctcct ggactcctgt
     3961 aaacccccat tctttccaag tcagatagtc ttctgctgct ggtacctggg tgggcaatgg
     4021 ccaccatgtc tgcacacacc agaaatggac attttcatat gcaatggaaa acagccacaa
     4081 aaaaacctac cttatatgga agttgtagcc ctctgcagct cagccctgta catatacctg
     4141 tccctctctg gcttggtccc cttcctccct actttctgta aatatctgta tctaaaccag
     4201 aatattttgg tcaaatataa aacaataata aaaaaagttc tgatgtca
//
